Iminooxymethylene anilides, process for preparing the same and their use

ABSTRACT

Iminooxymephyleneanilides of the formula I ##STR1## where the index and the substituents have the following meanings: n is 0, 1, 2, 3 or 4; 
     R is nitro, cyano, halogen, unsubst. or subst. alkyl, alkenyl, alkynyl, alkoxy, alkenyloxy, alkynyloxy or an unsubst. or subst. bridge bonded to two adjacent ring atoms; 
     X is a direct bond or CH 2 , O or NR a  ; 
     R a  is hydrogen, alkyl, alkenyl, alkynyl, cycloalkyl or cycloalkenyl; 
     R 1  is hydrogen, 
     unsubst. or subst. alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkenyl, alkylcarbonyl or alkoxycarbonyl; 
     R 2  is alkyl, alkenyl, alkynyl, cycloalkyl or cycloalkenyl, or in the case where X is NR a , additionally hydrogen; 
     R 3  is hydrogen, cyano, halogen, alkyl, haloalkyl, alkoxy, haloalkoxy, alkylthio, haloalkylthio or cycloalkyl; 
     R 4  is a 6- to 10-membered mono- or bicyclic, substituted heteroaromatic ring system, 
     and process and intermediates for their preparation and their use.

This is a National Stage Application under 35 U.S.C. §371, based onInternational Application No. PCT/EP 95/04,430, filed Nov. 10, 1995.

The present invention relates to iminooxymethyleneanilides of theformula I ##STR2## where the index and the substituents have thefollowing meanings: n is 0, 1, 2, 3 or 4, it being possible for thesubstituents R to be different if n is greater than 1;

R is nitro, cyano, halogen,

unsubst. or subst. alkyl, alkenyl, alkynyl, alkoxy, alkenyloxy,alkynyloxy or

in the case where n is 2 additionally an unsubst. or subst. bridgebonded to two adjacent ring atoms, which contains three or four membersfrom the group consisting of 3 or 4 carbon atoms, and 2 or 3 carbonatoms and 1 or 2 nitrogen, oxygen and/or sulfur atoms, it being possiblefor this bridge, together with the ring to which it is bonded, to form apartially unsaturated or aromatic radical;

X is a direct bond or CH₂, O or NR^(a) ;

R^(a) is hydrogen, alkyl, alkenyl, alkynyl, cycloalkyl or cycloalkenyl;

R¹ is hydrogen,

unsubst. or subst. alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkenyl,alkylcarbonyl or alkoxycarbonyl;

R² is alkyl, alkenyl, alkyziyl, cycloalkyl or cycloalkenyl, or in thecase where X is NR^(a), additionally hydrogen;

R³ is hydrogen, cyano, halogen, alkyl, haloalkyl, alkoxy, haloalkoxy,alkylthio, haloalkylthio or cycloalkyl;

R⁴ is a 6- to 10-membered mono- or bicyclic, heteroaromatic ring systemwhich is substituted by customary groups,

and processes for their preparation and their use.

WO-A 93/15,046 discloses anilides having fungicidal activity.

It is an object of the present invention to make available activecompounds having improved activity.

We have found that this object is achieved by the compounds I defined atthe beginning. We have additionally found processes for theirpreparation, compositions containing them and methods for their use, inparticular for controlling animal pests and harmful fungi.

The compounds I are obtainable by various methods. Compounds I, where R¹is not hydrogen, are particularly advantageously obtained by reacting amethyleneanilide of the formula II with an oxime of the formula III orits salt. ##STR3##

L¹ in the formula II is a leaving group, ie. a nucleophilicallyreplaceable group such as halogen (eg. chlorine, bromine or iodine), oran alkyl- or arylsulfonate (eg. methylsulfonate,trifluoromethylsulfonate, phenylsulfonate or 4-methylphenylsulfonate).

The oximes III can also be used in the form of their salts, eg. withinorganic acids, such as hydrochlorides, hydrobromides, hydrosulfatesand hydrophosphonates.

The reaction of the compounds II and III is customarily carried out atfrom 0° C. to 80° C., preferably 20° C. to 60° C., in an inert solventin the presence of a base.

Suitable solvents are aromatic hydrocarbons such as toluene, o-, m- andp-xylene, halogenated hydrocarbons such as methylene chloride,chloroform and chlorobenzene, ethers such as diethyl ether, diisopropylether, tert-butyl methyl ether, dioxane, anisole and tetrahydrofuran,nitrites such as acetonitrile and propionitrile, alcohols such asmethanol, ethanol, n-propanol, i-propanol, n-butanol and tert-butanol,ketones such as acetone and methyl ethyl ketone, and dimethyl sulfoxide,dimethylformamide, dimethylacetamide, 1,3-dimethylimidazolidin-2-one and1,2-dimethyltetrahydro-2(1H)-pyrimidine, preferably methylene chloride,acetone, toluene, tert-butyl methyl ether and dimethylformamide.Mixtures of the solvents mentioned can also be used.

Suitable bases are generally inorganic compounds such as alkali metaland alkaline earth metal hydroxides (eg. lithium hydroxide, sodiumhydroxide, potassium hydroxide and calcium hydroxide), alkali metal andalkaline earth metal oxides (eg. lithium oxide, sodium oxide, calciumoxide and magnesium oxide), alkali metal and alkaline earth metalhydrides (eg. lithium hydride, sodium hydride, potassium hydride andcalcium hydride), alkali metal amides (eg. lithium amide, sodium amideand potassium amide), alkali metal and alkaline earth metal carbonates(eg. lithium carbonate and calcium carbonate) and also alkali metalhydrogen carbonates (eg. sodium hydrogen carbonate), organometalliccompounds, in particular alkali metal alkyls (eg. methyllithium,butyllithium and phenyllithium), alkylmagnesium halides (eg.methylmagnesium chloride) and also alkali metal and alkaline earth metalalkoxides (eg. sodium methoxide, sodium ethoxide, potassium ethoxide,potassium tert-butoxide and dimethoxymagnesium), additionally organicbases, eg. tertiary amines such as trimethylamine, triethylamine,triisopropylethylamine and N-methylpiperidine, pyridine, substitutedpyridines such as collidine, lutidine and 4-dimethylaminopyridine aswell as bicyclic amines.

Particularly preferred bases are sodium hydroxide, potassium carbonateand potassium tert-butoxide.

The bases are in general used in an equimolar amount, in an excess or ifappropriate as solvents.

It can be advantageous for the reaction to add a catalytic amount of acrown ether (eg. 18-crown-6 or 15-crown-5).

The reaction can also be carried out in two-phase systems consisting ofa solution of alkali metal or alkaline earth metal hydroxides orcarbonates in water and an organic phase (eg. aromatic and/orhalogenated hydrocarbons). Suitable phase-transfer catalysts in thiscase are, for example, ammonium halides and tetrafluoroborates (eg.benzyltriethylammonium chloride, benzyltributylammonium bromide,tetrabutylammonium chloride, hexadecyltrimethylammonium bromide ortetrabutylammonium tetrafluoroborate) and phosphonium halides (eg.tetrabutylphosphonium chloride and tetraphenylphosphonium bromide).

The starting substances II needed for the preparation of the compounds Iare disclosed in WO-A 93/15,046 or can be prepared by the methodsdescribed there.

The oximes III and their salts are disclosed in the literature WO-A92/13,830, WO-A 92/18,487, WO-A 94/08,968 and Comprehensive HeterocyclicChemistry, Vol. 13, pp. 1-572 (1984); A. Weissberger et al., TheChemistry of Heterocyclic Compounds, Verlag John Wiley & Sons; E. Rodd,Heterocyclic Compounds, Vol. IV^(c), Elsevier Publishing Company (1960);E. Rodd, Heterocyclic Compounds, Vol. IV^(b), Elsevier PublishingCompany (1959)! or can be prepared by the methods described there.

It can be advantageous for the reaction first to convert the oxime IIIor its salt with the base into the corresponding base, which is thenreacted with the benzyl derivative II.

The compounds I can contain acidic or basic centers and accordingly formacid addition products or base addition products or salts.

Acids for acid addition products are, inter alia, mineral acids (eg.halohydric acids such as hydrochloric and hydrobromic acid, phosphoricacid, sulfuric acid, nitric acid), organic acids (eg. formic acid,acetic acid, oxalic acid, malonic acid, lactic acid, malic acid,succinic acid, tartaric acid, citric acid, salicylic acid,p-toluenesulfonic acid, dodecylbenzenesulfonic acid) or otherproton-acidic compounds (eg. saccharin).

Alternatively, the compounds I, where R¹ is hydrogen, can be obtained byconverting a nitrobenzene IV with an oxime III into the correspondingoxime ether V, reducing V in a manner known per se to the hydroxylamineVI and then reacting VI with an acylating agent VIIa or with anisocyanate VIIb or with a cyanate VIIc to give I. ##STR4##

L² in the formula IV is a leaving group, ie. a nucleophilicallyreplaceable group such as halogen (eg. chlorine, bromine or iodine), oran alkyl- or arylsulfonate (eg. methylsulfonate,trifluoromethylsulfonate, phenylsulfonate or 4-methylphenylsulfonate).

L³ in the formula VIIa is halogen (eg. chlorine, bromine or iodine),phenoxy or the group R² XCO₂.

M⁺ in the formula VIIc is an equivalent of a metal ion (eg. an alkalimetal or alkaline earth metal ion such as sodium, potassium or calcium).

The reaction of the benzyl compounds IV with the oxime III is carriedout in general and in particular by the methods of reaction of thebenzyl compound II with the oximes III (see above).

The reduction of the nitroaromatics V to the hydroxylamines VI iscarried out either using zinc (in a similar manner to Bamberger et al.,Am. Chem. 316 (1901), 278) or using hydrogen in the presence of suitablecatalysts, eg. platinum (similarly to EP 85 890).

The reaction of the hydroxylamines VI with the carbonyl compounds VIIaor VIIb or the cyanate VIIc is preferably carried out under alkalineconditions at from -40° to 60° C., preferably -10° to 30° C.

The preparation of the compounds I where R¹ is not hydrogen is carriedout by reacting a compound of the formula I, where R¹ is hydrogen, in amanner known per se with a compound VIII.

Suitable solvents are aromatic hydrocarbons such as toluene, o-, m- andp-xylene, halogenated hydrocarbons such as methylene chloride,chloroform and chlorobenzene, ethers such as diethyl ether, diisopropylether, tert-butyl methyl ether, dioxane, anisole and tetrahydrofuran,nitriles such as acetonitrile and propionitrile, alcohols such asmethanol, ethanol, n-propanol, i-propanol, n-butanol and tert-butanol,ketones such as acetone and methyl ethyl ketone, and dimethyl sulfoxide,dimethylformamide, dimethylacetamide, 1,3-dimethylimidazolidin-2-one and1,2-dimethyltetrahy-dro-2(1H)-pyrimidine, preferably methylene chloride,acetone, toluene, tert-butyl methyl ether and dimethylformamide.Mixtures of the solvents mentioned can also be used.

Preferred solvents are inert solvents, eg. toluene, methylene chloride,methyl t-butyl ether, acetonitrile, cyclohexane, acetone,tetrahydrofuran, dimethylformamide or N-methylpyrrolidone.

Suitable bases are generally inorganic compounds such as alkali metaland alkaline earth metal hydroxides (eg. lithium hydroxide, sodiumhydroxide, potassium hydroxide and calcium hydroxide), alkali metal andalkaline earth metal oxides (eg. lithium oxide, sodium oxide, calciumoxide and magnesium oxide), alkali metal and alkaline earth metalhydrides (eg. lithium hydride, sodium hydride, potassium hydride andcalcium hydride), alkali metal amides (eg. lithium amide, sodium amideand potassium amide), alkali metal and alkaline earth metal carbonates(eg. lithium carbonate and calcium carbonate) and also alkali metalhydrogen carbonates (eg. sodium hydrogen carbonate), organometalliccompounds, in particular alkali metal alkyls (eg. methyllithium,butyllithium and phenyllithium), alkylmagnesium halides (eg.methylmagnesium chloride) and also alkali metal and alkaline earth metalalkoxides (eg. sodium methoxide, sodium ethoxide, potassium ethoxide,potassium tert-butoxide and dimethoxymagnesium), additionally organicbases, eg. tertiary amines such as trimethylamine, triethylamine,triisopropylethylamine and N-methylpiperidine, pyridine, substitutedpyridines such as collidine, lutidine and 4-dimethylaminopyridine aswell as bicyclic amines.

Particularly preferred bases are triethylamine, morpholine,ethyldiisopropylamine, sodium hydroxide, potassium carbonate, potassiumtert-butoxide, sodium carbonate, sodium hydrogen carbonate, potassiumhydrogen carbonate, potassium phosphate, dipotassium hydrogen phosphateor potassium dihydrogen phosphate.

The bases are in general used in an equimolar amount, in an excess or ifappropriate as solvents.

The reaction can also be carried out in two-phase systems consisting ofa solution of alkali metal or alkaline earth metal hydroxides orcarbonates in water and an organic phase (eg. aromatic and/orhalogenated hydrocarbons). Suitable phase-transfer catalysts in thiscase are, for example, ammonium halides and tetrafluoroborates (eg.benzyltriethylammonium chloride, benzyltributylammonium bromide,tetrabutylammonium chloride, hexadecyltrimethylammonium bromide ortetrabutylammonium tetrafluoroborate) and phosphonium halides (eg.tetrabutylphosphonium chloride and tetraphenylphosphonium bromide).##STR5##

L⁴ in the formula VIII is a leaving group, ie. a nucleophilicallyreplaceable group such as halogen (eg. chlorine, bromine or iodine),phenoxy or an alkyl- or arylsulfonate (eg. methylsulfonate,trifluoromethylsulfonate, phenylsulfonate or 4-methylphenylsulfonate).

The reaction of the compounds I (R¹ =H) to give the compounds I (R¹ ≠H)is carried out in general and in particular by the methods described forthe reaction of the hydroxylamines VI to give the compounds I (R¹ =H).

According to a further process, the compounds I are also obtained byfirst converting a methyleneanilide II with N-hydroxyphthalimide (IX)into the benzyl ether X, then hydrolyzing X with ammonia, hydrazine oran amine or with acid catalysis to the hydroxylamine ether XI and thenreacting XI with a carbonyl compound XII to give I. ##STR6##

The reaction of the benzyl compound II with N-hydroxyphthalimide IX iscarried out in general and in particular by the methods described forthe reaction of the benzyl compounds II with the oximes III.

The reaction of the N-hydroxyphthalimide ether XI to give thebenzyloxyamine XVa or its salts is carried out by the methods describedin EP 463 488.

The reaction of the benzyloxyamine XI with the carbonyl compounds O=CR³R⁴ is carried out in general and in particular according to theconditions for the reaction of the benzyl compounds II with the oximesIII.

Additionally, the reaction of the benzyloxyamine XI with the carbonylcompounds O=CR³ R⁴ can also be carried out under neutral or acidicconditions.

Suitable acidic catalysts are mineral acids, eg. hydrochloric acid,sulfuric acid, phosphoric acid or nitric acid, or alternatively organicacids, eg. formic acid, acetic acid, propionic acid, triethylaminehydrochloride, p-toluenesulfonic acid, methanesulfonic acid, citric acidor acidic ion exchangers.

The compounds I, where X is NR^(a), are additionally obtained, forexample, by first converting a methyleneanilide of the formula IIa withan oxime III into the corresponding oxime ether XIII and then reactingXIII with an amine XIV to give I. ##STR7##

L¹ in the formula IIa is a leaving group, ie. a nucleophilicallyreplaceable group such as halogen (eg. chlorine, bromine or iodine), oran alkyl- or arylsulfonate (eg. methylsulfonate,trifluoromethylsulfonate, phenylsulfonate or 4-methylphenylsulfonate).

The reaction of the methyleneanilides IIa with the oximes III is carriedout in general and in particular by the methods of reaction of thebenzyl compounds II with the oximes III.

The reaction of the compounds XIII with the amines of the formulaHNR^(a) R² is carried out at from 0° C. to 100° C. in an inert solventor in a solvent mixture.

Suitable solvents are, in particular, water, tert-butyl methyl ether andtoluene or mixtures thereof. It can be advantageous to improve thesolubility of the starting materials additionally to add one of thefollowing solvents (as solubilizers): tetrahydrofuran, methanol,dimethylformamide or ethylene glycol ether.

The amines XIV are customarily employed in an excess of up to 100% basedon the compounds XIII or can be used as solvents. With respect to theyield it can be advantageous to carry out the reaction under pressure.

Bases for base addition products are, inter alia, oxides, hydroxides,carbonates or hydrogencarbonates of alkali metals or alkaline earthmetals (eg. potassium or sodium hydroxide or potassium or sodiumcarbonate) or ammonium compounds (eg. ammonium hydroxide).

Acids for acid addition products are, inter alia, mineral acids (eg.hydrohalic acids such as hydrochloric and hydrobromic acid, phosphoricacid, sulfuric acid, nitric acid), organic acids (eg. formic acid,acetic acid, oxalic acid, malonic acid, lactic acid, malic acid,succinic acid, tartaric acid, citric acid, salicylic acid,p-toluenesulfonic acid, dodecylbenzenesulfonic acid) or otherproton-acidic compounds (eg. saccharin).

In the definitions of the symbols indicated in the above formulae, insome cases collective terms were used which are generally representativeof the following substituents:

Halogen: fluorine, chlorine, bromine or iodine;

Alkyl: saturated, straight-chain or branched hydrocarbon radicalspreferably having 1 to 10 carbon atoms, eg. methyl, ethyl, propyl,1-methylethyl, butyl, 1-methylpropyl, 2-methylpropyl and1,1-dimethylethyl;

Haloalkyl: straight-chain or branched alkyl groups preferably having 1to 10 carbon atoms (as mentioned above), it being possible in thesegroups for the hydrogen atoms to be partly or completely replaced byhalogen atoms as mentioned above, eg. C₁ -C₂ -haloalkyl such aschloromethyl, dichloromethyl, trichloromethyl, fluoromethyl,difluoromethyl, trifluoromethyl, chlorofluoromethyl,dichlorofluoromethyl, chlorodifluoromethyl, 1-fluoroethyl,2-fluoroethyl, 2,2-difluoroethyl, 2,2,2-trifluoroethyl,2-chloro-2-fluoroethyl, 2-chloro-2,2-difluoroethyl,2,2-dichloro-2-fluoroethyl, 2,2,2-trichloroethyl and pentafluoroethyl;

Alkylcarbonyl: straight-chain or branched alkyl groups preferably having1 to 10 carbon atoms (as mentioned above), which are bonded to thestructure via a carbonyl group (--CO--);

Alkoxy: straight-chain or branched alkyl groups preferably having 1 to10 carbon atoms (as mentioned above), which are bonded to the structurevia an oxygen atom (--O--);

Haloalkoxy: straight-chain or branched haloalkyl groups preferablyhaving 1 to 10 carbon atoms (as mentioned above), which are bonded tothe structure via an oxygen atom (--O--);

Alkoxycarbonyl: straight-chain or branched alkoxy groups preferablyhaving 1 to 10 carbon atoms (as mentioned above), which are bonded tothe structure via a carbonyl group (--CO--);

Alkylthio: straight-chain or branched alkyl groups preferably having 1to 10 carbon atoms (as mentioned above), which are bonded to thestructure via a sulfur atom (--S--);

Haloalkylthio: straight-chain or branched haloalkyl groups preferablyhaving 1 to 4 carbon atoms (as mentioned above), which are bonded to thestructure via a sulfur atom (--S--);

Alkenyl: unsaturated, straight-chain or branched hydrocarbon radicalspreferably having 2 to 10 carbon atoms and a double bond in any desiredposition, eg. C₂ -C₆ -alkenyl such as ethenyl, 1-propenyl, 2-propenyl,1-methylethenyl, 1-butenyl, 2-butenyl, 3-butenyl, 1-methyl-1-propenyl,2-methyl-1-propenyl, 1-methyl-2-propenyl, 2-methyl-2-propenyl,1-pentenyl, 2-pentenyl, 3-pentenyl, 4-pentenyl, 1-methyl-1-butenyl,2-methyl-1-butenyl, 3-methyl-1-butenyl, 1-methyl-2-butenyl,2-methyl-2-butenyl, 3-methyl-2-butenyl, 1-methyl-3-butenyl,2-methyl-3-butenyl, 3-methyl-3-butenyl, 1,1-dimethyl-2-propenyl,1,2-dimethyl-1-propenyl, 1,2-dimethyl-2-propenyl, 1-ethyl-1-propenyl,1-ethyl-2-propenyl, 1-hexenyl, 2-hexenyl, 3-hexenyl, 4-hexenyl,5-hexenyl, 1-methyl-1-pentenyl, 2-methyl-1-pentenyl,3-methyl-1-pentenyl, 4-methyl-1-pentenyl, 1-methyl-2-pentenyl,2-methyl-2-pentenyl, 3-methyl-2-pentenyl, 4-methyl-2-pentenyl,1-methyl-3-pentenyl, 2-methyl-3-pentenyl, 3-methyl-3-pentenyl,4-methyl-3-pentenyl, 1-methyl-4-pentenyl, 2-methyl-4-pentenyl,3-methyl-4-pentenyl, 4-methyl-4-pentenyl, 1,1-dimethyl-2-butenyl,1,1-dimethyl-3-butenyl, 1,2-dimethyl-1-butenyl, 1,2-dimethyl-2-butenyl,1,2-dimethyl-3-butenyl, 1,3-dimethyl-1-butenyl, 1,3-dimethyl-2-butenyl,1,3-dimethyl-3-butenyl, 2,2-dimethyl-3-butenyl, 2,3-dimethyl-1-butenyl,2,3-dimethyl-2-butenyl, 2,3-dimethyl-3-butenyl, 3,3-dimethyl-1-butenyl,3,3-dimethyl-2-butenyl, 1-ethyl-1-butenyl, 1-ethyl-2-butenyl,1-ethyl-3-butenyl, 2-ethyl-1-butenyl, 2-ethyl-2-butenyl,2-ethyl-3-butenyl, 1,1,2-trimethyl-2-propenyl,1-ethyl-1-methyl-2-propenyl, 1-ethyl-2-methyl-1-propenyl and1-ethyl-2-methyl-2-propenyl;

Alkenyloxy: straight-chain or branched alkenyl groups preferably having3 to 10 carbon atoms (as mentioned above), which are bonded to thestructure via an oxygen atom (--O--);

Alkynyl: straight-chain or branched hydrocarbon groups preferably having2 to 10 carbon atoms and a triple bond in any desired position, eg. C₂-C₆ -alkynyl such as ethynyl, 1-propynyl, 2-propynyl, 1-butynyl,2-butynyl, 3-butynyl, 1-methyl-2-propynyl, 1-pentynyl, 2-pentynyl,3-pentynyl, 4-pentynyl, 1-methyl-2-butynyl, 1-methyl-3-butynyl,2-methyl-3-butynyl, 3-methyl-1-butynyl, 1,1-dimethyl-2-propynyl,1-ethyl-2-propynyl, 1-hexynyl, 2-hexynyl, 3-hexynyl, 4-hexynyl,5-hexynyl, 1-methyl-2-pentynyl, 1-methyl-3-pentynyl,1-methyl-4-pentynyl, 2-methyl-3-pentynyl, 2-methyl-4-pentynyl,3-methyl-1-pentynyl, 3-methyl-4-pentynyl, 4-methyl-1-pentynyl,4-methyl-2-pentynyl, 1,1-dimethyl-2-butynyl, 1,1-dimethyl-3-butynyl,1,2-dimethyl-3-butynyl, 2,2-dimethyl-3-butynyl, 3,3-dimethyl-1-butynyl,1-ethyl-2-butynyl, 1-ethyl-3-butynyl, 2-ethyl-3-butynyl and1-ethyl-1-methyl-2-propynyl;

Alkynyloxy: straight-chain or branched alkynyl groups preferably having3 to 10 carbon atoms (as mentioned above), which are bonded to thestructure via an oxygen atom (--O--);

Cycloalkyl: mono- or bicyclic hydrocarbon radicals preferably having 3to 10 carbon atoms, eg. C₃ -C₁₀ -(bi)cycloalkyl such as cyclopropyl,cyclobutyl, cyclopentyl, cyclohexyl, cycloheptyl, bornanyl, norbornanyl,dicyclohexyl, bicyclo 3.3.0!octyl, bicyclo 3.2.1!octyl, bicyclo2.2.2!octyl or bicyclo 3.3.1!nonyl;

Cycloalkenyl: mono- or bicyclic hydrocarbon radicals preferably having 5to 10 carbon atoms and a double bond in any desired ring position, eg.C₅ -C₁₀ -(bi)cycloalkenyl such as cyclopentenyl, cyclohexenyl,cycloheptenyl, bornenyl, norbornenyl, dicyclohexenyl and bicyclo3.3.0!octenyl;

a bridge bonded to two adjacent ring atoms, which contains three or fourmembers from the group consisting of 3 or 4 carbon atoms, and 2 or 3carbon atoms and 1 or 2 nitrogen, oxygen and/or sulfur atoms, it beingpossible for this bridge, together with the ring to which it is bonded,to form a partially unsaturated or aromatic ring: eg. bridges which,with the ring to which they are bonded, for example form one of thefollowing systems: quinolinyl, benzofuranyl and naphthyl;

Heterocyclyl: 3- to 8-membered saturated or unsaturated heterocycles,containing one to three nitrogen atoms and/or one or two oxygen orsulfur atoms, such as 2-tetrahydrofuranyl,3-tetrahydrofuranyl,2-tetrahydrothienyl, 3-tetrahydrothienyl,2-pyrrolidinyl, 3-pyrrolidinyl, 3-isoxazolidinyl, 4-isoxazolidinyl,5-isoxazolidinyl, 3-isothiazolidinyl, 4-isothiazolidinyl,5-isothiazolidinyl, 3-pyrazolidinyl, 4-pyrazolidinyl, 5-pyrazolidinyl,2-oxazolidinyl, 4-oxazolidinyl, 5-oxazolidinyl, 2-thiazolidinyl,4-thiazolidinyl, 5-thiazolidinyl, 2-imidazolidiniyl, 4-imidazolidinyl,1,2,4-oxazolidin-3-yl, 1,2,4-oxadiazolidin-5-yl,1,2,4-thiadiazolidin-3-yl, 1,2,3-thiadiazolidin-5-yl,1,2,4-triazolidin-3-yl, 1,3,4-oxadiazolidin-2-yl,1,3,4-thiadiazolidin-2-yl, 1,3,4-triazolidin-2-yl, 2,3-dihydrofur-2-yl,2,3-dihydrofur-3-yl, 2,4-dihydrofur-2-yl, 2,4-dihydrofur-3-yl,2,3-dihydrothien-2-yl, 2,3-dihydrothien-3-yl, 2,4-dihydrothien-2-yl,2,4-dihydrothien-3-yl, 2,3-pyrrolin-2-yl, 2,3-pyrrolin-3-yl,2,4-pyrrolin-2-yl, 2,4-pyrrolin-3-yl, 2,3-isoxazolin-3-yl,3,4-isoxazolin-3-yl, 4,5-isoxazolin-3-yl, 2,3-isoxazolin-4-yl,3,4-isoxazolin-4-yl, 4,5-isoxazolin-4-yl, 2,3-isoxazolin-5-yl,3,4-isoxazolin-5-yl, 4,5-isoxazolin-5-yl, 2,3-isothiazolin-3-yl,3,4-isothiazolin-3-yl, 4,5-isothiazolin-3-yl, 2,3-isothiazolin-4-yl,3,4-isothiazolin-4-yl, 4,5-isothiazolin-4-yl, 2,3-isothiazolin-5-yl,3,4-isothiazolin-5-yl, 4,5-isothiazolin-5-yl, 2,3-dihydropyrazol-1-yl,2,3-dihydropyrazol-2-yl, 2,3-dihydropyrazol-3-yl,2,3-dihydropyrazol-4-yl, 2,3-dihydropyrazol-5-yl,3,4-dihydropyrazol-1-yl, 3,4-dihydropyrazol-3-yl,3,4-dihydropyrazol-4-yl, 3,4-dihydropyrazol-5-yl,4,5-dihydropyrazol-1-yl, 4,5-dihydropyrazol-3-yl,4,5-dihydropyrazol-4-yl, 4,5-dihydropyrazol-5-yl,2,3-dihydrooxazol-2-yl, 2,3-dihydrooxazol-3-yl, 2,3-dihydrooxazol-4-yl,2,3-dihydrooxazol-5-yl, 3,4-dihydrooxazol-2-yl, 3,4-dihydrooxazol-3-yl,3,4-dihydrooxazol-4-yl, 3,4-dihydrooxazol-5-yl, 3,4-dihydrooxazol-2-yl,3,4-dihydrooxazol-3-yl, 3,4-dihydrooxazol-4-yl, 2-piperidinyl,3-piperidinyl, 4-piperidinyl, 1,3-dioxan-5-yl, 2-tetrahydropyranyl,4-tetrahydropyranyl, 2-tetrahydrothienyl, 3-tetrahydropyridazinyl,4-tetrahydropyridazinyl, 2-tetrahydropyrimidinyl,4-tetrahydropyrimidinyl, 5-tetrahydropyrimidinyl, 2-tetrahydropyrazinyl,1,3,5-tetrahydro-triazin-2-yl and 1,2,4-tetrahydrotriazin-3-yl,preferably 2-tetrahydrofuranyl, 2-tetrahydrothienyl, 2-pyrrolidinyl,3-isoxazolidinyl, 3-isothiazolidinyl, 1,3,4-oxazolidin-2-yl,2,3-dihydrothien-2-yl, 4,5-isoxazolin-3-yl, 3-piperidinyl,1,3-dioxan-5-yl, 4-piperidinyl, 2-tetrahydropyranyl,4-tetrahydropyranyl, morpholinyl or 2,6-dimethylmorpholidinyl.

The bonding of the heteroaromatic or heterocyclic radical can beeffected via a carbon atom or a nitrogen atom of the heteroaromatic orheterocyclic radical.

a 6- to 10-membered mono- or bicyclic, heteroaromatic ring system:6-membered heteroaromatics which can additionally be benzofused or fusedto a further 5- or 6-membered heteroaromatic ring system, eg.

5-membered heteroaryl, containing one to three nitrogen atoms:5-membered ring heteroaryl groups which, besides carbon atoms, containone to three nitrogen atoms as ring members, eg. 2-pyrrolyl, 3-pyrrolyl,3-pyrazolyl, 4-pyrazolyl, 5-pyrazolyl, 2-imidazolyl, 4-imidazolyl,1,2,4-triazol-3-yl, 1,2,3-triazolyl and 1,3,4-triazol-2-yl;

5-membered heteroaryl, containing one to four nitrogen atoms or one tothree nitrogen atoms and a sulfur or an oxygen atom: 5-membered ringheteroaryl groups which, besides carbon atoms, can contain one to fournitrogen atoms or one to three nitrogen atoms and a sulfur or oxygenatom, or an oxygen or sulfur atom, as ring members, eg. 2-furyl,3-furyl, 2-thienyl, 3-thienyl, 2-pyrrolyl, 3-pyrrolyl, 3-isoxazolyl,4-isoxazolyl, 5-isoxazolyl, 3-isothiazolyl, 4-isothiazolyl,5-isothiazolyl, 3-pyrazolyl, 4-pyrazolyl, 5-pyrazolyl, 2-oxazolyl,4-oxazolyl, 5-oxazolyl, 2-thiazolyl, 4-thiazolyl, 5-thiazolyl,2-imidazolyl, 4-imidazolyl, 1,2,4-oxadiazol-3-yl, 1,2,4-oxadiazol-5-yl,1,2,4-thiadiazol-3-yl, 1,2,4-thiadiazol-5-yl, 1,2,4-triazol-3-yl,1,3,4-oxadiazol-2-yl, 1,3,4-thiadiazol-2-yl, 1,3,4- triazol-2-yl;

benzo-fused 5-membered heteroaryl, containing one to three nitrogenatoms or a nitrogen atom and/or an oxygen or sulfur atom: 5-memberedring heteroaryl groups which, besides carbon atoms, can contain one tofour nitrogen atoms, or one to three nitrogen atoms and a sulfur oroxygen atom or an oxygen or a sulfur atom as ring members, and in whichtwo adjacent carbon ring members or a nitrogen and an adjacent carbonring member can be bridged by a buta-1,3-diene-1,4-diyl group;

5-membered heteroaryl bonded via nitrogen, containing one to fournitrogen atoms, or benzo-fused 5-membered heteroaryl bonded vianitrogen, containing one to three nitrogen atoms: 5-membered ringheteroaryl groups which, besides carbon atoms, can contain one to fournitrogen atoms or one to three nitrogen atoms as ring members, and inwhich two adjacent carbon ring members or a nitrogen and an adjacentcarbon ring member can be bridged by a buta-1,3-diene-1,4-diyl group,these rings being bonded to the structure via one of the nitrogen ringmembers;

6-membered heteroaryl. containing one to three or one to four nitrogenatoms: 6-membered ring heteroaryl groups which, besides carbon atoms,can contain one to three or one to four nitrogen atoms as ring members,eg. 2-pyridinyl, 3-pyridinyl, 4-pyridinyl, 3-pyridazinyl, 4-pyridazinyl,2-pyrimidinyl, 4-pyrimidinyl, 5-pyrimidinyl, 2-pyrazinyl,1,3,5-triazin-2-yl and 1,2,4-triazin-3-yl;

benzo- or hetero-fused 6-membered heteroaryl, containing one to three orone to four nitrogen atoms and/or an oxygen or sulfur atom: 6-memberedring heteroaryl groups which, besides carbon atoms, can contain one tothree nitrogen atoms as ring members, and in which two adjacent carbonring members or a nitrogen and an adjacent carbon ring member can bebridged by a buta-1,3-diene-1,4-diyl group or a 3- to 4-memberedunsaturated chain which, besides carbon members, can contain, forexample, nitrogen atoms and/or an oxygen or sulfur atom, eg. indolyl,quinolinyl, isoquinolinyl and purinyl.

or the corresponding oxy, thio, carbonyl or sulfonyl groups.

The addition of unsubst. or subst. with respect to alkyl, alkenyl andalkynyl groups is intended to express that these groups can be partiallyor completely halogenated, ie. that the hydrogen atoms of these groupscan be partly or completely replaced by identical or different halogenatoms as mentioned above (preferably fluorine, chlorine or bromine)and/or can carry one to three (preferably one) of the followingradicals:

cyano, nitro, hydroxyl, amino, formyl, carboxyl, aminocarbonyl, alkoxy,haloalkoxy, alkylthio, haloalkylthio, alkylamino, dialkylamino,alkylcarbonyl, alkoxycarbonyl, alkylcarbonyloxy, alkylaminocarbonyl,dialkylaminocarbonyl, alkylcarbonylamino, alkoxycarbonylamino,alkylcarbonyl-N-alkylamino and alkylcarbonyl-N-alkylamino, and CR^(iii)= NOR^(iv), R^(iii) being hydrogen, alkyl, alkenyl, alkynyl orcycloalkyl and R^(iv) being alkyl, alkenyl, alkynyl or arylalkyl andsaid alkyl groups preferably containing 1 to 6 carbon atoms, inparticular 1 to 4 carbon atoms, and the alkenyl or alkynyl groupspreferably containing 2 to 6 carbon atoms and aryl in particular beingphenyl which is unsubstituted or can be substituted by customary groups;

unsubstituted or customarily substituted cycloalkyl, cycloalkoxy,cycloalkylthio, cycloalkylamino, cycloalkyl-N-alkylamino, heterocyclyl,heterocyclyloxy, heterocyclylthio, heterocyclylamino orheterocyclyl-N-alkylamino, the cyclic systems containing 3 to 12 ringmembers, preferably 2 to 8 ring members, in particular 3 to 6 ringmembers, and the alkyl groups in these radicals preferably containing 1to 6 carbon atoms, in particular 1 to 4 carbon atoms;

unsubstituted or customarily substituted aryl, aryloxy, arylthio,arylamino, aryl-N-alkylamino, arylalkoxy, arylalkylthio, arylalkylamino,arylalkyl-N-alkylamino, hetaryl, hetaryloxy, hetarylthio, hetarylamino,hetaryl-N-alkylamino, hetarylalkoxy, hetarylalkylthio,hetarylalkylamino, hetarylalkyl-N-alkylamino, arylcarbonyl,aryloxycarbonyl, arylcarbonyloxy, arylaminocarbonyl,N-aryl-N-alkylaminocarbonyl, arylcarbonyl-N-alkylamino,aryloxycarbonylamino, hetarylcarbonyl, hetaryloxycarbonyl,hetarylcarbonyloxy, hetarylaminocarbonyl,N-hetaryl-N-alkylaminocarbonyl, hetarylcarbonyl-N-alkylamino andhetaryloxycarbonylamino, the aryl radicals preferably containing 6 to 10ring members, in particular 6 ring members (phenyl), the hetarylradicals in particular containing 5 or 6 ring members and the alkylgroups in these radicals preferably containing 1 to 6 carbon atoms, inparticular 1 45 to 4 carbon atoms.

The addition of unsubst. or subst. with respect to the cyclic(saturated, unsaturated or aromatic) groups is intended to express thatthese groups can be partially or completely halogenated, ie. that thehydrogen atoms of these groups can be partly or completely replaced byidentical or different halogen atoms such as mentioned above (preferablyfluorine, chlorine or bromine, in particular fluorine or chlorine),and/or can carry one to four (in particular one to three) of thefollowing radicals cyano, nitro, hydroxyl, amino, carboxyl,aminocarbonyl, alkyl, haloalkyl, alkenyl, haloalkenyl, alkenyloxy,haloalkenyloxy, alkynyl, haloalkynyl, alkynyloxy, haloalkynyloxy,alkoxy, haloalkoxy, alkylthio, haloalkylthio, alkylamino, dialkylamino,alkylcarbonyl, alkoxycarbonyl, alkylcarbonyloxy, alkylaminocarbonyl,dialkylaminocarbonyl, alkylcarbonylamino, alkoxycarbonylamino,alkylcarbonyl-N-alkylamino and alkylcarbonyl- N-alkylamino, the alkylgroups in these radicals preferably containing 1 to 6 carbon atoms, inparticular 1 to 4 carbon atoms, and said alkenyl or alkynyl groups inthese radicals containing 2 to 8, preferably 2 to 6, in particular 2 to4 carbon atoms;

and/or one to three (in particular one) of the following radicals

unsubstituted or customarily substituted cycloalkyl, cycloalkoxy,cycloalkylthio, cycloalkylamino, cycloalkyl-N-alkylamino, heterocyclyl,heterocyclyloxy, heterocyclylthio, heterocyclylamino orheterocyclyl-N-alkylamino, the cyclic systems containing 3 to 12 ringmembers, preferably 2 to 8 ring members, in particular 3 to 6 ringmembers, and the alkyl groups in these radicals preferably containing 1to 6 carbon atoms, in particular 1 to 4 carbon atoms;

unsubstituted or customarily substituted aryl, aryloxy, arylthio,arylamino, aryl-N-alkylamino, arylalkoxy, arylalkylthio, arylalkylamino,arylalkyl-N-alkylamino, hetaryl, hetaryloxy, hetarylthio, hetarylamino,hetaryl-N-alkylamino, hetarylalkoxy, hetarylalkylthio,hetarylalkylamino, hetarylalkyl-N-alkylamino, arylcarbonyl,aryloxycarbonyl, arylcarbonyloxy, arylaminocarbonyl,Naryl-N-alkylaminocarbonyl, arylcarbonyl-N-alkylamino,aryloxycarbonylamino, hetarylcarbonyl, hetaryloxycarbonyl,hetarylcarbonyloxy, hetarylaminocarbonyl,N-hetaryl-N-alkylaminocarbonyl, hetarylcarbonyl-N-alkylamino andhetaryloxycarbonylamino, the aryl radicals preferably containing 6 to 10ring members, in particular 6 ring members (phenyl), the hetarylradicals in particular containing 5 or 6 ring members and the alkylgroups in these radicals preferably containing 1 to 6 carbon atoms, inparticular 1 to 4 carbon atoms,

and/or one or two (in particular one) of the following radicals

formyl or CR^(iii) =NOR^(iv), R^(iii) being hydrogen, alkyl, alkenyl,cycloalkyl or alkynyl and Riv being alkyl, alkenyl, alkynyl andarylalkyl and said alkyl groups preferably containing 1 to 6 carbonatoms, in particular 1 to 4 carbon atoms, and the alkenyl or alkynylgroups preferably containing 2 to 6 carbon atoms and aryl in particularbeing phenyl which is unsubstituted or customarily substituted,

or in which two adjacent C atoms of the cyclic systems can carry a C₃-C₅ -alkylene, C₃ -C₅ -alkenylene, oxy-C₂ -C₄ -alkylene, oxy-C₁ -C₃-alkyleneoxy, oxy-C₂ -C₄ -alkenylene, oxy-C₂ -C₄ -alkenyleneoxy orbutadiendiyl group, it being possible for these bridges in turn to bepartially or completely halogenated and/or to carry one to three, inparticular one or two, of the following radicals: C₁ -C₄ -alkyl, C₁ -C₄-haloalkyl, C₁ -C₄ -alkoxy, C₁ -C₄ -haloalkoxy and C₁ -C₄ -alkylthio.

Customary groups which are suitable as substituents of R⁴ are understoodas meaning the radicals mentioned above as possible substituents ofcyclic systems.

With respect to their biological action, preferred compounds I are thosewhere n is 0 or 1, in particular 0.

In the case where n is 1, preferred compounds I are those where R is oneof the following groups: fluorine, chlorine, cyano, methyl or methoxy.

Additionally, preferred compounds I where n is 1 are those where R is inthe 3- or 6-position relative to the anilide nitrogen.

In addition, preferred compounds I are those where X is oxygen.

Additionally, particularly preferred compounds I are those where X isNH.

Equally, compounds I are particularly preferred where X is CH₂.

In addition, particularly preferred compounds I are those where X is adirect bond.

In addition, preferred compounds I are those where R¹ is C₁ -C₄ -alkyl,in particular methyl.

Additionally, particularly preferred compounds I are those where R¹ ishydrogen.

Equally, compounds I are particularly preferred where R¹ is allyl,propargyl or methoxymethyl.

In addition, preferred compounds I are those where R² is C₁ -C ₄ -alkyl,in particular methyl.

Additionally, particularly preferred compounds I are those where R² iscyclopropyl.

Equally, compounds I are particularly preferred where R² istrifluoromethyl.

In addition, preferred compounds I are those where R³ is C₁ -C ₄ -alkyl,in particular methyl.

Additionally, particularly preferred compounds I are those where R³ iscyclopropyl.

Equally, compounds I are particularly preferred where R³ is cyano,trifluoromethyl, halogen, methoxy or methylthio.

In addition, preferred compounds I are those where R⁴ is substitutedpyrimidin-2-yl.

Additionally, particularly preferred compounds I are those where R⁴ issubstituted pyrimidin-4-yl.

Equally, compounds I are particularly preferred where R⁴ is substitutedpyrimidin-5-yl.

In addition, particularly preferred compounds I are those where R⁴ issubstituted pyridyl, 1,3,5-triazinyl or isoquinolinyl.

In addition, preferred compounds I are those where R⁴ is substituted bypyridin-2-yl.

Additionally, particularly preferred compounds I are those where R⁴ issubstituted by cyano, halogen, C₁ -C₆ -alkyl, C₂ -C₆ -alkenyl, C₂ -C₆-alkynyl, C₁ -C₆ -haloalkyl, C₂ -C₆ -haloalkenyl and C₂ -C₆-haloalkynyl.

Equally, compounds I are particularly preferred where R⁴ is substitutedby C₁ -C₆ -alkoxy, C₂ -C₆ -alkenyloxy, C₂ -C₆ -alkynyloxy, C₁ -C₆-haloalkoxy, C₂ -C₆ -haloalkenyloxy and C₂ -C₆ -haloalkynyloxy.

In addition, particularly preferred compounds I are those where R⁴ issubstituted by phenyl, phenoxy, hetaryl or hetaryloxy, it being possiblefor these groups in turn to be customarily substituted.

In particular, with respect to their use preferred compounds I are thosecompiled in the following tables. The groups mentioned for thesubstituents in these tables are additionally considered per se(independently of the combination in which they are mentioned) in eachcase to be a particular embodiment of the substituent concerned.

Table 1

Compounds of the formula I (n=0) where R¹ is hydrogen, R² X is methyl,R³ is hydrogen and R⁴ for a compound in each case corresponds to oneline of Table A.

Table 2

Compounds of the formula I (n=0) where R¹ is hydrogen, R² X is ethyl, R³is hydrogen and R⁴ for a compound in each case corresponds to one lineof Table A.

Table 3

Compounds of the formula I (n=0) where R¹ is hydrogen, R² X is methoxy,R³ is hydrogen and R⁴ for a compound in each case corresponds to oneline of Table A.

Table 4

Compounds of the formula I (n=0) where R¹ is hydrogen, R² X is ethoxy,R³ is hydrogen and R⁴ for a compound in each case corresponds to oneline of Table A.

Table 5

Compounds of the formula I (n=0) where R¹ is hydrogen, R² X ismethylamino, R³ is hydrogen and R⁴ for a compound in each casecorresponds to one line of Table A.

Table 6

Compounds of the formula I (n=0) where R¹ is methyl, R² X is methyl, R³is hydrogen and R⁴ for a compound in each case corresponds to one lineof Table A.

Table 7

Compounds of the formula I (n=0) where R¹ is methyl, R² X is ethyl, R³is hydrogen and R⁴ for a compound in each case corresponds to one lineof Table A.

Table 8

Compounds of the formula I (n=0) where R¹ is methyl, R² X is methoxy, R³is hydrogen and R⁴ for a compound in each case corresponds to one lineof Table A.

Table 9

Compounds of the formula I (n=0) where R¹ is methyl, R² X is ethoxy, R³is hydrogen and R⁴ for a compound in each case corresponds to one lineof Table A.

Table 10

Compounds of the formula I (n=0) where R¹ is methyl, R² X ismethylamino, R³ is hydrogen and R⁴ for a compound in each casecorresponds to one line of Table A.

Table 11

Compounds of the formula I (n=0) where R¹ is ethyl, R² X is methyl, R³is hydrogen and R⁴ for a compound in each case corresponds to one lineof Table A.

Table 12

Compounds of the formula I (n=0) where R¹ is ethyl, R² X is ethyl, R³ ishydrogen and R⁴ for a compound in each case corresponds to one line ofTable A.

Table 13

Compounds of the formula I (n=0) where R¹ is ethyl, R² X is methoxy, R³is hydrogen and R⁴ for a compound in each case corresponds to one lineof Table A.

Table 14

Compounds of the formula I (n=0) where R¹ is ethyl, R² X is ethoxy, R³is hydrogen and R⁴ for a compound in each case corresponds to one lineof Table A.

Table 15

Compounds of the formula I (n=0) where R¹ is ethyl, R² X is methylamino,R³ is hydrogen and R⁴ for a compound in each case corresponds to oneline of Table A.

Table 16

Compounds of the formula I where R_(n) is 3-chloro, R¹ is hydrogen, R² Xis methyl, R₃ is hydrogen and R⁴ for a compound in each case correspondsto one line of Table A.

Table 17

Compounds of the formula I where R_(n) is 3-chloro, R¹ is hydrogen, R² Xis ethyl, R³ is hydrogen and R⁴ for a compound in each case correspondsto one line of Table A.

Table 18

Compounds of the formula I where R_(n) is 3-chloro, R¹ is hydrogen, R² Xis methoxy, R³ is hydrogen and R⁴ for a compound in each casecorresponds to one line of Table A.

Table 19

Compounds of the formula I where R_(n) is 3-chloro, R¹ is hydrogen, R² Xis ethoxy, R³ is hydrogen and R⁴ for a compound in each case correspondsto one line of Table A.

Table 20

Compounds of the formula I where R_(n) is 3-chloro, R¹ is hydrogen, R² Xis methylamino, R³ is hydrogen and R⁴ for a compound in each casecorresponds to one line of Table A.

Table 21

Compounds of the formula I where R_(n) is 3-chloro, R¹ is methyl, R² Xis methyl, R³ is hydrogen and R⁴ for a compound in each case correspondsto one line of Table A.

Table 22

Compounds of the formula I where R_(n) is 3-chloro, R¹ is methyl, R² Xis ethyl, R³ is hydrogen and R⁴ for a compound in each case correspondsto one line of Table A.

Table 23

Compounds of the formula I where R_(n) is 3-chloro, R¹ is methyl, R² Xis methoxy, R³ is hydrogen and R⁴ for a compound in each casecorresponds to one line of Table A.

Table 24

Compounds of the formula I where R_(n) is 3-chloro, R¹ is methyl, R² Xis ethoxy, R³ is hydrogen and R⁴ for a compound in each case correspondsto one line of Table A.

Table 25

Compounds of the formula I where R_(n) is 3-chloro, R¹ is methyl, R² Xis methylamino, R³ is hydrogen and R⁴ for a compound in each casecorresponds to one line of Table A.

Table 26

Compounds of the formula I where R_(n) is 3-chloro, R¹ is ethyl, R² X ismethyl, R³ is hydrogen and R⁴ for a compound in each case corresponds toone line of Table A.

Table 27

Compounds of the formula I where R_(n) is 3-chloro, R¹ is ethyl, R² X isethyl, R³ is hydrogen and R⁴ for a compound in each case corresponds toone line of Table A.

Table 28

Compounds of the formula I where R_(n) is 3-chloro, R¹ is ethyl, R² X ismethoxy, R³ is hydrogen and R⁴ for a compound in each case correspondsto one line of Table A.

Table 29

Compounds of the formula I where R_(n) is 3-chloro, R¹ is ethyl, R² X isethoxy, R³ is hydrogen and R⁴ for a compound in each case corresponds toone line of Table A.

Table 30

Compounds of the formula I where R_(n) is 3-chloro, R¹ is ethyl, R² X ismethylamino, R³ is hydrogen and R⁴ for a compound in each casecorresponds to one line of Table A.

Table 31

Compounds of the formula I (n=0) where R¹ is hydrogen, R² X is methyl,R³ is cyano and R⁴ for a compound in each case corresponds to one lineof Table A.

Table 32

Compounds of the formula I (n=0) where R¹ is hydrogen, R² X is ethyl, R³is cyano and R⁴ for a compound in each case corresponds to one line ofTable A.

Table 33

Compounds of the formula I (n=0) where R¹ is hydrogen, R² X is methoxy,R³ is cyano and R⁴ for a compound in each case corresponds to one lineof Table A.

Table 34

Compounds of the formula I (n=0) where R¹ is hydrogen, R² X is ethoxy,R³ is cyano and R⁴ for a compound in each case corresponds to one lineof Table A.

Table 35

Compounds of the formula I (n=0) where R¹ is hydrogen, R² X ismethylamino, R³ is cyano and R⁴ for a compound in each case correspondsto one line of Table A.

Table 36

Compounds of the formula I (n=0) where R¹ is methyl, R² X is methyl, R³is cyano and R⁴ for a compound in each case corresponds to one line ofTable A.

Table 37

Compounds of the formula I (n=0) where R¹ is methyl, R² X is ethyl, R³is cyano and R⁴ for a compound in each case corresponds to one line ofTable A.

Table 38

Compounds of the formula I (n=0) where R¹ is methyl, R² X is methoxy, R³is cyano and R⁴ for a compound in each case corresponds to one line ofTable A.

Table 39

Compounds of the formula I (n=0) where R¹ is methyl, R² X is ethoxy, R³is cyano and R⁴ for a compound in each case corresponds to one line ofTable A.

Table 40

Compounds of the formula I (n=0) where R¹ is methyl, R² X ismethylamino, R³ is cyano and R⁴ for a compound in each case correspondsto one line of Table A.

Table 41

Compounds of the formula I (n=0) where R¹ is ethyl, R² X is methyl, R³is cyano and R⁴ for a compound in each case corresponds to one line ofTable A.

Table 42

Compounds of the formula I (n=0) where R¹ is ethyl, R² X is ethyl, R³ iscyano and R⁴ for a compound in each case corresponds to one line ofTable A.

Table 43

Compounds of the formula I (n=0) where R¹ is ethyl, R² X is methoxy, R³is cyano and R⁴ for a compound in each case corresponds to one line ofTable A.

Table 44

Compounds of the formula I (n=0) where R¹ is ethyl, R² X is ethoxy, R³is cyano and R⁴ for a compound in each case corresponds to one line ofTable A.

Table 45

Compounds of the formula I (n=0) where R¹ is ethyl, R² X is methylamino,R³ is cyano and R⁴ for a compound in each case corresponds to one lineof Table A.

Table 46

Compounds of the formula I where R_(n) is 3-chloro, R¹ is hydrogen, R² Xis methyl, R³ is cyano and R⁴ for a compound in each case corresponds toone line of Table A.

Table 47

Compounds of the formula I where R_(n) is 3-chloro, R¹ is hydrogen, R² Xis ethyl, R³ is cyano and R⁴ for a compound in each case corresponds toone line of Table A.

Table 48

Compounds of the formula I where R_(n) is 3-chloro, R¹ is hydrogen, R² Xis methoxy, R³ is cyano and R⁴ for a compound in each case correspondsto one line of Table A.

Table 49

Compounds of the formula I where R_(n) is 3-chloro, R¹ is hydrogen, R² Xis ethoxy, R³ is cyano and R⁴ for a compound in each case corresponds toone line of Table A.

Table 50

Compounds of the formula I where R_(n) is 3-chloro, R¹ is hydrogen, R² Xis methylamino, R³ is cyano and R⁴ for a compound in each casecorresponds to one line of Table A.

Table 51

Compounds of the formula I where R_(n) is 3-chloro, R¹ is methyl, R² Xis methyl, R³ is cyano and R⁴ for a compound in each case corresponds toone line of Table A.

Table 52

Compounds of the formula I where R_(n) is 3-chloro, R¹ is methyl, R² Xis ethyl, R³ is cyano and R⁴ for a compound in each case corresponds toone line of Table A.

Table 53

Compounds of the formula I where R_(n) is 3-chloro, R¹ is methyl, R² Xis methoxy, R³ is cyano and R⁴ for a compound in each case correspondsto one line of Table A.

Table 54

Compounds of the formula I where R_(n) is 3-chloro, R¹ is methyl, R² Xis ethoxy, R³ is cyano and R⁴ for a compound in each case corresponds toone line of Table A.

Table 55

Compounds of the formula I where R_(n) is 3-chloro, R¹ is methyl, R² Xis methylamino, R³ is cyano and R⁴ for a compound in each casecorresponds to one line of Table A.

Table 56

Compounds of the formula I where R_(n) is 3-chloro, R¹ is ethyl, R² X ismethyl, R³ is cyano and R⁴ for a compound in each case corresponds toone line of Table A.

Table 57

Compounds of the formula I where R_(n) is 3-chloro, R¹ is ethyl, R² X isethyl, R³ is cyano and R⁴ for a compound in each case corresponds to oneline of Table A.

Table 58

Compounds of the formula I where R_(n) is 3-chloro, R¹ is ethyl, R² X ismethoxy, R³ is cyano and R⁴ for a compound in each case corresponds toone line of Table A.

Table 59

Compounds of the formula I where R_(n) is 3-chloro, R¹ is ethyl, R² X isethoxy, R³ is cyano and R⁴ for a compound in each case corresponds toone line of Table A.

Table 60

Compounds of the formula I where R_(n) is 3-chloro, R¹ is ethyl, R² X ismethylamino, R³ is cyano and R⁴ for a compound in each case correspondsto one line of Table A.

Table 61

Compounds of the formula I (n=0) where R¹ is hydrogen, R² X is methyl,R³ is chloro and R⁴ for a compound in each case corresponds to one lineof Table A.

Table 62

Compounds of the formula I (n=0) where R¹ is hydrogen, R² X is ethyl, R³is chloro and R⁴ for a compound in each case corresponds to one line ofTable A.

Table 63

Compounds of the formula I (n=0) where R¹ is hydrogen, R² X is methoxy,R³ is chloro and R⁴ for a compound in each case corresponds to one lineof Table A.

Table 64

Compounds of the formula I (n=0) where R¹ is hydrogen, R² X is ethoxy,R³ is chloro and R⁴ for a compound in each case corresponds to one lineof Table A.

Table 65

Compounds of the formula I (n=0) where R¹ is hydrogen, R² X ismethylamino, R³ is chloro and R⁴ for a compound in each case correspondsto one line of Table A.

Table 66

Compounds of the formula I (n=0) where R¹ is methyl, R² X is methyl, R³is chloro and R⁴ for a compound in each case corresponds to one line ofTable A.

Table 67

Compounds of the formula I (n=0) where R¹ is methyl, R² X is ethyl, R³is chloro and R⁴ for a compound in each case corresponds to one line ofTable A.

Table 68

Compounds of the formula I (n=0) where R¹ is methyl, R² X is methoxy, R³is chloro and R⁴ for a compound in each case corresponds to one line ofTable A.

Table 69

Compounds of the formula I (n=0) where R¹ is methyl, R² X is ethoxy, R³is chloro and R⁴ for a compound in each case corresponds to one line ofTable A.

Table 70

Compounds of the formula I (n=0) where R¹ is methyl, R² X ismethylamino, R³ is chloro and R⁴ for a compound in each case correspondsto one line of Table A.

Table 71

Compounds of the formula I (n=0) where R¹ is ethyl, R² X is methyl, R³is chloro and R⁴ for a compound in each case corresponds to one line ofTable A.

Table 72

Compounds of the formula I (n=0) where R¹ is ethyl, R² X is ethyl, R³ ischloro and R⁴ for a compound in each case corresponds to one line ofTable A.

Table 73

Compounds of the formula I (n=0) where R¹ is ethyl, R² X is methoxy, R³is chloro and R⁴ for a compound in each case corresponds to one line ofTable A.

Table 74

Compounds of the formula I (n=0) where R¹ is ethyl, R² X is ethoxy, R³is chloro and R⁴ for a compound in each case corresponds to one line ofTable A.

Table 75

Compounds of the formula I (n=0) where R¹ is ethyl, R² X is methylamino,R³ is chloro and R⁴ for a compound in each case corresponds to one lineof Table A.

Table 76

Compounds of the formula I where R_(n) is 3-chloro, R¹ is hydrogen, R² Xis methyl, R³ is chloro and R⁴ for a compound in each case correspondsto one line of Table A.

Table 77

Compounds of the formula I where R_(n) is 3-chloro, R¹ is hydrogen, R² Xis ethyl, R³ is chloro and R⁴ for a compound in each case corresponds toone line of Table A.

Table 78

Compounds of the formula I where R_(n) is 3-chloro, R¹ is hydrogen, R² Xis methoxy, R³ is chloro and R⁴ for a compound in each case correspondsto one line of Table A.

Table 79

Compounds of the formula I where R_(n) is 3-chloro, R¹ is hydrogen, R² Xis ethoxy, R³ is chloro and R⁴ for a compound in each case correspondsto one line of Table A.

Table 80

Compounds of the formula I where R_(n) is 3-chloro, R¹ is hydrogen, R² Xis methylamino, R³ is chloro and R⁴ for a compound in each casecorresponds to one line of Table A.

Table 81

Compounds of the formula I where R_(n) is 3-chloro, R¹ is methyl, R² Xis methyl, R³ is chloro and R⁴ for a compound in each case correspondsto one line of Table A.

Table 82

Compounds of the formula I where R_(n) is 3-chloro, R¹ is methyl, R² Xis ethyl, R³ is chloro and R⁴ for a compound in each case corresponds toone line of Table A.

Table 83

Compounds of the formula I where R_(n) is 3-chloro, R¹ is methyl, R² Xis methoxy, R³ is chloro and R⁴ for a compound in each case correspondsto one line of Table A.

Table 84

Compounds of the formula I where R_(n) is 3-chloro, R¹ is methyl, R² Xis ethoxy, R³ is chloro and R⁴ for a compound in each case correspondsto one line of Table A.

Table 85

Compounds of the formula I where R_(n) is 3-chloro, R¹ is methyl, R² Xis methylamino, R³ is chloro and R⁴ for a compound in each casecorresponds to one line of Table A.

Table 86

Compounds of the formula I where R_(n) is 3-chloro, R¹ is ethyl, R² X ismethyl, R³ is chloro and R⁴ for a compound in each case corresponds toone line of Table A.

Table 87

Compounds of the formula I where R_(n) is 3-chloro, R¹ is ethyl, R² X isethyl, R³ is chloro and R⁴ for a compound in each case corresponds toone line of Table A.

Table 88

Compounds of the formula I where R_(n) is 3-chloro, R¹ is ethyl, R² X ismethoxy, R³ is chloro and R⁴ for a compound in each case corresponds toone line of Table A.

Table 89

Compounds of the formula I where R_(n) is 3-chloro, R¹ is ethyl, R² X isethoxy, R³ is chloro and R⁴ for a compound in each case corresponds toone line of Table A.

Table 90

Compounds of the formula I where R_(n) is 3-chloro, R¹ is ethyl, R² X ismethylamino, R³ is chloro and R⁴ for a compound in each case correspondsto one line of Table A.

Table 91

Compounds of the formula I (n=0) where R¹ is hydrogen, R² X is methyl,R³ is methyl and R⁴ for a compound in each case corresponds to one lineof Table A.

Table 92

Compounds of the formula I (n=0) where R¹ is hydrogen, R² X is ethyl, R³is methyl and R⁴ for a compound in each case corresponds to one line ofTable A.

Table 93

Compounds of the formula I (n=0) where R¹ is hydrogen, R² X is methoxy,R³ is methyl and R⁴ for a compound in each case corresponds to one lineof Table A.

Table 94

Compounds of the formula I (n=0) where R¹ is hydrogen, R² X is ethoxy,R³ is methyl and R⁴ for a compound in each case corresponds to one lineof Table A.

Table 95

Compounds of the formula I (n=0) where R¹ is hydrogen, R² X ismethylamino, R³ is methyl and R⁴ for a compound in each case correspondsto one line of Table A.

Table 96

Compounds of the formula I (n=0) where R¹ is methyl, R² X is methyl, R³is methyl and R⁴ for a compound in each case corresponds to one line ofTable A.

Table 97

Compounds of the formula I (n=0) where R¹ is methyl, R² X is ethyl, R³is methyl and R⁴ for a compound in each case corresponds to one line ofTable A.

Table 98

Compounds of the formula I (n=0) where R¹ is methyl, R² X is methoxy, R³is methyl and R⁴ for a compound in each case corresponds to one line ofTable A.

Table 99

Compounds of the formula I (n=0) where R¹ is methyl, R² X is ethoxy, R³is methyl and R⁴ for a compound in each case corresponds to one line ofTable A.

Table 100

Compounds of the formula I (n=0) where R¹ is methyl, R² X ismethylamino, R³ is methyl and R⁴ for a compound in each case correspondsto one line of Table A.

Table 101

Compounds of the formula I (n=0) where R¹ is ethyl, R² X is methyl, R³is methyl and R⁴ for a compound in each case corresponds to one line ofTable A.

Table 102

Compounds of the formula I (n=0) where R¹ is ethyl, R² X is ethyl, R³ ismethyl and R⁴ for a compound in each case corresponds to one line ofTable A.

Table 103

Compounds of the formula I (n=0) where R¹ is ethyl, R² X is methoxy, R³is methyl and R⁴ for a compound in each case corresponds to one line ofTable A.

Table 104

Compounds of the formula I (n=0) where R¹ is ethyl, R² X is ethoxy, R³is methyl and R⁴ for a compound in each case corresponds to one line ofTable A.

Table 105

Compounds of the formula I (n=0) where R¹ is ethyl, R² X is methylamino,R³ is methyl and R⁴ for a compound in each case corresponds to one lineof Table A.

Table 106

Compounds of the formula I where R_(n) is 3-chloro, R¹ is hydrogen, R² Xis methyl, R³ is methyl and R⁴ for a compound in each case correspondsto one line of Table A.

Table 107

Compounds of the formula I where R_(n) is 3-chloro, R¹ is hydrogen, R² Xis ethyl, R³ is methyl and R⁴ for a compound in each case corresponds toone line of Table A.

Table 108

Compounds of the formula I where R_(n) is 3-chloro, R¹ is hydrogen, R² Xis methoxy, R³ is methyl and R⁴ for a compound in each case correspondsto one line of Table A.

Table 109

Compounds of the formula I where R_(n) is 3-chloro, R¹ is hydrogen, R² Xis ethoxy, R³ is methyl and R⁴ for a compound in each case correspondsto one line of Table A.

Table 110

Compounds of the formula I where R_(n) is 3-chloro, R¹ is hydrogen, R² Xis methylamino, R³ is methyl and R⁴ for a compound in each casecorresponds to one line of Table A.

Table 111

Compounds of the formula I where R_(n) is 3-chloro, R¹ is methyl, R² Xis methyl, R³ is methyl and R⁴ for a compound in each case correspondsto one line of Table A.

Table 112

Compounds of the formula I where R_(n) is 3-chloro, R¹ is methyl, R² Xis ethyl, R³ is methyl and R⁴ for a compound in each case corresponds toone line of Table A.

Table 113

Compounds of the formula I where R_(n) is 3-chloro, R¹ is methyl, R² Xis methoxy, R³ is methyl and R⁴ for a compound in each case correspondsto one line of Table A.

Table 114

Compounds of the formula I where R_(n) is 3-chloro, R¹ is methyl, R² Xis ethoxy, R³ is methyl and R⁴ for a compound in each case correspondsto one line of Table A.

Table 115

Compounds of the formula I where R_(n) is 3-chloro, R¹ is methyl, R² Xis methylamino, R³ is methyl and R⁴ for a compound in each casecorresponds to one line of Table A.

Table 116

Compounds of the formula I where R_(n) is 3-chloro, R¹ is ethyl, R² X ismethyl, R³ is methyl and R⁴ for a compound in each case corresponds toone line of Table A.

Table 117

Compounds of the formula I where R_(n) is 3-chloro, R¹ is ethyl, R² X isethyl, R³ is methyl and R⁴ for a compound in each case corresponds toone line of Table A.

Table 118

Compounds of the formula I where R_(n) is 3-chloro, R¹ is ethyl, R² X ismethoxy, R³ is methyl and R⁴ for a compound in each case corresponds toone line of Table A.

Table 119

Compounds of the formula I where R_(n) is 3-chloro, R¹ is ethyl, R² X isethoxy, R³ is methyl and R⁴ for a compound in each case corresponds toone line of Table A.

Table 120

Compounds of the formula I where R_(n) is 3-chloro, R¹ is ethyl, R² X ismethylamino, R³ is methyl and R⁴ for a compound in each case correspondsto one line of Table A.

Table 121

Compounds of the formula I (n=0) where R¹ is hydrogen, R² X is methyl,R³ is ethyl and R⁴ for a compound in each case corresponds to one lineof Table A.

Table 122

Compounds of the formula I (n=0) where R¹ is hydrogen, R² X is ethyl, R³is ethyl and R⁴ for a compound in each case corresponds to one line ofTable A.

Table 123

Compounds of the formula I (n=0) where R¹ is hydrogen, R² X is methoxy,R³ is ethyl and R⁴ for a compound in each case corresponds to one lineof Table A.

Table 124

Compounds of the formula I (n=0) where R¹ is hydrogen, R² X is ethoxy,R³ is ethyl and R⁴ for a compound in each case corresponds to one lineof Table A.

Table 125

Compounds of the formula I (n=0) where R¹ is hydrogen, R² X ismethylamino, R³ is ethyl and R⁴ for a compound in each case correspondsto one line of Table A.

Table 126

Compounds of the formula I (n=0) where R¹ is methyl, R² X is methyl, R³is ethyl and R⁴ for a compound in each case corresponds to one line ofTable A.

Table 127

Compounds of the formula I (n=0) where R¹ is methyl, R² X is ethyl, R³is ethyl and R⁴ for a compound in each case corresponds to one line ofTable A.

Table 128

Compounds of the formula I (n=0) where R¹ is methyl, R² X is methoxy, R³is ethyl and R⁴ for a compound in each case corresponds to one line ofTable A.

Table 129

Compounds of the formula I (n=0) where R¹ is methyl, R² X is ethoxy, R³is ethyl and R⁴ for a compound in each case corresponds to one line ofTable A.

Table 130

Compounds of the formula I (n=0) where R¹ is methyl, R² X ismethylamino, R³ is ethyl and R⁴ for a compound in each case correspondsto one line of Table A.

Table 131

Compounds of the formula I (n=0) where R¹ is ethyl, R² X is methyl, R³is ethyl and R⁴ for a compound in each case corresponds to one line ofTable A.

Table 132

Compounds of the formula I (n=0) where R¹ is ethyl, R² X is ethyl, R³ isethyl and R⁴ for a compound in each case corresponds to one line ofTable A.

Table 133

Compounds of the formula I (n=0) where R¹ is ethyl, R² X is methoxy, R³is ethyl and R⁴ for a compound in each case corresponds to one line ofTable A.

Table 134

Compounds of the formula I (n=0) where R¹ is ethyl, R² X is ethoxy, R³is ethyl and R⁴ for a compound in each case corresponds to one line ofTable A.

Table 135

Compounds of the formula I (n=0) where R¹ is ethyl, R² X is methylamino,R³ is ethyl and R⁴ for a compound in each case corresponds to one lineof Table A.

Table 136

Compounds of the formula I where R_(n) is 3-chloro, R¹ is hydrogen, R² Xis methyl, R³ is ethyl and R⁴ for a compound in each case corresponds toone line of Table A.

Table 137

Compounds of the formula I where R_(n) is 3-chloro, R¹ is hydrogen, R² Xis ethyl, R³ is ethyl and R⁴ for a compound in each case corresponds toone line of Table A.

Table 138

Compounds of the formula I where R_(n) is 3-chloro, R¹ is hydrogen, R² Xis methoxy, R³ is ethyl and R⁴ for a compound in each case correspondsto one line of Table A.

Table 139

Compounds of the formula I where R_(n) is 3-chloro, R¹ is hydrogen, R² Xis ethoxy, R³ is ethyl and R⁴ for a compound in each case corresponds toone line of Table A.

Table 140

Compounds of the formula I where R_(n) is 3-chloro, R¹ is hydrogen, R² Xis methylamino, R³ is ethyl and R⁴ for a compound in each casecorresponds to one line of Table A.

Table 141

Compounds of the formula I where R_(n) is 3-chloro, R¹ is methyl, R² Xis methyl, R³ is ethyl and R⁴ for a compound in each case corresponds toone line of Table A.

Table 142

Compounds of the formula I where R_(n) is 3-chloro, R¹ is methyl, R² Xis ethyl, R³ is ethyl and R⁴ for a compound in each case corresponds toone line of Table A.

Table 143

Compounds of the formula I where R_(n) is 3-chloro, R¹ is methyl, R² Xis methoxy, R³ is ethyl and R⁴ for a compound in each case correspondsto one line of Table A.

Table 144

Compounds of the formula I where R_(n) is 3-chloro, R¹ is methyl, R² Xis ethoxy, R³ is ethyl and R⁴ for a compound in each case corresponds toone line of Table A.

Table 145

Compounds of the formula I where R_(n) is 3-chloro, R¹ is methyl, R² Xis methylamino, R³ is ethyl and R⁴ for a compound in each casecorresponds to one line of Table A.

Table 146

Compounds of the formula I where R_(n) is 3-chloro, R¹ is ethyl, R² X ismethyl, R³ is ethyl and R⁴ for a compound in each case corresponds toone line of Table A.

Table 147

Compounds of the formula I where R_(n) is 3-chloro, R¹ is ethyl, R² X isethyl, R³ is ethyl and R⁴ for a compound in each case corresponds to oneline of Table A.

Table 148

Compounds of the formula I where R_(n) is 3-chloro, R¹ is ethyl, R² X ismethoxy, R³ is ethyl and R⁴ for a compound in each case corresponds toone line of Table A.

Table 149

Compounds of the formula I where R_(n) is 3-chloro, R¹ is ethyl, R² X isethoxy, R³ is ethyl and R⁴ for a compound in each case corresponds toone line of Table A.

Table 150

Compounds of the formula I where R_(n) is 3-chloro, R¹ is ethyl, R² X ismethylamino, R³ is ethyl and R⁴ for a compound in each case correspondsto one line of Table A.

Table 151

Compounds of the formula I (n=0) where R¹ is hydrogen, R² X is methyl,R³ is isopropyl and R⁴ for a compound in each case corresponds to oneline of Table A.

Table 152

Compounds of the formula I (n=0) where R¹ is hydrogen, R² X is ethyl, R³is isopropyl and R⁴ for a compound in each case corresponds to one lineof Table A.

Table 153

Compounds of the formula I (n=0) where R¹ is hydrogen, R² X is methoxy,R³ is isopropyl and R⁴ for a compound in each case corresponds to oneline of Table A.

Table 154

Compounds of the formula I (n=0) where R¹ is hydrogen, R² X is ethoxy,R³ is isopropyl and R⁴ for a compound in each case corresponds to oneline of Table A.

Table 155

Compounds of the formula I (n=0) where R¹ is hydrogen, R² X ismethylamino, R³ is isopropyl and R⁴ for a compound in each casecorresponds to one line of Table A.

Table 156

Compounds of the formula I (n=0) where R¹ is methyl, R² X is methyl, R³is isopropyl and R⁴ for a compound in each case corresponds to one lineof Table A.

Table 157

Compounds of the formula I (n=0) where R¹ is methyl, R² X is ethyl, R³is isopropyl and R⁴ for a compound in each case corresponds to one lineof Table A.

Table 158

Compounds of the formula I (n=0) where R¹ is methyl, R² X is methoxy, R³is isopropyl and R⁴ for a compound in each case corresponds to one lineof Table A.

Table 159

Compounds of the formula I (n=0) where R¹ is methyl, R² X is ethoxy, R³is isopropyl and R⁴ for a compound in each case corresponds to one lineof Table A.

Table 160

Compounds of the formula I (n=0) where R¹ is methyl, R² X ismethylamino, R³ is isopropyl and R⁴ for a compound in each casecorresponds to one line of Table A.

Table 161

Compounds of the formula I (n=0) where R¹ is ethyl, R² X is methyl, R³is isopropyl and R⁴ for a compound in each case corresponds to one lineof Table A.

Table 162

Compounds of the formula I (n=0) where R¹ is ethyl, R² X is ethyl, R³ isisopropyl and R⁴ for a compound in each case corresponds to one line ofTable A.

Table 163

Compounds of the formula I (n=0) where R¹ is ethyl, R² X is methoxy, R³is isopropyl and R⁴ for a compound in each case corresponds to one lineof Table A.

Table 164

Compounds of the formula I (n=0) where R¹ is ethyl, R² X is ethoxy, R³is isopropyl and R⁴ for a compound in each case corresponds to one lineof Table A.

Table 165

Compounds of the formula I (n=0) where R¹ is ethyl, R² X is methylamino,R³ is isopropyl and R⁴ for a compound in each case corresponds to oneline of Table A.

Table 166

Compounds of the formula I where R_(n) is 3-chloro, R¹ is hydrogen, R² Xis methyl, R³ is isopropyl and R⁴ for a compound in each casecorresponds to one line of Table A.

Table 167

Compounds of the formula I where R_(n) is 3-chloro, R¹ is hydrogen, R² Xis ethyl, R³ is isopropyl and R⁴ for a compound in each case correspondsto one line of Table A.

Table 168

Compounds of the formula I where R_(n) is 3-chloro, R¹ is hydrogen, R² Xis methoxy, R³ is isopropyl and R⁴ for a compound in each casecorresponds to one line of Table A.

Table 169

Compounds of the formula I where R_(n) is 3-chloro, R¹ is hydrogen, R² Xis ethoxy, R³ is isopropyl and R⁴ for a compound in each casecorresponds to one line of Table A.

Table 170

Compounds of the formula I where R_(n) is 3-chloro, R¹ is hydrogen, R² Xis methylamino, R³ is isopropyl and R⁴ for a compound in each casecorresponds to one line of Table A.

Table 171

Compounds of the formula I where R_(n) is 3-chloro, R¹ is methyl, R² Xis methyl, R³ is isopropyl and R⁴ for a compound in each casecorresponds to one line of Table A.

Table 172

Compounds of the formula I where R_(n) is 3-chloro, R¹ is methyl, R² Xis ethyl, R³ is isopropyl and R⁴ for a compound in each case correspondsto one line of Table A.

Table 173

Compounds of the formula I where R_(n) is 3-chloro, R¹ is methyl, R² Xis methoxy, R³ is isopropyl and R⁴ for a compound in each casecorresponds to one line of Table A.

Table 174

Compounds of the formula I where R_(n) is 3-chloro, R¹ is methyl, R² Xis ethoxy, R³ is isopropyl and R⁴ for a compound in each casecorresponds to one line of Table A.

Table 175

Compounds of the formula I where R_(n) is 3-chloro, R¹ is methyl, R² Xis methylamino, R³ is isopropyl and R⁴ for a compound in each casecorresponds to one line of Table A.

Table 176

Compounds of the formula I where R_(n) is 3-chloro, R¹ is ethyl, R² X ismethyl, R³ is isopropyl and R⁴ for a compound in each case correspondsto one line of Table A.

Table 177

Compounds of the formula I where R_(n) is 3-chloro, R¹ is ethyl, R² X isethyl, R³ is isopropyl and R⁴ for a compound in each case corresponds toone line of Table A.

Table 178

Compounds of the formula I where R_(n) is 3-chloro, R¹ is ethyl, R² X ismethoxy, R³ is isopropyl and R⁴ for a compound in each case correspondsto one line of Table A.

Table 179

Compounds of the formula I where R_(n) is 3-chloro, R¹ is ethyl, R² X isethoxy, R³ is isopropyl and R⁴ for a compound in each case correspondsto one line of Table A.

Table 180

Compounds of the formula I where R_(n) is 3-chloro, R¹ is ethyl, R² X ismethylamino, R³ is isopropyl and R⁴ for a compound in each casecorresponds to one line of Table A.

Table 181

Compounds of the formula I (n=0) where R¹ is hydrogen, R² X is methyl,R³ is trifluoromethyl and R⁴ for a compound in each case corresponds toone line of Table A.

Table 182

Compounds of the formula I (n=0) where R¹ is hydrogen, R² X is ethyl, R³is trifluoromethyl and R⁴ for a compound in each case corresponds to oneline of Table A.

Table 183

Compounds of the formula I (n=0) where R¹ is hydrogen, R² X is methoxy,R³ is trifluoromethyl and R⁴ for a compound in each case corresponds toone line of Table A.

Table 184

Compounds of the formula I (n=0) where R¹ is hydrogen, R² X is ethoxy,R³ is trifluoromethyl and R⁴ for a compound in each case corresponds toone line of Table A.

Table 185

Compounds of the formula I (n=0) where R¹ is hydrogen, R² X ismethylamino, R³ is trifluoromethyl and R⁴ for a compound in each casecorresponds to one line of Table A.

Table 186

Compounds of the formula I (n=0) where R¹ is methyl, R² X is ethyl, R³is trifluoromethyl and R⁴ for a compound in each case corresponds to oneline of Table A.

Table 187

Compounds of the formula I (n=0) where R¹ is methyl, R² X is ethyl, R³is trifluoromethyl and R⁴ for a compound in each case corresponds to oneline of Table A.

Table 188

Compounds of the formula I (n=0) where R¹ is methyl, R² X is methoxy, R³is trifluoromethyl and R⁴ for a compound in each case corresponds to oneline of Table A.

Table 189

Compounds of the formula I (n=0) where R¹ is methyl, R² X is ethoxy, R³is trifluoromethyl and R⁴ for a compound in each case corresponds to oneline of Table A.

Table 190

Compounds of the formula I (n=0) where R¹ is methyl, R² X ismethylamino, R³ is trifluoromethyl and R⁴ for a compound in each casecorresponds to one line of Table A.

Table 191

Compounds of the formula I (n=0) where R¹ is ethyl, R² X is methyl, R³is trifluoromethyl and R⁴ for a compound in each case corresponds to oneline of Table A.

Table 192

Compounds of the formula I (n=0) where R¹ is ethyl, R² X is ethyl, R³ istrifluoromethyl and R⁴ for a compound in each case corresponds to oneline of Table A.

Table 193

Compounds of the formula I (n=0) where R¹ is ethyl, R² X is methoxy, R³is trifluoromethyl and R⁴ for a compound in each case corresponds to oneline of Table A.

Table 194

Compounds of the formula I (n=0) where R¹ is ethyl, R² X is ethoxy, R³is trifluoromethyl and R⁴ for a compound in each case corresponds to oneline of Table A.

Table 195

Compounds of the formula I (n=0) where R¹ is ethyl, R² X is ethylamino,R³ is trifluoromethyl and R⁴ for a compound in each case corresponds toone line of Table A.

Table 196

Compounds of the formula I where R_(n) is 3-chloro, R¹ is hydrogen, R² Xis methyl, R³ is trifluoromethyl and R⁴ for a compound in each casecorresponds to one line of Table A.

Table 197

Compounds of the formula I where R_(n) is 3-chloro, R¹ is hydrogen, R² Xis ethyl, R³ is trifluoromethyl and R⁴ for a compound in each casecorresponds to one line of Table A.

Table 198

Compounds of the formula I where R_(n) is 3-chloro, R¹ is hydrogen, R² Xis methoxy, R³ is trifluoromethyl and R⁴ for a compound in each casecorresponds to one line of Table A.

Table 199

Compounds of the formula I where R_(n) is 3-chloro, R¹ is hydrogen, R² Xis ethoxy, R³ is trifluoromethyl and R⁴ for a compound in each casecorresponds to one line of Table A.

Table 200

Compounds of the formula I where R_(n) is 3-chloro, R¹ is hydrogen, R² Xis methylamino, R³ is trifluoromethyl and R⁴ for a compound in each casecorresponds to one line of Table A.

Table 201

Compounds of the formula I where R_(n) is 3-chloro, R¹ is methyl, R² Xis methyl, R³ is trifluoromethyl and R⁴ for a compound in each casecorresponds to one line of Table A.

Table 202

Compounds of the formula I where R_(n) is 3-chloro, R¹ is methyl, R² Xis ethyl, R³ is trifluoromethyl and R⁴ for a compound in each casecorresponds to one line of Table A.

Table 203

Compounds of the formula I where R_(n) is 3-chloro, R¹ is methyl, R² Xis methoxy, R³ is trifluoromethyl and R⁴ for a compound in each casecorresponds to one line of Table A.

Table 204

Compounds of the formula I where R_(n) is 3-chloro, R¹ is methyl, R² Xis ethoxy, R³ is trifluoromethyl and R⁴ for a compound in each casecorresponds to one line of Table A.

Table 205

Compounds of the formula I where R_(n) is 3-chloro, R¹ is methyl, R² Xis methylamino, R³ is trifluoromethyl and R⁴ for a compound in each casecorresponds to one line of Table A.

Table 206

Compounds of the formula I where R_(n) is 3-chloro, R¹ is ethyl, R² X ismethyl, R³ is trifluoromethyl and R⁴ for a compound in each casecorresponds to one line of Table A.

Table 207

Compounds of the formula I where R_(n) is 3-chloro, R¹ is ethyl, R² X isethyl, R³ is trifluoromethyl and R⁴ for a compound in each casecorresponds to one line of Table A.

Table 208

Compounds of the formula I where R_(n) is 3-chloro, R¹ is ethyl, R² X ismethoxy, R³ is trifluoromethyl and R⁴ for a compound in each casecorresponds to one line of Table A.

Table 209

Compounds of the formula I where R_(n) is 3-chloro, R¹ is ethyl, R² X isethoxy, R³ is trifluoromethyl and R⁴ for a compound in each casecorresponds to one line of Table A.

Table 210

Compounds of the formula I where R_(n) is 3-chloro, R¹ is ethyl, R² X ismethylamino, R³ is trifluoromethyl and R⁴ for a compound in each casecorresponds to one line of Table A.

Table 211

Compounds of the formula I (n=0) where R¹ is hydrogen, R² X is methyl,R³ is methoxy and R⁴ for a compound in each case corresponds to one lineof Table A.

Table 212

Compounds of the formula I (n=0) where R¹ is hydrogen, R² X is ethyl, R³is methoxy and R⁴ for a compound in each case corresponds to one line ofTable A.

Table 213

Compounds of the formula I (n=0) where R¹ is hydrogen, R² X is methoxy,R³ is methoxy and R⁴ for a compound in each case corresponds to one lineof Table A.

Table 214

Compounds of the formula I (n=0) where R¹ is hydrogen, R² X is ethoxy,R³ is methoxy and R⁴ for a compound in each case corresponds to one lineof Table A.

Table 215

Compounds of the formula I (n=0) where R¹ is hydrogen, R² X ismethylamino, R³ is methoxy and R⁴ for a compound in each casecorresponds to one line of Table A.

Table 216

Compounds of the formula I (n=0) where R¹ is methyl, R² X is methyl, R³is methoxy and R⁴ for a compound in each case corresponds to one line ofTable A.

Table 217

Compounds of the formula I (n=0) where R¹ is methyl, R² X is ethyl, R³is methoxy and R⁴ for a compound in each case corresponds to one line ofTable A.

Table 218

Compounds of the formula I (n=0) where R¹ is methyl, R² X is methoxy, R³is methoxy and R⁴ for a compound in each case corresponds to one line ofTable A.

Table 219

Compounds of the formula I (n=0) where R¹ is methyl, R² X is ethoxy, R³is methoxy and R⁴ for a compound in each case corresponds to one line ofTable A.

Table 220

Compounds of the formula I (n=0) where R¹ is methyl, R² X ismethylamino, R³ is methoxy and R⁴ for a compound in each casecorresponds to one line of Table A.

Table 221

Compounds of the formula I (n=0) where R¹ is ethyl, R² X is methyl, R³is methoxy and R⁴ for a compound in each case corresponds to one line ofTable A.

Table 222

Compounds of the formula I (n=0) where R¹ is ethyl, R² X is ethyl, R³ ismethoxy and R⁴ for a compound in each case corresponds to one line ofTable A.

Table 223

Compounds of the formula I (n=0) where R¹ is ethyl, R² X is methoxy, R³is methoxy and R⁴ for a compound in each case corresponds to one line ofTable A.

Table 224

Compounds of the formula I (n=0) where R¹ is ethyl, R² X is ethoxy, R³is methoxy and R⁴ for a compound in each case corresponds to one line ofTable A.

Table 225

Compounds of the formula I (n=0) where R¹ is ethyl, R² X is methylamino,R³ is methoxy and R⁴ for a compound in each case corresponds to one lineof Table A.

Table 226

Compounds of the formula I where R_(n) is 3-chloro, R¹ is hydrogen, R² Xis methyl, R³ is methoxy and R⁴ for a compound in each case correspondsto one line of Table A.

Table 227

Compounds of the formula I where R_(n) is 3-chloro, R¹ is hydrogen, R² Xis ethyl, R³ is methoxy and R⁴ for a compound in each case correspondsto one line of Table A.

Table 228

Compounds of the formula I where R_(n) is 3-chloro, R¹ is hydrogen, R² Xis methoxy, R³ is methoxy and R⁴ for a compound in each case correspondsto one line of Table A.

Table 229

Compounds of the formula I where R_(n) is 3-chloro, R¹ is hydrogen, R² Xis ethoxy, R³ is methoxy and R⁴ for a compound in each case correspondsto one line of Table A.

Table 230

Compounds of the formula I where R_(n) is 3-chloro, R¹ is hydrogen, R² Xis methylamino, R³ is methoxy and R⁴ for a compound in each casecorresponds to one line of Table A.

Table 231

Compounds of the formula I where R_(n) is 3-chloro, R¹ is methyl, R² Xis methyl, R³ is methoxy and R⁴ for a compound in each case correspondsto one line of Table A.

Table 232

Compounds of the formula I where R_(n) is 3-chloro, R¹ is methyl, R² Xis ethyl, R³ is methoxy and R⁴ for a compound in each case correspondsto one line of Table A.

Table 233

Compounds of the formula I where R_(n) is 3-chloro, R¹ is methyl, R² Xis methoxy, R³ is methoxy and R⁴ for a compound in each case correspondsto one line of Table A.

Table 234

Compounds of the formula I where R_(n) is 3-chloro, R¹ is methyl, R² Xis ethoxy, R³ is methoxy and R⁴ for a compound in each case correspondsto one line of Table A.

Table 235

Compounds of the formula I where R_(n) is 3-chloro, R¹ is methyl, R² Xis methylamino, R³ is methoxy and R⁴ for a compound in each casecorresponds to one line of Table A.

Table 236

Compounds of the formula I where R_(n) is 3-chloro, R¹ is ethyl, R² X ismethyl, R³ is methoxy and R⁴ for a compound in each case corresponds toone line of Table A.

Table 237

Compounds of the formula I where R_(n) is 3-chloro, R¹ is ethyl, R² X isethyl, R³ is methoxy and R⁴ for a compound in each case corresponds toone line of Table A.

Table 238

Compounds of the formula I where R_(n) is 3-chloro, R¹ is ethyl, R² X ismethoxy, R³ is methoxy and R⁴ for a compound in each case corresponds toone line of Table A.

Table 239

Compounds of the formula I where R_(n) is 3-chloro, R¹ is ethyl, R² X isethoxy, R³ is methoxy and R⁴ for a compound in each case corresponds toone line of Table A.

Table 240

Compounds of the formula I where R_(n) is 3-chloro, R¹ is ethyl, R² X ismethylamino, R³ is methoxy and R⁴ for a compound in each casecorresponds to one line of Table A.

Table 241

Compounds of the formula I (n=0) where R¹ is hydrogen, R² X is methyl,R³ is ethoxy and R⁴ for a compound in each case corresponds to one lineof Table A.

Table 242

Compounds of the formula I (n=0) where R¹ is hydrogen, R² X is ethyl, R³is ethoxy and R⁴ for a compound in each case corresponds to one line ofTable A.

Table 243

Compounds of the formula I (n=0) where R¹ is hydrogen, R² X is methoxy,R³ is ethoxy and R⁴ for a compound in each case corresponds to one lineof Table A.

Table 244

Compounds of the formula I (n=0) where R¹ is hydrogen, R² X is ethoxy,R³ is ethoxy and R⁴ for a compound in each case corresponds to one lineof Table A.

Table 245

Compounds of the formula I (n=0) where R¹ is hydrogen, R² X ismethylamino, R³ is ethoxy and R⁴ for a compound in each case correspondsto one line of Table A.

Table 246

Compounds of the formula I (n=0) where R¹ is methyl, R² X is methyl, R³is ethoxy and R⁴ for a compound in each case corresponds to one line ofTable A.

Table 247

Compounds of the formula I (n=0) where R¹ is methyl, R² X is ethyl, R³is ethoxy and R⁴ for a compound in each case corresponds to one line ofTable A.

Table 248

Compounds of the formula I (n=0) where R¹ is methyl, R² X is methoxy, R³is ethoxy and R⁴ for a compound in each case corresponds to one line ofTable A.

Table 249

Compounds of the formula I (n=0) where R¹ is methyl, R² X is ethoxy, R³is ethoxy and R⁴ for a compound in each case corresponds to one line ofTable A.

Table 250

Compounds of the formula I (n=0) where R¹ is methyl, R² X ismethylamino, R³ is ethoxy and R⁴ for a compound in each case correspondsto one line of Table A.

Table 251

Compounds of the formula I (n=0) where R¹ is ethyl, R² X is methyl, R³is ethoxy and R⁴ for a compound in each case corresponds to one line ofTable A.

Table 252

Compounds of the formula I (n=0) where R¹ is ethyl, R² X is ethyl, R³ isethoxy and R⁴ for a compound in each case corresponds to one line ofTable A.

Table 253

Compounds of the formula I (n=0) where R¹ is ethyl, R² X is methoxy, R³is ethoxy and R⁴ for a compound in each case corresponds to one line ofTable A.

Table 254

Compounds of the formula I (n=0) where R¹ is ethyl, R² X is ethoxy, R³is ethoxy and R⁴ for a compound in each case corresponds to one line ofTable A.

Table 255

Compounds of the formula I (n=0) where R¹ is ethyl, R² X is methylamino,R³ is ethoxy and R⁴ for a compound in each case corresponds to one lineof Table A.

Table 256

Compounds of the formula I where R_(n) is 3-chloro, R¹ is hydrogen, R² Xis methyl, R³ is ethoxy and R⁴ for a compound in each case correspondsto one line of Table A.

Table 257

Compounds of the formula I where R_(n) is 3-chloro, R¹ is hydrogen, R² Xis ethyl, R³ is ethoxy and R⁴ for a compound in each case corresponds toone line of Table A.

Table 258

Compounds of the formula I where R_(n) is 3-chloro, R¹ is hydrogen, R² Xis methoxy, R³ is ethoxy and R⁴ for a compound in each case correspondsto one line of Table A.

Table 259

Compounds of the formula I where R_(n) is 3-chloro, R¹ is hydrogen, R² Xis ethoxy, R³ is ethoxy and R⁴ for a compound in each case correspondsto one line of Table A.

Table 260

Compounds of the formula I where R_(n) is 3-chloro, R¹ is hydrogen, R² Xis methylamino, R³ is ethoxy and R⁴ for a compound in each casecorresponds to one line of Table A.

Table 261

Compounds of the formula I where R_(n) is 3-chloro, R¹ is methyl, R² Xis methyl, R³ is ethoxy and R⁴ for a compound in each case correspondsto one line of Table A.

Table 262

Compounds of the formula I where R_(n) is 3-chloro, R¹ is methyl, R² Xis ethyl, R³ is ethoxy and R⁴ for a compound in each case corresponds toone line of Table A.

Table 263

Compounds of the formula I where R_(n) is 3-chloro, R¹ is methyl, R² Xis methoxy, R³ is ethoxy and R⁴ for a compound in each case correspondsto one line of Table A.

Table 264

Compounds of the formula I where R_(n) is 3-chloro, R¹ is methyl, R² Xis ethoxy, R³ is ethoxy and R⁴ for a compound in each case correspondsto one line of Table A.

Table 265

Compounds of the formula I where R_(n) is 3-chloro, R¹ is methyl, R² Xis methylamino, R³ is ethoxy and R⁴ for a compound in each casecorresponds to one line of Table A.

Table 266

Compounds of the formula I where R_(n) is 3-chloro, R¹ is ethyl, R² X ismethyl, R³ is ethoxy and R⁴ for a compound in each case corresponds toone line of Table A.

Table 267

Compounds of the formula I where R_(n) is 3-chloro, R¹ is ethyl, R² X isethyl, R³ is ethoxy and R⁴ for a compound in each case corresponds toone line of Table A.

Table 268

Compounds of the formula I where R_(n) is 3-chloro, R¹ is ethyl, R² X ismethoxy, R³ is ethoxy and R⁴ for a compound in each case corresponds toone line of Table A.

Table 269

Compounds of the formula I where R_(n) is 3-chloro, R¹ is ethyl, R² X isethoxy, R³ is ethoxy and R⁴ for a compound in each case corresponds toone line of Table A.

Table 270

Compounds of the formula I where R_(n) is 3-chloro, R¹ is ethyl, R² X ismethylamino, R³ is ethoxy and R⁴ for a compound in each case correspondsto one line of Table A.

Table 271

Compounds of the formula I (n=0) where R¹ is hydrogen, R² X is ethyl, R³is difluoromethoxy and R⁴ for a compound in each case corresponds to oneline of Table A.

Table 272

Compounds of the formula I (n=0) where R¹ is hydrogen, R² X is ethyl, R³is difluoromethoxy and R⁴ for a compound in each case corresponds to oneline of Table A.

Table 273

Compounds of the formula I (n=0) where R¹ is hydrogen, R² X is methoxy,R³ is difluoromethoxy and R⁴ for a compound in each case corresponds toone line of Table A.

Table 274

Compounds of the formula I (n=0) where R¹ is hydrogen, R² X is ethoxy,R³ is difluoromethoxy and R⁴ for a compound in each case corresponds toone line of Table A.

Table 275

Compounds of the formula I (n=0) where R¹ is hydrogen, R² X ismethylamino, R³ is difluoromethoxy and R⁴ for a compound in each casecorresponds to one line of Table A.

Table 276

Compounds of the formula I (n=0) where R¹ is methyl, R² X is methyl, R³is difluoromethoxy and R⁴ for a compound in each case corresponds to oneline of Table A.

Table 277

Compounds of the formula I (n=0) where R¹ is methyl, R² X is ethyl, R³is difluoromethoxy and R⁴ for a compound in each case corresponds to oneline of Table A.

Table 278

Compounds of the formula I (n=0) where R¹ is methyl, R² X is methoxy, R³is difluoromethoxy and R⁴ for a compound in each case corresponds to oneline of Table A.

Table 279

Compounds of the formula I (n=0) where R¹ is methyl, R² X is ethoxy, R³is difluoromethoxy and R⁴ for a compound in each case corresponds to oneline of Table A.

Table 280

Compounds of the formula I (n=0) where R¹ is methyl, R² X ismethylamino, R³ is difluoromethoxy and R⁴ for a compound in each casecorresponds to one line of Table A.

Table 281

Compounds of the formula I (n=0) where R¹ is ethyl, R² X is methyl, R³is difluoromethoxy and R⁴ for a compound in each case corresponds to oneline of Table A.

Table 282

Compounds of the formula I (n=0) where R¹ is ethyl, R² X is ethyl, R³ isdifluoromethoxy and R⁴ for a compound in each case corresponds to oneline of Table A.

Table 283

Compounds of the formula I (n=0) where R¹ is ethyl, R² X is methoxy, R³is difluoromethoxy and R⁴ for a compound in each case corresponds to oneline of Table A.

Table 284

Compounds of the formula I (n=0) where R¹ is ethyl, R² X is ethoxy, R³is difluoromethoxy and R⁴ for a compound in each case corresponds to oneline of Table A.

Table 285

Compounds of the formula I (n=0) where R¹ is ethyl, R² X is methylamino,R³ is difluoromethoxy and R⁴ for a compound in each case corresponds toone line of Table A.

Table 286

Compounds of the formula I where R_(n) is 3-chloro, R¹ is hydrogen, R² Xis methyl, R³ is difluoromethoxy and R⁴ for a compound in each casecorresponds to one line of Table A.

Table 287

Compounds of the formula I where R_(n) is 3-chloro, R¹ is hydrogen, R² Xis ethyl, R³ is difluoromethoxy and R⁴ for a compound in each casecorresponds to one line of Table A.

Table 288

Compounds of the formula I where R_(n) is 3-chloro, R¹ is hydrogen, R² Xis methoxy, R³ is difluoromethoxy and R⁴ for a compound in each casecorresponds to one line of Table A.

Table 289

Compounds of the formula I where R_(n) is 3-chloro, R¹ is hydrogen, R² Xis ethoxy, R³ is difluoromethoxy and R⁴ for a compound in each casecorresponds to one line of Table A.

Table 290

Compounds of the formula I where R_(n) is 3-chloro, R¹ is hydrogen, R² Xis methylamino, R³ is difluoromethoxy and R⁴ for a compound in each casecorresponds to one line of Table A.

Table 291

Compounds of the formula I where R_(n) is 3-chloro, R¹ is methyl, R² Xis methyl, R³ is difluoromethoxy and R⁴ for a compound in each casecorresponds to one line of Table A.

Table 292

Compounds of the formula I where R_(n) is 3-chloro, R¹ is methyl, R² Xis ethyl, R³ is difluoromethoxy and R⁴ for a compound in each casecorresponds to one line of Table A.

Table 293

Compounds of the formula I where R_(n) is 3-chloro, R¹ is methyl, R² Xis methoxy, R³ is difluoromethoxy and R⁴ for a compound in each casecorresponds to one line of Table A.

Table 294

Compounds of the formula I where R_(n) is 3-chloro, R¹ is methyl, R² Xis ethoxy, R³ is difluoromethoxy and R⁴ for a compound in each casecorresponds to one line of Table A.

Table 295

Compounds of the formula I where R_(n) is 3-chloro, R¹ is methyl, R² Xis methylamino, R³ is difluoromethoxy and R⁴ for a compound in each casecorresponds to one line of Table A.

Table 296

Compounds of the formula I where R_(n) is 3-chloro, R¹ is ethyl, R² X ismethyl, R³ is difluoromethoxy and R⁴ for a compound in each casecorresponds to one line of Table A.

Table 297

Compounds of the formula I where R_(n) is 3-chloro, R¹ is ethyl, R² X isethyl, R³ is difluoromethoxy and R⁴ for a compound in each casecorresponds to one line of Table A.

Table 298

Compounds of the formula I where R_(n) is 3-chloro, R¹ is ethyl, R² X ismethoxy, R³ is difluoromethoxy and R⁴ for a compound in each casecorresponds to one line of Table A.

Table 299

Compounds of the formula I where R_(n) is 3-chioro, R¹ is ethyl, R² X isethoxy, R³ is difluoromethoxy and R⁴ for a compound in each casecorresponds to one line of Table A.

Table 300

Compounds of the formula I where R_(n) is 3-chloro, R¹ is ethyl, R² X ismethylamino, R³ is difluoromethoxy and R⁴ for a compound in each casecorresponds to one line of Table A.

Table 301

Compounds of the formula I (n=0) where R¹ is hydrogen, R² X is methyl,R³ is methylthio and R⁴ for a compound in each case corresponds to oneline of Table A.

Table 302

Compounds of the formula I (n=0) where R¹ is hydrogen, R² X is ethyl, R³is methylthio and R⁴ for a compound in each case corresponds to one lineof Table A.

Table 303

Compounds of the formula I (n=0) where R¹ is hydrogen, R² X is methoxy,R³ is methylthio and R⁴ for a compound in each case corresponds to oneline of Table A.

Table 304

Compounds of the formula I (n=0) where R¹ is hydrogen, R² X is ethoxy,R³ is methylthio and R⁴ for a compound in each case corresponds to oneline of Table A.

Table 305

Compounds of the formula I (n=0) where R¹ is hydrogen, R² X ismethylamino, R³ is methylthio and R⁴ for a compound in each casecorresponds to one line of Table A.

Table 306

Compounds of the formula I (n=0) where R¹ is methyl, R² X is methyl, R³is methylthio and R⁴ for a compound in each case corresponds to one lineof Table A.

Table 307

Compounds of the formula I (n=0) where R¹ is methyl, R² X is ethyl, R³is methylthio and R⁴ for a compound in each case corresponds to one lineof Table A.

Table 308

Compounds of the formula I (n=0) where R¹ is methyl, R² X is methoxy, R³is methylthio and R⁴ for a compound in each case corresponds to one lineof Table A.

Table 309

Compounds of the formula I (n=0) where R¹ is methyl, R² X is ethoxy, R³is methylthio and R⁴ for a compound in each case corresponds to one lineof Table A.

Table 310

Compounds of the formula I (n=0) where R¹ is methyl, R² X ismethylamino, R³ is methylthio and R⁴ for a compound in each casecorresponds to one line of Table A.

Table 311

Compounds of the formula I (n=0) where R¹ is ethyl, R² X is methyl, R³is methylthio and R⁴ for a compound in each case corresponds to one lineof Table A.

Table 312

Compounds of the formula I (n=0) where R¹ is ethyl, R² X is ethyl, R³ ismethylthio and R⁴ for a compound in each case corresponds to one line ofTable A.

Table 313

Compounds of the formula I (n=0) where R¹ is ethyl, R² X is methoxy, R³is methylthio and R⁴ for a compound in each case corresponds to one lineof Table A.

Table 314

Compounds of the formula I (n=0) where R¹ is ethyl, R² X is ethoxy, R³is methylthio and R⁴ for a compound in each case corresponds to one lineof Table A.

Table 315

Compounds of the formula I (n=0) where R¹ is ethyl, R² X is methylamino,R³ is methylthio and R⁴ for a compound in each case corresponds to oneline of Table A.

Table 316

Compounds of the formula I where R_(n) is 3-chloro, R¹ is hydrogen, R² Xis methyl, R³ is methylthio and R⁴ for a compound in each casecorresponds to one line of Table A.

Table 317

Compounds of the formula I where R_(n) is 3-chloro, R¹ is hydrogen, R² Xis ethyl, R³ is methylthio and R⁴ for a compound in each casecorresponds to one line of Table A.

Table 318

Compounds of the formula I where R_(n) is 3-chloro, R¹ is hydrogen, R² Xis methoxy, R³ is methylthio and R⁴ for a compound in each casecorresponds to one line of Table A.

Table 319

Compounds of the formula I where R_(n) is 3-chloro, R¹ is hydrogen, R² Xis ethoxy, R³ is methylthio and R⁴ for a compound in each casecorresponds to one line of Table A.

Table 320

Compounds of the formula I where R_(n) is 3-chloro, R¹ is hydrogen, R² Xis methylamino, R³ is methylthio and R⁴ for a compound in each casecorresponds to one line of Table A.

Table 321

Compounds of the formula I where R_(n) is 3-chloro, R¹ is methyl, R² Xis methyl, R³ is methylthio and R⁴ for a compound in each casecorresponds to one line of Table A.

Table 322

Compounds of the formula I where R_(n) is 3-chloro, R¹ is methyl, R² Xis ethyl, R³ is methylthio and R⁴ for a compound in each casecorresponds to one line of Table A.

Table 323

Compounds of the formula I where R_(n) is 3-chloro, R¹ is methyl, R² Xis methoxy, R³ is methylthio and R⁴ for a compound in each casecorresponds to one line of Table A.

Table 324

Compounds of the formula I where R_(n) is 3-chloro, R¹ is methyl, R² Xis ethoxy, R³ is methylthio and R⁴ for a compound in each casecorresponds to one line of Table A.

Table 325

Compounds of the formula I where R_(n) is 3-chloro, R¹ is methyl, R² Xis methylamino, R³ is methylthio and R⁴ for a compound in each casecorresponds to one line of Table A.

Table 326

Compounds of the formula I where R_(n) is 3-chloro, R¹ is ethyl, R² X ismethyl, R³ is methylthio and R⁴ for a compound in each case correspondsto one line of Table A.

Table 327

Compounds of the formula I where R_(n) is 3-chloro, R¹ is ethyl, R² X isethyl, R³ is methylthio and R⁴ for a compound in each case correspondsto one line of Table A.

Table 328

Compounds of the formula I where R_(n) is 3-chloro, R¹ is ethyl, R² X ismethoxy, R³ is methylthio and R⁴ for a compound in each case correspondsto one line of Table A.

Table 329

Compounds of the formula I where R_(n) is 3-chloro, R¹ is ethyl, R² X isethoxy, R³ is methylthio and R⁴ for a compound in each case correspondsto one line of Table A.

Table 330

Compounds of the formula I where R_(n) is 3-chloro, R¹ is ethyl, R² X ismethylamino, R³ is methylthio and R⁴ for a compound in each casecorresponds to one line of Table A.

Table 331

Compounds of the formula I (n=0) where R¹ is hydrogen, R² X is methyl,R³ is ethylthio and R⁴ for a compound in each case corresponds to oneline of Table A.

Table 332

Compounds of the formula I (n=0) where R¹ is hydrogen, R² X is ethyl, R³is ethylthio and R⁴ for a compound in each case corresponds to one lineof Table A.

Table 333

Compounds of the formula I (n=0) where R¹ is hydrogen, R² X is methoxy,R³ is ethylthio and R⁴ for a compound in each case corresponds to oneline of Table A.

Table 334

Compounds of the formula I (n=0) where R¹ is hydrogen, R² X is ethoxy,R³ is ethylthio and R⁴ for a compound in each case corresponds to oneline of Table A.

Table 335

Compounds of the formula I (n=0) where R¹ is hydrogen, R² X ismethylamino, R³ is ethylthio and R⁴ for a compound in each casecorresponds to one line of Table A.

Table 336

Compounds of the formula I (n=0) where R¹ is methyl, R² X is methyl, R³is ethylthio and R⁴ for a compound in each case corresponds to one lineof Table A.

Table 337

Compounds of the formula I (n=0) where R¹ is methyl, R² X is ethyl, R³is ethylthio and R⁴ for a compound in each case corresponds to one lineof Table A.

Table 338

Compounds of the formula I (n=0) where R¹ is methyl, R² X is methoxy, R³is ethylthio and R⁴ for a compound in each case corresponds to one lineof Table A.

Table 339

Compounds of the formula I (n=0) where R¹ is methyl, R² X is ethoxy, R³is ethylthio and R⁴ for a compound in each case corresponds to one lineof Table A.

Table 340

Compounds of the formula I (n=0) where R¹ is methyl, R² X ismethylamino, R³ is ethylthio and R⁴ for a compound in each casecorresponds to one line of Table A.

Table 341

Compounds of the formula I (n=0) where R¹ is ethyl, R² X is methyl, R³is ethylthio and R⁴ for a compound in each case corresponds to one lineof Table A.

Table 342

Compounds of the formula I (n=0) where R¹ is ethyl, R² X is ethyl, R³ isethylthio and R⁴ for a compound in each case corresponds to one line ofTable A.

Table 343

Compounds of the formula I (n=0) where R¹ is ethyl, R² X is methoxy, R³is ethylthio and R⁴ for a compound in each case corresponds to one lineof Table A.

Table 344

Compounds of the formula I (n=0) where R¹ is ethyl, R² X is ethoxy, R³is ethylthio and R⁴ for a compound in each case corresponds to one lineof Table A.

Table 345

Compounds of the formula I (n=0) where R¹ is ethyl, R² X is methylamino,R³ is ethylthio and R⁴ for a compound in each case corresponds to oneline of Table A.

Table 346

Compounds of the formula I where R_(n) is 3-chloro, R¹ is hydrogen, R² Xis methyl, R³ is ethylthio and R⁴ for a compound in each casecorresponds to one line of Table A.

Table 347

Compounds of the formula I where R_(n) is 3-chloro, R¹ is hydrogen, R² Xis ethyl, R³ is ethylthio and R⁴ for a compound in each case correspondsto one line of Table A.

Table 348

Compounds of the formula I where R_(n) is 3-chloro, R¹ is hydrogen, R² Xis methoxy, R³ is ethylthio and R⁴ for a compound in each casecorresponds to one line of Table A.

Table 349

Compounds of the formula I where R_(n) is 3-chloro, R¹ is hydrogen, R² Xis ethoxy, R³ is ethylthio and R⁴ for a compound in each casecorresponds to one line of Table A.

Table 350

Compounds of the formula I where R_(n) is 3-chloro, R¹ is hydrogen, R² Xis methylamino, R³ is ethylthio and R⁴ for a compound in each casecorresponds to one line of Table A.

Table 351

Compounds of the formula I where R_(n) is 3-chloro, R¹ is methyl, R² Xis methyl, R³ is ethylthio and R⁴ for a compound in each casecorresponds to one line of Table A.

Table 352

Compounds of the formula I where R_(n) is 3-chloro, R¹ is methyl, R² Xis ethyl, R³ is ethylthio and R⁴ for a compound in each case correspondsto one line of Table A.

Table 353

Compounds of the formula I where R_(n) is 3-chloro, R¹ is methyl, R² Xis methoxy, R³ is ethylthio and R⁴ for a compound in each casecorresponds to one line of Table A.

Table 354

Compounds of the formula I where R_(n) is 3-chloro, R¹ is methyl, R² Xis ethoxy, R³ is ethylthio and R⁴ for a compound in each casecorresponds to one line of Table A.

Table 355

Compounds of the formula I where R_(n) is 3-chloro, R¹ is methyl, R² Xis methylamino, R³ is ethylthio and R⁴ for a compound in each casecorresponds to one line of Table A.

Table 356

Compounds of the formula I where R_(n) is 3-chloro, R¹ is ethyl, R² X ismethyl, R³ is ethylthio and R⁴ for a compound in each case correspondsto one line of Table A.

Table 357

Compounds of the formula I where R_(n) is 3-chloro, R¹ is ethyl, R² X isethyl, R³ is ethylthio and R⁴ for a compound in each case corresponds toone line of Table A.

Table 358

Compounds of the formula I where R_(n) is 3-chloro, R¹ is ethyl, R² X ismethoxy, R³ is ethylthio and R⁴ for a compound in each case correspondsto one line of Table A.

Table 359

Compounds of the formula I where R_(n) is 3-chloro, R¹ is ethyl, R² X isethoxy, R³ is ethylthio and R⁴ for a compound in each case correspondsto one line of Table A.

Table 360

Compounds of the formula I where R_(n) is 3-chloro, R¹ is ethyl, R² X ismethylamino, R³ is ethylthio and R⁴ for a compound in each casecorresponds to one line of Table A.

Table 361

Compounds of the formula I (n=0) where R¹ is hydrogen, R² X is methyl,R³ is cyclopropyl and R⁴ for a compound in each case corresponds to oneline of Table A.

Table 362

Compounds of the formula I (n=0) where R¹ is hydrogen, R² X is ethyl, R³is cyclopropyl and R⁴ for a compound in each case corresponds to oneline of Table A.

Table 363

Compounds of the formula I (n=0) where R¹ is hydrogen, R² X is methoxy,R³ is cyclopropyl and R⁴ for a compound in each case corresponds to oneline of Table A.

Table 364

Compounds of the formula I (n=0) where R¹ is hydrogen, R² X is ethoxy,R³ is cyclopropyl and R⁴ for a compound in each case corresponds to oneline of Table A.

Table 365

Compounds of the formula I (n=0) where R¹ is hydrogen, R² X ismethylamino, R³ is cyclopropyl and R⁴ for a compound in each casecorresponds to one line of Table A.

Table 366

Compounds of the formula I (n=0) where R¹ is methyl, R² X is methyl, R³is cyclopropyl and R⁴ for a compound in each case corresponds to oneline of Table A.

Table 367

Compounds of the formula I (n=0) where R¹ is methyl, R² X is ethyl, R³is cyclopropyl and R⁴ for a compound in each case corresponds to oneline of Table A.

Table 368

Compounds of the formula I (n=0) where R¹ is methyl, R² X is methoxy, R³is cyclopropyl and R⁴ for a compound in each case corresponds to oneline of Table A.

Table 369

Compounds of the formula I (n=0) where R¹ is methyl, R² X is ethoxy, R³is cyclopropyl and R⁴ for a compound in each case corresponds to oneline of Table A.

Table 370

Compounds of the formula I (n=0) where R¹ is methyl, R² X ismethylamino, R³ is cyclopropyl and R⁴ for a compound in each casecorresponds to one line of Table A.

Table 371

Compounds of the formula I (n=0) where R¹ is ethyl, R² X is methyl, R³is cyclopropyl and R⁴ for a compound in each case corresponds to oneline of Table A.

Table 372

Compounds of the formula I (n=0) where R¹ is ethyl, R² X is ethyl, R³ iscyclopropyl and R⁴ for a compound in each case corresponds to one lineof Table A.

Table 373

Compounds of the formula I (n=0) where R¹ is ethyl, R² X is methoxy, R³is cyclopropyl and R⁴ for a compound in each case corresponds to oneline of Table A.

Table 374

Compounds of the formula I (n=0) where R¹ is ethyl, R² X is ethoxy, R³is cyclopropyl and R⁴ for a compound in each case corresponds to oneline of Table A.

Table 375

Compounds of the formula I (n=0) where R¹ is ethyl, R² X is methylamino,R³ is cyclopropyl and R⁴ for a compound in each case corresponds to oneline of Table A.

Table 376

Compounds of the formula I where R_(n) is 3-chloro, R¹ is hydrogen, R² Xis methyl, R³ is cyclopropyl and R⁴ for a compound in each casecorresponds to one line of Table A.

Table 377

Compounds of the formula I where R_(n) is 3-chloro, R¹ is hydrogen, R² Xis ethyl, R³ is cyclopropyl and R⁴ for a compound in each casecorresponds to one line of Table A.

Table 378

Compounds of the formula I where R_(n) is 3-chloro, R¹ is hydrogen, R² Xis methoxy, R³ is cyclopropyl and R⁴ for a compound in each casecorresponds to one line of Table A.

Table 379

Compounds of the formula I where R_(n) is 3-chloro, R¹ is hydrogen, R² Xis ethoxy, R³ is cyclopropyl and R⁴ for a compound in each casecorresponds to one line of Table A.

Table 380

Compounds of the formula I where R_(n) is 3-chloro, R¹ is hydrogen, R² Xis methylamino, R³ is cyclopropyl and R⁴ for a compound in each casecorresponds to one line of Table A.

Table 381

Compounds of the formula I where R_(n) is 3-chloro, R¹ is methyl, R² Xis methyl, R³ is cyclopropyl and R⁴ for a compound in each casecorresponds to one line of Table A.

Table 382

Compounds of the formula I where R_(n) is 3-chloro, R¹ is methyl, R² Xis ethyl, R³ is cyclopropyl and R⁴ for a compound in each casecorresponds to one line of Table A.

Table 383

Compounds of the formula I where R_(n) is 3-chloro, R¹ is methyl, R² Xis methoxy, R³ is cyclopropyl and R⁴ for a compound in each casecorresponds to one line of Table A.

Table 384

Compounds of the formula I where R_(n) is 3-chloro, R¹ is methyl, R² Xis ethoxy, R³ is cyclopropyl and R⁴ for a compound in each casecorresponds to one line of Table A.

Table 385

Compounds of the formula I where R_(n) is 3-chloro, R¹ is methyl, R² Xis methylamino, R³ is cyclopropyl and R⁴ for a compound in each casecorresponds to one line of Table A.

Table 386

Compounds of the formula I where R_(n) is 3-chloro, R¹ is ethyl, R² X ismethyl, R³ is cyclopropyl and R⁴ for a compound in each case correspondsto one line of Table A.

Table 387

Compounds of the formula I where R_(n) is 3-chloro, R¹ is ethyl, R² X isethyl, R³ is cyclopropyl and R⁴ for a compound in each case correspondsto one line of Table A.

Table 388

Compounds of the formula I where R_(n) is 3-chloro, R¹ is ethyl, R² X ismethoxy, R³ is cyclopropyl and R⁴ for a compound in each casecorresponds to one line of Table A.

Table 389

Compounds of the formula I where R_(n) is 3-chloro, R¹ is ethyl, R² X isethoxy, R³ is cyclopropyl and R⁴ for a compound in each case correspondsto one line of Table A.

Table 390

Compounds of the formula I where R_(n) is 3-chloro, R¹ is ethyl, R² X ismethylamino, R³ is cyclopropyl and R⁴ for a compound in each casecorresponds to one line of Table A.

Table 391

Compounds of the formula I where R_(n) is 6-methyl, R¹ is hydrogen, R² Xis methyl, R³ is methyl and R⁴ for a compound in each case correspondsto one line of Table A.

Table 392

Compounds of the formula I where R_(n) is 6-methyl, R¹ is hydrogen, R² Xis ethyl, R³ is methyl and R⁴ for a compound in each case corresponds toone line of Table A.

Table 393

Compounds of the formula I where R_(n) is 6-methyl, R¹ is hydrogen, R² Xis methoxy, R³ is methyl and R⁴ for a compound in each case correspondsto one line of Table A.

Table 394

Compounds of the formula I where R_(n) is 6-methyl, R¹ is hydrogen, R² Xis ethoxy, R³ is methyl and R⁴ for a compound in each case correspondsto one line of Table A.

Table 395

Compounds of the formula I where R_(n) is 6-methyl, R¹ is hydrogen, R² Xis methylamino, R³ is methyl and R⁴ for a compound in each casecorresponds to one line of Table A.

Table 396

Compounds of the formula I where R_(n) is 6-methyl, R¹ is methyl, R² Xis methyl, R³ is methyl and R⁴ for a compound in each case correspondsto one line of Table A.

Table 397

Compounds of the formula I where R_(n) is 6-methyl, R¹ is methyl, R² Xis ethyl, R³ is methyl and R⁴ for a compound in each case corresponds toone line of Table A.

Table 398

Compounds of the formula I where R_(n) is 6-methyl, R¹ is methyl, R² Xis methoxy, R³ is methyl and R⁴ for a compound in each case correspondsto one line of Table A.

Table 399

Compounds of the formula I where R_(n) is 6-methyl, R¹ is methyl, R² Xis ethoxy, R³ is methyl and R⁴ for a compound in each case correspondsto one line of Table A.

Table 400

Compounds of the formula I where R_(n) is 6-methyl, R¹ is methyl, R² Xis methylamino, R³ is methyl and R⁴ for a compound in each casecorresponds to one line of Table A.

Table 401

Compounds of the formula I where R_(n) is 6-methyl, R¹ is ethyl, R² X ismethyl, R³ is methyl and R⁴ for a compound in each case corresponds toone line of Table A.

Table 402

Compounds of the formula I where R_(n) is 6-methyl, R¹ is ethyl, R² X isethyl, R³ is methyl and R⁴ for a compound in each case corresponds toone line of Table A.

Table 403

Compounds of the formula I where R_(n) is 6-methyl, R¹ is ethyl, R² X ismethoxy, R³ is methyl and R⁴ for a compound in each case corresponds toone line of Table A.

Table 404

Compounds of the formula I where R_(n) is 6-methyl, R¹ is ethyl, R² X isethoxy, R³ is methyl and R⁴ for a compound in each case corresponds toone line of Table A.

Table 405

Compounds of the formula I where R_(n) is 6-methyl, R¹ is ethyl, R² X ismethylamino, R³ is methyl and R⁴ for a compound in each case correspondsto one line of Table A.

Table 406

Compounds of the formula I where R_(n) is 3-chloro, R¹ is hydrogen, R² Xis methyl, R³ is cyclopentyl and R⁴ for a compound in each casecorresponds to one line of Table A.

Table 407

Compounds of the formula I where R_(n) is 3-chloro, R¹ is hydrogen, R² Xis ethyl, R³ is cyclopentyl and R⁴ for a compound in each casecorresponds to one line of Table A.

Table 408

Compounds of the formula I where R_(n) is 3-chloro, R¹ is hydrogen, R² Xis methoxy, R³ is cyclopentyl and R⁴ for a compound in each casecorresponds to one line of Table A.

Table 409

Compounds of the formula I where R_(n) is 3-chloro, R¹ is hydrogen, R² Xis ethoxy, R³ is cyclopentyl and R⁴ for a compound in each casecorresponds to one line of Table A.

Table 410

Compounds of the formula I where R_(n) is 3-chloro, R¹ is hydrogen, R² Xis methylamino, R³ is cyclopentyl and R⁴ for a compound in each casecorresponds to one line of Table A.

Table 411

Compounds of the formula I where R_(n) is 3-chloro, R¹ is methyl, R² Xis methyl, R³ is cyclopentyl and R⁴ for a compound in each casecorresponds to one line of Table A.

Table 412

Compounds of the formula I where R_(n) is 3-chloro, R¹ is methyl, R² Xis ethyl, R³ is cyclopentyl and R⁴ for a compound in each casecorresponds to one line of Table A.

Table 413

Compounds of the formula I where R_(n) is 3-chloro, R¹ is methyl, R² Xis methoxy, R³ is cyclopentyl and R⁴ for a compound in each casecorresponds to one line of Table A.

Table 414

Compounds of the formula I where R_(n) is 3-chloro, R¹ is methyl, R² Xis ethoxy, R³ is cyclopentyl and R⁴ for a compound in each casecorresponds to one line of Table A.

Table 415

Compounds of the formula I where R_(n) is 3-chloro, R¹ is methyl, R² Xis methylamino, R³ is cyclopentyl and R⁴ for a compound in each casecorresponds to one line of Table A.

Table 416

Compounds of the formula I where R_(n) is 3-chloro, R¹ is ethyl, R² X ismethyl, R³ is cyclopentyl and R⁴ for a compound in each case correspondsto one line of Table A.

Table 417

Compounds of the formula I where R_(n) is 3-chloro, R¹ is ethyl, R² X isethyl, R³ is cyclopentyl and R⁴ for a compound in each case correspondsto one line of Table A.

Table 418

Compounds of the formula I where R_(n) is 3-chloro, R¹ is ethyl, R² X ismethoxy, R³ is cyclopentyl and R⁴ for a compound in each casecorresponds to one line of Table A.

Table 419

Compounds of the formula I where R_(n) is 3-chloro, R¹ is ethyl, R² X isethoxy, R³ is cyclopentyl and R⁴ for a compound in each case correspondsto one line of Table A.

Table 420

Compounds of the formula I where R_(n) is 3-chloro, R¹ is ethyl, R² X ismethylamino, R³ is cyclopentyl and R⁴ for a compound in each casecorresponds to one line of Table A.

Table 421

Compounds of the formula I (n=0) where R¹ is hydrogen, R² X is methyl,R³ is cyclohexyl and R⁴ for a compound in each case corresponds to oneline of Table A.

Table 422

Compounds of the formula I (n=0) where R¹ is hydrogen, R² X is ethyl, R³is cyclohexyl and R⁴ for a compound in each case corresponds to one lineof Table A.

Table 423

Compounds of the formula I (n=0) where R¹ is hydrogen, R² X is methoxy,R³ is cyclohexyl and R⁴ for a compound in each case corresponds to oneline of Table A.

Table 424

Compounds of the formula I (n=0) where R¹ is hydrogen, R² X is ethoxy,R³ is cyclohexyl and R⁴ for a compound in each case corresponds to oneline of Table A.

Table 425

Compounds of the formula I (n=0) where R¹ is hydrogen, R² X ismethylamino, R³ is cyclohexyl and R⁴ for a compound in each casecorresponds to one line of Table A.

Table 426

Compounds of the formula I (n=0) where R¹ is methyl, R² X is methyl, R³is cyclohexyl and R⁴ for a compound in each case corresponds to one lineof Table A.

Table 427

Compounds of the formula I (n=0) where R¹ is methyl, R² X is ethyl, R³is cyclohexyl and R⁴ for a compound in each case corresponds to one lineof Table A.

Table 428

Compounds of the formula I (n=0) where R¹ is methyl, R² X is ethoxy, R³is cyclohexyl and R⁴ for a compound in each case corresponds to one lineof Table A.

Table 429

Compounds of the formula I (n=0) where R¹ is methyl, R² X is ethoxy, R³is cyclohexyl and R⁴ for a compound in each case corresponds to one lineof Table A.

Table 430

Compounds of the formula I (n=0) where R¹ is methyl, R² X ismethylamino, R³ is cyclohexyl and R⁴ for a compound in each casecorresponds to one line of Table A.

Table 431

Compounds of the formula I (n=0) where R¹ is ethyl, R² X is methyl, R³is cyclohexyl and R⁴ for a compound in each case corresponds to one lineof Table A.

Table 432

Compounds of the formula I (n=0) where R¹ is ethyl, R² X is ethyl, R³ iscyclohexyl and R⁴ for a compound in each case corresponds to one line ofTable A.

Table 433

Compounds of the formula I (n=0) where R¹ is ethyl, R² X is methoxy, R³is cyclohexyl and R⁴ for a compound in each case corresponds to one lineof Table A.

Table 434

Compounds of the formula I (n=0) where R¹ is ethyl, R² X is ethoxy, R³is cyclohexyl and R⁴ for a compound in each case corresponds to one lineof Table A.

Table 435

Compounds of the formula I (n=0) where R¹ is ethyl, R² X is methylamino,R³ is cyclohexyl and R⁴ for a compound in each case corresponds to oneline of Table A.

Table 436

Compounds of the formula I where R_(n) is 3-chloro, R¹ is hydrogen, R² Xis methyl, R³ is cyclohexyl and R⁴ for a compound in each casecorresponds to one line of Table A.

Table 437

Compounds of the formula I where R_(n) is 3-chloro, R¹ is hydrogen, R² Xis ethyl, R³ is cyclohexyl and R⁴ for a compound in each casecorresponds to one line of Table A.

Table 438

Compounds of the formula I where R_(n) is 3-chloro, R¹ is hydrogen, R² Xis methoxy, R³ is cyclohexyl and R⁴ for a compound in each casecorresponds to one line of Table A.

Table 439

Compounds of the formula I where R_(n) is 3-chloro, R¹ is hydrogen, R² Xis ethoxy, R³ is cyclohexyl and R⁴ for a compound in each casecorresponds to one line of Table A.

Table 440

Compounds of the formula I where R_(n) is 3-chloro, R¹ is hydrogen, R² Xis methylamino, R³ is cyclohexyl and R⁴ for a compound in each casecorresponds to one line of Table A.

Table 441

Compounds of the formula I where R_(n) is 3-chloro, R¹ is methyl, R² Xis methyl, R³ is cyclohexyl and R⁴ for a compound in each casecorresponds to one line of Table A.

Table 442

Compounds of the formula I where R_(n) is 3-chloro, R¹ is methyl, R² Xis ethyl, R³ is cyclohexyl and R⁴ for a compound in each casecorresponds to one line of Table A.

Table 443

Compounds of the formula I where R_(n) is 3-chloro, R¹ is methyl, R² Xis methoxy, R³ is cyclohexyl and R⁴ for a compound in each casecorresponds to one line of Table A.

Table 444

Compounds of the formula I where R_(n) is 3-chloro, R¹ is methyl, R² Xis ethoxy, R³ is cyclohexyl and R⁴ for a compound in each casecorresponds to one line of Table A.

Table 445

Compounds of the formula I where R_(n) is 3-chloro, R¹ is methyl, R² Xis methylamino, R³ is cyclohexyl and R⁴ for a compound in each casecorresponds to one line of Table A.

Table 446

Compounds of the formula I where R_(n) is 3-chloro, R¹ is ethyl, R² X ismethyl, R³ is cyclohexyl and R⁴ for a compound in each case correspondsto one line of Table A.

Table 447

Compounds of the formula I where R_(n) is 3-chloro, R¹ is ethyl, R² X isethyl, R³ is cyclohexyl and R⁴ for a compound in each case correspondsto one line of Table A.

Table 448

Compounds of the formula I where R_(n) is 3-chloro, R¹ is ethyl, R² X ismethoxy, R³ is cyclohexyl and R⁴ for a compound in each case correspondsto one line of Table A.

Table 449

Compounds of the formula I where R_(n) is 3-chloro, R¹ is ethyl, R² X isethoxy, R³ is cyclohexyl and R⁴ for a compound in each case correspondsto one line of Table A.

Table 450

Compounds of the formula I where R_(n) is 3-chloro, R¹ is ethyl, R² X ismethylamino, R³ is cyclohexyl and R⁴ for a compound in each casecorresponds to one line of Table A.

                  TABLE A                                                         ______________________________________                                        No.    R.sup.4                                                                ______________________________________                                        1      3-CH.sub.3 -pyridin-2-yl                                               2      4-CH.sub.3 -pyridin-2-yl                                               3      5-CH.sub.3 -pyridin-2-yl                                               4      6-CH.sub.3 -pyridin-2-yl                                               5      3-CH.sub.2 CH.sub.3 -pyridin-2-yl                                      6      4-CH.sub.2 CH.sub.3 -pyridin-2-yl                                      7      5-CH.sub.2 CH.sub.3 -pyridin-2-yl                                      8      6-CH.sub.2 CH.sub.3 -pyridin-2-yl                                      9      3-CF.sub.3 -pyridin-2-yl                                               10     4-CF.sub.3 -pyridin-2-yl                                               11     5-CF.sub.3 -pyridin-2-yl                                               12     6-CF.sub.3 -pyridin-2-yl                                               13     3-OCH.sub.3 -pyridin-2-yl                                              14     4-OCH.sub.3 -pyridin-2-yl                                              15     5-OCH.sub.3 -pyridin-2-yl                                              16     6-OCH.sub.3 -pyridin-2-yl                                              17     3-OCH.sub.2 CH.sub.3 -pyridin-2-yl                                     18     4-OCH.sub.2 CH.sub.3 -pyridin-2-yl                                     19     5-OCH.sub.2 CH.sub.3 -pyridin-2-yl                                     20     6-OCH.sub.2 CH.sub.3 -pyridin-2-yl                                     21     3-OCH(CH.sub.3).sub.2 -pyridin-2-yl                                    22     4-OCH(CH.sub.3).sub.2 -pyridin-2-yl                                    23     5-OCH(CH.sub.3).sub.2 -pyridin-2-yl                                    24     6-OCH(CH.sub.3).sub.2 -pyridin-2-yl                                    25     3-OCH.sub.2 CH.sub.2 OCH.sub.3 -pyridin-2-yl                           26     4-OCH.sub.2 CH.sub.2 OCH.sub.3 -pyridin-2-yl                           27     5-OCH.sub.2 CH.sub.2 OCH.sub.3 -pyridin-2-yl                           28     6-OCH.sub.2 CH.sub.2 OCH.sub.3 -pyridin-2-yl                           29     3-OCH.sub.2 CF.sub.3 -pyridin-2-yl                                     30     4-OCH.sub.2 CF.sub.3 -pyridin-2-yl                                     31     5-OCH.sub.2 CF.sub.3 -pyridin-2-yl                                     32     6-OCH.sub.2 CF.sub.3 -pyridin-2-yl                                     33     3-NO.sub.2 -pyridin-2-yl                                               34     4-NO.sub.2 -pyridin-2-yl                                               35     5-NO.sub.2 -pyridin-2-yl                                               36     6-NO.sub.2 -pyridin-2-yl                                               37     3-CN-pyridin-2-yl                                                      38     4-CN-pyridin-2-yl                                                      39     5-CN-pyridin-2-yl                                                      40     6-CN-pyridin-2-yl                                                      41     4-C(O)NH.sub.2 -pyridin-2-yl                                           42     5-C(O)NH.sub.2 -pyridin-2-yl                                           43     6-C(O)NH.sub.2 -pyridin-2-yl                                           44     4-C(S)NH.sub.2 -pyridin-2-yl                                           45     5-C(S)NH.sub.2 -pyridin-2-yl                                           46     6-C(S)NH.sub.2 -pyridin-2-yl                                           47     3-CO.sub.2 CH.sub.3 -pyridin-2-yl                                      48     4-CO.sub.2 CH.sub.3 -pyridin-2-yl                                      49     5-CO.sub.2 CH.sub.3 -pyridin-2-yl                                      50     6-CO.sub.2 CH.sub.3 -pyridin-2-yl                                      51     4- 2-Cl--C.sub.6 H.sub.4 !-pyridin-2-yl                                52     5- 2-Cl--C.sub.6 H.sub.4 !-pyridin-2-yl                                53     6- 2-Cl--C.sub.6 H.sub.4 !-pyridin-2-yl                                54     4- 1-CH.sub.3 -imidazol-2-yl!pyridin-2-yl                              55     5- 1-CH.sub.3 -imidazol-2-yl!pyridin-2-yl                              56     6- 1-CH.sub.3 -imidazol-2-yl!pyridin-2-yl                              57     4-CF.sub.3, 3-OCH.sub.3 -pyridin-2-yl                                  58     4-CF.sub.3, 6-OCH.sub.3 -pyridin-2-yl                                  59     4-CF.sub.3, 3-OCH.sub.2 CH.sub.3 -pyridin-2-yl                         60     4-CF.sub.3, 6-OCH.sub.2 CH.sub.3 -pyridin-2-yl                         61     4-CF.sub.3, 3-OCH.sub.2 CF.sub.3 -pyridin-2-yl                         62     4-CF.sub.3, 6-OCH.sub.2 CF.sub.3 -pyridin-2-yl                         63     2-CH.sub.3 -pyridin-3-yl                                               64     4-CH.sub.3 -pyridin-3-yl                                               65     5-CH.sub.3 -pyridin-3-yl                                               66     6-CH.sub.3 -pyridin-3-yl                                               67     2-CH.sub.2 CH.sub.3 -pyridin-3-yl                                      68     4-CH.sub.2 CH.sub.3 -pyridin-3-yl                                      69     5-CH.sub.2 CH.sub.3 -pyridin-3-yl                                      70     6-CH.sub.2 CH.sub.3 -pyridin-3-yl                                      71     2-CF.sub.3 -pyridin-3-yl                                               72     4-CF.sub.3 -pyridin-3-yl                                               73     5-CF.sub.3 -pyridin-3-yl                                               74     6-CF.sub.3 -pyridin-3-yl                                               75     2-OCH.sub.3 -pyridin-3-yl                                              76     4-OCH.sub.3 -pyridin-3-yl                                              77     5-OCH.sub.3 -pyridin-3-yl                                              78     6-OCH.sub.3 -pyridin-3-yl                                              79     2-OCH.sub.2 CH.sub.3 -pyridin-3-yl                                     80     4-OCH.sub.2 CH.sub.3 -pyridin-3-yl                                     81     5-OCH.sub.2 CH.sub.3 -pyridin-3-yl                                     82     6-OCH.sub.2 CH.sub.3 -pyridin-3-yl                                     83     2-CH.sub.3 -pyridin-4-yl                                               84     3-CH.sub.3 -pyridin-4-yl                                               85     2-CH.sub.2 CH.sub.3 -pyridin-4-yl                                      86     3-CH.sub.2 CH.sub.3 -pyridin-4-yl                                      87     2-CF.sub.3 -pyridin-4-yl                                               88     3-CF.sub.3 -pyridin-4-yl                                               89     2-OCH.sub.3 -pyridin-4-yl                                              90     3-OCH.sub.3 -pyridin-4-yl                                              91     2-OCH.sub.2 CH.sub.3 -pyridin-4-yl                                     92     3-OCH.sub.2 CH.sub.3 -pyridin-4-yl                                     93     4-CH.sub.3 -pyridin-2-yl                                               94     5-CH.sub.3 -pyrimidin-2-yl                                             95     4-CH.sub.2 CH.sub.3 -pyrimidin-2-yl                                    96     5-CH.sub.2 CH.sub.3 -pyrimidin-2-yl                                    97     4-CH(CH.sub.3).sub.2 -pyrimidin-2-yl                                   96     5-CH(CH.sub.3).sub.2 -pyrimidin-2-yl                                   99     4-CH(CH.sub.3)CH.sub.2 CH.sub.3 -pyrimidin-2-yl                        100    5-CH(CH.sub.3)CH.sub.2 CH.sub.3 -pyrimidin-2-yl                        101    4-CF.sub.3 -pyrimidin-2-yl                                             102    5-CF.sub.3 -pyrimidin-2-yl                                             103    4-CH═CH.sub.2 -pyrimidin-2-yl                                      104    5-CH═CH.sub.2 -pyrimidin-2-yl                                      105    4-CH═CHCH.sub.3 -pyrimidin-2-yl                                    106    5-CH═CHCH.sub.3 -pyrimidin-2-yl                                    107    4-CH═CHCl-pyrimidin-2-yl                                           108    5-CH═CHCl-pyrimidin-2-yl                                           109    4-C.tbd.CH-pyrimidin-2-yl                                              110    5-C.tbd.CH-pyrimidin-2-yl                                              111    4-CH.sub.2 C.tbd.CH-pyrimidin-2-yl                                     112    5-CH.sub.2 C.tbd.CH-pyrimidin-2-yl                                     113    4-CH.sub.2 C.tbd.CCH.sub.3 -pyrimidin-2-yl                             114    5-CH.sub.2 C.tbd.CCH.sub.3 -pyrimidin-2-yl                             115    4-cyclopropyl-pyrimidin-2-yl                                           116    5-cyclopropyl-pyrimidin-2-yl                                           117    4-cyclopentyl-pyrimidin-2-yl                                           118    5-cyclopentyl-pyrimidin-2-yl                                           119    4-OCH.sub.3 -pyrimidin-2-yl                                            120    5-OCH.sub.3 -pyrimidin-2-yl                                            121    4-OCH.sub.2 CH.sub.3 -pyrimidin-2-yl                                   122    5-OCH.sub.2 CH.sub.3 -pyrimidin-2-yl                                   123    4-OCH.sub.2 CH.sub.2 CH.sub.3 -pyrimidin-2-yl                          124    5-OCH.sub.2 CH.sub.2 CH.sub.3 -pyrimidin-2-yl                          125    4-OCH(CH.sub.3).sub.2 -pyrimidin-2-yl                                  126    5-OCH(CH.sub.3).sub.2 -pyrimidin-2-yl                                  127    4-OCH.sub.2 CH.sub.2 CH.sub.2 CH.sub.3 -pyrimidin-2-yl                 128    5-OCH.sub.2 CH.sub.2 CH.sub.2 CH.sub.3 -pyrimidin-2-yl                 129    4-OCH(CH.sub.3)CH.sub.2 CH.sub.3 -pyrimidin-2-yl                       130    5-OCH(CH.sub.3)CH.sub.2 CH.sub.3 -pyrimidin-2-yl                       131    4-OCH.sub.2 CH(CH.sub.3).sub.2 -pyrimidin-2-yl                         132    5-OCH.sub.2 CH(CH.sub.3).sub.2 -pyrimidin-2-yl                         133    4-OC(CH.sub.3).sub.3 -pyrimidin-2-yl                                   134    5-OC(CH.sub.3).sub.3 -pyrimidin-2-yl                                   135    4-OCH(CH.sub.3)CH.sub.2 CH.sub.2 CH.sub.3 -pyrimidin-2-yl              136    5-OCH(CH.sub.3)CH.sub.2 CH.sub.2 CH.sub.3 -pyrimidin-2-yl              137    4-OCH.sub.2 OCH.sub.3 -pyrimidin-2-yl                                  138    5-OCH.sub.2 OCH.sub.3 -pyrimidin-2-yl                                  139    4-OCH.sub.2 OCH.sub.2 CH.sub.3 -pyrimidin-2-yl                         140    5-OCH.sub.2 OCH.sub.2 CH.sub.3 -pyrimidin-2-yl                         141    4-OCH(CH.sub.3)OCH.sub.3 -pyrimidin-2-yl                               142    5-OCH(CH.sub.3)OCH.sub.3 -pyrimidin-2-yl                               143    4-OCH(CH.sub.3)OCH.sub.2 CH.sub.3 -pyrimidin-2-yl                      144    5-OCH(CH.sub.3)OCH.sub.2 CH.sub.3 -pyrimidin-2-yl                      145    4-OCH.sub.2 CH.sub.2 OCH.sub.3 -pyrimidin-2-yl                         146    5-OCH.sub.2 CH.sub.2 OCH.sub.3 -pyrimidin-2-yl                         147    4-OCH.sub.2 CH.sub.2 OCH.sub.2 CH.sub.3 -pyrimidin-2-yl                148    5-OCH.sub.2 CH.sub.2 OCH.sub.2 CH.sub.3 -pyrimidin-2-yl                149    4-OCH.sub.2 CH.sub.2 OCH(CH.sub.3).sub.2 -pyrimidin-2-yl               150    5-OCH.sub.2 CH.sub.2 OCH(CH.sub.3).sub.2 -pyrimidin-2-yl               151    4-OCH.sub.2 CH.sub.2 SCH.sub.3 -pyrimidin-2-yl                         152    5-OCH.sub.2 CH.sub.2 SCH.sub.3 -pyrimidin-2-yl                         153    4-OCH.sub.2 CH.sub.2 SO.sub.2 CH.sub.3 -pyrimidin-2-yl                 154    5-OCH.sub.2 CH.sub.2 SO.sub.2 CH.sub.3 -pyrimidin-2-yl                 155    4-OCH.sub.2 CH.sub.2 SCH(CH.sub.3).sub.2 -pyrimidin-2-yl               156    5-OCH.sub.2 CH.sub.2 SCH(CH.sub.3).sub.2 -pyrimidin-2-yl               157    4-OCH.sub.2 CH.sub.2 CN-pyrimidin-2-yl                                 158    5-OCH.sub.2 CH.sub.2 CN-pyrimidin-2-yl                                 159    4-OCH.sub.2 CH.sub.2 SCH.sub.2 CH.sub.2 CN-pyrimidin-2-yl              160    5-OCH.sub.2 CH.sub.2 SCH.sub.2 CH.sub.2 CN-pyrimidin-2-yl              161    4-OCH.sub.2 CH.sub.2 OC.sub.6 H.sub.5 -pyrimidin-2-yl                  162    5-OCH.sub.2 CH.sub.2 OC.sub.6 H.sub.5 -pyrimidin-2-yl                  163    4-OCH.sub.2 CH.sub.2 OCH.sub.2 C.sub.6 H.sub.5 -pyrimidin-2-yl         164    5-OCH.sub.2 CH.sub.2 OCH.sub.2 C.sub.6 H.sub.5 -pyrimidin-2-yl         165    4-OCH.sub.2 CH.sub.2 N(CH.sub.3).sub.2 -pyrimidin-2-yl                 166    5-OCH.sub.2 CH.sub.2 N(CH.sub.3).sub.2 -pyrimidin-2-yl                 167    4-OCH.sub.2 CH.sub.2 CONH.sub.2 -pyrimidin-2-yl                        168    5-OCH.sub.2 CH.sub.2 CONH.sub.2 -pyrimidin-2-yl                        169    4-OCH.sub.2 CH.sub.2 CO.sub.2 CH.sub.2 CH.sub.2 CH.sub.3 -pyrimidin           -2-yl                                                                  170    5-OCH.sub.2 CH.sub.2 CO.sub.2 CH.sub.2 CH.sub.2 CH.sub.3 -pyrimidin           -2-yl                                                                  171    4-OCH(CH.sub.3)CH.sub.2 OCH.sub.3 -pyrimidin-2-yl                      172    5-OCH(CH.sub.3)CH.sub.2 OCH.sub.3 -pyrimidin-2-yl                      173    4-OCH(CH.sub.3)CH.sub.2 CO.sub.2 CH.sub.3 -pyrimidin-2-yl              174    5-OCH(CH.sub.3)CH.sub.2 CO.sub.2 CH.sub.3 -pyrimidin-2-yl              175    4-OCH(CH.sub.3)CH.sub.2 CO.sub.2 CH.sub.2 CH.sub.3 -pyrimidin-2-yl            .                                                                      176    5-OCH(CH.sub.3)CH.sub.2 CO.sub.2 CH.sub.2 CH.sub.3 -pyrimidin-2-yl            7                                                                      177    4-OCH.sub.2 CH(CH.sub.3)CO.sub.2 CH.sub.3 -pyrimidin-2-yl              178    5-OCH.sub.2 CH(CH.sub.3)CO.sub.2 CH.sub.3 -pyrimidin-2-yl              179    4-OCH.sub.2 C(═O)CH.sub.3 -pyrimidin-2-yl                          180    5-OCH.sub.2 C(═O)CH.sub.3 -pyrimidin-2-yl                          181    4-OCH.sub.2 C(═O)CH.sub.2 CH.sub.3 -pyrimidin-2-yl                 182    5-OCH.sub.2 C(═O)CH.sub.2 CH.sub.3 -pyrimidin-2-yl                 183    4-OCH.sub.2 CO.sub.2 CH.sub.3 -pyrimidin-2-yl                          184    5-OCH.sub.2 CO.sub.2 CH.sub.3 -pyrimidin-2-yl                          185    4-OCH.sub.2 CO.sub.2 CH.sub.2 CH.sub.3 -pyrimidin-2-yl                 186    5-OCH.sub.2 CO.sub.2 CH.sub.2 CH.sub.3 -pyrimidin-2-yl                 187    4-OCH.sub.2 C(═O)NH.sub.2 -pyrimidin-2-yl                          188    5-OCH.sub.2 C(═O)NH.sub.2 -pyrimidin-2-yl                          189    4-OCH.sub.2 C(═O)NHCH.sub.3 -pyrimidin-2-yl                        190    5-OCH.sub.2 C(═O)NHCH.sub.3 -pyrimidin-2-yl                        191    4-OCH.sub.2 C(═O)SCH.sub.3 -pyrimidin-2-yl                         192    5-OCH.sub.2 C(═O)SCH.sub.3 -pyrimidin-2-yl                         193    4-OCH(CH.sub.3)C(═O)NH.sub.2 -pyrimidin-2-yl                       194    5-OCH(CH.sub.3)C(═O)NH.sub.2 -pyrimidin-2-yl                       195    4-OCH(CH.sub.3)C(═O)NHCH.sub.3 -pyrimidin-2-yl                     196    5-OCH(CH.sub.3)C(═O)NHCH.sub.3 -pyrimidin-2-yl                     197    4-OCH(CH.sub.3)C(═O)NHNH.sub.2 -pyrimidin-2-yl                     198    5-OCH(CH.sub.3)C(═O)NHNH.sub.2 -pyrimidin-2-yl                     199    4-OCH(CH.sub.3)CO.sub.2 CH.sub.3 -pyrimidin-2-yl                       200    5-OCH(CH.sub.3)CO.sub.2 CH.sub.3 -pyrimidin-2-yl                       201    4-OCH(CH.sub.3)CO.sub.2 CH.sub.2 CH.sub.3 -pyrimidin-2-yl              202    5-OCH(CH.sub.3)CO.sub.2 CH.sub.2 CH.sub.3 -pyrimidin-2-yl              203    4-OCH(CH.sub.3)C(═O)CH.sub.3 -pyrimidin-2-yl                       204    5-OCH(CH.sub.3)C(═O)CH.sub.3 -pyrimidin-2-yl                       205    4-OCH(CH.sub.3)C(═O)CH.sub.2 CH.sub.3 -pyrimidin-2-yl              206    5-OCH(CH.sub.3)C(═O)CH.sub.2 CH.sub.3 -pyrimidin-2-yl              207    4-OCH(CH.sub.3)CH.sub.2 C(═O)CH.sub.3 -pyrimidin-2-yl              208    5-OCH(CH.sub.3)CH.sub.2 C(═O)CH.sub.3 -pyrimidin-2-yl              209    4-OCH(CH.sub.3)CH.sub.2 OC(CH.sub.3).sub.3 -pyrimidin-2-yl             210    5-OCH(CH.sub.3)CH.sub.2 OC(CH.sub.3).sub.3 -pyrimidin-2-yl             211    4-OCH(CH.sub.3)CH.sub.2 OCH.sub.2 CH.sub.3 -pyrimidin-2-yl             212    5-OCH(CH.sub.3)CH.sub.2 OCH.sub.2 CH.sub.3 -pyrimidin-2-yl             213    4-OCH(CH.sub.3)CH.sub.2 O(CH.sub.3).sub.2 CH.sub.3 -pyrimidin-2-yl            4                                                                      214    5-OCH(CH.sub.3)CH.sub.2 O(CH.sub.3).sub.2 CH.sub.3 -pyrimidin-2-yl     215    4-OCH(CH.sub.3)CH.sub.2 OCH.sub.2 CH═CH.sub.2 -pyrimidin-2-yl      216    5-OCH(CH.sub.3)CH.sub.2 OCH.sub.2 CH═CH.sub.2 -pyrimidin-2-yl      217    4-O(CH.sub.2).sub.3 OCH.sub.3 -pyrimidin-2-yl                          218    5-O(CH.sub.2).sub.3 OCH.sub.3 -pyrimidin-2-yl                          219    4-O(CH.sub.2).sub.3 OCH.sub.2 CH.sub.3 -pyrimidin-2-yl                 220    5-O(CH.sub.2).sub.3 OCH.sub.2 CH.sub.3 -pyrimidin-2-yl                 221    4-O(CH.sub.2).sub.3 OCH(CH.sub.3).sub.2 -pyrimidin-2-yl                222    5-O(CH.sub.2).sub.3 OCH(CH.sub.3).sub.2 -pyrimidin-2-yl                223    4-O(CH.sub.2).sub.3 OC.sub.6 H.sub.5 -pyrimidin-2-yl                   224    5-O(CH.sub.2).sub.3 OC.sub.6 H.sub.5 -pyrimidin-2-yl                   225    4-O(CH.sub.2).sub.3 OCH.sub.2 C.sub.6 H.sub.5 -pyrimidin-2-yl          226    5-O(CH.sub.2).sub.3 OCH.sub.2 C.sub.6 H.sub.5 -pyrimidin-2-yl          227    4-OCH(CH.sub.2 CH.sub.3)CH.sub.2 OCH.sub.3 -pyrimidin-2-yl             228    5-OCH(CH.sub.2 CH.sub.3)CH.sub.2 OCH.sub.3 -pyrimidin-2-yl             229    4-OCH(CH.sub.2 CH.sub.3)CH.sub.2 CH.sub.2 OCH.sub.3 -pyrimidin-2-yl           N                                                                      230    5-OCH(CH.sub.2 CH.sub.3)CH.sub.2 CH.sub.2 OCH.sub.3 -pyrimidin-2-yl           O                                                                      231    4-OCH(CH.sub.2 CH.sub.3)CH.sub.2 CH.sub.2 OCH.sub.2 CH.sub.3                  -pyrimidin-2-yl                                                        232    5-OCH(CH.sub.2 CH.sub.3)CH.sub.2 CH.sub.2 OCH.sub.2 CH.sub.3                  -pyrimidin-2-yl                                                        233    4-O (CH.sub.2).sub.3 O!.sub.2 CH.sub.3 -pyrimidin-2-yl                 234    5-O (CH.sub.2).sub.3 O!.sub.2 CH.sub.3 -pyrimidin-2-yl                 235    4-OCH.sub.2 CH(CH.sub.3)CH.sub.2 OCH.sub.3 -pyrimidin-2-yl             236    5-OCH.sub.2 CH(CH.sub.3)CH.sub.2 OCH.sub.3 -pyrimidin-2-yl             237    4-OCH.sub.2 CH(CH.sub.3)CH.sub.2 OCH.sub.2 CH.sub.3 -pyrimidin-2-yl    238    5-OCH.sub.2 CH(CH.sub.3)CH.sub.2 OCH.sub.2 CH.sub.3 -pyrimidin-2-yl    239    4-OCH(CH.sub.2 Cl)CH.sub.2 OCH.sub.3 -pyrimidin-2-yl                   240    5-OCH(CH.sub.2 Cl)CH.sub.2 OCH.sub.3 -pyrimidin-2-yl                   241    4-OCH(CH.sub.2 Cl)CH.sub.2 OCH.sub.2 CH.sub.3 -pyrimidin-2-yl          242    5-OCH(CH.sub.2 Cl)CH.sub.2 OCH.sub.2 CH.sub.3 -pyrimidin-2-yl          243    4-OCH(CH.sub.2 Cl)CH.sub.2 OCH(CH.sub.3).sub.2 -pyrimidin-2-yl         244    5-OCH(CH.sub.2 Cl)CH.sub.2 OCH(CH.sub.3).sub.2 -pyrimidin-2-yl         245    4-OCH(CH.sub.2 Cl)CH.sub.2 OCH.sub.2 CH═CH.sub.2 -pyrimidin-2-y           l                                                                      246    5-OCH(CH.sub.2 Cl)CH.sub.2 OCH.sub.2 CH═CH.sub.2 -pyrimidin-2-y           l                                                                      247    4-OCH CH.sub.2 OCH.sub.3 !.sub.2 -pyrimidin-2-yl                       248    5-OCH CH.sub.2 OCH.sub.3 !.sub.2 -pyrimidin-2-yl                       249    4-OCH CH.sub.2 OCH.sub.2 CH.sub.3 !.sub.2 -pyrimidin-2-yl              250    5-OCH CH.sub.2 OCH.sub.2 CH.sub.3 !.sub.2 -pyrimidin-2-yl              251    4-OCCl.sub.3 -pyrimidin-2-yl                                           252    5-OCCl.sub.3 -pyrimidin-2-yl                                           253    4-OCHF.sub.2 -pyrimidin-2-yl                                           254    5-OCHF.sub.2 -pyrimidin-2-yl                                           255    4-OCF.sub.3 -pyrimidin-2-yl                                            256    5-OCF.sub.3 -pyrimidin-2-yl                                            257    4-OCF.sub.2 CHF.sub.2 -pyrimidin-2-yl                                  258    5-OCF.sub.2 CHF.sub.2 -pyrimidin-2-yl                                  259    4-OCH.sub.2 CF.sub.3 -pyrimidin-2-yl                                   260    5-OCH.sub.2 CF.sub.3 -pyrimidin-2-yl                                   261    4-OCH.sub.2 CHF.sub.2 -pyrimidin-2-yl                                  262    5-OCH.sub.2 CHF.sub.2 -pyrimidin-2-yl                                  263    4-O(CH.sub.2).sub.3 F-pyrimidin-2-yl                                   264    5-O(CH.sub.2).sub.3 F-pyrimidin-2-yl                                   265    4-OCH(CH.sub.3)CF.sub.3 -pyrimidin-2-yl                                266    5-OCH(CH.sub.3)CF.sub.3 -pyrimidin-2-yl                                267    4-O(CH.sub.2).sub.4 F-pyrimidin-2-yl                                   268    5-O(CH.sub.2).sub.4 F-pyrimidin-2-yl                                   269    4-O(CH.sub.2).sub.3 CF.sub.3 -pyrimidin-2-yl                           270    5-O(CH.sub.2).sub.3 CF.sub.3 -pyrimidin-2-yl                           271    4-OCH(CH.sub.3)CF.sub.2 CF.sub.3 -pyrimidin-2-yl                       272    5-OCH(CH.sub.3)CF.sub.2 CF.sub.3 -pyrimidin-2-yl                       273    4-OCH(CH.sub.3)CF.sub.2 CHF.sub.2 -pyrimidin-2-yl                      274    5-OCH(CH.sub.3)CF.sub.2 CHF.sub.2 -pyrimidin-2-yl                      275    4-OCH.sub.2 CF.sub.2 CHFCH.sub.3 -pyrimidin-2-yl                       276    5-OCH.sub.2 CF.sub.2 CHFCH.sub.3 -pyrimidin-2-yl                       277    4-OCH.sub.2 (CF.sub.2).sub.2 CF.sub.3 -pyrimidin-2-yl                  276    5-OCH.sub.2 (CF.sub.2).sub.2 CF.sub.3 -pyrimidin-2-yl                  279    4-O(CF.sub.2).sub.3 CF.sub.3 -pyrimidin-2-yl                           280    5-O(CF.sub.2).sub.3 CF.sub.3 -pyrimidin-2-yl                           281    4-OCH.sub.2 CF.sub.2 CHF.sub.2 -pyrimidin-2-yl                         282    5-OCH.sub.2 CF.sub.2 CHF.sub.2 -pyrimidin-2-yl                         283    4-CH.sub.2 CH═CH.sub.2 -pyrimidin-2-yl                             284    5-CH.sub.2 CH═CH.sub.2 -pyrimidin-2-yl                             285    4-CH.sub.2 C(CH.sub.3)═CH.sub.2 -pyrimidin-2-yl                    286    5-CH.sub.2 C(CH.sub.3)═CH.sub.2 -pyrimidin-2-yl                    287    4-OCH.sub.2 CH═CHCH.sub.3 -pyrimidin-2-yl                          288    5-OCH.sub.2 CH═CHCH.sub.3 -pyrimidin-2-yl                          289    4-O(CH.sub.2).sub.2 CH═CH.sub.2 -pyrimidin-2-yl                    290    5-O(CH.sub.2).sub.2 CH═CH.sub.2 -pyrimidin-2-yl                    291    4-OCH.sub.2 C(CH.sub.3)═CH.sub.2 -pyrimidin-2-yl                   292    5-OCH.sub.2 C(CH.sub.3)═CH.sub.2 -pyrimidin-2-yl                   293    4-OCH(CH.sub.3)CH═CH.sub.2 -pyrimidin-2-yl                         294    5-OCH(CH.sub.3)CH═CH.sub.2 -pyrimidin-2-yl                         295    4-OCH.sub.2 C.tbd.CH-pyrimidin-2-yl                                    296    5-OCH.sub.2 C.tbd.CH-pyrimidin-2-yl                                    297    4-OCH.sub.2 C.tbd.CCH.sub.3 -pyrimidin-2-yl                            298    5-OCH.sub.2 C.tbd.CCH.sub.3 -pyrimidin-2-yl                            299    4-O(CH.sub.2).sub.2 C.tbd.CH-pyrimidin-2-yl                            300    5-O(CH.sub.2).sub.2 C.tbd.CH-pyrimidin-2-yl                            301    4-SCH.sub.3 -pyrimidin-2-yl                                            302    5-SCH.sub.3 -pyrimidin-2-yl                                            303    4-SCH.sub.2 CH.sub.3 -pyrimidin-2-yl                                   304    5-SCH.sub.2 CH.sub.3 -pyrimidin-2-yl                                   305    4-OC.sub.6 H.sub.5 -pyrimidin-2-yl                                     306    5-OC.sub.6 H.sub.5 -pyrimidin-2-yl                                     307    4-OCH.sub.2 C.sub.6 H.sub.5 -pyrimidin-2-yl                            308    5-OCH.sub.2 C.sub.6 H.sub.5 -pyrimidin-2-yl                            309    4-NO.sub.2 -pyrimidin-2-yl                                             310    5-NO.sub.2 -pyrimidin-2-yl                                             311    4-NHCH.sub.3 -pyrimidin-2-yl                                           312    5-NHCH.sub.3 -pyrimidin-2-yl                                           313    4-N(CH.sub.3).sub.2 -pyrimidin-2-yl                                    314    5-N(CH.sub.3).sub.2 -pyrimidin-2-yl                                    315    4-N(CH.sub.3)C.sub.2 H.sub.5 -pyrimidin-2-yl                           316    5-N(CH.sub.3)C.sub.2 H.sub.5 -pyrimidin-2-yl                           317    4-NHCH.sub.2 CF.sub.3 -pyrimidin-2-yl                                  318    5-NHCH.sub.2 CF.sub.3 -pyrimidin-2-yl                                  319    4-F-pyrimidin-2-yl                                                     320    5-F-pyrimidin-2-yl                                                     321    4-Cl-pyrimidin-2-yl                                                    322    5-Cl-pyrimidin-2-yl                                                    323    4-OH-pyrimidin-2-yl                                                    324    5-OH-pyrimidin-2-yl                                                    325    4-CN-pyrimidin-2-yl                                                    326    5-CN-pyrimidin-2-yl                                                    327    4-C(O)NH.sub.2 -pyrimidin-2-yl                                         328    5-C(O)NH.sub.2 -pyrimidin-2-yl                                         329    4-C(S)NH.sub.2 -pyrimidin-2-yl                                         330    5-C(S)NH.sub.2 -pyrimidin-2-yl                                         331    4-CO.sub.2 CH.sub.3 -pyrimidin-2-yl                                    332    5-CO.sub.2 CH.sub.3 -pyrimidin-2-yl                                    333    4-ON═C(CH.sub.3).sub.2 -pyrimidin-2-yl                             334    5-ON═C(CH.sub.3).sub.2 -pyrimidin-2-yl                             335    4- O-cyclopropyl!pyrimidin-2-yl                                        336    5- O-cyclopropyl!pyrimidin-2-yl                                        337    4- O-cyclobutyl!pyrimidin-2-yl                                         338    5- O-cyclobutyl!pyrimidin-2-yl                                         339    4- O-cyclopentyl!pyrimidin-2-yl                                        340    5- O-cyclopentyl!pyrimidin-2-yl                                        341    4- O-cyclohexyl!pyrimidin-2-yl                                         342    5- O-cyclohexyl!pyrimidin-2-yl                                         343    4- OCH.sub.2 -cyclopropyl!pyrimidin-2-yl                               344    5- OCH.sub.2 -cyclopropyl!pyrimidin-2-yl                               345    5-F, 4- OCH.sub.2 -cyclopropyl!pyrimidin-2-yl                          346    4-F, 5- OCH.sub.2 -cyclopropyl!pyrimidin-2-yl                          347    5-CH.sub.3, 4- OCH.sub.2 -cyclopropyl!pyrimidin-2-yl                   348    4-CH.sub.3, 5- OCH.sub.2 -cyclopropyl!pyrimidin-2-yl                   349    5-CF.sub.3, 4- OCH.sub.2 -cyclopropyl!pyrimidin-2-yl                   350    4-CF.sub.3, 5- OCH.sub.2 -cyclopropyl!pyrimidin-2-yl                   351    4- OCH(CH.sub.3)-cyclopropyl!pyrimidin-2-yl                            352    5- OCH(CH.sub.3)-cyclopropyl!pyrimidin-2-yl                            353    5-F, 4- OCH(CH.sub.3)-cyclopropyl!pyrimidin-2-yl                       354    4-F, 5- OCH(CH.sub.3)-cyclopropyl!pyrimidin-2-yl                       355    5-CH.sub.3, 4- OCH(CH.sub.3)-cyclopropyl!pyrimidin-2-yl                356    4-CH.sub.3, 5- OCH(CH.sub.3)-cyclopropyl!pyrimidin-2-yl                357    5-CF.sub.3, 4- OCH(CH.sub.3)-cyclopropyl!pyrimidin-2-yl                358    4-CF.sub.3, 5- OCH(CH.sub.3)-cyclopropyl!pyrimidin-2-yl                359    4- O-(1-CH.sub.3 -cyclopropyl)!pyrimidin-2-yl                          360    5- O-(1-CH.sub.3 -cyclopropyl)!pyrimidin-2-yl                          361    5-F, 4- O-(1-CH.sub.3 -cyclopropyl)!pyrimidin-2-yl                     362    4-F, 5- O-(1-CH.sub.3 -cyclopropyl)!pyrimidin-2-yl                     363    5-CH.sub.3, 4- O-(1-CH.sub.3 -cyclopropyl)!pyrimidin-2-yl              364    4-CH.sub.3, 5- O-(1-CH.sub.3 -cyclopropyl)!pyrimidin-2-yl              365    5-CF.sub.3, 4- O-(1-CH.sub.3 -cyclopropyl)!pyrimidin-2-yl              366    4-CF.sub.3, 5- O-(1-CH.sub.3 -cyclopropyl)!pyrimidin-2-yl              367    4- OCH.sub.2 -(1-CH.sub.3 -cyclopropyl)!pyrimidin-2-yl                 368    5- OCH.sub.2 -(1-CH.sub.3 -cyclopropyl)!pyrimidin-2-yl                 369    5-F, 4- OCH.sub.2 -(1-CH.sub.3 -cyclopropyl)!pyrimidin-2-yl            370    4-F, 5- OCH.sub.2 -(1-CH.sub.3 -cyclopropyl)!pyrimidin-2-yl            371    5-CH.sub.3, 4- OCH.sub.2 -(1-CH.sub.3 -cyclopropyl)!pyrimidin-2-yl            N                                                                      372    4-CH.sub.3, 5- OCH.sub.2 -(1-CH.sub.3 -cyclopropyl)!pyrimidin-2-yl            O                                                                      373    5-CF.sub.3, 4- OCH.sub.2 -(1-CH.sub.3 -cyclopropyl)!pyrimidin-2-yl     374    4-CF.sub.3, 5- OCH.sub.2 -(1-CH.sub.3 -cyclopropyl)!pyrimidin-2-yl            N                                                                      375    4- OCH.sub.2 -(2-CH.sub.3 -cyclopropyl)!pyrimidin-2-yl                 376    5- OCH.sub.2 -(2-CH.sub.3 -cyclopropyl)!pyrimidin-2-yl                 377    5-F, 4- OCH.sub.2 -(2-CH.sub.3 -cyclopropyl)!pyrimidin-2-yl            378    4-F, 5- OCH.sub.2 -(2-CH.sub.3 -cyclopropyl)!pyrimidin-2-yl            379    5-CH.sub.3, 4- OCH.sub.2 -(2-CH.sub.3 -cyclopropyl)!pyrimidin-2-yl            O                                                                      380    4-CH.sub.3, 5- OCH.sub.2 -(2-CH.sub.3 -cyclopropyl)!pyrimidin-2-yl     381    5-CF.sub.3, 4- OCH.sub.2 -(2-CH.sub.3 -cyclopropyl)!pyrimidin-2-yl     382    4-CF.sub.3, 5- OCH.sub.2 -(2-CH.sub.3 -cyclopropyl)!pyrimidin-2-yl     383    4- OCH.sub.2 -(tetrahydropyran-2-yl)!pyrimidin-2-yl                    384    5- OCH.sub.2 -(tetrahydropyran-2-yl)!pyrimidin-2-yl                    385    5-F, 4- OCH.sub.2 -(tetrahydropyran-2-yl)!pyrimidin-2-yl               386    4-F, 5- OCH.sub.2 -(tetrahydropyran-2-yl)!pyrimidin-2-yl               387    5-CH.sub.3, 4- OCH.sub.2 -(tetrahydropyran-2-yl)!pyrimidin-2-yl        388    4-CH.sub.3, 5- OCH.sub.2 -(tetrahydropyran-2-yl)!pyrimidin-2-yl        389    5-CF.sub.3, 4- OCH.sub.2 -(tetrahydropyran-2-yl)!pyrimidin-2-yl        390    4-CF.sub.3, 5- OCH.sub.2 -(tetrahydropyran-2-yl)!pyrimidin-2-yl        391    4- OCH.sub.2 -(furan-2-yl)!pyrimidin-2-yl                              392    5- OCH.sub.2 -(furan-2-yl)!pyrimidin-2-yl                              393    5-F, 4- OCH.sub.2 -(furan-2-yl)!pyrimidin-2-yl                         394    4-F, 5- OCH.sub.2 -(furan-2-yl)!pyrimidin-2-yl                         395    5-CH.sub.3, 4- OCH.sub.2 -(furan-2-yl)!pyrimidin-2-yl                  396    4-CH.sub.3, 5- OCH.sub.2 -(furan-2-yl)!pyrimidin-2-yl                  397    5-CF.sub.3, 4- OCH.sub.2 -(furan-2-yl)!pyrimidin-2-yl                  398    4-CF.sub.3, 5- OCH.sub.2 -(furan-2-yl)!pyrimidin-2-yl                  399    4- OCH.sub.2 -(furan-3-yl)!pyrimidin-2-yl                              400    5- OCH.sub.2 -(furan-3-yl)!pyrimidin-2-yl                              401    5-F, 4- OCH.sub.2 -(furan-3-yl)!pyrimidin-2-yl                         402    4-F, 5- OCH.sub.2 -(furan-3-yl)!pyrimidin-2-yl                         403    5-CH.sub.3, 4- OCH.sub.2 -(furan-3-yl)!pyrimidin-2-yl                  404    4-CH.sub.3, 5- OCH.sub.2 -(furan-3-yl)!pyrimidin-2-yl                  405    5-CF.sub.3, 4- OCH.sub.2 -(furan-3-yl)!pyrimidin-2-yl                  406    4-CF.sub.3, 5- OCH.sub.2 -(furan-3-yl)!pyrimidin-2-yl                  407    4- OCH.sub.2 -(tetrahydrofuran-3-yl)!pyrimidin-2-yl                    408    5- OCH.sub.2 -(tetrahydrofuran-3-yl)!pyrimidin-2-yl                    409    5-F, 4- OCH.sub.2 -(tetrahydrofuran-3-yl)!pyrimidin-2-yl               410    4-F, 5- OCH.sub.2 -(tetrahydrofuran-3-yl)!pyrimidin-2-yl               411    5-CH.sub.3, 4- OCH.sub.2 -(tetrahydrofuran-3-yl)!pyrimidin-2-yl        412    4-CH.sub.3, 5- OCH.sub.2 -(tetrahydrofuran-3-yl)!pyrimidin-2-yl        413    5-CF.sub.3, 4- OCH.sub.2 -(tetrahydrofuran-3-yl)!pyrimidin-2-yl        414    4-CF.sub.3, 5- OCH.sub.2 -(tetrahydrofuran-3-yl)!pyrimidin-2-yl        415    4- OCH.sub.2 -(tetrahydrofuran-2-yl)!pyrimidin-2-yl                    416    5- OCH.sub.2 -(tetrahydrofuran-2-yl)!pyrimidin-2-yl                    417    5-F, 4- OCH.sub.2 -(tetrahydrofuran-2-yl)!pyrimidin-2-yl               418    4-F, 5- OCH.sub.2 -(tetrahydrofuran-2-yl)!pyrimidin-2-yl               419    5-CH.sub.3, 4- OCH.sub.2 -(tetrahydrofuran-2-yl)!pyrimidin-2-yl        420    4-CH.sub.3, 5- OCH.sub.2 -(tetrahydrofuran-2-yl)!pyrimidin-2-yl        421    5-CF.sub.3, 4- OCH.sub.2 -(tetrahydrofuran-2-yl)!pyrimidin-2-yl        422    4-CF.sub.3, 5- OCH.sub.2 -(tetrahydrofuran-2-yl)!pyrimidin-2-yl        423    4- O-(tetrahydropyran-4-yl)!pyrimidin-2-yl                             424    5- O-(tetrahydropyran-4-yl)!pyrimidin-2-yl                             425    5-F, 4- O-(tetrahydropyran-4-yl)!pyrimidin-2-yl                        426    4-F, 5- O-(tetrahydropyran-4-yl)!pyrimidin-2-yl                        427    5-CH.sub.3, 4- O-(tetrahydropyran-4-yl)!pyrimidin-2-yl                 429    4-CH.sub.3, 5- O-(tetrahydropyran-4-yl)!pyrimidin-2-yl                 429    5-CF.sub.3, 4- O-(tetrahydropyran-4-yl)!pyrimidin-2-yl                 430    4-CF.sub.3, 5- O-(tetrahydropyran-4-yl)!pyrimidin-2-yl                 431    4- 2-Cl--C.sub.6 H.sub.4 !pyrimidin-2-yl                               432    5- 2-Cl--C.sub.6 H.sub.4 !pyrimidin-2-yl                               433    5-F, 4- 2-Cl--C.sub.6 H.sub.4 !pyrimidin-2-yl                          434    4-F, 5- 2-Cl--C.sub.6 H.sub.4 !pyrimidin-2-yl                          435    5-CH.sub.3, 4- 2-Cl--C.sub.6 H.sub.4 !pyrimidin-2-yl                   436    4-CH.sub.3, 5- 2-Cl--C.sub.6 H.sub.4 !pyrimidin-2-yl                   437    5-CF.sub.3, 4- 2-Cl--C.sub.6 H.sub.4 !pyrimidin-2-yl                   438    4-CF.sub.3, 5- 2-Cl--C.sub.6 H.sub.4 !pyrimidin-2-yl                   439    4- OCH.sub.2 -(pyridin-2-yl)!pyrimidin-2-yl                            440    5- OCH.sub.2 -(pyridin-2-yl)!pyrimidin-2-yl                            441    5-F, 4- OCH.sub.2 -(pyridin-2-yl)!pyrimidin-2-yl                       442    4-F, 5- OCH.sub.2 -(pyridin-2-yl)!pyrimidin-2-yl                       443    5-CH.sub.3, 4- OCH.sub.2 -(pyridin-2-yl)!pyrimidin-2-yl                444    4-CH.sub.3, 5- OCH.sub.2 -(pyridin-2-yl)!pyrimidin-2-yl                445    5-CF.sub.3, 4- OCH.sub.2 -(pyridin-2-yl)!pyrimidin-2-yl                446    4-CF.sub.3, 5- OCH.sub.2 -(pyridin-2-yl)!pyrimidin-2-yl                447    4- OCH.sub.2 -(pyridin-3-yl)!pyrimidin-2-yl                            448    5- OCH.sub.2 -(pyridin-3-yl)!pyrimidin-2-yl                            449    5-F, 4- OCH.sub.2 -(pyridin-3-yl)!pyrimidin-2-yl                       450    4-F, 5- OCH.sub.2 -(pyridin-3-yl)!pyrimidin-2-yl                       451    5-CH.sub.3, 4- OCH.sub.2 -(pyridin-3-yl)!pyrimidin-2-yl                452    4-CH.sub.3, 5- OCH.sub.2 -(pyridin-3-yl)!pyrimidin-2-yl                453    5-CF.sub.3, 4- OCH.sub.2 -(pyridin-3-yl)!pyrimidin-2-yl                454    4-CF.sub.3, 5- OCH.sub.2 -(pyridin-3-yl)!pyrimidin-2-yl                455    4- morpholin-4-yl!pyrimidin-2-yl                                       456    5- morpholin-4-yl!pyrimidin-2-yl                                       457    4- 1-CH.sub.3 -imidazol-2-yl!pyrimidin-2-yl                            458    5- 1-CH.sub.3 -imidazol-2-yl!pyrimidin-2-yl                            459    5-F, 4- 1-CH.sub.3 -imidazol-2-yl!pyrimidin-2-yl                       460    4-F, 5- 1-CH.sub.3 -imidazol-2-yl!pyrimidin-2-yl                       461    5-CH.sub.3, 4- 1-CH.sub.3 -imidazol-2-yl!pyrimidin-2-yl                462    4-CH.sub.3, 5- 1-CH.sub.3 -imidazol-2-yl!pyrimidin-2-yl                463    5-CF.sub.3, 4- 1-CH.sub.3 -imidazol-2-yl!pyrimidin-2-yl                464    4-CF.sub.3, 5- 1-CH.sub.3 -imidazol-2-yl!pyrimidin-2-yl                465    4- 1,2,4-triazol-1-yl!pyrimidin-2-yl                                   466    5- 1,2,4-triazol-1-yl!pyrimidin-2-yl                                   467    5-F, 4- 1,2,4-triazol-1-yl!pyrimidin-2-yl                              468    4-F, 5- 1,2,4-triazol-1-yl!pyrimidin-2-yl                              469    5-CH.sub.3, 4- 1,2,4-triazol-1-yl!pyrimidin-2-yl                       470    4-CH.sub.3, 5- 1,2,4-triazol-1-yl!pyrimidin-2-yl                       471    5-CF.sub.3, 4- 1,2,4-triazol-1-yl!pyrimidin-2-yl                       472    4-CF.sub.3, 5- 1,2,4-triazol-1-yl!pyrimidin-2-yl                       473    4,5-Cl.sub.2 -pyrimidin-2-yl                                           474    4,6-Cl.sub.2 -pyrimidin-2-yl                                           475    4,5-(CH.sub.3).sub.2 -pyrimidin-2-yl                                   476    4,6-(CH.sub.3).sub.2 -pyrimidin-2-yl                                   477    4,5-(OCH.sub.3).sub.2 -pyrimidin-2-yl                                  478    4,6-(OCH.sub.3).sub.2 -pyrimidin-2-yl                                  479    4,5-(OCH.sub.2 CH.sub.3).sub.2 -pyrimidin-2-yl                         480    4,6-(OCH.sub.2 CH.sub.3).sub.2 -pyrimidin-2-yl                         481    4-F, 5-CH.sub.3 -pyrimidin-2-yl                                        482    4-F, 6-CH.sub.3 -pyrimidin-2-yl                                        483    5-F, 4-CH.sub.3 -pyrimidin-2-yl                                        484    6-F, 4-CH.sub.3 -pyrimidin-2-yl                                        485    4-F, 5-OCH.sub.3 -pyrimidin-2-yl                                       486    4-F, 6-OCH.sub.3 -pyrimidin-2-yl                                       487    5-F, 4-OCH.sub.3 -pyrimidin-2-yl                                       488    6-F, 4-OCH.sub.3 -pyrimidin-2-yl                                       489    4-F, 5-OCH.sub.2 CH.sub.3 -pyrimidin-2-yl                              490    4-F, 6-OCH.sub.2 CH.sub.3 -pyrimidin-2-yl                              491    5-F, 4-OCH.sub.2 CH.sub.3 -pyrimidin-2-yl                              492    6-F, 4-OCH.sub.2 CH.sub.3 -pyrimidin-2-yl                              493    4-F, 5-OCH.sub.2 CF.sub.3 -pyrimidin-2-yl                              494    4-F, 6-OCH.sub.2 CF.sub.3 -pyrimidin-2-yl                              495    5-F, 4-OCH.sub.2 CF.sub.3 -pyrimidin-2-yl                              496    6-F, 4-OCH.sub.2 CF.sub.3 -pyrimidin-2-yl                              497    4-F, 5-OCH(CH.sub.3).sub.2 -pyrimidin-2-yl                             499    4-F, 6-OCH(CH.sub.3).sub.2 -pyrimidin-2-yl                             499    5-F, 4-OCH(CH.sub.3).sub.2 -pyrimidin-2-yl                             500    6-F, 4-OCH(CH.sub.3).sub.2 -pyrimidin-2-yl                             501    4-Cl, 5-CH.sub.3 -pyrimidin-2-yl                                       502    4-Cl, 6-CH.sub.3 -pyrimidin-2-yl                                       503    5-Cl, 4-CH.sub.3 -pyrimidin-2-yl                                       504    6-Cl, 4-CH.sub.3 -pyrimidin-2-yl                                       505    4-Cl, 5-OCH.sub.3 -pyrimidin-2-yl                                      506    4-Cl, 6-OCH.sub.3 -pyrimidin-2-yl                                      507    5-Cl, 4-OCH.sub.3 -pyrimidin-2-yl                                      508    6-Cl, 4-OCH.sub.3 -pyrimidin-2-yl                                      509    4-Cl, 5-OCH.sub.2 CH.sub.3 -pyrimidin-2-yl                             510    4-Cl, 6-OCH.sub.2 CH.sub.3 -pyrimidin-2-yl                             511    5-Cl, 4-OCH.sub.2 CH.sub.3 -pyrimidin-2-yl                             512    6-Cl, 4-OCH.sub.2 CH.sub.3 -pyrimidin-2-yl                             513    4-Cl, 5-OCH.sub.2 CF.sub.3 -pyrimidin-2-yl                             514    4-Cl, 6-OCH.sub.2 CF.sub.3 -pyrimidin-2-yl                             515    5-Cl, 4-OCH.sub.2 CF.sub.3 -pyrimidin-2-yl                             516    6-Cl, 4-OCH.sub.2 CF.sub.3 -pyrimidin-2-yl                             517    4-Cl, 5-OCH(CH.sub.3).sub.2 -pyrimidin-2-yl                            518    4-Cl, 6-OCH(CH.sub.3).sub.2 -pyrimidin-2-yl                            519    5-Cl, 4-OCH(CH.sub.3).sub.2 -pyrimidin-2-yl                            520    6-Cl, 4-OCH(CH.sub.3).sub.2 -pyrimidin-2-yl                            521    4-CH.sub.3, 5-OCH.sub.3 -pyrimidin-2-yl                                522    4-CH.sub.3, 6-OCH.sub.3 -pyrimidin-2-yl                                523    5-CH.sub.3, 4-OCH.sub.3 -pyrimidin-2-yl                                524    6-CH.sub.3, 4-OCH.sub.3 -pyrimidin-2-yl                                525    6-CH.sub.3, 4-OCH.sub.2 CH.sub.3 -pyrimidin-2-yl                       526    5-CH.sub.3, 4-OCH.sub.2 CH.sub.3 -pyrimidin-2-yl                       527    4-CH.sub.3, 5-OCH.sub.2 CH.sub.3 -pyrimidin-2-yl                       528    4-CH.sub.3, 6-OCH.sub.2 CH.sub.3 -pyrimidin-2-yl                       529    4-CH.sub.3, 5-OCH.sub.2 CF.sub.3 -pyrimidin-2-yl                       530    4-CH.sub.3, 6-OCH.sub.2 CF.sub.3 -pyrimidin-2-yl                       531    5-CH.sub.3, 4-OCH.sub.2 CF.sub.3 -pyrimidin-2-yl                       532    6-CH.sub.3, 4-OCH.sub.2 CF.sub.3 -pyrimidin-2-yl                       533    4-CH.sub.3, 5-OCH(CH.sub.3).sub.2 -pyrimidin-2-yl                      534    4-CH.sub.3, 5-OCH(CH.sub.3).sub.2 -pyrimidin-2-yl                      535    5-CH.sub.3, 4-OCH(CH.sub.3).sub.2 -pyrimidin-2-yl                      536    6-CH.sub.3, 4-OCH(CH.sub.3).sub.2 -pyrimidin-2-yl                      537    4-CH.sub.3, 5-OCH.sub.2 CH═CH.sub.2 -pyrimidin-2-yl                538    4-CH.sub.3, 6-OCH.sub.2 CH═CH.sub.2 -pyrimidin-2-yl                539    5-CH.sub.3, 4-OCH.sub.2 CH═CH.sub.2 -pyrimidin-2-yl                540    6-CH.sub.3, 4-OCH.sub.2 CH═CH.sub.2 -pyrimidin-2-yl                541    4-CH.sub.3, 5-CO.sub.2 CH.sub.3 -pyrimidin-2-yl                        542    4-CH.sub.3, 6-CO.sub.2 CH.sub.3 -pyrimidin-2-yl                        543    4-CH.sub.3, 5-CF.sub.3 -pyrimidin-2-yl                                 544    4-CH.sub.3, 6-CF.sub.3 -pyrimidin-2-yl                                 545    5-CH.sub.3, 4-CF.sub.3 -pyrimidin-2-yl                                 546    6-CH.sub.3, 4-CF.sub.3 -pyrimidin-2-yl                                 547    4-CF.sub.3, 5-CH.sub.2 CH.sub.3 -pyrimidin-2-yl                        548    4-CF.sub.3, 6-CH.sub.2 CH.sub.3 -pyrimidin-2-yl                        549    5-CF.sub.3, 4-CH.sub.2 CH.sub.3 -pyrimidin-2-yl                        550    6-CF.sub.3, 4-CH.sub.2 CH.sub.3 -pyrimidin-2-yl                        551    4-CF.sub.3, 5-OCH.sub.3 -pyrimidin-2-yl                                552    4-CF.sub.3, 6-OCH.sub.3 -pyrimidin-2-yl                                553    5-CF.sub.3, 4-OCH.sub.3 -pyrimidin-2-yl                                554    6-CF.sub.3, 4-OCH.sub.3 -pyrimidin-2-yl                                555    4-CF.sub.3, 5-OCH.sub.2 CH.sub.3 -pyrimidin-2-yl                       556    4-CF.sub.3, 6-OCH.sub.2 CH.sub.3 -pyrimidin-2-yl                       557    5-CF.sub.3, 4-OCH.sub.2 CH.sub.3 -pyrimidin-2-yl                       558    6-CF.sub.3, 4-OCH.sub.2 CH.sub.3 -pyrimidin-2-yl                       559    4-CF.sub.3, 5-OCH.sub.2 CF.sub.3 -pyrimidin-2-yl                       560    4-CF.sub.3, 6-OCH.sub.2 CF.sub.3 -pyrimidin-2-yl                       561    5-CF.sub.3, 4-OCH.sub.2 CF.sub.3 -pyrimidin-2-yl                       562    6-CF.sub.3, 4-OCH.sub.2 CF.sub.3 -pyrimidin-2-yl                       563    4-OCH.sub.3, 5-OCH.sub.2 CH.sub.3 -pyrimidin-2-yl                      564    4-OCH.sub.3, 6-OCH.sub.2 CH.sub.3 -pyrimidin-2-yl                      565    5-OCH.sub.3, 4-OCH.sub.2 CH.sub.3 -pyrimidin-2-yl                      566    6-OCH.sub.3, 4-OCH.sub.2 CH.sub.3 -pyrimidin-2-yl                      567    4-OCH.sub.3, 5-OCH.sub.2 CF.sub.3 -pyrimidin-2-yl                      568    4-OCH.sub.3, 6-OCH.sub.2 CF.sub.3 -pyrimidin-2-yl                      569    5-OCH.sub.3, 4-OCH.sub.2 CF.sub.3 -pyrimidin-2-yl                      570    6-OCH.sub.3, 4-OCH.sub.2 CF.sub.3 -pyrimidin-2-yl                      571    4-OCH.sub.3, 5-OCH(CH.sub.3)-pyrimidin-2-yl                            572    4-OCH.sub.3, 6-OCH(CH.sub.3)-pyrimidin-2-yl                            573    5-OCH.sub.3, 4-OCH(CH.sub.3)-pyrimidin-2-yl                            574    6-OCH.sub.3, 4-OCH(CH.sub.3)-pyrimidin-2-yl                            575    4-OCH.sub.2 CH.sub.3, 5-CH.sub.2 OCH.sub.2 CH.sub.3 -pyrimidin-2-yl           N                                                                      576    4-OCH.sub.2 CH.sub.3, 6-CH.sub.2 OCH.sub.2 CH.sub.3 -pyrimidin-2-yl           O                                                                      577    5-OCH.sub.2 CH.sub.3, 4-CH.sub.2 OCH.sub.2 CH.sub.3 -pyrimidin-2-yl    578    6-OCH.sub.2 CH.sub.3, 4-CH.sub.2 OCH.sub.2 CH.sub.3 -pyrimidin-2-yl    579    4-NO.sub.2, 5-CH.sub.3 -pyrimidin-2-yl                                 580    4-NO.sub.2, 6-CH.sub.3 -pyrimidin-2-yl                                 581    5-NO.sub.2, 4-CH.sub.3 -pyrimidin-2-yl                                 582    6-NO.sub.2, 4-CH.sub.3 -pyrimidin-2-yl                                 583    4-NO.sub.2, 5-OCH.sub.3 -pyrimidin-2-yl                                584    4-NO.sub.2, 6-OCH.sub.3 -pyrimidin-2-yl                                585    5-NO.sub.2, 4-OCH.sub.3 -pyrimidin-2-yl                                586    6-NO.sub.2, 4-OCH.sub.3 -pyrimidin-2-yl                                587    4-NO.sub.2, 5-OCH.sub.2 CH.sub.3 -pyrimidin-2-yl                       588    4-NO.sub.2, 6-OCH.sub.2 CH.sub.3 -pyrimidin-2-yl                       589    5-NO.sub.2, 4-OCH.sub.2 CH.sub.3 -pyrimidin-2-yl                       590    6-NO.sub.2, 4-OCH.sub.2 CH.sub.3 -pyrimidin-2-yl                       591    4-NO.sub.2, 5-OCH(CH.sub.3).sub.2 -pyrimidin-2-yl                      592    4-NO.sub.2, 6-OCH(CH.sub.3).sub.2 -pyrimidin-2-yl                      593    5-NO.sub.2, 4-OCH(CH.sub.3).sub.2 -pyrimidin-2-yl                      594    6-NO.sub.2, 4-OCH(CH.sub.3).sub.2 -pyrimidin-2-yl                      595    4-NO.sub.2, 5-OCH.sub.2 CF.sub.3 -pyrimidin-2-yl                       596    4-NO.sub.2, 6-OCH.sub.2 CF.sub.3 -pyrimidin-2-yl                       597    5-NO.sub.2, 4-OCH.sub.2 CF.sub.3 -pyrimidin-2-yl                       598    6-NO.sub.2, 4-OCH.sub.2 CF.sub.3 -pyrimidin-2-yl                       599    4-CN, 5-CH.sub.3 -pyrimidin-2-yl                                       600    4-CN, 6-CH.sub.3 -pyrimidin-2-yl                                       601    5-CN, 4-CH.sub.3 -pyrimidin-2-yl                                       602    6-CN, 4-CH.sub.3 -pyrimidin-2-yl                                       603    4-CN, 5-OCH.sub.3 -pyrimidin-2-yl                                      604    4-CN, 6-OCH.sub.3 -pyrimidin-2-yl                                      605    5-CN, 4-OCH.sub.3 -pyrimidin-2-yl                                      606    6-CN, 4-OCH.sub.3 -pyrimidin-2-yl                                      607    4-CN, 5-OCH.sub.2 CH.sub.3 -pyrimidin-2-yl                             609    4-CN, 6-OCH.sub.2 CH.sub.3 -pyrimidin-2-yl                             609    5-CN, 4-OCH.sub.2 CH.sub.3 -pyrimidin-2-yl                             610    6-CN, 4-OCH.sub.2 CH.sub.3 -pyrimidin-2-yl                             611    4-CN, 5-OCH(CH.sub.3).sub.2 -pyrimidin-2-yl                            612    4-CN, 6-OCH(CH.sub.3).sub.2 -pyrimidin-2-yl                            613    5-CN, 4-OCH(CH.sub.3).sub.2 -pyrimidin-2-yl                            614    6-CN, 4-OCH(CH.sub.3).sub.2 -pyrimidin-2-yl                            615    4-CN, 5-OCH.sub.2 CF.sub.3 -pyrimidin-2-yl                             616    4-CN, 6-OCH.sub.2 CF.sub.3 -pyrimidin-2-yl                             617    5-CN, 4-OCH.sub.2 CF.sub.3 -pyrimidin-2-yl                             618    6-CN, 4-OCH.sub.2 CF.sub.3 -pyrimidin-2-yl                             619    5,6-(CH.sub.3).sub.2, 4-OCH.sub.3 -pyrimidin-2-yl                      620    2-CH.sub.3 -pyrimidin-4-yl                                             621    5-CH.sub.3 -pyrimidin-4-yl                                             622    6-CH.sub.3 -pyrimidin-4-yl                                             623    2-CH.sub.2 CH.sub.3 -pyrimidin-4-yl                                    624    5-CH.sub.2 CH.sub.3 -pyrimidin-4-yl                                    625    6-CH.sub.2 CH.sub.3 -pyrimidin-4-yl.                                   626    2-CH(CH.sub.3).sub.2 -pyrimidin-4-yl                                   627    5-CH(CH.sub.3).sub.2 -pyrimidin-4-yl                                   628    6-CH(CH.sub.3).sub.2 -pyrimidin-4-yl                                   629    2-CH(CH.sub.3)CH.sub.2 CH.sub.3 -pyrimidin-4-yl                        630    5-CH(CH.sub.3)CH.sub.2 CH.sub.3 -pyrimidin-4-yl                        631    6-CH(CH.sub.3)CH.sub.2 CH.sub.3 -pyrimidin-4-yl                        632    2-CF.sub.3 -pyrimidin-4-yl                                             633    5-CF.sub.3 -pyrimidin-4-yl                                             634    6-CF.sub.3 -pyrimidin-4-yl                                             635    2-CH═CH.sub.2 -pyrimidin-4-yl                                      636    5-CH═CH.sub.2 -pyrimidin-4-yl                                      637    6-CH═CH.sub.2 -pyrimidin-4-yl                                      638    2-CH═CHCH.sub.3 -pyrimidin-4-yl                                    639    5-CH═CHCH.sub.3 -pyrimidin-4-yl                                    640    6-CH═CHCH.sub.3 -pyrimidin-4-yl                                    641    2-CH═CHCl-pyrimidin-4-yl                                           642    5-CH═CHCl-pyrimidin-4-yl                                           643    6-CH═CHCl-pyrimidin-4-yl                                           644    2-C.tbd.CH-pyrimidin-4-yl                                              645    5-C.tbd.CH-pyrimidin-4-yl                                              646    6-C.tbd.CH-pyrimidin-4-yl                                              647    2-CH.sub.2 C.tbd.CH-pyrimidin-4-yl                                     648    5-CH.sub.2 C.tbd.CH-pyrimidin-4-yl                                     649    6-CH.sub.2 C.tbd.CH-pyrimidin-4-yl                                     650    2-CH.sub.2 C.tbd.CCH.sub.3 -pyrimidin-4-yl                             651    5-CH.sub.2 C.tbd.CCH.sub.3 -pyrimidin-4-yl                             652    6-CH.sub.2 C.tbd.CCH.sub.3 -pyrimidin-4-yl                             653    2-cyclopropyl-pyrimidin-4-yl                                           654    5-cyclopropyl-pyrimidin-4-yl                                           655    6-cyclopropyl-pyrimidin-4-yl                                           656    2-cyclopentyl-pyrimidin-4-yl                                           657    5-cyclopentyl-pyrimidin-4-yl                                           658    6-cyclopentyl-pyrimidin-4-yl                                           659    2-OCH.sub.3 -pyrimidin-4-yl                                            660    5-OCH.sub.3 -pyrimidin-4-yl                                            661    6-OCH.sub.3 -pyrimidin-4-yl                                            662    2-OCH.sub.2 CH.sub.3 -pyrimidin-4-yl                                   663    5-OCH.sub.2 CH.sub.3 -pyrimidin-4-yl                                   664    6-OCH.sub.2 CH.sub.3 -pyrimidin-4-yl                                   665    2-OCH.sub.2 CH.sub.2 CH.sub.3 -pyrimidin-4-yl                          666    5-OCH.sub.2 CH.sub.2 CH.sub.3 -pyrimidin-4-yl                          667    6-OCH.sub.2 CH.sub.2 CH.sub.3 -pyrimidin-4-yl                          668    2-OCH(CH.sub.3).sub.2 -pyrimidin-4-yl                                  669    5-OCH(CH.sub.3).sub.2 -pyrimidin-4-yl                                  670    6-OCH(CH.sub.3).sub.2 -pyrimidin-4-yl                                  671    2-OCH.sub.2 CH.sub.2 CH.sub.2 CH.sub.3 -pyrimidin-4-yl                 672    5-OCH.sub.2 CH.sub.2 CH.sub.2 CH.sub.3 -pyrimidin-4-yl                 673    6-OCH.sub.2 CH.sub.2 CH.sub.2 CH.sub.3 -pyrimidin-4-yl                 674    2-OCH(CH.sub.3)CH.sub.2 CH.sub.3 -pyrimidin-4-yl                       675    5-OCH(CH.sub.3)CH.sub.2 CH.sub.3 -pyrimidin-4-yl                       676    6-OCH(CH.sub.3)CH.sub.2 CH.sub.3 -pyrimidin-4-yl                       677    2-OCH.sub.2 CH(CH.sub.3).sub.2 -pyrimidin-4-yl                         678    5-OCH.sub.2 CH(CH.sub.3).sub.2 -pyrimidin-4-yl                         679    6-OCH.sub.2 CH(CH.sub.3).sub.2 -pyrimidin-4-yl                         680    2-OC(CH.sub.3).sub.3 -pyrimidin-4-yl                                   681    5-OC(CH.sub.3).sub.3 -pyrimidin-4-yl                                   662    6-OC(CH.sub.3).sub.3 -pyrimidin-4-yl                                   683    2-OCH(CH.sub.3)CH.sub.2 CH.sub.2 CH.sub.3 -pyrimidin-4-yl              684    5-OCH(CH.sub.3)CH.sub.2 CH.sub.2 CH.sub.3 -pyrimidin-4-yl              685    6-OCH(CH.sub.3)CH.sub.2 CH.sub.2 CH.sub.3 -pyrimidin-4-yl              686    2-OCH.sub.2 OCH.sub.3 -pyrimidin-4-yl                                  687    5-OCH.sub.2 OCH.sub.3 -pyrimidin-4-yl                                  688    6-OCH.sub.2 OCH.sub.3 -pyrimidin-4-yl                                  689    2-OCH.sub.2 OCH.sub.2 CH.sub.3 -pyrimidin-4-yl                         690    5-OCH.sub.2 OCH.sub.2 CH.sub.3 -pyrimidin-4-yl                         691    6-OCH.sub.2 OCH.sub.2 CH.sub.3 -pyrimidin-4-yl                         692    2-OCH(CH.sub.3)OCH.sub.3 -pyrimidin-4-yl                               693    5-OCH(CH.sub.3)OCH.sub.3 -pyrimidin-4-yl                               694    6-OCH(CH.sub.3)OCH.sub.3 -pyrimidin-4-yl                               695    2-OCH(CH.sub.3)OCH.sub.2 CH.sub.3 -pyrimidin-4-yl                      696    5-OCH(CH.sub.3)OCH.sub.2 CH.sub.3 -pyrimidin-4-yl                      697    6-OCH(CH.sub.3)OCH.sub.2 CH.sub.3 -pyrimidin-4-yl                      698    2-OCH.sub.2 CH.sub.2 OCH.sub.3 -pyrimidin-4-yl                         699    5-OCH.sub.2 CH.sub.2 OCH.sub.3 -pyrimidin-4-yl                         700    6-OCH.sub.2 CH.sub.2 OCH.sub.3 -pyrimidin-4-yl                         701    2-OCH.sub.2 CH.sub.2 OCH.sub.2 CH.sub.3 -pyrimidin-4-yl                702    5-OCH.sub.2 CH.sub.2 OCH.sub.2 CH.sub.3 -pyrimidin-4-yl                703    6-OCH.sub.2 CH.sub.2 OCH.sub.2 CH.sub.3 -pyrimidin-4 -yl               704    2-OCH.sub.2 CH.sub.2 OCH(CH.sub.3).sub.2 -pyrimidin-4-yl               705    5-OCH.sub.2 CH.sub.2 OCH(CH.sub.3).sub.2 -pyrimidin-4-yl               706    6-OCH.sub.2 CH.sub.2 OCH(CH.sub.3).sub.2 -pyrimidin-4-yl               707    2-OCH.sub.2 CH.sub.2 SCH.sub.3 -pyrimidin-4-yl                         708    5-OCH.sub.2 CH.sub.2 SCH.sub.3 -pyrimidin-4-yl                         709    6-OCH.sub.2 CH.sub.2 SCH.sub.3 -pyrimidin-4-yl                         710    2-OCH.sub.2 CH.sub.2 SO.sub.2 CH.sub.3 -pyrimidin-4-yl                 711    5-OCH.sub.2 CH.sub.2 SO.sub.2 CH.sub.3 -pyrimidin-4-yl                 712    6-OCH.sub.2 CH.sub.2 SO.sub.2 CH.sub.3 -pyrimidin-4-yl                 713    2-OCH.sub.2 CH.sub.2 SCH(CH.sub.3).sub.2 -pyrimidin-4-yl               714    5-OCH.sub.2 CH.sub.2 SCH(CH.sub.3).sub.2 -pyrimidin-4-yl               715    6-OCH.sub.2 CH.sub.2 SCH(CH.sub.3).sub.2 -pyrimidin-4-yl               716    2-OCH.sub.2 CH.sub.2 CN-pyrimidin-4-yl                                 717    5-OCH.sub.2 CH.sub.2 CN-pyrimidin-4-yl                                 718    6-OCH.sub.2 CH.sub.2 CN-pyrimidin-4-yl                                 719    2-OCH.sub.2 CH.sub.2 SCH.sub.2 CH.sub.2 CN-pyrimidin-4-yl              720    5-OCH.sub.2 CH.sub.2 SCH.sub.2 CH.sub.2 CN-pyrimidin-4-yl              721    6-OCH.sub.2 CH.sub.2 SCH.sub.2 CH.sub.2 CN-pyrimidin-4-yl              722    2-OCH.sub.2 CH.sub.2 OC.sub.6 H.sub.5 -pyrimidin-4-yl                  723    5-OCH.sub.2 CH.sub.2 OC.sub.6 H.sub.5 -pyrimidin-4-yl                  724    6-OCH.sub.2 CH.sub.2 OC.sub.6 H.sub.5 -pyrimidin- 4-yl                 725    2-OCH.sub.2 CH.sub.2 OCH.sub.2 C.sub.6 H.sub.5 -pyrimidin-4-yl         726    5-OCH.sub.2 CH.sub.2 OCH.sub.2 C.sub.6 H.sub.5 -pyrimidin-4-yl         727    6-OCH.sub.2 CH.sub.2 OCH.sub.2 C.sub.6 H.sub.5 -pyrimidin-4-yl         728    2-OCH.sub.2 CH.sub.2 N(CH.sub.3).sub.2 -pyrimidin-4-yl                 729    5-OCH.sub.2 CH.sub.2 N(CH.sub.3).sub.2 -pyrimidin-4-yl                 730    6-OCH.sub.2 CH.sub.2 N(CH.sub.3).sub.2 -pyrimidin-4-yl                 731    2-OCH.sub.2 CH.sub.2 CONH.sub.2 -pyrimidin-4-yl                        732    5-OCH.sub.2 CH.sub.2 CONH.sub.2 -pyrimidin-4-yl                        733    6-OCH.sub.2 CH.sub.2 CONH.sub.2 -pyrimidin-4-yl                        734    2-OCH.sub.2 CH.sub.2 CO.sub.2 CH.sub.2 CH.sub.2 CH.sub.3 -pyrimidin           -4-yl                                                                  735    5-OCH.sub.2 CH.sub.2 CO.sub.2 CH.sub.2 CH.sub.2 CH.sub.3 -pyrimidin           -4-yl                                                                  736    6-OCH.sub.2 CH.sub.2 CO.sub.2 CH.sub.2 CH.sub.2 CH.sub.3 -pyrimidin           -4-yl                                                                  737    2-OCH(CH.sub.3)CH.sub.2 OCH.sub.3 -pyrimidin-4-yl                      738    5-OCH(CH.sub.3)CH.sub.2 OCH.sub.3 -pyrimidin-4-yl                      739    6-OCH(CH.sub.3)CH.sub.2 OCH.sub.3 -pyrimidin-4-yl                      740    2-OCH(CH.sub.3)CH.sub.2 CO.sub.2 CH.sub.3 -pyrimidin-4-yl              741    5-OCH(CH.sub.3)CH.sub.2 CO.sub.2 CH.sub.3 -pyrimidin-4-yl              742    6-OCH(CH.sub.3)CH.sub.2 CO.sub.2 CH.sub.3 -pyrimidin-4-yl              743    2-OCH(CH.sub.3)CH.sub.2 CO.sub.2 CH.sub.2 CH.sub.3 -pyrimidin-4-yl            O                                                                      744    5-OCH(CH.sub.3)CH.sub.2 CO.sub.2 CH.sub.2 CH.sub.3 -pyrimidin-4-yl     745    6-OCH(CH.sub.3)CH.sub.2 CO.sub.2 CH.sub.2 CH.sub.3 -pyrimidin-4-yl     746    2-OCH.sub.2 CH(CH.sub.3)CO.sub.2 CH.sub.3 -pyrimidin-4-yl              747    5-OCH.sub.2 CH(CH.sub.3)CO.sub.2 CH.sub.3 -pyrimidin-4-yl              748    6-OCH.sub.2 CH(CH.sub.3)CO.sub.2 CH.sub.3 -pyrimidin-4-yl              749    2-OCH.sub.2 C(═O)CH.sub.3 -pyrimidin-4-yl                          750    5-OCH.sub.2 C(═O)CH.sub.3 -pyrimidin-4-yl                          751    6-OCH.sub.2 C(═O)CH.sub.3 -pyrimidin-4-yl                          752    2-OCH.sub.2 C(═O)CH.sub.2 CH.sub.3 -pyrimidin-4-yl                 753    5-OCH.sub.2 C(═O)CH.sub.2 CH.sub.3 -pyrimidin-4-yl                 744    6-OCH.sub.2 C(═O)CH.sub.2 CH.sub.3 -pyrimidin-4-yl                 755    2-OCH.sub.2 CO.sub.2 CH.sub.3 -pyrimidin-4-yl                          756    5-OCH.sub.2 CO.sub.2 CH.sub.3 -pyrimidin-4-yl                          757    6-OCH.sub.2 CO.sub.2 CH.sub.3 -pyrimidin-4-yl                          758    2-OCH.sub.2 CO.sub.2 CH.sub.2 CH.sub.3 -pyrimidin-4-yl                 759    4-OCH.sub.2 CO.sub.2 CH.sub.2 CH.sub.3 -pyrimidin-4-yl                 760    6-OCH.sub.2 CO.sub.2 CH.sub.2 CH.sub.3 -pyrimidin-4-yl                 761    2-OCH.sub.2 C(═O)NH.sub.2 -pyrimidin-4-yl                          762    5-OCH.sub.2 C(═O)NH.sub.2 -pyrimidin-4-yl                          763    6-OCH.sub.2 C(═O)NH.sub.2 -pyrimidin-4-yl                          764    2-OCH.sub.2 C(═O)NHCH.sub.3 -pyrimidin-4-yl                        765    5-OCH.sub.2 C(═O)NHCH.sub.3 -pyrimidin-4-yl                        766    6-OCH.sub.2 C(═O)NHCH.sub.3 -pyrimidin-4-yl                        767    2-OCH.sub.2 C(═O)SCH.sub.3 -pyrimidin-4-yl                         768    5-OCH.sub.2 C(═O)SCH.sub.3 -pyrimidin-4 -yl                        769    6-OCH.sub.2 C(═O)SCH.sub.3 -pyrimidin-4-yl                         770    2-OCH(CH.sub.3)C(═O)NH.sub.2 -pyrimidin-4-yl                       771    5-OCH(CH.sub.3)C(═O)NH.sub.2 -pyrimidin-4-yl                       772    6-OCH(CH.sub.3)C(═O)NH.sub.2 -pyrimidin-4-yl                       773    2-OCH(CH.sub.3)C(═O)NHCH.sub.3 -pyrimidin-4-yl                     774    5-OCH(CH.sub.3)C(═O)NHCH.sub.3 -pyrimidin-4-yl                     775    6-OCH(CH.sub.3)C(═O)NHCH.sub.3 -pyrimidin-4-yl                     776    2-OCH(CH.sub.3)C(═O)NHNH.sub.2 -pyrimidin-4-yl                     777    5-OCH(CH.sub.3)C(═O)NHNH.sub.2 -pyrimidin-4-yl                     778    6-OCH(CH.sub.3)C(═O)NHNH.sub.2 -pyrimidin-4-yl                     779    2-OCH(CH.sub.3)CO.sub.2 CH.sub.3 -pyrimidin-4-yl                       780    5-OCH(CH.sub.3)CO.sub.2 CH.sub.3 -pyrimidin-4-yl                       781    6-OCH(CH.sub.3)CO.sub.2 CH.sub.3 -pyrimidin-4-yl                       782    2-OCH(CH.sub.3)CO.sub.2 CH.sub.2 CH.sub.3 -pyrimidin-4 -yl             783    5-OCH(CH.sub.3)CO.sub.2 CH.sub.2 CH.sub.3 -pyrimidin-4-yl              784    6-OCH(CH.sub.3)CO.sub.2 CH.sub.2 CH.sub.3 -pyrimidin-4-yl              785    2-OCH(CH.sub.3)C(═O)CH.sub.3 -pyrimidin-4-yl                       786    5-OCH(CH.sub.3)C(═O)CH.sub.3 -pyrimidin-4-yl                       787    6-OCH(CH.sub.3)C(═O)CH.sub.3 -pyrimidin-4-yl                       788    2-OCH(CH.sub.3)C(═O)CH.sub.2 CH.sub.3 -pyrimidin-4-yl              789    5-OCH(CH.sub.3)C(═O)CH.sub.2 CH.sub.3 -pyrimidin-4-yl              790    6-OCH(CH.sub.3)C(═O)CH.sub.2 CH.sub.3 -pyrimidin-4-yl              791    2-OCH(CH.sub.3)CH.sub.2 C(═O)CH.sub.3 -pyrimidin-4-yl              792    5-OCH(CH.sub.3)CH.sub.2 C(═O)CH.sub.3 -pyrimidin-4-yl              793    6-OCH(CH.sub.3)CH.sub.2 C(═O)CH.sub.3 -pyrimidin-4-yl              794    2-OCH(CH.sub.3)CH.sub.2 OC(CH.sub.3).sub.3 -pyrimidin-4-yl             795    5-OCH(CH.sub.3)CH.sub.2 OC(CH.sub.3).sub.3 -pyrimidin-4-yl             796    6-OCH(CH.sub.3)CH.sub.2 OC(CH.sub.3).sub.3 -pyrimidin-4-yl             797    2-OCH(CH.sub.3)CH.sub.2 OCH.sub.2 CH.sub.3 -pyrimidin-4-yl             798    5-OCH(CH.sub.3)CH.sub.2 OCH.sub.2 CH.sub.3 -pyrimidin-4-yl             799    6-OCH(CH.sub.3)CH.sub.2 OCH.sub.2 CH.sub.3 -pyrimidin-4-yl             800    2-OCH(CH.sub.3)CH.sub.2 O(CH.sub.3).sub.2 CH.sub.3 -pyrimidin-4-yl            N                                                                      801    5-OCH(CH.sub.3)CH.sub.2 O(CH.sub.3).sub.2 CH.sub.3 -pyrimidin-4-yl            O                                                                      802    6-OCH(CH.sub.3)CH.sub.2 O(CH.sub.3).sub.2 CH.sub.3 -pyrimidin-4-yl     803    2-OCH(CH.sub.3)CH.sub.2 OCH.sub.2 CH═CH.sub.2 -pyrimidin-4-yl      804    5-OCH(CH.sub.3)CH.sub.2 OCH.sub.2 CH═CH.sub.2 -pyrimidin-4-yl      805    6-OCH(CH.sub.3)CH.sub.2 OCH.sub.2 CH═CH.sub.2 -pyrimidin-4-yl      806    2-O(CH.sub.2).sub.3 OCH.sub.3 -pyrimidin-4-yl                          807    5-O(CH.sub.2).sub.3 OCH.sub.3 -pyrimidin-4-yl                          808    6-O(CH.sub.2).sub.3 OCH.sub.3 -pyrimidin-4-yl                          809    2-O(CH.sub.2).sub.3 OCH.sub.2 CH.sub.3 -pyrimidin-4-yl                 810    5-O(CH.sub.2).sub.3 OCH.sub.2 CH.sub.3 -pyrimidin-4-yl                 811    6-O(CH.sub.2).sub.3 OCH.sub.2 CH.sub.3 -pyrimidin-4-yl                 812    2-O(CH.sub.2).sub.3 OCH(CH.sub.3).sub.2 -pyrimidin-4-yl                813    5-O(CH.sub.2).sub.3 OCH(CH.sub.3).sub.2 -pyrimidin-4-yl                814    6-O(CH.sub.2).sub.3 OCH(CH.sub.3).sub.2 -pyrimidin-4-yl                815    2-O(CH.sub.2).sub.3 OC.sub.6 H.sub.5 -pyrimidin-4-yl                   816    5-O(CH.sub.2).sub.3 OC.sub.6 H.sub.5 -pyrimidin-4-yl                   817    6-O(CH.sub.2).sub.3 OC.sub.6 H.sub.5 -pyrimidin-4-yl                   818    2-O(CH.sub.2).sub.3 OCH.sub.2 C.sub.6 H.sub.5 -pyrimidin-4-yl          819    5-O(CH.sub.2).sub.3 OCH.sub.2 C.sub.6 H.sub.5 -pyrimidin-4-yl          820    6-O(CH.sub.2).sub.3 OCH.sub.2 C.sub.6 H.sub.5 -pyrimidin-4-yl          821    2-OCH(CH.sub.2 CH.sub.3)CH.sub.2 OCH.sub.3 -pyrimidin-4-yl             822    5-OCH(CH.sub.2 CH.sub.3)CH.sub.2 OCH.sub.3 -pyrimidin-4-yl             823    6-OCH(CH.sub.2 CH.sub.3)CH.sub.2 OCH.sub.3 -pyrimidin-4-yl             824    2-OCH(CH.sub.2 CH.sub.3)CH.sub.2 CH.sub.2 OCH.sub.3 -pyrimidin-4-yl           N                                                                      825    5-OCH(CH.sub.2 CH.sub.3)CH.sub.2 CH.sub.2 OCH.sub.3 -pyrimidin-4-yl           O                                                                      826    6-OCH(CH.sub.2 CH.sub.3)CH.sub.2 CH.sub.2 OCH.sub.3 -pyrimidin-4-yl    827    2-OCH(CH.sub.2 CH.sub.3)CH.sub.2 CH.sub.2 OCH.sub.2 CH.sub.3                  -pyrimidin-4-yl                                                        828    5-OCH(CH.sub.2 CH.sub.3)CH.sub.2 CH.sub.2 OCH.sub.2 CH.sub.3                  -pyrimidin-4-yl                                                        829    6-OCH(CH.sub.2 CH.sub.3)CH.sub.2 CH.sub.2 OCH.sub.2 CH.sub.3                  -pyrimidin-4-yl                                                        830    2-O (CH.sub.2).sub.3 O!.sub.2 CH.sub.3 -pyrimidin-4-yl                 831    5-O (CH.sub.2).sub.3 O!.sub.2 CH.sub.3 -pyrimidin-4-yl                 832    6-O (CH.sub.2).sub.3 O!.sub.2 CH.sub.3 -pyrimidin-4-yl                 833    2-OCH.sub.2 CH(CH.sub.3)CH.sub.2 OCH.sub.3 -pyrimidin-4-yl             834    5-OCH.sub.2 CH(CH.sub.3)CH.sub.2 OCH.sub.3 -pyrimidin-4-yl             835    6-OCH.sub.2 CH(CH.sub.3)CH.sub.2 OCH.sub.3 -pyrimidin-4-yl             836    2-OCH.sub.2 CH(CH.sub.3)CH.sub.2 OCH.sub.2 CH.sub.3 -pyrimidin-4-yl    837    5-OCH.sub.2 CH(CH.sub.3)CH.sub.2 OCH.sub.2 CH.sub.3 -pyrimidin-4-yl           N                                                                      838    6-OCH.sub.2 CH(CH.sub.3)CH.sub.2 OCH.sub.2 CH.sub.3 -pyrimidin-4-yl           O                                                                      839    2-OCH(CH.sub.2 Cl)CH.sub.2 OCH.sub.3 -pyrimidin-4-yl                   840    5-OCH(CH.sub.2 Cl)CH.sub.2 OCH.sub.3 -pyrimidin-4-yl                   841    6-OCH(CH.sub.2 Cl)CH.sub.2 OCH.sub.3 -pyrimidin-4-yl                   842    2-OCH(CH.sub.2 Cl)CH.sub.2 OCH.sub.2 CH.sub.3 -pyrimidin-4-yl          843    5-OCH(CH.sub.2 Cl)CH.sub.2 OCH.sub.2 CH.sub.3 -pyrimidine-yl           844    6-OCH(CH.sub.2 Cl)CH.sub.2 OCH.sub.2 CH.sub.3 -pyrimidin-4-yl          845    2-OCH(CH.sub.2 Cl)CH.sub.2 OCH(CH.sub.3).sub.2 -pyrimidin-4-yl         846    5-OCH(CH.sub.2 Cl)CH.sub.2 OCH(CH.sub.3).sub.2 -pyrimidin-4-yl         847    6-OCH(CH.sub.2 Cl)CH.sub.2 OCH(CH.sub.3).sub.2 -pyrimidin-4-yl         848    2-OCH(CH.sub.2 Cl)CH.sub.2 OCH.sub.2 CH═CH.sub.2 -pyrimidin-4-y           l                                                                      849    5-OCH(CH.sub.2 Cl)CH.sub.2 OCH.sub.2 CH═CH.sub.2 -pyrimidin-4-y           l                                                                      850    6-OCH(CH.sub.2 Cl)CH.sub.2 OCH.sub.2 CH═CH.sub.2 -pyrimidin-4-y           l                                                                      851    2-OCH CH.sub.2 OCH.sub.3 !.sub.2 -pyrimidin-4-yl                       852    5-OCH CH.sub.2 OCH.sub.3 !.sub.2 -pyrimidin-4-yl                       853    6-OCH CH.sub.2 OCH.sub.3 !.sub.2 -pyrimidin-4-yl                       854    2-OCH(CH.sub.2 OCH.sub.2 CH.sub.3).sub.2 -pyrimidin-4-yl               855    5-OCH(CH.sub.2 OCH.sub.2 CH.sub.3).sub.2 -pyrimidin-4-yl               856    6-OCH(CH.sub.2 OCH.sub.2 CH.sub.3).sub.2 -pyrimidin-4-yl               857    2-OCCl.sub.3 -pyrimidin-4-yl                                           858    5-OCCl.sub.3 -pyrimidin-4-yl                                           859    6-OCCl.sub.3 -pyrimidin-4-yl                                           860    2-OCHF.sub.2 -pyrimidin-4-yl                                           861    5-OCHF.sub.2 -pyrimidin-4-yl                                           862    6-OCHF.sub.2 -pyrimidin-4-yl                                           863    2-OCF.sub.3 -pyrimidin-4-yl                                            864    5-OCF.sub.3 -pyrimidin-4-yl                                            865    6-OCF.sub.3 -pyrimidin-4-yl                                            866    2-OCF.sub.2 CHF.sub.2 -pyrimidin-4-yl                                  867    5-OCF.sub.2 CHF.sub.2 -pyrimidin-4-yl                                  868    6-OCF.sub.2 CHF.sub.2 -pyrimidin-4-yl                                  869    2-OCH.sub.2 CF.sub.3 -pyrimidin-4-yl                                   870    5-OCH.sub.2 CF.sub.3 -pyrimidin-4-yl                                   871    6-OCH.sub.2 CF.sub.3 -pyrimidin-4-yl                                   872    2-OCH.sub.2 CHF.sub.2 -pyrimidin-4-yl                                  873    5-OCH.sub.2 CHF.sub.2 -pyrimidin-4-yl                                  874    6-OCH.sub.2 CHF.sub.2 -pyrimidin-4-yl                                  875    2-O(CH.sub.2).sub.3 F-pyrimidin-4-yl                                   876    5-O(CH.sub.2).sub.3 F-pyrimidin-4-yl                                   877    6-O(CH.sub.2).sub.3 F-pyrimidin-4-yl                                   878    2-OCH(CH.sub.3)CF.sub.3 -pyrimidin-4-yl                                879    5-OCH(CH.sub.3)CF.sub.3 -pyrimidin-4-yl                                880    6-OCH(CH.sub.3)CF.sub.3 -pyrimidin-4-yl                                881    2-O(CH.sub.2).sub.4 F-pyrimidin-4-yl                                   882    5-O(CH.sub.2).sub.4 F-pyrimidin-4-yl                                   883    6-O(CH.sub.2)4F-pyrimidin-4-yl                                         884    2-O(CH.sub.2).sub.3 CF.sub.3 -pyrimidin-4-yl                           865    5-O(CH.sub.2).sub.3 CF.sub.3 -pyrimidin-4-yl                           886    6-O(CH.sub.2).sub.3 CF.sub.3 -pyrimidin-4-yl                           887    2-OCH(CH.sub.3)CF.sub.2 CF.sub.3 -pyrimidin-4-yl                       888    5-OCH(CH.sub.3)CF.sub.2 CF.sub.3 -pyrimidin-4-yl                       889    6-OCH(CH.sub.3)CF.sub.2 CF.sub.3 -pyrimidin-4-yl                       890    2-OCH(CH.sub.3)CF.sub.2 CHF.sub.2 -pyrimidin-4-yl                      891    5-OCH(CH.sub.3)CF.sub.2 CHF.sub.2 -pyrimidin-4-yl                      892    6-OCH(CH.sub.3)CF.sub.2 CHF.sub.2 -pyrimidin-4-yl                      893    2-OCH.sub.2 CF.sub.2 CHFCH.sub.3 -pyrimidin-4-yl                       894    5-OCH.sub.2 CF.sub.2 CHFCH.sub.3 -pyrimidin-4-yl                       895    6-OCH.sub.2 CF.sub.2 CHFCH.sub.3 -pyrimidin-4-yl                       896    2-OCH.sub.2 (CF.sub.2).sub.2 CF.sub.3 -pyrimidin-4-yl                  897    5-OCH.sub.2 (CF.sub.2).sub.2 CF.sub.3 -pyrimidin-4-yl                  898    6-OCH.sub.2 (CF.sub.2).sub.2 CF.sub.3 -pyrimidin-4-yl                  899    2-O(CF.sub.2).sub.3 CF.sub.3 -pyrimidin-4-yl                           900    5-O(CF.sub.2).sub.3 CF.sub.3 -pyrimidin-4-yl                           901    6-O(CF.sub.2).sub.3 CF.sub.3 -pyrimidin-4-yl                           902    2-OCH.sub.2 CF.sub.2 CHF.sub.2 -pyrimidin-4-yl                         903    5-OCH.sub.2 CF.sub.2 CHF.sub.2 -pyrimidin-4-yl                         904    6-OCH.sub.2 CF.sub.2 CHF.sub.2 -pyrimidin-4-yl                         905    2-CH.sub.2 CH═CH.sub.2 -pyrimidin-4-yl                             906    5-CH.sub.2 CH═CH.sub.2 -pyrimidin-4-yl                             907    6-CH.sub.2 CH═CH.sub.2 -pyrimidin-4-yl                             908    2-CH.sub.2 C(CH.sub.3)═CH.sub.2 -pyrimidin-4-yl                    909    5-CH.sub.2 C(CH.sub.3)═CH.sub.2 -pyrimidin-4-yl                    910    6-CH.sub.2 C(CH.sub.3)═CH.sub.2 -pyrimidin-4-yl                    911    2-OCH.sub.2 CH═CHCH.sub.3 -pyrimidin-4-yl                          912    5-OCH.sub.2 CH═CHCH.sub.3 -pyrimidin-4-yl                          913    6-OCH.sub.2 CH═CHCH.sub.3 -pyrimidin- 4-yl                         914    2-O(CH.sub.2).sub.2 CH═CH.sub.2 -pyrimidin-4-yl                    915    5-O(CH.sub.2).sub.2 CH═CH.sub.2 -pyrimidin-4-yl                    916    6-O(CH.sub.2).sub.2 CH═CH.sub.2 -pyrimidin-4-yl                    917    2-OCH.sub.2 C(CH.sub.3)═CH.sub.2 -pyrimidin-4-yl                   918    5-OCH.sub.2 C(CH.sub.3)═CH.sub.2 -pyrimidin-4-yl                   919    6-OCH.sub.2 C(CH.sub.3)═CH.sub.2 -pyrimidin-4-yl                   920    2-OCH(CH.sub.3)CH═CH.sub.2 -pyrimidin-4-yl                         921    5-OCH(CH.sub.3)CH═CH.sub.2 -pyrimidin-4-yl                         922    6-OCH(CH.sub.3)CH═CH.sub.2 -pyrimidin-4-yl                         923    2-OCH.sub.2 C.tbd.CH-pyrimidin-4-yl                                    924    5-OCH.sub.2 C.tbd.CH-pyrimidin-4-yl                                    925    6-OCH.sub.2 C.tbd.CH-pyrimidin-4-yl                                    926    2-OCH.sub.2 C.tbd.CCH.sub.3 -pyrimidin-4-yl                            927    5-OCH.sub.2 C.tbd.CCH.sub.3 -pyrimidin-4-yl                            928    6-OCH.sub.2 C.tbd.CCH.sub.3 -pyrimidin-4-yl                            929    2-O(CH.sub.2).sub.2 C.tbd.CH-pyrimidin-4-yl                            930    5-O(CH.sub.2).sub.2 C.tbd.CH-pyrimidin-4-yl                            931    6-O(CH.sub.2).sub.2 C.tbd.CH-pyrimidin-4-yl                            932    2-SCH.sub.3 -pyrimidin-4-yl                                            933    5-SCH.sub.3 -pyrimidin-4-yl                                            934    6-SCH.sub.3 -pyrimidin-4-yl                                            935    2-SCH.sub.2 CH.sub.3 -pyrimidin-4-yl                                   936    5-SCH.sub.2 CH.sub.3 -pyrimidin-4-yl                                   937    6-SCH.sub.2 CH.sub.3 -pyrimidin-4-yl                                   938    2-OC.sub.6 H.sub.5 -pyrimidin-4-yl                                     939    5-OC.sub.6 H.sub.5 -pyrimidin-4-yl                                     940    6-OC.sub.6 H.sub.5 -pyrimidin-4-yl                                     941    2-OCH.sub.2 C.sub.6 H.sub.5 -pyrimidin-4-yl                            942    5-OCH.sub.2 C.sub.6 H.sub.5 -pyrimidin-4-yl                            943    6-OCH.sub.2 C.sub.6 H.sub.5 -pyrimidin-4-Yl                            944    2-NO.sub.2 -pyrimidin-4-yl                                             945    5-NO.sub.2 -pyrimidin-4-yl                                             946    6-NO.sub.2 -pyrimidin-4-yl                                             947    2-NHCH.sub.3 -pyrimidin-4-yl                                           948    5-NHCH.sub.3 -pyrimidin-4-yl                                           949    6-NHCH.sub.3 -pyrimidin-4-yl                                           950    2-N(CH.sub.3).sub.2 -pyrimidin-4-yl                                    951    5-N(CH.sub.3).sub.2 -pyrimidin-4-yl                                    952    6-N(CH.sub.3).sub.2 -pyrimidin-4-yl                                    953    2-N(CH.sub.3)C.sub.2 H.sub.5 -pyrimidin-4-yl                           954    5-N(CH.sub.3)C.sub.2 H.sub.5 -pyrimidin-4-yl                           955    6-N(CH.sub.3)C.sub.2 H.sub.5 -pyrimidin-4-yl                           956    2-NHCH.sub.2 CF.sub.3 -pyrimidin-4-yl                                  957    5-NHCH.sub.2 CF.sub.3 -pyrimidin-4-yl                                  958    6-NHCH.sub.2 CF.sub.3 -pyrimidin-4-yl                                  959    2-F-pyrimidin-4-yl                                                     960    5-F-pyrimidin-4-yl                                                     961    6-F-pyrimidin-4-yl                                                     962    2-Cl-pyrimidin-4-yl                                                    963    5-Cl-pyrimidin-4-yl                                                    964    6-Cl-pyrimidin-4-yl                                                    965    2-OH-pyrimidin-4-yl                                                    966    5-OH-pyrimidin-4-yl                                                    967    6-OH-pyrimidin-4-yl                                                    968    2-CN-pyrimidin-4-yl                                                    969    5-CN-pyrimidin-4-yl                                                    970    6-CN-pyrimidin-4-yl                                                    971    2-C(O)NH.sub.2 -pyrimidin-4-yl                                         972    5-C(O)NH.sub.2 -pyrimidin-4-yl                                         973    6-C(O)NH.sub.2 -pyrimidin-4-yl                                         974    2-C(S)NH.sub.2 -pyrimidin-4-yl                                         975    5-C(S)NH.sub.2 -pyrimidin-4-yl                                         976    6-C(S)NH.sub.2 -pyrimidin-4-yl                                         977    2-CO.sub.2 CH.sub.3 -pyrimidin-4-yl                                    978    5-CO.sub.2 CH.sub.3 -pyrimidin-4-yl                                    979    6-CO.sub.2 CH.sub.3 -pyrimidin-4-yl                                    980    2-ON═C(CH.sub.3).sub.2 -pyrimidin-4-yl                             981    5-ON═C(CH.sub.3).sub.2 -pyrimidin-4-yl                             982    6-ON═C(CH.sub.3).sub.2 -pyrimidin-4-yl                             983    2- O-cyclopropyl!pyrimidin-4-yl                                        984    5- O-cyclopropyl!pyrimidin-4-yl                                        985    6- O-cyclopropyl!pyrimidin-4-yl                                        986    2- O-cyclobutyl!pyrimidin-4-yl                                         987    5- O-cyclobutyl!pyrimidin-4-yl                                         988    6- O-cyclobutyl!pyrimidin-4-yl                                         989    2- O-cyclopentyl!pyrimidin-4-yl                                        990    5- O-cyclopentyl!pyrimidin-4-yl                                        991    6- O-cyclopentyl!pyrimidin-4-yl                                        992    2- O-cyclohexyl!pyrimidin-4-yl                                         993    5- O-cyclohexyl!pyrimidin-4-yl                                         994    6- O-cyclohexyl!pyrimidin-4-yl                                         995    2-(OCH.sub.2 -cyclopropyl!pyrimidin-4-yl                               996    5-(OCH.sub.2 -cyclopropyl!pyrimidin-4-yl                               997    6-(OCH.sub.2 -cyclopropyl!pyrimidin-4-yl                               998    6-F, 2-(OCH.sub.2 -cyclopropyl!pyrimidin-4-yl                          999    2-F, 6-(OCH.sub.2 -cyclopropyl!pyrimidin-4-yl                          1000   5-F, 2-(OCH.sub.2 -cyclopropyl!pyrimidin-4-yl                          1001   6-CH.sub.3, 2-(OCH.sub.2 -cyclopropyl!pyrimidin-4-yl                   1002   2-CH.sub.3, 6-(OCH.sub.2 -cyclopropyl!pyrimidin-4-yl                   1003   5-CH.sub.3, 2-(OCH.sub.2 -cyclopropyl!pyrimidin-4-yl                   1004   6-CF.sub.3, 2-(OCH.sub.2 -cyclopropyl!pyrimidin-4-yl                   1005   2-CF.sub.3, 6-(OCH.sub.2 -cyclopropyl!pyrimidin-4-yl                   1006   5-CF.sub.3, 2- OCH.sub.2 -cyclopropyl!pyrimidin-4-yl                   1007   2- OCH(CH.sub.3)-cyclopropyl)!pyrimidin-4-yl                           1008   5- OCH(CH.sub.3)-cyclopropyl!pyrimidin-4-yl                            1009   6- OCH(CH.sub.3)-cyclopropyl!pyrimidin-4-yl                            1010   6-F, 2- OCH(CH.sub.3)-cyclopropyl!pyrimidin-4-yl                       1011   2-F, 6- OCH(CH.sub.3)-cyclopropyl!pyrimidin-4-yl                       1012   5-F, 2- OCH(CH.sub.3)-cyclopropyl!pyrimidin-4-yl                       1013   6-CH.sub.3, 2- OCH(CH.sub.3)-cyclopropyl!pyrimidin-4-yl                1014   2-CH.sub.3, 6- OCH(CH.sub.3)-cyclopropyl!pyrimidin-4-yl                1015   5-CH.sub.3, 2- OCH(CH.sub.3)-cyclopropyl!pyrimidin-4-yl                1016   6-CF.sub.3, 2- OCH(CH.sub.3)-cyclopropyl!pyrimidin-4-yl                1017   2-CF.sub.3, 6- OCH(CH.sub.3)-cyclopropyl!pyrimidin-4-yl                1018   5-CF.sub.3, 2- OCH(CH.sub.3)-cyclopropyl!pyrimidin-4-yl                1019   2- O-(1-CH.sub.3 -cyclopropyl!pyrimidin-4-yl                           1020   5- O-(1-CH.sub.3 -cyclopropyl!pyrimidin-4-yl                           1021   6- O-(1-CH.sub.3 -cyclopropyl!pyrimidin-4-yl                           1022   6-F, 2- O-(1-CH.sub.3 -cyclopropyl)!pyrimidin-4-yl                     1023   2-F, 6- O-(1-CH.sub.3 -cyclopropyl)!pyrimidin-4-yl                     1024   5-F, 2- O-(1-CH.sub.3 -cyclopropyl)!pyrimidin-4-yl                     1025   6-CH.sub.3, 2- O-(1-CH.sub.3 -cyclopropyl)!pyrimidin-4-yl              1026   2-CH.sub.3, 6- O-(1-CH.sub.3 -cyclopropyl)!pyrimidin-4-yl              1027   5-CH.sub.3, 2- O-(1-CH.sub.3 -cyclopropyl)!pyrimidin-4-yl              1028   6-CF.sub.3, 2- O-(1-CH.sub.3 -cyclopropyl)!pyrimidin-4-yl              1029   2-CF.sub.3, 6- O-(1-CH.sub.3 -cyclopropyl)!pyrimidin-4-yl              1030   5-CF.sub.3, 2- O-(1-CH.sub.3 -cyclopropyl)!pyrimidin-4-yl              1031   2- OCH.sub.2 -(1-CH.sub.3 -cyclopropyl)!pyrimidin-4-yl                 1032   5- OCH.sub.2 -(1-CH.sub.3 -cyclopropyl)!pyrimidin-4-yl                 1033   6- OCH.sub.2 -(1-CH.sub.3 -cyclopropyl)!pyrimidin-4-yl                 1034   6-F, 2- OCH.sub.2 -(1-CH.sub.3 -cyclopropyl)!pyrimidin-4-yl            1035   2-F, 6- OCH.sub.2 -(1-CH.sub.3 -cyclopropyl)!pyrimidin-4-yl            1036   5-F, 2- OCH.sub.2 -(1-CH.sub.3 -cyclopropyl)!pyrimidin-4-yl            1037   6-CH.sub.3, 2- OCH.sub.2 -(1-CH.sub.3 -cyclopropyl)!pyrimidin-4-yl            N                                                                      1038   2-CH.sub.3, 6- OCH.sub.2 -(1-CH.sub.3 -cyclopropyl)!pyrimidin-4-yl            O                                                                      1039   5-CH.sub.3, 2- OCH.sub.2 -(1-CH.sub.3 -cyclopropyl)!pyrimidin-4-yl     1040   6-CF.sub.3, 2- OCH.sub.2 -(1-CH.sub.3 -cyclopropyl)!pyrimidin-4-yl     1041   2-CF.sub.3, 6- OCH.sub.2 -(1-CH.sub.3 -cyclopropyl)!pyrimidin-4-yl            N                                                                      1042   5-CF.sub.3, 2- OCH.sub.2 -(1-CH.sub.3 -cyclopropyl)!pyrimidin-4-yl            O                                                                      1043   2- OCH.sub.2 -(2-CH.sub.3 -cyclopropyl!pyrimidin-4-yl                  1044   5- OCH.sub.2 -(2-CH.sub.3 -cyclopropyl!pyrimidin-4-yl                  1045   6- OCH.sub.2 -(2-CH.sub.3 -cyclopropyl!pyrimidin-4-yl                  1046   6-F, 2- OCH.sub.2 -(2-CH.sub.3 -cyclopropyl)!pyrimidin-4-yl            1047   2-F, 6- OCH.sub.2 -(2-CH.sub.3 -cyclopropyl)!pyrimidin-4-yl            1048   5-F, 2- OCH.sub.2 -(2-CH.sub.3 -cyclopropyl)!pyrimidin-4-yl            1049   6-CH.sub.3, 2- OCH.sub.2 -(2-CH.sub.3 -cyclopropyl)!pyrimidin-4-yl     1050   2-CH.sub.3, 6- OCH.sub.2 -(2-CH.sub.3 -cyclopropyl)!pyrimidin-4-yl     1051   5-CH.sub.3, 2- OCH.sub.2 -(2-CH.sub.3 -cyclopropyl)!pyrimidin-4-yl     1052   6-CF.sub.3, 2- OCH.sub.2 -(2-CH.sub.3 -cyclopropyl)!pyrimidin-4-yl     1053   2-CF.sub.3, 6- OCH.sub.2 -(2-CH.sub.3 -cyclopropyl)!pyrimidin-4-yl     1054   5-CF.sub.3, 2- OCH.sub.2 -(2-CH.sub.3 -cyclopropyl)!pyrimidin-4-yl     1055   2- OCH.sub.2 -(tetrahydropyran-2-yl)!pyrimidin-4-yl                    1056   5- OCH.sub.2 -(tetrahydropyran-2-yl)!pyrimidin-4-yl                    1057   6- OCH.sub.2 -(tetrahydropyran-2-yl)!pyrimidin-4-yl                    1058   6-F, 2- OCH.sub.2 -(tetrahydropyran-2-yl)!pyrimidin-4-yl               1059   2-F, 6- OCH.sub.2 -(tetrahydropyran-2-yl)!pyrimidin-4-yl               1060   5-F, 2- OCH.sub.2 -(tetrahydropyran-2-yl)!pyrimidin-4-yl               1061   6-CH.sub.3, 2- OCH.sub.2 -(tetrahydropyran-2-yl)!pyrimidin-4-yl        1062   2-CH.sub.3, 6- OCH.sub.2 -(tetrahydropyran-2-yl)!pyrimidin-4-yl        1063   5-CH.sub.3, 2- OCH.sub.2 -(tetrahydropyran-2-yl)!pyrimidin-4-yl        1064   6-CF.sub.3, 2- OCH.sub.2 -(tetrahydropyran-2-yl)!pyrimidin-4-yl        1065   2-CF.sub.3, 6- OCH.sub.2 -(tetrahydropyran-2-yl)!pyrimidin-4-yl        1066   5-CF.sub.3, 2- OCH.sub.2 -(tetrahydropyran-2-yl)!pyrimidin-4-yl        1067   2- OCH.sub.2 -(furan-2-yl)!pyrimidin-4-yl                              1068   5- OCH.sub.2 -(furan-2-yl)!pyrimidin-4-yl                              1069   6- OCH.sub.2 -(furan-2-yl)!pyrimidin-4-yl                              1070   6-F, 2- OCH.sub.2 -(furan-2-yl)!pyrimidin-4-yl                         1071   2-F, 6- OCH.sub.2 -(furan-2-yl)!pyrimidin-4-yl                         1072   5-F, 2- OCH.sub.2 -(furan-2-yl)!pyrimidin-4-yl                         1073   6-CH.sub.3, 2-(OCH.sub.2 -(furan-2-yl)!pyrimidin-4-yl                  1074   2-CH.sub.3, 6-(OCH.sub.2 -(furan-2-yl)!pyrimidin-4-yl                  1075   5-CH.sub.3, 2- OCH.sub.2 -(furan-2-yl)!pyrimidin-4-yl                  1076   6-CF.sub.3, 2- OCH.sub.2 -(furan-2-yl)!pyrimidin-4-yl                  1077   2-CF.sub.3, 6- OCH.sub.2 -(furan-2-yl)!pyrimidin-4-yl                  1078   5-CF.sub.3, 2- OCH.sub.2 -(furan-2-yl)!pyrimidin-4-yl                  1079   2- OCH.sub.2 -(furan-3-yl)!pyrimidin-4-yl                              1080   5- OCH.sub.2 -(furan-3-yl)!pyrimidin-4-yl                              1081   6- OCH.sub.2 -(furan-3-yl)!pyrimidin-4-yl                              1082   6-F, 2- OCH.sub.2 -(furan-3-yl)!pyrimidin-4-yl                         1083   2-F, 6- OCH.sub.2 -(furan-3-yl)!pyrimidin-4-yl                         1084   5-F, 2- OCH.sub.2 -(furan-3-yl)!pyrimidin-4-yl                         1085   6-CH.sub.3, 2- OCH.sub.2 -(furan-3-yl)!pyrimidin-4-yl                  1086   2-CH.sub.3, 6- OCH.sub.2 -(furan-3-yl)!pyrimidin-4-yl                  1087   5-CH.sub.3, 2- OCH.sub.2 -(furan-3-yl)!pyrimidin-4-yl                  1088   6-CF.sub.3, 2- OCH.sub.2 -(furan-3-yl)!pyrimidin-4-yl                  1089   2-CF.sub.3, 6- OCH.sub.2 -(furan-3-yl)!pyrimidin-4-yl                  1090   5-CF.sub.3, 2- OCH.sub.2 -(furan-3-yl)!pyrimidin-4-yl                  1091   2- OCH.sub.2 -(tetrahydrofuran-3-yl)!pyrimidin-4-yl                    1092   5- OCH.sub.2 -(tetrahydrofuran-3-yl)!pyrimidin-4-yl                    1093   6- OCH.sub.2 -(tetrahydrofuran-3-yl)!pyrimidin-4-yl                    1094   6-F, 2- OCH.sub.2 -(tetrahydrofuran-3-yl)!pyrimidin-4-yl               1095   2-F, 6- OCH.sub.2 -(tetrahydrofuran-3-yl)!pyrimidin-4-yl               1096   5-F, 2- OCH.sub.2 -(tetrahydrofuran-3-yl)!pyrimidin-4-yl               1097   6-CH.sub.3, 2- OCH.sub.2 -(tetrahydrofuran-3-yl)!pyrimidin-4-yl        1098   2-CH.sub.3, 6- OCH.sub.2 -(tetrahydrofuran-3-yl)!pyrimidin-4-yl        1099   5-CH.sub.3, 2- OCH.sub.2 -(tetrahydrofuran-3-yl)!pyrimidin-4-yl        1100   6-CF.sub.3, 2- OCH.sub.2 -(tetrahydrofuran-3-yl)!pyrimidin-4-yl        1101   2-CF.sub.3, 6- OCH.sub.2 -(tetrahydrofuran-3-yl)!pyrimidin-4-yl        1102   5-CF.sub.3, 2- OCH.sub.2 -(tetrahydrofuran-3-yl)!pyrimidin-4-yl        1103   2- OCH.sub.2 -(tetrahydrofuran-2-yl)!pyrimidin-4-yl                    1104   5- OCH.sub.2 -(tetrahydrofuran-2-yl)!pyrimidin-4-yl                    1105   6- OCH.sub.2 -(tetrahydrofuran-2-yl)!pyrimidin-4-yl                    1106   6-F, 2- OCH.sub.2 -(tetrahydrofuran-2-yl)!pyrimidin-4-yl               1107   2-F, 6- OCH.sub.2 -(tetrahydrofuran-2-yl)!pyrimidin-4-yl               1108   5-F, 2- OCH.sub.2 -(tetrahydrofuran-2-yl)!pyrimidin-4-yl               1109   6-CH.sub.3, 2- OCH.sub.2 -(tetrahydrofuran-2-yl)!pyrimidin-4-yl        1110   2-CH.sub.3, 6- OCH.sub.2 -(tetrahydrofuran-2-yl)!pyrimidin-4-yl        1111   4-CH.sub.3, 2- OCH.sub.2 -(tetrahydrofuran-2-yl)!pyrimidin-4-yl        1112   6-CF.sub.3, 2- OCH.sub.2 -(tetrahydrofuran-2-yl)!pyrimidin-4-yl        1113   2-CF.sub.3, 6- OCH.sub.2 -(tetrahydrofuran-2-yl)!pyrimidin-4-yl        1114   5-CF.sub.3, 2- OCH.sub.2 -(tetrahydrofuran-2-yl)!pyrimidin-4-yl        1115   2- O-(tetrahydropyran-2-yl)!pyrimidin-4-yl                             1116   5- O-(tetrahydropyran-2-yl)!pyrimidin-4-yl                             1117   6- O-(tetrahydropyran-2-yl)!pyrimidin-4-yl                             1118   6-F, 2- O-(tetrahydropyran-2-yl)!pyrimidin-4-yl                        1119   2-F, 6- O-(tetrahydropyran-2-yl)!pyrimidin-4-yl                        1120   5-F, 2- O-(tetrahydropyran-2-yl)!pyrimidin-4-yl                        1121   6-CH.sub.3, 2- O-(tetrahydropyran-2-yl)!pyrimidin-4-yl                 1122   2-CH.sub.3, 6- O-(tetrahydropyran-2-yl)!pyrimidin-4-yl                 1123   5-CH.sub.3, 2- O-(tetrahydropyran-2-yl)!pyrimidin-4-yl                 1124   6-CF.sub.3, 2- O-(tetrahydropyran-2-yl)!pyrimidin-4-yl                 1125   2-CF.sub.3, 6- O-(tetrahydropyran-2-yl)!pyrimidin-4-yl                 1126   5-CF.sub.3, 2- O-(tetrahydropyran-2-yl)!pyrimidin-4-yl                 1127   2- 2-Cl--C.sub.6 H.sub.4 !pyrimidin-4-yl                               1128   5- 2-Cl--C.sub.6 H.sub.4 !pyrimidin-4-yl                               1129   6- 2-Cl--C.sub.6 H.sub.4 !pyrimidin-4-yl                               1130   6-F, 2- 2-Cl--C.sub.6 H.sub.4 !pyrimidin-4-yl                          1131   2-F, 6- 2-Cl--C.sub.6 H.sub.4 !pyrimidin-4-yl                          1132   5-F, 2- 2-Cl--C.sub.6 H.sub.4 !pyrimidin-4-yl                          1133   6-CH.sub.3, 2- 2-Cl--C.sub.6 H.sub.4 !pyrimidin-4-yl                   1134   2-CH.sub.3, 6- 2-Cl--C.sub.6 H.sub.4 !pyrimidin-4-yl                   1135   5-CH.sub.3, 2- 2-Cl--C.sub.6 H.sub.4 !pyrimidin-4-yl                   1136   6-CF.sub.3, 2- 2-Cl--C.sub.6 H.sub.4 !pyrimidin-4-yl                   1137   2-CF.sub.3, 6- 2-Cl--C.sub.6 H.sub.4 !pyrimidin-4-yl                   1138   5-CF.sub.3, 2- 2-Cl--C.sub.6 H.sub.4 !pyrimidin-4-yl                   1139   2- OCH.sub.2 -(pyridin-4-yl)!pyrimidin-4-yl                            1140   5- OCH.sub.2 -(pyridin-4-yl)!pyrimidin-4-yl                            1141   6- OCH.sub.2 -(pyridin-4-yl)!pyrimidin-4-yl                            1142   6-F, 2- OCH.sub.2 -(pyridin-4-yl)!pyrimidin-4-yl                       1143   2-F, 6- OCH.sub.2 -(pyridin-4-yl)!pyrimidin-4-yl                       1144   5-F, 2- OCH.sub.2 -(pyridin-4-yl)!pyrimidin-4-yl                       1145   6-CH.sub.3, 2- OCH.sub.2 -(pyridin-4-yl)!pyrimidin-4-yl                1146   2-CH.sub.3, 6- OCH.sub.2 -(pyridin-4-yl)!pyrimidin-4-yl                1147   5-CH.sub.3, 2- OCH.sub.2 -(pyridin-4-yl)!pyrimidin-4-yl                1148   6-CH.sub.3, 2- OCH.sub.2 -(pyridin-4-yl)!pyrimidin-4-yl                1149   2-CF.sub.3, 6- OCH.sub.2 -(pyridin-4-yl)!pyrimidin-4-yl                1150   5-CF.sub.3, 2- OCH.sub.2 -(pyridin-4-yl)!pyrimidin-4-yl                1151   2- OCH.sub.2 -(pyridin-3-yl)!pyrimidin-4-yl                            1152   5- OCH.sub.2 -(pyridin-3-yl)!pyrimidin-4-yl                            1153   6- OCH.sub.2 -(pyridin-3-yl)!pyrimidin-4-yl                            1154   6-F, 2- OCH.sub.2 -(pyridin-3-yl)!pyrimidin-4-yl                       1155   2-F, 6- OCH.sub.2 -(pyridin-3-yl)!pyrimidin-4-yl                       1156   5-F, 2- OCH.sub.2 -(pyridin-3-yl)!pyrimidin-4-yl                       1157   6-CH.sub.3, 2- OCH.sub.2 -(pyridin-3-yl)!pyrimidin-4-yl                1158   2-CH.sub.3, 6- OCH.sub.2 -(pyridin-3-yl)!pyrimidin-4-yl                1159   5-CH.sub.3, 2- OCH.sub.2 -(pyridin-3-yl)!pyrimidin-4-yl                1160   6-CH.sub.3, 2- OCH.sub.2 -(pyridin-3-yl)!pyrimidin-4-yl                1161   2-CF.sub.3, 6- OCH.sub.2 -(pyridin-3-yl)!pyrimidin-4-yl                1162   5-CF.sub.3, 2- OCH.sub.2 -(pyridin-3-yl)!pyrimidin-4-yl                1163   2- morpholin-2-yl)!pyrimidin-4-yl                                      1164   5- morpholin-2-yl)!pyrimidin-4-yl                                      1165   6- morpholin-2-yl)!pyrimidin-4-yl                                      1166   2- 1-CH.sub.3 -imidazol-2-yl)!pyrimidin-4-yl                           1167   5- 1-CH.sub.3 -imidazol-2-yl)!pyrimidin-4-yl                           1168   6- 1-CH.sub.3 -imidazol-2-yl)!pyrimidin-4-yl                           1169   6-F, 2- 1-CH.sub.3 -imidazol-2-yl!pyrimidin-4-yl                       1170   2-F, 6- 1-CH.sub.3 -imidazol-2-yl!pyrimidin-4-yl                       1171   5-F, 2- 1-CH.sub.3 -imidazol-2-yl!pyrimidin-4-yl                       1172   6-CH.sub.3, 2- 1-CH.sub.3 -imidazol-2-yl!pyrimidin-4-yl                1173   2-CH.sub.3, 6- 1-CH.sub.3 -imidazol-2-yl!pyrimidin-4-yl                1174   5-CH.sub.3, 2- 1-CH.sub.3 -imidazol-2-yl!pyrimidin-4-yl                1175   6-CF.sub.3, 2- 1-CH.sub.3 -imidazol-2-yl!pyrimidin-4-yl                1176   2-CF.sub.3, 6- 1-CH.sub.3 -imidazol-2-yl!pyrimidin-4-yl                1177   5-CF.sub.3, 2- 1-CH.sub.3 -imidazol-2-yl!pyrimidin-4-yl                1178   2- 1,2,2-triazol-1-yl!pyrimidin-4-yl                                   1179   5- 1,2,2-triazol-1-yl!pyrimidin-4-yl                                   1180   6- 1,2,2-triazol-1-yl!pyrimidin-4-yl                                   1181   6-F, 2- 1,2,2-triazol-1-yl!pyrimidin-4-yl                              1182   2-F, 6- 1,2,2-triazol-1-yl!pyrimidin-4-yl                              1183   5-F, 2- 1,2,2-triazol-1-yl!pyrimidin-4-yl                              1184   6-CH.sub.3, 2- 1,2,2-triazol-1-yl!pyrimidin-4-yl                       1185   2-CH.sub.3, 6- 1,2,2-triazol-1-yl!pyrimidin-4-yl                       1186   5-CH.sub.3, 2- 1,2,2-triazol-1-yl!pyrimidin-4-yl                       1187   6-CF.sub.3, 2- 1,2,2-triazol-1-yl!pyrimidin-4-yl                       1188   2-CF.sub.3, 6- 1,2,2-triazol-1-yl!pyrimidin-4-yl                       1189   5-CF.sub.3, 2- 1,2,2-triazol-1-yl!pyrimidin-4-yl                       1190   2,5-Cl.sub.2 -pyrimidin-4-yl                                           1191   2,6-Cl.sub.2 -pyrimidin-4-yl                                           1192   5,6-Cl.sub.2 -pyrimidin-4-yl                                           1193   2,5-(CH.sub.3).sub.2 -pyrimidin-4-yl                                   1194   2,6-(CH.sub.3).sub.2 -pyrimidin-4-yl                                   1195   5,6-(CH.sub.3).sub.2 -pyrimidin-4-yl                                   1196   2,5-(OCH.sub.3).sub.2 -pyrimidin-4-yl                                  1197   2,6-(OCH.sub.3).sub.2 -pyrimidin-4-yl                                  1198   5,6-(OCH.sub.3).sub.2 -pyrimidin-4-yl                                  1199   2,5-(OCH.sub.2 CH.sub.3).sub.2 -pyrimidin-4-yl                         1200   2,6-(OCH.sub.2 CH.sub.3).sub.2 -pyrimidin-4-yl                         1201   5,6-(OCH.sub.2 CH.sub.3).sub.2 -pyrimidin-4-yl                         1202   2-F, 5-CH.sub.3 -pyrimidin-4-yl                                        1203   2-F, 6-CH.sub.3 -pyrimidin-4-yl                                        1204   5-F, 6-CH.sub.3 -pyrimidin-4-yl                                        1205   5-F, 2-CH.sub.3 -pyrimidin-4-yl                                        1206   6-F, 2-CH.sub.3 -pyrimidin-4-yl                                        1207   6-F, 5-CH.sub.3 -pyrimidin-4-yl                                        1208   2-F, 5-OCH.sub.3 -pyrimidin-4-yl                                       1209   2-F, 6-OCH.sub.3 -pyrimidin-4-yl                                       1210   5-F, 6-OCH.sub.3 -pyrimidin-4-yl                                       1211   5-F, 2-OCH.sub.3 -pyrimidin-4-yl                                       1212   6-F, 2-OCH.sub.3 -pyrimidin-4-yl                                       1213   6-F, 5-OCH.sub.3 -pyrimidin-4-yl                                       1214   2-F, 5-OCH.sub.2 CH.sub.3 -pyrimidin-4-yl                              1215   2-F, 6-OCH.sub.2 CH.sub.3 -pyrimidin-4-yl                              1216   5-F, 6-OCH.sub.2 CH.sub.3 -pyrimidin-4-yl                              1217   5-F, 2-OCH.sub.2 CH.sub.3 -pyrimidin-4-yl                              1218   6-F, 2-OCH.sub.2 CH.sub.3 -pyrimidin-4-yl                              1219   6-F, 5-OCH.sub.2 CH.sub.3 -pyrimidin-4-yl                              1220   2-F, 5-OCH.sub.2 CF.sub.3 -pyrimidin-4-yl                              1221   2-F, 6-OCH.sub.2 CF.sub.3 -pyrimidin-4-yl                              1222   5-F, 6-OCH.sub.2 CF.sub.3 -pyrimidin-4-yl                              1223   5-F, 2-OCH.sub.2 CF.sub.3 -pyrimidin-4-yl                              1224   6-F, 2-OCH.sub.2 CF.sub.3 -pyrimidin-4-yl                              1225   6-F, 5-OCH.sub.2 CF.sub.3 -pyrimidin-4-yl                              1226   2-F, 5-OCH(CH.sub.3).sub.2 -pyrimidin-4-yl                             1227   2-F, 6-OCH(CH.sub.3).sub.2 -pyrimidin-4-yl                             1228   5-F, 6-OCH(CH.sub.3).sub.2 -pyrimidin-4-yl                             1229   5-F, 2-OCH(CH.sub.3).sub.2 -pyrimidin-4-yl                             1230   6-F, 2-OCH(CH.sub.3).sub.2 -pyrimidin-4-yl                             1231   6-F, 5-OCH(CH.sub.3).sub.2 -pyrimidin-4-yl                             1232   2-Cl, 5-CH.sub.3 -pyrimidin-4-yl                                       1233   2-Cl, 6-CH.sub.3 -pyrimidin-4-yl                                       1234   5-Cl, 6-CH.sub.3 -pyrimidin-4-yl                                       1235   5-Cl, 2-CH.sub.3 -pyrimidin-4-yl                                       1236   6-Cl, 2-CH.sub.3 -pyrimidin-4-yl                                       1237   6-Cl, 5-CH.sub.3 -pyrimidin-4-yl                                       1238   2-Cl, 5-OCH.sub.3 -pyrimidin-4-yl                                      1239   2-Cl, 6-OCH.sub.3 -pyrimidin-4-yl                                      1240   5-Cl, 6-OCH.sub.3 -pyrimidin-4-yl                                      1241   5-Cl, 2-OCH.sub.3 -pyrimidin-4-yl                                      1242   6-Cl, 2-OCH.sub.3 -pyrimidin-4-yl                                      1243   6-Cl, 5-OCH.sub.3 -pyrimidin-4-yl                                      1244   2-Cl, 5-OCH.sub.2 CH.sub.3 -pyrimidin-4-yl                             1245   2-Cl, 6-OCH.sub.2 CH.sub.3 -pyrimidin-4-yl                             1246   5-Cl, 6-OCH.sub.2 CH.sub.3 -pyrimidin-4-yl                             1247   5-Cl, 2-OCH.sub.2 CH.sub.3 -pyrimidin-4-yl                             1248   6-Cl, 2-OCH.sub.2 CH.sub.3 -pyrimidin-4-yl                             1249   6-Cl, 5-OCH.sub.2 CH.sub.3 -pyrimidin-4-yl                             1250   2-Cl, 5-OCH.sub.2 CF.sub.3 -pyrimidin-4-yl                             1251   2-Cl, 6-OCH.sub.2 CF.sub.3 -pyrimidin-4-yl                             1252   5-Cl, 6-OCH.sub.2 CF.sub.3 -pyrimidin-4-yl                             1253   5-Cl, 2-OCH.sub.2 CF.sub.3 -pyrimidin-4-yl                             1254   6-Cl, 2-OCH.sub.2 CF.sub.3 -pyrimidin-4-yl                             1255   6-Cl, 5-OCH.sub.2 CF.sub.3 -pyrimidin-4-yl                             1256   2-Cl, 5-OCH(CH.sub.3)-pyrimidin-4-yl                                   1257   2-Cl, 6-OCH(CH.sub.3)-pyrimidin-4-yl                                   1258   5-Cl, 6-OCH(CH.sub.3)-pyrimidin-4-yl                                   1259   5-Cl, 2-OCH(CH.sub.3)-pyrimidin-4-yl                                   1260   6-Cl, 2-OCH(CH.sub.3)-pyrimidin-4-yl                                   1261   6-Cl, 5-OCH(CH.sub.3)-pyrimidin-4-yl                                   1262   2-CH.sub.3, 5-OCH.sub.3 -pyrimidin-4-yl                                1263   2-CH.sub.3, 6-OCH.sub.3 -pyrimidin-4-yl                                1264   5-CH.sub.3, 6-OCH.sub.3 -pyrimidin-4-yl                                1265   5-CH.sub.3, 2-OCH.sub.3 -pyrimidin-4-yl                                1266   6-CH.sub.3, 2-OCH.sub.3 -pyrimidin-4-yl                                1267   6-CH.sub.3, 5-OCH.sub.3 -pyrimidin-4-yl                                1268   2-CH.sub.3, 5-OCH.sub.2 CH.sub.3 -pyrimidin-4-yl                       1269   2-CH.sub.3, 6-OCH.sub.2 CH.sub.3 -pyrimidin-4-yl                       1270   5-CH.sub.3, 6-OCH.sub.2 CH.sub.3 -pyrimidin-4-yl                       1271   5-CH.sub.3, 2-OCH.sub.2 CH.sub.3 -pyrimidin-4-yl                       1272   6-CH.sub.3, 2-OCH.sub.2 CH.sub.3 -pyrimidin-4-yl                       1273   6-CH.sub.3, 5-OCH.sub.2 CH.sub.3 -pyrimidin-4-yl                       1274   2-CH.sub.3, 5-OCH.sub.2 CF.sub.3 -pyrimidin-4-yl                       1275   2-CH.sub.3, 6-OCH.sub.2 CF.sub.3 -pyrimidin-4-yl                       1276   5-CH.sub.3, 6-OCH.sub.2 CF.sub.3 -pyrimidin-4-yl                       1277   5-CH.sub.3, 2-OCH.sub.2 CF.sub.3 -pyrimidin-4-yl                       1278   6-CH.sub.3, 2-OCH.sub.2 CF.sub.3 -pyrimidin-4-yl                       1279   6-CH.sub.3, 5-OCH.sub.2 CF.sub.3 -pyrimidin-4-yl                       1280   2-CH.sub.3, 5-OCH(CH.sub.3).sub.2 -pyrimidin-4-yl                      1281   2-CH.sub.3, 5-OCH(CH.sub.3).sub.2 -pyrimidin-4-yl                      1282   5-CH.sub.3, 6-OCH(CH.sub.3).sub.2 -pyrimidin-4-yl                      1283   5-CH.sub.3, 2-OCH(CH.sub.3).sub.2 -pyrimidin-4-yl                      1284   6-CH.sub.3, 2-OCH(CH.sub.3).sub.2 -pyrimidin-4-yl                      1285   6-CH.sub.3, 5-OCH(CH.sub.3).sub.2 -pyrimidin-4-yl                      1286   2-CH.sub.3, 5-OCH.sub.2 CH═CH.sub.2 -pyrimidin-4-yl                1287   2-CH.sub.3, 6-OCH.sub.2 CH═CH.sub.2 -pyrimidin-4-yl                1288   5-CH.sub.3, 6-OCH.sub.2 CH═CH.sub.2 -pyrimidin-4-yl                1289   5-CH.sub.3, 2-OCH.sub.2 CH═CH.sub.2 -pyrimidin-4-yl                1290   6-CH.sub.3, 2-OCH.sub.2 CH═CH.sub.2 -pyrimidin-4-yl                1291   6-CH.sub.3, 5-OCH.sub.2 CH═CH.sub.2 -pyrimidin-4-yl                1292   2-CH.sub.3, 5-CO.sub.2 CH.sub.3 -pyrimidin-4-yl                        1293   2-CH.sub.3, 6-CO.sub.2 CH.sub.3 -pyrimidin-4-yl                        1294   5-CH.sub.3, 6-CO.sub.2 CH.sub.3 -pyrimidin-4-yl                        1295   2-CH.sub.3, 5-CF.sub.3 -pyrimidin-4-yl                                 1296   2-CH.sub.3, 6-CF.sub.3 -pyrimidin-4-yl                                 1297   5-CH.sub.3, 6-CF.sub.3 -pyrimidin-4-yl                                 1298   5-CH.sub.3, 2-CF.sub.3 -pyrimidin-4-yl                                 1299   6-CH.sub.3, 6-CF.sub.3 -pyrimidin-4-yl                                 1300   6-CH.sub.3, 5-CF.sub.3 -pyrimidin-4-yl                                 1301   2-CF.sub.3, 5-CH.sub.2 CH.sub.3 -pyrimidin-4-yl                        1302   2-CF.sub.3, 6-CH.sub.2 CH.sub.3 -pyrimidin-4-yl                        1303   5-CF.sub.3, 6-CH.sub.2 CH.sub.3 -pyrimidin-4-yl                        1304   5-CF.sub.3, 2-CH.sub.2 CH.sub.3 -pyrimidin-4-yl                        1305   6-CF.sub.3, 2-CH.sub.2 CH.sub.3 -pyrimidin-4-yl                        1306   6-CF.sub.3, 5-CH.sub.2 CH.sub.3 -pyrimidin-4-yl                        1307   2-CF.sub.3, 5-OCH.sub.3 -pyrimidin-4-yl                                1308   2-CF.sub.3, 6-OCH.sub.3 -pyrimidin-4-yl                                1309   5-CF.sub.3, 6-OCH.sub.3 -pyrimidin-4-yl                                1310   5-CF.sub.3, 2-OCH.sub.3 -pyrimidin-4-yl                                1311   6-CF.sub.3, 2-OCH.sub.3 -pyrimidin-4-yl                                1312   6-CF.sub.3, 5-OCH.sub.3 -pyrimidin-4-yl                                1313   2-CF.sub.3, 5-OCH.sub.2 CH.sub.3 -pyrimidin-4-yl                       1314   2-CF.sub.3, 6-OCH.sub.2 CH.sub.3 -pyrimidin-4-yl                       1315   5-CF.sub.3, 6-OCH.sub.2 CH.sub.3 -pyrimidin-4-yl                       1316   5-CF.sub.3, 2-OCH.sub.2 CH.sub.3 -pyrimidin-4-yl                       1317   6-CF.sub.3, 2-OCH.sub.2 CH.sub.3 -pyrimidin-4-yl                       1318   6-CF.sub.3, 5-OCH.sub.2 CH.sub.3 -pyrimidin-4-yl                       1319   2-CF.sub.3, 5-OCH.sub.2 CF.sub.3 -pyrimidin-4-yl                       1320   2-CF.sub.3, 6-OCH.sub.2 CF.sub.3 -pyrimidin-4-yl                       1321   5-CF.sub.3, 6-OCH.sub.2 CF.sub.3 -pyrimidin-4-yl                       1322   2-CF.sub.3, 2-OCH.sub.2 CF.sub.3 -pyrimidin-4-yl                       1323   6-CF.sub.3, 2-OCH.sub.2 CF.sub.3 -pyrimidin-4-yl                       1324   6-CF.sub.3, 5-OCH.sub.2 CF.sub.3 -pyrimidin-4-yl                       1325   2-OCH.sub.3, 5-OCH.sub.2 CH.sub.3 -pyrimidin-4-yl                      1326   2-OCH.sub.3, 6-OCH.sub.2 CH.sub.3 -pyrimidin-4-yl                      1327   5-OCH.sub.3, 6-OCH.sub.2 CH.sub.3 -pyrimidin-4-yl                      1328   5-OCH.sub.3, 2-OCH.sub.2 CH.sub.3 -pyrimidin-4-yl                      1329   6-OCH.sub.3, 6-OCH.sub.2 CH.sub.3 -pyrimidin-4-yl                      1330   6-OCH.sub.3, 5-OCH.sub.2 CH.sub.3 -pyrimidin-4-yl                      1331   2-OCH.sub.3, 5-OCH.sub.2 CF.sub.3 -pyrimidin-4-yl                      1332   2-OCH.sub.3, 6-OCH.sub.2 CF.sub.3 -pyrimidin-4-yl                      1333   5-OCH.sub.3, 6-OCH.sub.2 CF.sub.3 -pyrimidin-4-yl                      1334   5-OCH.sub.3, 2-OCH.sub.2 CF.sub.3 -pyrimidin-4-yl                      1335   6-OCH.sub.3, 2-OCH.sub.2 CF.sub.3 -pyrimidin-4-yl                      1336   6-OCH.sub.3, 5-OCH.sub.2 CF.sub.3 -pyrimidin-4-yl                      1337   2-OCH.sub.3, 5-OCH(CH.sub.3)pyrimidin-4-yl                             1338   2-OCH.sub.3, 6-OCH(CH.sub.3)pyrimidin-4-yl                             1339   5-OCH.sub.3, 6-OCH(CH.sub.3)pyrimidin-4-yl                             1340   5-OCH.sub.3, 2-OCH(CH.sub.3)pyrimidin-4-yl                             1341   6-OCH.sub.3, 2-OCH(CH.sub.3)pyrimidin-4-yl                             1342   6-OCH.sub.3, 5-OCH(CH.sub.3)pyrimidin-4-yl                             1343   2-OCH.sub.2 CH.sub.3, 5-CH.sub.2 OCH.sub.2 CH.sub.3 -pyrimidin-4-yl           N                                                                      1344   2-OCH.sub.2 CH.sub.3, 6-CH.sub.2 OCH.sub.2 CH.sub.3 -pyrimidin-4-yl           O                                                                      1345   5-OCH.sub.2 CH.sub.3, 5-CH.sub.2 OCH.sub.2 CH.sub.3 -pyrimidin-4-yl    1346   5-OCH.sub.2 CH.sub.3, 2-CH.sub.2 OCH.sub.2 CH.sub.3 -pyrimidin-4-yl           A                                                                      1347   6-OCH.sub.2 CH.sub.3, 2-CH.sub.2 OCH.sub.2 CH.sub.3 -pyrimidin-4-yl           B                                                                      1348   6-OCH.sub.2 CH.sub.3, 5-CH.sub.2 OCH.sub.2 CH.sub.3 -pyrimidin-4-yl           S                                                                      1349   2-NO.sub.2, 5-CH.sub.3 -pyrimidin-4-yl                                 1350   2-NO.sub.2, 6-CH.sub.3 -pyrimidin-4-yl                                 1351   5-NO.sub.2, 6-CH.sub.3 -pyrimidin-4-yl                                 1352   2-NO.sub.2, 2-CH.sub.3 -pyrimidin-4-yl                                 1353   6-NO.sub.2, 2-CH.sub.3 -pyrimidin-4-yl                                 1354   6-NO.sub.2, 5-CH.sub.3 -pyrimidin-4-yl                                 1355   2-NO.sub.2, 5-OCH.sub.3 -pyrimidin-4-yl                                1356   2-NO.sub.2, 6-OCH.sub.3 -pyrimidin-4-yl                                1357   5-NO.sub.2, 6-OCH.sub.3 -pyrimidin-4-yl                                1358   5-NO.sub.2, 2-OCH.sub.3 -pyrimidin-4-yl                                1359   6-NO.sub.2, 2-OCH.sub.3 -pyrimidin-4-yl                                1360   6-NO.sub.2, 5-OCH.sub.3 -pyrimidin-4-yl                                1361   2-NO.sub.2, 5-OCH.sub.2 CH.sub.3 -pyrimidin-4-yl                       1362   2-NO.sub.2, 6-OCH.sub.2 CH.sub.3 -pyrimidin-4-yl                       1363   5-NO.sub.2, 6-OCH.sub.2 CH.sub.3 -pyrimidin-4-yl                       1364   5-NO.sub.2, 2-OCH.sub.2 CH.sub.3 -pyrimidin-4-yl                       1365   6-NO.sub.2, 2-OCH.sub.2 CH.sub.3 -pyrimidin-4-yl                       1366   6-NO.sub.2, 5-OCH.sub.2 CH.sub.3 -pyrimidin-4-yl                       1367   2-NO.sub.2, 5-OCH(CH.sub.3).sub.2 -pyrimidin-4-yl                      1368   2-NO.sub.2, 6-OCH(CH.sub.3).sub.2 -pyrimidin-4-yl                      1369   5-NO.sub.2, 6-OCH(CH.sub.3).sub.2 -pyrimidin-4-yl                      1370   5-NO.sub.2, 2-OCH(CH.sub.3).sub.2 -pyrimidin-4-yl                      1371   6-NO.sub.2, 2-OCH(CH.sub.3).sub.2 -pyrimidin-4-yl                      1372   6-NO.sub.2, 5-OCH(CH.sub.3).sub.2 -pyrimidin-4-yl                      1373   2-NO.sub.2, 5-OCH.sub.2 CF.sub.3 -pyrimidin-4-yl                       1374   2-NO.sub.2, 6-OCH.sub.2 CF.sub.3 -pyrimidin-4-yl                       1375   5-NO.sub.2, 6-OCH.sub.2 CF.sub.3 -pyrimidin-4-yl                       1376   5-NO.sub.2, 2-OCH.sub.2 CF.sub.3 -pyrimidin-4-yl                       1377   6-NO.sub.2, 2-OCH.sub.2 CF.sub.3 -pyrimidin-4-yl                       1378   6-NO.sub.2, 5-OCH.sub.2 CF.sub.3 -pyrimidin-4-yl                       1379   2-CN, 5-CH.sub.3 -pyrimidin-4-yl                                       1380   2-CN, 6-CH.sub.3 -pyrimidin-4-yl                                       1381   5-CN, 6-CH.sub.3 -pyrimidin-4-yl                                       1382   5-CN, 2-CH.sub.3 -pyrimidin-4-yl                                       1383   6-CN, 2-CH.sub.3 -pyrimidin-4-yl                                       1384   6-CN, 5-CH.sub.3 -pyrimidin-4-yl                                       1385   2-CN, 5-OCH.sub.3 -pyrimidin-4-yl                                      1386   2-CN, 6-OCH.sub.3 -pyrimidin-4-yl                                      1387   5-CN, 6-OCH.sub.3 -pyrimidin-4-yl                                      1388   5-CN, 2-OCH.sub.3 -pyrimidin-4-yl                                      1389   6-CN, 2-OCH.sub.3 -pyrimidin-4-yl                                      1390   6-CN, 5-OCH.sub.3 -pyrimidin-4-yl                                      1391   2-CN, 5-OCH.sub.2 CH.sub.3 -pyrimidin-4-yl                             1392   2-CN, 6-OCH.sub.2 CH.sub.3 -pyrimidin-4-yl                             1393   5-CN, 6-OCH.sub.2 CH.sub.3 -pyrimidin-4-yl                             1394   5-CN, 2-OCH.sub.2 CH.sub.3 -pyrimidin-4-yl                             1395   6-CN, 2-OCH.sub.2 CH.sub.3 -pyrimidin-4-yl                             1396   6-CN, 5-OCH.sub.2 CH.sub.3 -pyrimidin-4-yl                             1397   2-CN, 5-OCH(CH.sub.3).sub.2 -pyrimidin-4-yl                            1398   2-CN, 6-OCH(CH.sub.3).sub.2 -pyrimidin-4-yl                            1399   5-CN, 6-OCH(CH.sub.3).sub.2 -pyrimidin-4-yl                            1400   2-CN, 2-OCH(CH.sub.3).sub.2 -pyrimidin-4-yl                            1401   6-CN, 2-OCH(CH.sub.3).sub.2 -pyrimidin-4-yl                            1402   6-CN, 5-OCH(CH.sub.3).sub.2 -pyrimidin-4-yl                            1403   2-CN, 5-OCH.sub.2 CF.sub.3 -pyrimidin-4-yl                             1404   2-CN, 6-OCH.sub.2 CF.sub.3 -pyrimidin-4-yl                             1405   5-CN, 6-OCH.sub.2 CF.sub.3 -pyrimidin-4-yl                             1406   5-CN, 2-OCH.sub.2 CF.sub.3 -pyrimidin-4-yl                             1407   6-CN, 2-OCH.sub.2 CF.sub.3 -pyrimidin-4-yl                             1408   6-CN, 5-OCH.sub.2 CF.sub.3 -pyrimidin-4-yl                             1409   2,5-(CH.sub.3).sub.2, 6-OCH.sub.3 -pyrimidin-4-yl                      1410   2,6-(CH.sub.3).sub.2, 5-OCH.sub.3 -pyrimidin-4-yl                      1411   5,6-(CH.sub.3).sub.2, 2-OCH.sub.3 -pyrimidin-4-yl                      1412   4-CH.sub.3 -pyrimidin-5-yl                                             1413   2-CH.sub.3 -pyrimidin-5-yl                                             1414   4-CH.sub.2 CH.sub.3 -pyrimidin-5-yl                                    1415   2-CH.sub.2 CH.sub.3 -pyrimidin-5-yl                                    1416   4-CH(CH.sub.3).sub.2 -pyrimidin-5-yl                                   1417   2-CH(CH.sub.3).sub.2 -pyrimidin-5-yl                                   1418   4-CH(CH.sub.3)CH.sub.2 CH.sub.3 -pyrimidin-5-yl                        1419   2-CH(CH.sub.3)CH.sub.2 CH.sub.3 -pyrimidin-5-yl                        1420   4-CF.sub.3 -pyrimidin-5-yl                                             1421   2-CF.sub.3 -pyrimidin-5-yl                                             1422   4-CH═CH.sub.2 -pyrimidin-5-yl                                      1423   2-CH═CH.sub.2 -pyrimidin-5-yl                                      1424   4-CH═CHCH.sub.3 -pyrimidin-5-yl                                    1425   2-CH═CHCH.sub.3 -pyrimidin-5-yl                                    1426   4-CH═CHCl-pyrimidin-5-yl                                           1427   2-CH═CHCl-pyrimidin-5-yl                                           1428   4-C.tbd.CH-pyrimidin-5-yl                                              1429   2-C.tbd.CH-pyrimidin-5-yl                                              1430   4-CH.sub.2 C.tbd.CH-pyrimidin-5-yl                                     1431   2-CH.sub.2 C.tbd.CH-pyrimidin-5-yl                                     1432   4-CH.sub.2 C.tbd.CCH.sub.3 -pyrimidin-5-yl                             1433   2-CH.sub.2 C.tbd.CCH.sub.3 -pyrimidin-5-yl                             1434   4-cyclopropyl-pyrimidin-5-yl                                           1435   2-cyclopropyl-pyrimidin-5-yl                                           1436   4-cyclopentyl-pyrimidin-5-yl                                           1437   2-cyclopropyl-pyrimidin-5-yl                                           1438   4-OCH.sub.3 -pyrimidin-5-yl                                            1439   2-OCH.sub.3 -pyrimidin-5-yl                                            1440   4-OCH.sub.2 CH.sub.3 -pyrimidin-5-yl                                   1441   2-OCH.sub.2 CH.sub.3 -pyrimidin-5-yl                                   1442   4-OCH.sub.2 CH.sub.2 CH.sub.3 -pyrimidin-5-yl                          1443   2-OCH.sub.2 CH.sub.2 CH.sub.3 -pyrimidin-5-yl                          1444   4-OCH(CH.sub.3).sub.2 -pyrimidin-5-yl                                  1445   2-OCH(CH.sub.3).sub.2 -pyrimidin-5-yl                                  1446   4-OCH.sub.2 CH.sub.2 CH.sub.2 CH.sub.3 -pyrimidin-5-yl                 1447   2-OCH.sub.2 CH.sub.2 CH.sub.2 CH.sub.3 -pyrimidin-5-yl                 1448   4-OCH(CH.sub.3)CH.sub.2 CH.sub.3 -pyrimidin-5-yl                       1449   2-OCH(CH.sub.3)CH.sub.2 CH.sub.3 -pyrimidin-5-yl                       1450   4-OCH.sub.2 CH(CH.sub.3).sub.2 -pyrimidin-5-yl                         1451   2-OCH.sub.2 CH(CH.sub.3).sub.2 -pyrimidin-5-yl                         1452   4-OC(CH.sub.3).sub.3 -pyrimidin-5-yl                                   1453   2-OC(CH.sub.3).sub.3 -pyrimidin-5-yl                                   1454   4-OCH(CH.sub.3)CH.sub.2 CH.sub.2 CH.sub.3 -pyrimidin-5-yl              1455   2-OCH(CH.sub.3)CH.sub.2 CH.sub.2 CH.sub.3 -pyrimidin-5-yl              1456   4-OCH.sub.2 OCH.sub.3 -pyrimidin-5-yl                                  1457   2-OCH.sub.2 OCH.sub.3 -pyrimidin-5-yl                                  1458   4-OCH.sub.2 OCH.sub.2 CH.sub.3 -pyrimidin-5-yl                         1459   2-OCH.sub.2 OCH.sub.2 CH.sub.3 -pyrimidin-5-yl                         1460   4-OCH(CH.sub.3)OCH.sub.3 -pyrimidin-5-yl                               1461   2-OCH(CH.sub.3)OCH.sub.3 -pyrimidin-5-yl                               1462   4-OCH(CH.sub.3)OCH.sub.2 CH.sub.3 -pyrimidin-5-yl                      1463   2-OCH(CH.sub.3)OCH.sub.2 CH.sub.3 -pyrimidin-5-yl                      1464   4-OCH.sub.2 CH.sub.2 OCH.sub.3 -pyrimidin-5-yl                         1465   2-OCH.sub.2 CH.sub.2 OCH.sub.3 -pyrimidin-5-yl                         1466   4-OCH.sub.2 CH.sub.2 OCH.sub.2 CH.sub.3 -pyrimidin-5-yl                1467   2-OCH.sub.2 CH.sub.2 OCH.sub.2 CH.sub.3 -pyrimidin-5-yl                1468   4-OCH.sub.2 CH.sub.2 OCH(CH.sub.3).sub.2 -pyrimidin-5-yl               1469   2-OCH.sub.2 CH.sub.2 OCH(CH.sub.3).sub.2 -pyrimidin-5-yl               1470   4-OCH.sub.2 CH.sub.2 SCH.sub.3 -pyrimidin-5-yl                         1471   2-OCH.sub.2 CH.sub.2 SCH.sub.3 -pyrimidin-5-yl                         1472   4-OCH.sub.2 CH.sub.2 SO.sub.2 CH.sub.3 -pyrimidin-5-yl                 1473   2-OCH.sub.2 CH.sub.2 SO.sub.2 CH.sub.3 -pyrimidin-5-yl                 1474   4-OCH.sub.2 CH.sub.2 SCH(CH.sub.3).sub.2 -pyrimidin-5-yl               1475   2-OCH.sub.2 CH.sub.2 SCH(CH.sub.3).sub.2 -pyrimidin-5-yl               1476   4-OCH.sub.2 CH.sub.2 CN-pyrimidin-5-yl                                 1477   2-OCH.sub.2 CH.sub.2 CN-pyrimidin-5-yl                                 1478   4-OCH.sub.2 CH.sub.2 SCH.sub.2 CH.sub.2 CN-pyrimidin-5-yl              1479   2-OCH.sub.2 CH.sub.2 SCH.sub.2 CH.sub.2 CN-pyrimidin-5-yl              1480   4-OCH.sub.2 CH.sub.2 OC.sub.6 H.sub.2 -pyrimidin-5-yl                  1481   2-OCH.sub.2 CH.sub.2 OC.sub.6 H.sub.2 -pyrimidin-5-yl                  1482   4-OCH.sub.2 CH.sub.2 OCH.sub.2 C.sub.6 H.sub.2 -pyrimidin-5-yl         1483   2-OCH.sub.2 CH.sub.2 OCH.sub.2 C.sub.6 H.sub.2 -pyrimidin-5-yl         1484   4-OCH.sub.2 CH.sub.2 N(CH.sub.3).sub.2 -pyrimidin-5-yl                 1485   2-OCH.sub.2 CH.sub.2 N(CH.sub.3).sub.2 -pyrimidin-5-yl                 1486   4-OCH.sub.2 CH.sub.2 CONH.sub.2 -pyrimidin-5-yl                        1487   2-OCH.sub.2 CH.sub.2 CONH.sub.2 -pyrimidin-5-yl                        1488   4-OCH.sub.2 CH.sub.2 CO.sub.2 CH.sub.2 CH.sub.2 CH.sub.3 -pyrimidin           -5-yl                                                                  1489   2-OCH.sub.2 CH.sub.2 CO.sub.2 CH.sub.2 CH.sub.2 CH.sub.3 -pyrimidin           -5-yl                                                                  1490   4-OCH(CH.sub.3)CH.sub.2 OCH.sub.3 -pyrimidin-5-yl                      1491   2-OCH(CH.sub.3)CH.sub.2 OCH.sub.3 -pyrimidin-5-yl                      1492   4-OCH(CH.sub.3)CH.sub.2 CO.sub.2 CH.sub.3 -pyrimidin-5-yl              1493   2-OCH(CH.sub.3)CH.sub.2 CO.sub.2 CH.sub.3 -pyrimidin-5-yl              1494   4-OCH(CH.sub.3)CH.sub.2 CO.sub.2 CH.sub.2 CH.sub.3 -pyrimidin-5-yl            T                                                                      1495   2-OCH(CH.sub.3)CH.sub.2 CO.sub.2 CH.sub.2 CH.sub.3 -pyrimidin-5-yl     1496   4-OCH.sub.2 CH(CH.sub.3)CO.sub.2 CH.sub.3 -pyrimidin-5-yl              1497   2-OCH.sub.2 CH(CH.sub.3)CO.sub.2 CH.sub.3 -pyrimidin-5-yl              1498   4-OCH.sub.2 C(═O)CH.sub.3 -pyrimidin-5-yl                          1499   2-OCH.sub.2 C(═O)CH.sub.3 -pyrimidin-5-yl                          1500   4-OCH.sub.2 C(═O)CH.sub.2 CH.sub.3 -pyrimidin-5-yl                 1501   2-OCH.sub.2 C(═O)CH.sub.2 CH.sub.3 -pyrimidin-5-yl                 1502   4-OCH.sub.2 CO.sub.2 CH.sub.3 -pyrimidin-5-yl                          1503   2-OCH.sub.2 CO.sub.2 CH.sub.3 -pyrimidin-5-yl                          1504   4-OCH.sub.2 CO.sub.2 CH.sub.2 CH.sub.3 -pyrimidin-5-yl                 1505   2-OCH.sub.2 CO.sub.2 CH.sub.2 CH.sub.3 -pyrimidin-5-yl                 1506   4-OCH.sub.2 C(═O)NH.sub.2 -pyrimidin-5-yl                          1507   2-OCH.sub.2 C(═O)NH.sub.2 -pyrimidin-5-yl                          1508   4-OCH.sub.2 C(═O)NHCH.sub.3 -pyrimidin-5-yl                        1509   2-OCH.sub.2 C(═O)NHCH.sub.3 -pyrimidin-5-yl                        1510   4-OCH.sub.2 C(═O)SCH.sub.3 -pyrimidin-5-yl                         1511   2-OCH.sub.2 C(═O)SCH.sub.3 -pyrimidin-5-yl                         1512   4-OCH(CH.sub.3)C(═O)NH.sub.2 -pyrimidin-5-yl                       1513   2-OCH(CH.sub.3)C(═O)NH.sub.2 -pyrimidin-5-yl                       1514   4-OCH(CH.sub.3)C(═O)NHCH.sub.3 -pyrimidin-5-yl                     1515   2-OCH(CH.sub.3)C(═O)NHCH.sub.3 -pyrimidin-5-yl                     1516   4-OCH(CH.sub.3)C(═O)NHNH.sub.2 -pyrimidin-5-yl                     1517   2-OCH(CH.sub.3)C(═O)NHNH.sub.2 -pyrimidin-5-yl                     1518   4-OCH(CH.sub.3)CO.sub.2 CH.sub.3 -pyrimidin-5-yl                       1519   2-OCH(CH.sub.3)CO.sub.2 CH.sub.3 -pyrimidin-5-yl                       1520   4-OCH(CH.sub.3)CO.sub.2 CH.sub.2 CH.sub.3 -pyrimidin-5-yl              1521   2-OCH(CH.sub.3)CO.sub.2 CH.sub.2 CH.sub.3 -pyrimidin-5-yl              1522   4-OCH(CH.sub.3)C(═O)CH.sub.3 -pyrimidin-5-yl                       1523   2-OCH(CH.sub.3)C(═O)CH.sub.3 -pyrimidin-5-yl                       1524   4-OCH(CH.sub.3)C(═O)CH.sub.2 CH.sub.3 -pyrimidin-5-yl              1525   2-OCH(CH.sub.3)C(═O)CH.sub.2 CH.sub.3 -pyrimidin-5-yl              1526   4-OCH(CH.sub.3)CH.sub.2 C(═O)CH.sub.3 -pyrimidin-5-yl              1527   2-OCH(CH.sub.3)CH.sub.2 C(═O)CH.sub.3 -pyrimidin-5-yl              1528   4-OCH(CH.sub.3)CH.sub.2 OC(CH.sub.3).sub.3 -pyrimidin-5-yl             1529   2-OCH(CH.sub.3)CH.sub.2 OC(CH.sub.3).sub.3 -pyrimidin-5-yl             1530   4-OCH(CH.sub.3)CH.sub.2 OCH.sub.2 CH.sub.3 -pyrimidin-5-yl             1531   2-OCH(CH.sub.3)CH.sub.2 OCH.sub.2 CH.sub.3 -pyrimidin-5-yl             1532   4-OCH(CH.sub.3)CH.sub.2 O(CH.sub.3).sub.2 CH.sub.3 -pyrimidin-5-yl            N                                                                      1533   2-OCH(CH.sub.3)CH.sub.2 O(CH.sub.3).sub.2 CH.sub.3 -pyrimidin-5-yl            O                                                                      1534   4-OCH(CH.sub.3)CH.sub.2 OCH.sub.2 CH═CH.sub.2 -pyrimidin-5-yl      1535   2-OCH(CH.sub.3)CH.sub.2 OCH.sub.2 CH═CH.sub.2 -pyrimidin-5-yl      1536   4-O(CH.sub.2).sub.3 OCH.sub.3 -pyrimidin-5-yl                          1537   2-O(CH.sub.2).sub.3 OCH.sub.3 -pyrimidin-5-yl                          1538   4-O(CH.sub.2).sub.3 OCH.sub.2 CH.sub.3 -pyrimidin-5-yl                 1539   2-O(CH.sub.2).sub.3 OCH.sub.2 CH.sub.3 -pyrimidin-5-yl                 1540   4-O(CH.sub.2).sub.3 OCH(CH.sub.3).sub.2 -pyrimidin-5-yl                1541   2-O(CH.sub.2).sub.3 OCH(CH.sub.3).sub.2 -pyrimidin-5-yl                1542   4-O(CH.sub.2).sub.3 OC.sub.6 H.sub.2 -pyrimidin-5-yl                   1543   2-O(CH.sub.2).sub.3 OC.sub.6 H.sub.2 -pyrimidin-5-yl                   1544   4-O(CH.sub.2).sub.3 OCH.sub.2 C.sub.6 H.sub.2 -pyrimidin-5-yl          1545   2-O(CH.sub.2).sub.3 OCH.sub.2 C.sub.6 H.sub.2 -pyrimidin-5-yl          1546   4-OCH(CH.sub.2 CH.sub.3)CH.sub.2 OCH.sub.3 -pyrimidin-5-yl             1547   2-OCH(CH.sub.2 CH.sub.3)CH.sub.2 OCH.sub.3 -pyrimidin-5-yl             1548   4-OCH(CH.sub.2 CH.sub.3)CH.sub.2 CH.sub.2 OCH.sub.3 -pyrimidin-5-yl    1549   2-OCH(CH.sub.2 CH.sub.3)CH.sub.2 CH.sub.2 OCH.sub.3 -pyrimidin-5-yl    1550   4-OCH(CH.sub.2 CH.sub.3)CH.sub.2 CH.sub.2 OCH.sub.2 CH.sub.3                  -pyrimidin-5-yl                                                        1551   2-OCH(CH.sub.2 CH.sub.3)CH.sub.2 CH.sub.2 OCH.sub.2 CH.sub.3                  -pyrimidin-5-yl                                                        1552   4-O (CH.sub.2).sub.3 O!.sub.2 CH.sub.3 -pyrimidin-5-yl                 1553   2-O (CH.sub.2).sub.3 O!.sub.2 CH.sub.3 -pyrimidin-5-yl                 1554   4-OCH.sub.2 CH(CH.sub.3)CH.sub.2 OCH.sub.3 -pyrimidin-5-yl             1555   2-OCH.sub.2 CH(CH.sub.3)CH.sub.2 OCH.sub.3 -pyrimidin-5-yl             1556   4-OCH.sub.2 CH(CH.sub.3)CH.sub.2 OCH.sub.2 CH.sub.3 -pyrimidin-5-yl    1557   2-OCH.sub.2 CH(CH.sub.3)CH.sub.2 OCH.sub.2 CH.sub.3 -pyrimidin-5-yl    1558   4-OCH(CH.sub.2 Cl)CH.sub.2 OCH.sub.3 -pyrimidin-5-yl                   1559   2-OCH(CH.sub.2 Cl)CH.sub.2 OCH.sub.3 -pyrimidin-5-yl                   1560   4-OCH(CH.sub.2 Cl)CH.sub.2 OCH.sub.2 CH.sub.3 -pyrimidin-5-yl          1561   2-OCH(CH.sub.2 Cl)CH.sub.2 OCH.sub.2 CH.sub.3 -pyrimidin-5-yl          1562   4-OCH(CH.sub.2 Cl)CH.sub.2 OCH(CH.sub.3).sub.2 -pyrimidin-5-yl         1563   4-OCH(CH.sub.2 Cl)CH.sub.2 OCH(CH.sub.3).sub.2 -pyrimidin-5-yl         1564   4-OCH(CH.sub.2 Cl)CH.sub.2 OCH.sub.2 CH═CH.sub.2 -pyrimidin-5-y           l                                                                      1565   2-OCH(CH.sub.2 Cl)CH.sub.2 OCH.sub.2 CH═CH.sub.2 -pyrimidin-5-y           l                                                                      1566   4-OCH CH.sub.2 OCH.sub.3 !.sub.2 -pyrimidin-5-yl                       1567   2-OCH CH.sub.2 OCH.sub.3 !.sub.2 -pyrimidin-5-yl                       1568   4-OCH CH.sub.2 OCH.sub.2 CH.sub.3 !.sub.2 -pyrimidin-5-yl              1569   2-OCH CH.sub.2 OCH.sub.2 CH.sub.3 !.sub.2 -pyrimidin-5-yl              1570   4-OCCl.sub.3 -pyrimidin-5-yl                                           1571   2-OCCl.sub.3 -pyrimidin-5-yl                                           1572   4-OCHF.sub.2 -pyrimidin-5-yl                                           1573   2-OCHF.sub.2 -pyrimidin-5-yl                                           1574   4-OCF.sub.3 -pyrimidin-5-yl                                            1575   2-OCF.sub.3 -pyrimidin-5-yl                                            1576   4-OCF.sub.2 CHF.sub.2 -pyrimidin-5-yl                                  1577   2-OCF.sub.2 CHF.sub.2 -pyrimidin-5-yl                                  1578   4-OCH.sub.2 CF.sub.3 -pyrimidin-5-yl                                   1579   2-OCH.sub.2 CF.sub.3 -pyrimidin-5-yl                                   1580   4-OCH.sub.2 CHF.sub.2 -pyrimidin-5-yl                                  1581   2-OCH.sub.2 CHF.sub.2 -pyrimidin-5-yl                                  1582   4-O(CH.sub.2).sub.3 F-pyrimidin-5-yl                                   1583   2-O(CH.sub.2).sub.3 F-pyrimidin-5-yl                                   1584   4-OCH(CH.sub.3)CF.sub.3 -pyrimidin-5-yl                                1585   2-OCH(CH.sub.3)CF.sub.3 -pyrimidin-5-yl                                1586   4-O(CH.sub.2).sub.4 F-pyrimidin-5-yl                                   1587   2-O(CH.sub.2).sub.4 F-pyrimidin-5-yl                                   1588   4-O(CH.sub.2).sub.3 CF.sub.3 -pyrimidin-5-yl                           1589   2-O(CH.sub.2).sub.3 CF.sub.3 -pyrimidin-5-yl                           1590   4-OCH(CH.sub.3)CF.sub.2 CF.sub.3 -pyrimidin-5-yl                       1591   2-OCH(CH.sub.3)CF.sub.2 CF.sub.3 -pyrimidin-5-yl                       1592   4-OCH(CH.sub.3)CF.sub.2 CHF.sub.2 -pyrimidin-5-yl                      1593   2-OCH(CH.sub.3)CF.sub.2 CHF.sub.2 -pyrimidin-5-yl                      1594   4-OCH.sub.2 CF.sub.2 CHFCH.sub.3 -pyrimidin-5-yl                       1595   2-OCH.sub.2 CF.sub.2 CHFCH.sub.3 -pyrimidin-5-yl                       1596   4-OCH.sub.2 (CF.sub.2).sub.2 CF.sub.3 -pyrimidin-5-yl                  1597   2-OCH.sub.2 (CF.sub.2).sub.2 CF.sub.3 -pyrimidin-5-yl                  1598   4-O(CF.sub.2).sub.3 CF.sub.3 -pyrimidin-5-yl                           1599   2-O(CF.sub.2).sub.3 CF.sub.3 -pyrimidin-5-yl                           1600   4-OCH.sub.2 CF.sub.2 CHF.sub.2 -pyrimidin-5-yl                         1601   2-OCH.sub.2 CF.sub.2 CHF.sub.2 -pyrimidin-5-yl                         1602   4-CH.sub.2 CH═CH.sub.2 -pyrimidin-5-yl                             1603   2-CH.sub.2 CH═CH.sub.2 -pyrimidin-5-yl                             1604   4-CH.sub.2 C(CH.sub.3)═CH.sub.2 -pyrimidin-5-yl                    1605   2-CH.sub.2 C(CH.sub.3)═CH.sub.2 -pyrimidin-5-yl                    1606   4-OCH.sub.2 CH═CHCH.sub.3 -pyrimidin-5-yl                          1607   2-OCH.sub.2 CH═CHCH.sub.3 -pyrimidin-5-yl                          1608   4-O(CH.sub.2).sub.2 CH═CH.sub.2 -pyrimidin-5-yl                    1609   2-O(CH.sub.2).sub.2 CH═CH.sub.2 -pyrimidin-5-yl                    1610   4-OCH.sub.2 C(CH.sub.3)═CH.sub.2 -pyrimidin-5-yl                   1611   2-OCH.sub.2 C(CH.sub.3)═CH.sub.2 -pyrimidin-5-yl                   1612   4-OCH(CH.sub.3)CH═CH.sub.2 -pyrimidin-5-yl                         1613   2-OCH(CH.sub.3)CH═CH.sub.2 -pyrimidin-5-yl                         1614   4-OCH.sub.2 C.tbd.CH-pyrimidin-5-yl                                    1615   2-OCH.sub.2 C.tbd.CH-pyrimidin-5-yl                                    1616   4-OCH.sub.2 C.tbd.CCH.sub.3 -pyrimidin-5-yl                            1617   2-OCH.sub.2 C.tbd.CCH.sub.3 -pyrimidin-5-yl                            1618   4-O(CH.sub.2).sub.2 C.tbd.CH-pyrimidin-5-yl                            1619   2-O(CH.sub.2).sub.2 C.tbd.CH-pyrimidin-5-yl                            1620   4-SCH.sub.3 -pyrimidin-5-yl                                            1621   2-SCH.sub.3 -pyrimidin-5-yl                                            1622   4-SCH.sub.2 CH.sub.3 -pyrimidin-5-yl                                   1623   2-SCH.sub.2 CH.sub.3 -pyrimidin-5-yl                                   1624   4-OC.sub.6 H.sub.2 -pyrimidin-5-yl                                     1625   2-OC.sub.6 H.sub.2 -pyrimidin-5-yl                                     1626   4-OCH.sub.2 C.sub.6 H.sub.2 -pyrimidin-5-yl                            1627   2-OCH.sub.2 C.sub.6 H.sub.2 -pyrimidin-5-yl                            1628   4-NO.sub.2 -pyrimidin-5-yl                                             1629   2-NO.sub.2 -pyrimidin-5-yl                                             1630   4-NHCH.sub.3 -pyrimidin-5-yl                                           1631   2-NHCH.sub.3 -pyrimidin-5-yl                                           1632   4-N(CH.sub.3).sub.2 -pyrimidin-5-yl                                    1633   2-N(CH.sub.3).sub.2 -pyrimidin-5-yl                                    1634   4-N(CH.sub.3)C.sub.2 H.sub.2 -pyrimidin-5-yl                           1635   2-N(CH.sub.3)C.sub.2 H.sub.2 -pyrimidin-5-yl                           1636   4-NHCH.sub.2 CF.sub.3 -pyrimidin-5-yl                                  1637   2-NHCH.sub.2 CF.sub.3 -pyrimidin-5-yl                                  1638   4-F-pyrimidin-5-yl                                                     1639   2-F-pyrimidin-5-yl                                                     1640   4-Cl-pyrimidin-5-yl                                                    1641   2-Cl-pyrimidin-5-yl                                                    1642   4-OH-pyrimidin-5-yl                                                    1643   2-OH-pyrimidin-5-yl                                                    1644   4-CN-pyrimidin-5-yl                                                    1645   2-CN-pyrimidin-5-yl                                                    1646   4-C(O)NH.sub.2 -pyrimidin-5-yl                                         1647   2-C(O)NH.sub.2 -pyrimidin-5-yl                                         1648   4-C(S)NH.sub.2 -pyrimidin-5-yl                                         1649   2-C(S)NH.sub.2 -pyrimidin-5-yl                                         1650   4-CO.sub.2 CH.sub.3 -pyrimidin-5-yl                                    1651   2-CO.sub.2 CH.sub.3 -pyrimidin-5-yl                                    1652   4-ON═C(CH.sub.3).sub.2 -pyrimidin-5-yl                             1653   2-ON═C(CH.sub.3).sub.2 -pyrimidin-5-yl                             1654   4- O-cyclopropyl!pyrimidin-5-yl                                        1655   2- O-cyclopropyl!pyrimidin-5-yl                                        1656   4- O-cyclobutyl!pyrimidin-5-yl                                         1657   2- O-cyclobutyl!pyrimidin-5-yl                                         1658   4- O-cyclopentyl!pyrimidin-5-yl                                        1659   2- O-cyclopentyl!pyrimidin-5-yl                                        1660   4- O-cyclohexyl!pyrimidin-5-yl                                         1661   2- O-cyclohexyl!pyrimidin-5-yl                                         1662   4- OCH.sub.2 -cyclopropyl!pyrimidin-5-yl                               1663   2- OCH.sub.2 -cyclopropyl!pyrimidin-5-yl                               1664   2-F, 4- OCH.sub.2 -cyclopropyl!pyrimidin-5-yl                          1665   4-F, 2- OCH.sub.2 -cyclopropyl!pyrimidin-5-yl                          1666   2-CH.sub.3, 4- OCH.sub.2 -cyclopropyl!pyrimidin-5-yl                   1667   4-CH.sub.3, 2- OCH.sub.2 -cyclopropyl!pyrimidin-5-yl                   1668   2-CF.sub.3, 4- OCH.sub.2 -cyclopropyl!pyrimidin-5-yl                   1669   4-CH.sub.3, 2- OCH.sub.2 -cyclopropyl!pyrimidin-5-yl                   1670   4- OCH(CH.sub.3)-cyclopropyl!pyrimidin-5-yl                            1671   2- OCH(CH.sub.3)-cyclopropyl!pyrimidin-5-yl                            1672   2-F, 4- OCH(CH.sub.3)-cyclopropyl!pyrimidin-5-yl                       1673   4-F, 2- OCH(CH.sub.3)-cyclopropyl!pyrimidin-5-yl                       1674   2-CH.sub.3, 4- OCH(CH.sub.3)-cyclopropyl!pyrimidin-5-yl                1675   4-CH.sub.3, 2- OCH(CH.sub.3)-cyclopropyl!pyrimidin-5-yl                1676   2-CF.sub.3, 4- OCH(CH.sub.3)-cyclopropyl!pyrimidin-5-yl                1677   4-CF.sub.3, 2- OCH(CH.sub.3)-cyclopropyl!pyrimidin-5-yl                1678   4- O-(1-CH.sub.3 -cyclopropyl)!pyrimidin-5-yl                          1679   2- O-(1-CH.sub.3 -cyclopropyl)!pyrimidin-5-yl                          1680   2-F, 4- O-(1-CH.sub.3 -cyclopropyl)!pyrimidin-5-yl                     1681   4-F, 2- O-(1-CH.sub.3 -cyclopropyl)!pyrimidin-5-yl                     1682   2-CH.sub.3, 4- O-(1-CH.sub.3 -cyclopropyl)!pyrimidin-5-yl              1683   4-CH.sub.3, 2- O-(1-CH.sub.3 -cyclopropyl)!pyrimidin-5-yl              1684   2-CF.sub.3, 4- O-(1-CH.sub.3 -cyclopropyl)!pyrimidin-5-yl              1685   4-CF.sub.3, 2- O-(1-CH.sub.3 -cyclopropyl)!pyrimidin-5-yl              1686   4- OCH.sub.2 -(1-CH.sub.2 -(1-CH.sub.3 -cyclopropyl)!pyrimidin-5-yl           N                                                                      1687   2- OCH.sub.2 -(1-CH.sub.2 -(1-CH.sub.3 -cyclopropyl)!pyrimidin-5-yl           O                                                                      1688   2-F, 4- OCH.sub.2 -(1-CH.sub.3 -cyclopropyl)!pyrimidin-5-yl            1689   4-F, 2- OCH.sub.2 -(1-CH.sub.3 -cyclopropyl)!pyrimidin-5-yl            1690   2-CH.sub.3, 4- OCH.sub.2 -(1-CH.sub.3 -cyclopropyl)!pyrimidin-5-yl     1691   4-CH.sub.3, 2- OCH.sub.2 -(1-CH.sub.3 -cyclopropyl)!pyrimidin-5-yl     1692   2-CF.sub.3, 4- OCH.sub.2 -(1-CH.sub.3 -cyclopropyl)!pyrimidin-5-yl     1693   4-CF.sub.3, 2- OCH.sub.2 -(1-CH.sub.3 -cyclopropyl)!pyrimidin-5-yl     1694   4- OCH.sub.2 -(2-CH.sub.3 -cyclopropyl)!pyrimidin-5-yl                 1695   2- OCH.sub.2 -(2-CH.sub.3 -cyclopropyl)!pyrimidin-5-yl                 1696   2-F, 4- OCH.sub.2 -(2-CH.sub.3 -cyclopropyl)!pyrimidin-5-yl            1697   4-F, 2- OCH.sub.2 -(2-CH.sub.3 -cyclopropyl)!pyrimidin-5-yl            1698   2-CH.sub.3, 4- OCH.sub.2 -(2-CH.sub.3 -cyclopropyl)!pyrimidin-5-yl     1699   4-CH.sub.3, 2- OCH.sub.2 -(2-CH.sub.3 -cyclopropyl)!pyrimidin-5-yl            0                                                                      1700   2-CF.sub.3, 4- OCH.sub.2 -(2-CH.sub.3 -cyclopropyl)!pyrimidin-5-yl            0                                                                      1701   4-CF.sub.3, 2- OCH.sub.2 -(2-CH.sub.3 -cyclopropyl)!pyrimidin-5-yl            3                                                                      1702   4- OCH.sub.2 -(tetrahydropyran-2-yl)!pyrimidin-5-yl                    1703   2- OCH.sub.2 -(tetrahydropyran-2-yl)!pyrimidin-5-yl                    1704   2-F, 4- OCH.sub.2 -(tetrahydropyran-2-yl)!pyrimidin-5-yl               1705   4-F, 2- OCH.sub.2 -(tetrahydropyran-2-yl)!pyrimidin-5-yl               1706   2-CH.sub.3, 4- OCH.sub.2 -(tetrahydropyran-2-yl)!pyrimidin-5-yl        1707   4-CH.sub.3, 2- OCH.sub.2 -(tetrahydropyran-2-yl)!pyrimidin-5-yl        1708   2-CF.sub.3, 4- OCH.sub.2 -(tetrahydropyran-2-yl)!pyrimidin-5-yl        1709   4-CF.sub.3, 2- OCH.sub.2 -(tetrahydropyran-2-yl)!pyrimidin-5-yl        1710   4- OCH.sub.2 -(furan-2-yl)!pyrimidin-5-yl                              1711   2- OCH.sub.2 -(furan-2-yl)!pyrimidin-5-yl                              1712   2-F, 4- OCH.sub.2 -(furan-2-yl)!pyrimidin-5-yl                         1713   4-F, 4- OCH.sub.2 -(furan-2-yl)!pyrimidin-5-yl                         1714   2-CH.sub.3, 4- OCH.sub.2 -(furan-2-yl)!pyrimidin-5-yl                  1715   4-CH.sub.3, 2- OCH.sub.2 -(furan-2-yl)!pyrimidin-5-yl                  1716   2-CF.sub.3, 4- OCH.sub.2 (furan-2-yl)!pyrimidin-5-yl                   1717   4-CF.sub.3, 2- OCH.sub.2 (furan-2-yl)!pyrimidin-5-yl                   1718   4- OCH.sub.2 -(furan-3-yl)!pyrimidin-5-yl                              1719   2- OCH.sub.2 -(furan-3-yl)!pyrimidin-5-yl                              1720   2-F, 4- OCH.sub.2 -(furan-3-yl)!pyrimidin-5-yl                         1721   4-F, 2- OCH.sub.2 -(furan-3-yl)!pyrimidin-5-yl                         1722   2-CH.sub.3, 4- OCH.sub.2 -(furan-3-yl)!pyrimidin-5-yl                  1723   4-CH.sub.3, 2- OCH.sub.2 -(furan-3-yl)!pyrimidin-5-yl                  1724   2-CF.sub.3, 4- OCH.sub.2 -(furan-3-yl)!pyrimidin-5-yl                  1725   4-CF.sub.3, 2- OCH.sub.2 -(furan-3-yl)!pyrimidin-5-yl                  1726   4- OCH.sub.2 -(tetrahydrofuran-3-yl)!pyrimidin-5-yl                    1727   2- OCH.sub.2 -(tetrahydrofuran-3-yl)!pyrimidin-5-yl                    1728   2-F, 4- OCH.sub.2 -(tetrahydrofuran-3-yl)!pyrimidin-5-yl               1729   4-F, 4- OCH.sub.2 -(tetrahydrofuran-3-yl)!pyrimidin-5-yl               1730   2-CH.sub.3, 4- OCH.sub.2 -(tetrahydrofuran-3-yl)!pyrimidin-5-yl        1731   4-CH.sub.3, 2- OCH.sub.2 -(tetrahydrofuran-3-yl)!pyrimidin-5-yl        1732   2-CF.sub.3, 4- OCH.sub.2 -(tetrahydrofuran-3-yl)!pyrimidin-5-yl        1733   4-CF.sub.3, 2- OCH.sub.2 -(tetrahydrofuran-3-yl)!pyrimidin-5-yl        1734   4- OCH.sub.2 -(tetrahydrofuran-2-yl)!pyrimidin-5-yl                    1735   2- OCH.sub.2 -(tetrahydrofuran-2-yl)!pyrimidin-5-yl                    1736   2-F, 4- OCH.sub.2 -(tetrahydrofuran-2-yl)!pyrimidin-5-yl               1737   4-F, 2- OCH.sub.2 -(tetrahydrofuran-2-yl)!pyrimidin-5-yl               1738   2-CH.sub.3, 4- OCH.sub.2 -(tetrahydrofuran-2-yl)!pyrimidin-5-yl        1739   4-CH.sub.3, 2- OCH.sub.2 -(tetrahydrofuran-2-yl)!pyrimidin-5-yl        1740   2-CF.sub.3, 4- OCH.sub.2 -(tetrahydrofuran-2-yl)!pyrimidin-5-yl        1741   4-CF.sub.3, 2- OCH.sub.2 -(tetrahydrofuran-2-yl)!pyrimidin-5-yl        1742   2- O-(tetrahydropyran-4-yl)!pyrimidin-5-yl                             1743   4- O-(tetrahydropyran-4-yl)!pyrimidin-5-yl                             1744   2-F, 4- O-(tetrahydropyran-4-yl)!pyrimidin-5-yl                        1745   4-F, 2- O-(tetrahydropyran-4-yl)!pyrimidin-5-yl                        1746   2-CH.sub.3, 4- O-(tetrahydropyran-4-yl)!pyrimidin-5-yl                 1747   4-CH.sub.3, 2- O-(tetrahydropyran-4-yl)!pyrimidin-5-yl                 1748   2-CF.sub.3, 4- O-(tetrahydropyran-4-yl)!pyrimidin-5-yl                 1749   4-CF.sub.3, 2- O-(tetrahydropyran-4-yl)!pyrimidin-5-yl                 1750   4- 2-Cl--C.sub.6 H.sub.4 !pyrimidin-5-yl                               1751   2- 2-Cl--C.sub.6 H.sub.4 !pyrimidin-5-yl                               1752   2-F, 4- 2-Cl--C.sub.6 H.sub.4 !pyrimidin-5-yl                          1753   4-F, 2- 2-Cl--C.sub.6 H.sub.4 !pyrimidin-5-yl                          1754   2-CH.sub.3, 4- 2-Cl--C.sub.6 H.sub.4 !pyrimidin-5-yl                   1755   4-CH.sub.3, 2- 2-Cl--C.sub.6 H.sub.4 !pyrimidin-5-yl                   1756   2-CF.sub.3, 4- 2-Cl--C.sub.6 H.sub.4 !pyrimidin-5-yl                   1757   4-CF.sub.3, 2- 2-Cl--C.sub.6 H.sub.4 !pyrimidin-5-yl                   1758   4- OCH.sub.2 -(pyridin-5-yl)!pyrimidin-5-yl                            1759   2- OCH.sub.2 -(pyridin-5-yl)!pyrimidin-5-yl                            1760   2-F, 4- OCH.sub.2 -(pyridin-5-yl)!pyrimidin-5-yl                       1761   4-F, 2- OCH.sub.2 -(pyridin-5-yl)!pyrimidin-5-yl                       1762   2-CH.sub.3, 4- OCH.sub.2 -(pyridin-5-yl)!pyrimidin-5-yl                1763   4-CH.sub.3, 2- OCH.sub.2 -(pyridin-5-yl)!pyrimidin-5-yl                1764   2-CF.sub.3, 4- OCH.sub.2 -(pyridin-5-yl)!pyrimidin-5-yl                1765   4-CF.sub.3, 2- OCH.sub.2 -(pyridin-5-yl)!pyrimidin-5-yl                1766   4- OCH.sub.2 -(pyridin-3-yl)!pyrimidin-5-yl                            1767   2- OCH.sub.2 -(pyridin-3-yl)!pyrimidin-5-yl                            1768   2-F, 4- OCH.sub.2 -(pyridin-3-yl)!pyrimidin-5-yl                       1769   4-F, 2- OCH.sub.2 -(pyridin-3-yl)!pyrimidin-5-yl                       1770   2-CH.sub.3, 4- OCH.sub.2 -(pyridin-3-yl)!pyrimidin-5-yl                1771   4-CH.sub.3, 2- OCH.sub.2 -(pyridin-3-yl)!pyrimidin-5-yl                1772   2-CF.sub.3, 4- OCH.sub.2 -(pyridin-3-yl)!pyrimidin-5-yl                1773   4-CF.sub.3, 2- OCH.sub.2 -(pyridin-3-yl)!pyrimidin-5-yl                1774   4- morpholin-4-yl!pyrimidin-5-yl                                       1775   2- morpholin-4-yl!pyrimidin-5-yl                                       1776   4- 1-CH.sub.3 -imidazol-2-yl!pyrimidin-5-yl                            1777   2- 1-CH.sub.3 -imidazol-2-yl!pyrimidin-5-yl                            1778   2-F, 4- 1-CH.sub.3 -imidazol-2-yl!pyrimidin-5-yl                       1779   4-F, 2- 1-CH.sub.3 -imidazol-2-yl!pyrimidin-5-yl                       1780   2-CH.sub.3, 4- 1-CH.sub.3 -imidazol-2-yl!pyrimidin-5-yl                1781   4-CH.sub.3, 2- 1-CH.sub.3 -imidazol-2-yl!pyrimidin-5-yl                1782   2-CF.sub.3, 4- 1-CH.sub.3 -imidazol-2-yl!pyrimidin-5-yl                1783   4-CF.sub.3, 2- 1-CH.sub.3 -imidazol-2-yl!pyrimidin-5-yl                1784   4- 1,2,4-triazol-1-yl!pyrimidin-5-yl                                   1785   2- 1,2,4-triazol-1-yl!pyrimidin-5-yl                                   1786   2-F, 4- 1,2,4-triazol-1-yl!pyrimidin-5-yl                              1787   4-F, 2- 1,2,4-triazol-1-yl!pyrimidin-5-yl                              1788   2-CH.sub.3, 4- 1,2,4-triazol-1-yl!pyrimidin-5-yl                       1789   4-CH.sub.3, 2- 1,2,4-triazol-1-yl!pyrimidin-5-yl                       1790   2-CF.sub.3, 4- 1,2,4-triazol-1-yl!pyrimidin-5-yl                       1791   4-CF.sub.3, 2- 1,2,4-triazol-1-yl!pyrimidin-5-yl                       1792   4,2-Cl.sub.2 -pyrimidin-5-yl                                           1793   4,6-Cl.sub.2 -pyrimidin-5-yl                                           1794   4,2-(CH.sub.3).sub.2 -pyrimidin-5-yl                                   1795   4,6-(CH.sub.3).sub.2 -pyrimidin-5-yl                                   1796   4,2-(OCH.sub.3).sub.2 -pyrimidin-5-yl                                  1797   4,6-(OCH.sub.3).sub.2 -pyrimidin-5-yl                                  1798   4,2-(OCH.sub.2 CH.sub.3).sub.2-pyrimidin-5-yl                          1799   4,6-(OCH.sub.2 CH.sub.3).sub.2-pyrimidin-5-yl                          1800   4-F, 2-CH.sub.3 -pyrimidin-5-yl                                        1801   4-F, 6-CH.sub.3 -pyrimidin-5-yl                                        1802   2-F, 4-CH.sub.3 -pyrimidin-5-yl                                        1803   6-F, 4-CH.sub.3 -pyrimidin-5-yl                                        1804   4-F, 2-OCH.sub.3 -pyrimidin-5-yl                                       1805   4-F, 6-OCH.sub.3 -pyrimidin-5-yl                                       1806   2-F, 4-OCH.sub.3 -pyrimidin-5-yl                                       1807   6-F, 4-OCH.sub.3 -pyrimidin-5-yl                                       1808   4-F, 2-OCH.sub.2 CH.sub.3 -pyrimidin-5-yl                              1809   4-F, 6-OCH.sub.2 CH.sub.3 -pyrimidin-5-yl                              1810   2-F, 4-OCH.sub.2 CH.sub.3 -pyrimidin-5-yl                              1811   6-F, 4-OCH.sub.2 CH.sub.3 -pyrimidin-5-yl                              1812   4-F, 2-OCH.sub.2 CF.sub.3 -pyrimidin-5-yl                              1813   4-F, 6-OCH.sub.2 CF.sub.3 -pyrimidin-5-yl                              1814   2-F, 4-OCH.sub.2 CF.sub.3 -pyrimidin-5-yl                              1815   6-F, 4-OCH.sub.2 CF.sub.3 -pyrimidin-5-yl                              1816   4-F, 2-OCH(CH.sub.3).sub.2 -pyrimidin-5-yl                             1817   4-F, 6-OCH(CH.sub.3).sub.2 -pyrimidin-5-yl                             1818   2-F, 4-OCH(CH.sub.3).sub.2 -pyrimidin-5-yl                             1819   6-F, 4-OCH(CH.sub.3).sub.2 -pyrimidin-5-yl                             1820   4-Cl, 2-CH.sub.3 -pyrimidin-5-yl                                       1821   4-Cl, 6-CH.sub.3 -pyrimidin-5-yl                                       1822   2-Cl, 4-CH.sub.3 -pyrimidin-5-yl                                       1823   6-Cl, 4-CH.sub.3 -pyrimidin-5-yl                                       1824   4-Cl, 2-OCH.sub.3 -pyrimidin-5-yl                                      1825   4-Cl, 6-OCH.sub.3 -pyrimidin-5-yl                                      1826   2-Cl, 4-OCH.sub.3 -pyrimidin-5-yl                                      1827   6-Cl, 4-OCH.sub.3 -pyrimidin-5-yl                                      1828   4-Cl, 2-OCH.sub.2 CH.sub.3 -pyrimidin-5-yl                             1829   4-Cl, 6-OCH.sub.2 CH.sub.3 -pyrimidin-5-yl                             1830   2-Cl, 4-OCH.sub.2 CH.sub.3 -pyrimidin-5-yl                             1831   6-Cl, 4-OCH.sub.2 CH.sub.3 -pyrimidin-5-yl                             1832   4-Cl, 2-OCH.sub.2 CF.sub.3 -pyrimidin-5-yl                             1833   4-Cl, 6-OCH.sub.2 CF.sub.3 -pyrimidin-5-yl                             1834   2-Cl, 4-OCH.sub.2 CF.sub.3 -pyrimidin-5-yl                             1835   6-Cl, 4-OCH.sub.2 CF.sub.3 -pyrimidin-5-yl                             1836   4-Cl, 2-OCH(CH.sub.3).sub.2 -pyrimidin-5-yl                            1837   4-Cl, 6-OCH(CH.sub.3).sub.2 -pyrimidin-5-yl                            1838   2-Cl, 4-OCH(CH.sub.3).sub.2 -pyrimidin-5-yl                            1839   6-Cl, 4-OCH(CH.sub.3).sub.2 -pyrimidin-5-yl                            1840   4-CH.sub.3, 2-OCH.sub.3 -pyrimidin-5-yl                                1841   4-CH.sub.3, 6-OCH.sub.3 -pyrimidin-5-yl                                1842   2-CH.sub.3, 4-OCH.sub.3 -pyrimidin-5-yl                                1843   6-CH.sub.3, 4-OCH.sub.3 -pyrimidin-5-yl                                1844   6-CH.sub.3, 4-OCH.sub.2 CH.sub.3 -pyrimidin-5-yl                       1845   2-CH.sub.3, 4-OCH.sub.2 CH.sub.3 -pyrimidin-5-yl                       1846   4-CH.sub.3, 2-OCH.sub.2 CH.sub.3 -pyrimidin-5-yl                       1847   4-CH.sub.3, 6-OCH.sub.2 CH.sub.3 -pyrimidin-5-yl                       1848   4-CH.sub.3, 2-OCH.sub.2 CF.sub.3 -pyrimidin-5-yl                       1849   4-CH.sub.3, 6-OCH.sub.2 CF.sub.3 -pyrimidin-5-yl                       1850   2-CH.sub.3, 4-OCH.sub.2 CF.sub.3 -pyrimidin-5-yl                       1851   6-CH.sub.3, 4-OCH.sub.2 CF.sub.3 -pyrimidin-5-yl                       1852   4-CH.sub.3, 2-OCH(CH.sub.3).sub.2 -pyrimidin-5-yl                      1853   4-CH.sub.3, 2-OCH(CH.sub.3).sub.2 -pyrimidin-5-yl                      1854   2-CH.sub.3, 4-OCH(CH.sub.3).sub.2 -pyrimidin-5-yl                      1855   6-CH.sub.3, 4-OCH(CH.sub.3).sub.2 -pyrimidin-5-yl                      1856   4-CH.sub.3, 2-OCH.sub.2 CH═CH.sub.2 -pyrimidin-5-yl                1857   4-CH.sub.3, 6-OCH.sub.2 CH═CH.sub.2 -pyrimidin-5-yl                1858   2-CH.sub.3, 4-OCH.sub.2 CH═CH.sub.2 -pyrimidin-5-yl                1859   6-CH.sub.3, 4-OCH.sub.2 CH═CH.sub.2 -pyrimidin-5-yl                1860   4-CH.sub.3, 2-CO.sub.2 CH.sub.3 -pyrimidin-5-yl                        1861   4-CH.sub.3, 6-CO.sub.2 CH.sub.3 -pyrimidin-5-yl                        1862   4-CH.sub.3, 2-CF.sub.3 -pyrimidin-5-yl                                 1863   4-CH.sub.3, 6-CF.sub.3 -pyrimidin-5-yl                                 1864   2-CH.sub.3, 4-CF.sub.3 -pyrimidin-5-yl                                 1865   6-CH.sub.3, 4-CF.sub.3 -pyrimidin-5-yl                                 1866   4-CF.sub.3, 2-CH.sub.2 CH.sub.3 -pyrimidin-5-yl                        1867   4-CF.sub.3, 6-CH.sub.2 CH.sub.3 -pyrimidin-5-yl                        1868   2-CF.sub.3, 4-CH.sub.2 CH.sub.3 -pyrimidin-5-yl                        1869   6-CF.sub.3, 4-CH.sub.2 CH.sub.3 -pyrimidin-5-yl                        1870   4-CF.sub.3, 2-OCH.sub.3 -pyrimidin-5-yl                                1871   4-CF.sub.3, 6-OCH.sub.3 -pyrimidin-5-yl                                1872   2-CF.sub.3, 4-OCH.sub.3 -pyrimidin-5-yl                                1873   6-CF.sub.3, 4-OCH.sub.3 -pyrimidin-5-yl                                1874   4-CF.sub.3, 2-OCH.sub.2 CH.sub.3 -pyrimidin-5-yl                       1875   4-CF.sub.3, 6-OCH.sub.2 CH.sub.3 -pyrimidin-5-yl                       1876   2-CF.sub.3, 4-OCH.sub.2 CH.sub.3 -pyrimidin-5-yl                       1877   2-CF.sub.3, 4-OCH.sub.2 CH.sub.3 -pyrimidin-5-yl                       1878   4-CF.sub.3, 2-OCH.sub.2 CF.sub.3 -pyrimidin-5-yl                       1879   4-CF.sub.3, 6-OCH.sub.2 CF.sub.3 -pyrimidin-5-yl                       1880   2-CF.sub.3, 4-OCH.sub.2 CF.sub.3 -pyrimidin-5-yl                       1881   6-CF.sub.3, 4-OCH.sub.2 CF.sub.3 -pyrimidin-5-yl                       1882   4-OCH.sub.3, 2-OCH.sub.2 CH.sub.3 -pyrimidin-5-yl                      1883   4-OCH.sub.3, 6-OCH.sub.2 CH.sub.3 -pyrimidin-5-yl                      1884   2-OCH.sub.3, 4-OCH.sub.2 CH.sub.3 -pyrimidin-5-yl                      1885   6-OCH.sub.3, 4-OCH.sub.2 CH.sub.3 -pyrimidin-5-yl                      1886   4-OCH.sub.3, 2-OCH.sub.2 CF.sub.3 -pyrimidin-5-yl                      1887   4-OCH.sub.3, 6-OCH.sub.2 CF.sub.3 -pyrimidin-5-yl                      1888   2-OCH.sub.3, 4-OCH.sub.2 CF.sub.3 -pyrimidin-5-yl                      1889   6-OCH.sub.3, 4-OCH.sub.2 CF.sub.3 -pyrimidin-5-yl                      1890   4-OCH.sub.3, 2-OCH(CH.sub.3)pyrimidin-5-yl                             1891   4-OCH.sub.3, 6-OCH(CH.sub.3)pyrimidin-5-yl                             1892   6-OCH.sub.3, 4-OCH(CH.sub.3)pyrimidin-5-yl                             1893   6-OCH.sub.3, 4-OCH(CH.sub.3)pyrimidin-5-yl                             1894   4-OCH.sub.2 CH.sub.3, 2-CH.sub.2 OCH.sub.2 CH.sub.3 -pyrimidin-5-yl           N                                                                      1895   4-OCH.sub.2 CH.sub.3, 6-CH.sub.2 OCH.sub.2 CH.sub.3 -pyrimidin-5-yl           O                                                                      1896   2-OCH.sub.2 CH.sub.3, 4-CH.sub.2 OCH.sub.2 CH.sub.3 -pyrimidin-5-yl    1897   6-OCH.sub.2 CH.sub.3, 4-CH.sub.2 OCH.sub.2 CH.sub.3 -pyrimidin-5-yl    1898   4-NO.sub.2, 2-CH.sub.3 -pyrimidin-5-yl                                 1899   4-NO.sub.2, 6-CH.sub.3 -pyrimidin-5-yl                                 1900   2-NO.sub.2, 4-CH.sub.3 -pyrimidin-5-yl                                 1901   6-NO.sub.2, 4-CH.sub.3 -pyrimidin-5-yl                                 1902   4-NO.sub.2, 2-OCH.sub.3 -pyrimidin-5-yl                                1903   4-NO.sub.2, 6-OCH.sub.3 -pyrimidin-5-yl                                1904   2-NO.sub.2, 4-OCH.sub.3 -pyrimidin-5-yl                                1905   6-NO.sub.2, 4-OCH.sub.3 -pyrimidin-5-yl                                1906   4-NO.sub.2, 2-OCH.sub.2 CH.sub.3 -pyrimidin-5-yl                       1907   4-NO.sub.2, 6-OCH.sub.2 CH.sub.3 -pyrimidin-5-yl                       1908   2-NO.sub.2, 4-OCH.sub.2 CH.sub.3 -pyrimidin-5-yl                       1909   6-NO.sub.2, 4-OCH.sub.2 CH.sub.3 -pyrimidin-5-yl                       1910   4-NO.sub.2, 2-OCH(CH.sub.3).sub.2 -pyrimidin-5-yl                      1911   4-NO.sub.2, 6-OCH(CH.sub.3).sub.2 -pyrimidin-5-yl                      1912   2-NO.sub.2, 4-OCH(CH.sub.3).sub.2 -pyrimidin-5-yl                      1913   6-NO.sub.2, 4-OCH(CH.sub.3).sub.2 -pyrimidin-5-yl                      1914   4-NO.sub.2, 2-OCH.sub.2 CF.sub.3 -pyrimidin-5-yl                       1915   4-NO.sub.2, 6-OCH.sub.2 CF.sub.3 -pyrimidin-5-yl                       1916   2-NO.sub.2, 4-OCH.sub.2 CF.sub.3 -pyrimidin-5-yl                       1917   6-NO.sub.2, 4-OCH.sub.2 CF.sub.3 -pyrimidin-5-yl                       1918   4-CN, 2-CH.sub.3 -pyrimidin-5-yl                                       1919   4-CN, 6-CH.sub.3 -pyrimidin-5-yl                                       1920   2-CN, 4-CH.sub.3 -pyrimidin-5-yl                                       1921   6-CN, 4-CH.sub.3 -pyrimidin-5-yl                                       1922   4-CN, 2-OCH.sub.3 -pyrimidin-5-yl                                      1923   4-CN, 6-OCH.sub.3 -pyrimidin-5-yl                                      1924   2-CN, 4-OCH.sub.3 -pyrimidin-5-yl                                      1925   6-CN, 4-OCH.sub.3 -pyrimidin-5-yl                                      1926   4-CN, 2-OCH.sub.2 CH.sub.3 -pyrimidin-5-yl                             1927   4-CN, 6-OCH.sub.2 CH.sub.3 -pyrimidin-5-yl                             1928   2-CN, 4-OCH.sub.2 CH.sub.3 -pyrimidin-5-yl                             1929   6-CN, 4-OCH.sub.2 CH.sub.3 -pyrimidin-5-yl                             1930   4-CN, 2-OCH(CH.sub.3).sub.2 -pyrimidin-5-yl                            1931   4-CN, 6-OCH(CH.sub.3).sub.2 -pyrimidin-5-yl                            1932   2-CN, 4-OCH(CH.sub.3).sub.2 -pyrimidin-5-yl                            1933   6-CN, 4-OCH(CH.sub.3).sub.2 -pyrimidin-5-yl                            1934   4-CN, 2-OCH.sub.2 CF.sub.3 -pyrimidin-5-yl                             1935   4-CN, 6-OCH.sub.2 CF.sub.3 -pyrimidin-5-yl                             1936   2-CN, 4-OCH.sub.2 CF.sub.3 -pyrimidin-5-yl                             1937   6-CN, 4-OCH.sub.2 CF.sub.3 -pyrimidin-5-yl                             1938   2,6-(CH.sub.3).sub.2, 4-OCH.sub.3 -pyrimidin-5-yl                      1939   4-CH.sub.3 -pyridazin-3-yl                                             1940   6-CH.sub.3 -pyridazin-3-yl                                             1941   4-CH.sub.2 CH.sub.3 -pyridazin-3-yl                                    1942   6-CH.sub.2 CH.sub.3 -pyridazin-3-yl                                    1943   4-CH(CH.sub.3).sub.2 -pyridazin-3-yl                                   1944   6-CH(CH.sub.3).sub.2 -pyridazin-3-yl                                   1945   4-CH(CH.sub.3)CH.sub.2 CH.sub.3 -pyridazin-3-yl                        1946   6-CH(CH.sub.3)CH.sub.2 CH.sub.3 -pyridazin-3-yl                        1947   4-CF.sub.3 -pyridazin-3-yl                                             1948   6-CF.sub.3 -pyridazin-3-yl                                             1949   4-CH═CH.sub.2 -pyridazin-3-yl                                      1950   6-CH═CH.sub.2 -pyridazin-3-yl                                      1951   4-CH═CHCH.sub.3 -pyridazin-3-yl                                    1952   6-CH═CHCH.sub.3 -pyridazin-3-yl                                    1953   4-CH═CHCl-pyridazin-3-yl                                           1954   6-CH═CHCl-pyridazin-3-yl                                           1955   4-C.tbd.CH-pyridazin-3-yl                                              1956   6-C.tbd.CH-pyridazin-3-yl                                              1957   4-CH.sub.2 C.tbd.CH-pyridazin-3-yl                                     1958   6-CH.sub.2 C.tbd.CH-pyridazin-3-yl                                     1959   4-CH.sub.2 C.tbd.CCH.sub.3 -pyridazin-3-yl                             1960   6-CH.sub.2 C.tbd.CCH.sub.3 -pyridazin-3-yl                             1961   4-cyclopropyl-pyridazin-3-yl                                           1962   6-cyclopropyl-pyridazin-3-yl                                           1963   4-cyclopentyl-pyridazin-3-yl                                           1964   6-cyclopentyl-pyridazin-3-yl                                           1965   4-OCH.sub.3 -pyridazin-3-yl                                            1966   6-OCH.sub.3 -pyridazin-3-yl                                            1967   4-OCH.sub.2 CH.sub.3 -pyridazin-3-yl                                   1968   6-OCH.sub.2 CH.sub.3 -pyridazin-3-yl                                   1969   4-OCH.sub.2 CH.sub.2 CH.sub.3 -pyridazin-3-yl                          1970   6-OCH.sub.2 CH.sub.2 CH.sub.3 -pyridazin-3-yl                          1971   4-OCH(CH.sub.3).sub.2 -pyridazin-3-yl                                  1972   6-OCH(CH.sub.3).sub.2 -pyridazin-3-yl                                  1973   4-OCH.sub.2 CH.sub.2 CH.sub.2 CH.sub.3 -pyridazin-3-yl                 1974   6-OCH.sub.2 CH.sub.2 CH.sub.2 CH.sub.3 -pyridazin-3-yl                 1975   4-OCH(CH.sub.3)CH.sub.2 CH.sub.3 -pyridazin-3-yl                       1976   6-OCH(CH.sub.3)CH.sub.2 CH.sub.3 -pyridazin-3-yl                       1977   4-OCH.sub.2 CH(CH.sub.3).sub.2 -pyridazin-3-yl                         1978   6-OCH.sub.2 CH(CH.sub.3).sub.2 -pyridazin-3-yl                         1979   4-OC(CH.sub.3).sub.3 -pyridazin-3-yl                                   1980   6-OC(CH.sub.3).sub.3 -pyridazin-3-yl                                   1981   4-OCH(CH.sub.3)CH.sub.2 CH.sub.2 CH.sub.3 -pyridazin-3-yl              1982   6-OCH(CH.sub.3)CH.sub.2 CH.sub.2 CH.sub.3 -pyridazin-3-yl              1983   4-OCH.sub.2 OCH.sub.3 -pyridazin-3-yl                                  1984   6-OCH.sub.2 OCH.sub.3 -pyridazin-3-yl                                  1985   4-OCH.sub.2 OCH.sub.2 CH.sub.3 -pyridazin-3-yl                         1986   6-OCH.sub.2 OCH.sub.2 CH.sub.3 -pyridazin-3-yl                         1987   4-OCH(CH.sub.3)OCH.sub.3 -pyridazin-3-yl                               1988   6-OCH(CH.sub.3)OCH.sub.3 -pyridazin-3-yl                               1989   4-OCH(CH.sub.3)OCH.sub.2 CH.sub.3 -pyridazin-3-yl                      1990   6-OCH(CH.sub.3)OCH.sub.2 CH.sub.3 -pyridazin-3-yl                      1991   4-OCH.sub.2 CH.sub.2 OCH.sub.3 -pyridazin-3-yl                         1992   6-OCH.sub.2 CH.sub.2 OCH.sub.3 -pyridazin-3-yl                         1993   4-OCH.sub.2 CH.sub.2 OCH.sub.2 CH.sub.3 -pyridazin-3-yl                1994   6-OCH.sub.2 CH.sub.2 OCH.sub.2 CH.sub.3 -pyridazin-3-yl                1995   4-OCH.sub.2 CH.sub.2 OCH(CH.sub.3).sub.2 -pyridazin-3-yl               1996   6-OCH.sub.2 CH.sub.2 OCH(CH.sub.3).sub.2 -pyridazin-3-yl               1997   4-OCH.sub.2 CH.sub.2 SCH.sub.3 -pyridazin-3-yl                         1998   6-OCH.sub.2 CH.sub.2 SCH.sub.3 -pyridazin-3-yl                         1999   4-OCH.sub.2 CH.sub.2 SO.sub.2 CH.sub.3 -pyridazin-3-yl                 2000   6-OCH.sub.2 CH.sub.2 SO.sub.2 CH.sub.3 -pyridazin-3-yl                 2001   4-OCH.sub.2 CH.sub.2 SCH(CH.sub.3).sub.2 -pyridazin-3-yl               2002   6-OCH.sub.2 CH.sub.2 SCH(CH.sub.3).sub.2 -pyridazin-3-yl               2003   4-OCH.sub.2 CH.sub.2 CN-pyridazin-3-yl                                 2004   6-OCH.sub.2 CH.sub.2 CN-pyridazin-3-yl                                 2005   4-OCH.sub.2 CH.sub.2 SCH.sub.2 CH.sub.2 CN-pyridazin-3-yl              2006   6-OCH.sub.2 CH.sub.2 SCH.sub.2 CH.sub.2 CN-pyridazin-3-yl              2007   4-OCH.sub.2 CH.sub.2 OC.sub.5 H.sub.6 -pyridazin-3-yl                  2008   6-OCH.sub.2 CH.sub.2 OC.sub.5 H.sub.6 -pyridazin-3-yl                  2009   4-OCH.sub.2 CH.sub.2 OCH.sub.2 C.sub.5 H.sub.6 -pyridazin-3-yl         2010   6-OCH.sub.2 CH.sub.2 OCH.sub.2 C.sub.5 H.sub.6 -pyridazin-3-yl         2011   4-OCH.sub.2 CH.sub.2 N(CH.sub.3).sub.2 -pyridazin-3-yl                 2012   6-OCH.sub.2 CH.sub.2 N(CH.sub.3).sub.2 -pyridazin-3-yl                 2013   4-OCH.sub.2 CH.sub.2 CONH.sub.2 -pyridazin-3-yl                        2014   6-OCH.sub.2 CH.sub.2 CONH.sub.2 -pyridazin-3-yl                        2015   4-OCH.sub.2 CH.sub.2 CO.sub.2 CH.sub.2 CH.sub.2 CH.sub.3 -pyridazin           -3-yl                                                                  2016   6-OCH.sub.2 CH.sub.2 CO.sub.2 CH.sub.2 CH.sub.2 CH.sub.3 -pyridazin           -3-yl                                                                  2017   4-OCH(CH.sub.3)CH.sub.2 OCH.sub.3 -pyridazin-3-yl                      2018   6-OCH(CH.sub.3)CH.sub.2 OCH.sub.3 -pyridazin-3-yl                      2019   4-OCH(CH.sub.3)CH.sub.2 CO.sub.2 CH.sub.3 -pyridazin-3-yl              2020   6-OCH(CH.sub.3)CH.sub.2 CO.sub.2 CH.sub.3 -pyridazin-3-yl              2021   4-OCH(CH.sub.3)CH.sub.2 CO.sub.2 CH.sub.2 CH.sub.3 -pyridazin-3-yl     2022   6-OCH(CH.sub.3)CH.sub.2 CO.sub.2 CH.sub.2 CH.sub.3 -pyridazin-3-yl     2023   4-OCH.sub.2 CH(CH.sub.3)CO.sub.2 CH.sub.3 -pyridazin-3-yl              2024   6-OCH.sub.2 CH(CH.sub.3)CO.sub.2 CH.sub.3 -pyridazin-3-yl              2025   4-OCH.sub.2 C(═O)CH.sub.3 -pyridazin-3-yl                          2026   6-OCH.sub.2 C(═O)CH.sub.3 -pyridazin-3-yl                          2027   4-OCH.sub.2 C(═O)CH.sub.2 CH.sub.3 -pyridazin-3-yl                 2028   6-OCH.sub.2 C(═O)CH.sub.2 CH.sub.3 -pyridazin-3-yl                 2029   4-OCH.sub.2 CO.sub.2 CH.sub.3 -pyridazin-3-yl                          2030   6-OCH.sub.2 CO.sub.2 CH.sub.3 -pyridazin-3-yl                          2031   4-OCH.sub.2 CO.sub.2 CH.sub.2 CH.sub.3 -pyridazin-3-yl                 2032   6-OCH.sub.2 CO.sub.2 CH.sub.2 CH.sub.3 -pyridazin-3-yl                 2033   4-OCH.sub.2 C(═O)NH.sub.2 -pyridazin-3-yl                          2034   6-OCH.sub.2 C(═O)NH.sub.2 -pyridazin-3-yl                          2035   4-OCH.sub.2 C(═O)NHCH.sub.3 -pyridazin-3-yl                        2036   6-OCH.sub.2 C(═O)NHCH.sub.3 -pyridazin-3-yl                        2037   4-OCH.sub.2 C(═O)SCH.sub.3 -pyridazin-3-yl                         2038   6-OCH.sub.2 C(═O)SCH.sub.3 -pyridazin-3-yl                         2039   4-OCH(CH.sub.3)C(═O)NH.sub.2 -pyridazin-3-yl                       2040   6-OCH(CH.sub.3)C(═O)NH.sub.2 -pyridazin-3-yl                       2041   4-OCH(CH.sub.3)C(═O)NHCH.sub.3 -pyridazin-3-yl                     2042   6-OCH(CH.sub.3)C(═O)NHCH.sub.3 -pyridazin-3-yl                     2043   4-OCH(CH.sub.3)C(═O)NHNH.sub.2 -pyridazin-3-yl                     2044   6-OCH(CH.sub.3)C(═O)NHNH.sub.2 -pyridazin-3-yl                     2045   4-OCH(CH.sub.3)CO.sub.2 CH.sub.3 -pyridazin-3-yl                       2046   6-OCH(CH.sub.3)CO.sub.2 CH.sub.3 -pyridazin-3-yl                       2047   4-OCH(CH.sub.3)CO.sub.2 CH.sub.2 CH.sub.3 -pyridazin-3-yl              2048   6-OCH(CH.sub.3)CO.sub.2 CH.sub.2 CH.sub.3 -pyridazin-3-yl              2049   4-OCH(CH.sub.3)C(═O)CH.sub.3 -pyridazin-3-yl                       2050   6-OCH(CH.sub.3)C(═O)CH.sub.3 -pyridazin-3-yl                       2051   4-OCH(CH.sub.3)C(═O)CH.sub.2 CH.sub.3 -pyridazin-3-yl              2052   6-OCH(CH.sub.3)C(═O)CH.sub.2 CH.sub.3 -pyridazin-3-yl              2053   4-OCH(CH.sub.3)CH.sub.2 C(═O)CH.sub.3 -pyridazin-3-yl              2054   6-OCH(CH.sub.3)CH.sub.2 C(═O)CH.sub.3 -pyridazin-3-yl              2055   4-OCH(CH.sub.3)CH.sub.2 OC(CH.sub.3).sub.3 -pyridazin-3-yl             2056   6-OCH(CH.sub.3)CH.sub.2 OC(CH.sub.3).sub.3 -pyridazin-3-yl             2057   4-OCH(CH.sub.3)CH.sub.2 OCH.sub.2 CH.sub.3 -pyridazin-3-yl             2058   6-OCH(CH.sub.3)CH.sub.2 OCH.sub.2 CH.sub.3 -pyridazin-3-yl             2059   4-OCH(CH.sub.3)CH.sub.2 O(CH.sub.3).sub.2 CH.sub.3 -pyridazin-3-yl            N                                                                      2060   6-OCH(CH.sub.3)CH.sub.2 O(CH.sub.3).sub.2 CH.sub.3 -pyridazin-3-yl            O                                                                      2061   4-OCH(CH.sub.3)CH.sub.2 OCH.sub.2 CH═CH.sub.2 -pyridazin-3-yl      2062   6-OCH(CH.sub.3)CH.sub.2 OCH.sub.2 CH═CH.sub.2 -pyridazin-3-yl      2063   4-O(CH.sub.2).sub.3 OCH.sub.3 -pyridazin-3-yl                          2064   6-O(CH.sub.2).sub.3 OCH.sub.3 -pyridazin-3-yl                          2065   4-O(CH.sub.2).sub.3 OCH.sub.2 CH.sub.3 -pyridazin-3-yl                 2066   6-O(CH.sub.2).sub.3 OCH.sub.2 CH.sub.3 -pyridazin-3-yl                 2067   4-O(CH.sub.2).sub.3 OCH(CH.sub.3).sub.2 pyridazin-3-yl                 2068   6-O(CH.sub.2).sub.3 OCH(CH.sub.3).sub.2 pyridazin-3-yl                 2069   4-O(CH.sub.2).sub.3 OC.sub.5 H.sub.6 -pyridazin-3-yl                   2070   6-O(CH.sub.2).sub.3 OC.sub.5 H.sub.6 -pyridazin-3-yl                   2071   4-O(CH.sub.2).sub.3 OCH.sub.2 C.sub.5 H.sub.6 -pyridazin-3-yl          2072   6-O(CH.sub.2).sub.3 OCH.sub.2 C.sub.5 H.sub.6 -pyridazin-3-yl          2073   4-OCH(CH.sub.2 CH.sub.3)CH.sub.2 OCH.sub.3 -pyridazin-3-yl             2074   6-OCH(CH.sub.2 CH.sub.3)CH.sub.2 OCH.sub.3 -pyridazin-3-yl             2075   4-OCH(CH.sub.2 CH.sub.3)CH.sub.2 CH.sub.2 OCH.sub.3 -pyridazin-3-yl    2076   6-OCH(CH.sub.2 CH.sub.3)CH.sub.2 CH.sub.2 OCH.sub.3 -pyridazin-3-yl    2077   4-OCH(CH.sub.2 CH.sub.3)CH.sub.2 CH.sub.2 OCH.sub.2 CH.sub.3                  -pyridazin-3-yl                                                        2078   6-OCH(CH.sub.2 CH.sub.3)CH.sub.2 CH.sub.2 OCH.sub.2 CH.sub.3                  -pyridazin-3-yl                                                        2079   4-O (CH.sub.2).sub.3 O!.sub.2 CH.sub.3 -pyridazin-3-yl                 2080   6-O (CH.sub.2).sub.3 O!.sub.2 CH.sub.3 -pyridazin-3-yl                 2081   4-OCH.sub.2 CH(CH.sub.3)CH.sub.2 OCH.sub.3 -pyridazin-3-yl             2082   6-OCH.sub.2 CH(CH.sub.3)CH.sub.2 OCH.sub.3 -pyridazin-3-yl             2083   4-OCH.sub.2 CH(CH.sub.3)CH.sub.2 OCH.sub.2 CH.sub.3 -pyridazin-3-yl    2084   6-OCH.sub.2 CH(CH.sub.3)CH.sub.2 OCH.sub.2 CH.sub.3 -pyridazin-3-yl    2085   4-OCH(CH.sub.2 Cl)CH.sub.2 OCH.sub.3 -pyridazin-3-yl                   2086   6-OCH(CH.sub.2 Cl)CH.sub.2 OCH.sub.3 -pyridazin-3-yl                   2087   4-OCH(CH.sub.2 Cl)CH.sub.2 OCH.sub.2 CH.sub.3 -pyridazin-3-yl          2088   6-OCH(CH.sub.2 Cl)CH.sub.2 OCH.sub.2 CH.sub.3 -pyridazin-3-yl          2089   4-OCH(CH.sub.2 Cl)CH.sub.2 OCH(CH.sub.3).sub.2 -pyridazin-3-yl         2090   6-OCH(CH.sub.2 Cl)CH.sub.2 OCH(CH.sub.3).sub.2 -pyridazin-3-yl         2091   4-OCH(CH.sub.2 Cl)CH.sub.2 OCH.sub.2 CH═CH.sub.2 -pyridazin-3-y           l                                                                      2092   6-OCH(CH.sub.2 Cl)CH.sub.2 OCH.sub.2 CH═CH.sub.2 -pyridazin-3-y           l                                                                      2093   4-OCH CH.sub.2 OCH.sub.3 !.sub.2 -pyridazin-3-yl                       2094   6-OCH CH.sub.2 OCH.sub.3 !.sub.2 -pyridazin-3-yl                       2095   4-OCH CH.sub.2 OCH.sub.2 CH.sub.3 !.sub.2 -pyridazin-3-yl              2096   6-OCH CH.sub.2 OCH.sub.2 CH.sub.3 !.sub.2 -pyridazin-3-yl              2097   4-OCCl.sub.3 -pyridazin-3-yl                                           2098   6-OCCl.sub.3 -pyridazin-3-yl                                           2099   4-OCHF.sub.2 -pyridazin-3-yl                                           2100   6-OCHF.sub.2 -pyridazin-3-yl                                           2101   4-OCF.sub.3 -pyridazin-3-yl                                            2102   6-OCF.sub.3 -pyridazin-3-yl                                            2103   4-OCF.sub.2 CHF.sub.2 -pyridazin-3-yl                                  2104   6-OCF.sub.2 CHF.sub.2 -pyridazin-3-yl                                  2105   4-OCH.sub.2 CF.sub.3 -pyridazin-3-yl                                   2106   6-OCH.sub.2 CF.sub.3 -pyridazin-3-yl                                   2107   4-OCH.sub.2 CHF.sub.2 -pyridazin-3-yl                                  2108   6-OCH.sub.2 CHF.sub.2 -pyridazin-3-yl                                  2109   4-O(CH.sub.2).sub.3 F-pyridazin-3-yl                                   2110   6-O(CH.sub.2).sub.3 F-pyridazin-3-yl                                   2111   4-OCH(CH.sub.3)CF.sub.3 -pyridazin-3-yl                                2112   6-OCH(CH.sub.3)CF.sub.3 -pyridazin-3-yl                                2113   4-O(CH.sub.2).sub.4 F-pyridazin-3-yl                                   2114   6-O(CH.sub.2).sub.4 F-pyridazin-3-yl                                   2115   4-O(CH.sub.2).sub.3 CF.sub.3 -pyridazin-3-yl                           2116   6-O(CH.sub.2).sub.3 CF.sub.3 -pyridazin-3-yl                           2117   4-OCH(CH.sub.3)CF.sub.2 CF.sub.3 -pyridazin-3-yl                       2118   6-OCH(CH.sub.3)CF.sub.2 CF.sub.3 -pyridazin-3-yl                       2119   4-OCH(CH.sub.3)CF.sub.2 CHF.sub.2 -pyridazin-3-yl                      2120   6-OCH(CH.sub.3)CF.sub.2 CHF.sub.2 -pyridazin-3-yl                      2121   4-OCH.sub.2 CF.sub.2 CHFCH.sub.3 -pyridazin-3-yl                       2122   6-OCH.sub.2 CF.sub.2 CHFCH.sub.3 -pyridazin-3-yl                       2123   4-OCH.sub.2 (CF.sub.2).sub.2 CF.sub.3 -pyridazin-3-yl                  2124   6-OCH.sub.2 (CF.sub.2).sub.2 CF.sub.3 -pyridazin-3-yl                  2125   4-O(CF.sub.2).sub.3 CF.sub.3 -pyridazin-3-yl                           2126   6-O(CF.sub.2).sub.3 CF.sub.3 -pyridazin-3-yl                           2127   4-OCH.sub.2 CF.sub.2 CHF.sub.2 -pyridazin-3-yl                         2128   6-OCH.sub.2 CF.sub.2 CHF.sub.2 -pyridazin-3-yl                         2129   4-CH.sub.2 CH═CH.sub.2 -pyridazin-3-yl                             2130   6-CH.sub.2 CH═CH.sub.2 -pyridazin-3-yl                             2131   4-CH.sub.2 C(CH.sub.3)═CH.sub.2 -pyridazin-3-yl                    2132   6-CH.sub.2 C(CH.sub.3)═CH.sub.2 -pyridazin-3-yl                    2133   4-OCH.sub.2 CH═CHCH.sub.3 -pyridazin-3-yl                          2134   6-OCH.sub.2 CH═CHCH.sub.3 -pyridazin-3-yl                          2135   4-O(CH.sub.2).sub.2 CH═CH.sub.2 -pyridazin-3-yl                    2136   6-O(CH.sub.2).sub.2 CH═CH.sub.2 -pyridazin-3-yl                    2137   4-OCH.sub.2 C(CH.sub.3)═CH.sub.2 -pyridazin-3-yl                   2138   6-OCH.sub.2 C(CH.sub.3)═CH.sub.2 -pyridazin-3-yl                   2139   4-OCH(CH.sub.3)CH═CH.sub.2 -pyridazin-3-yl                         2140   6-OCH(CH.sub.3)CH═CH.sub.2 -pyridazin-3-yl                         2141   4-OCH.sub.2 C.tbd.CH-pyridazin-3-yl                                    2142   6-OCH.sub.2 C.tbd.CH-pyridazin-3-yl                                    2143   4-OCH.sub.2 C.tbd.CCH.sub.3 -pyridazin-3-yl                            2144   6-OCH.sub.2 C.tbd.CCH.sub.3 -pyridazin-3-yl                            2145   4-O(CH.sub.2).sub.2 C.tbd.CH-pyridazin-3-yl                            2146   6-O(CH.sub.2).sub.2 C.tbd.CH-pyridazin-3-yl                            2147   4-SCH.sub.2 -pyridazin-3-yl                                            2148   6-SCH.sub.2 -pyridazin-3-yl                                            2149   4-SCH.sub.2 CH.sub.3 -pyridazin-3-yl                                   2150   6-SCH.sub.2 CH.sub.3 -pyridazin-3-yl                                   2151   4-OC.sub.5 H.sub.6 -pyridazin-3-yl                                     2152   6-OC.sub.5 H.sub.6 -pyridazin-3-yl                                     2153   4-OCH.sub.2 C.sub.5 H.sub.6 -pyridazin-3-yl                            2154   6-OCH.sub.2 C.sub.5 H.sub.6 -pyridazin-3-yl                            2155   4-NO.sub.2 -pyridazin-3-yl                                             2156   6-NO.sub.2 -pyridazin-3-yl                                             2157   4-NHCH.sub.3 -pyridazin-3-yl                                           2158   6-NHCH.sub.3 -pyridazin-3-yl                                           2159   4-N(CH.sub.3).sub.2 -pyridazin-3-yl                                    2160   6-N(CH.sub.3).sub.2 -pyridazin-3-yl                                    2161   4-N(CH.sub.3)C.sub.2 H.sub.6 -pyridazin-3-yl                           2162   6-N(CH.sub.3)C.sub.2 H.sub.6 -pyridazin-3-yl                           2163   4-NHCH.sub.2 CF.sub.3 -pyridazin-3-yl                                  2164   6-NHCH.sub.2 CF.sub.3 -pyridazin-3-yl                                  2165   4-F-pyridazin-3-yl                                                     2166   6-F-pyridazin-3-yl                                                     2167   4-Cl-pyridazin-3-yl                                                    2168   6-Cl-pyridazin-3-yl                                                    2169   4-OH-pyridazin-3-yl                                                    2170   6-OH-pyridazin-3-yl                                                    2171   4-CN-pyridazin-3-yl                                                    2172   6-CN-pyridazin-3-yl                                                    2173   4-C(O)NH.sub.2 -pyridazin-3-yl                                         2174   6-C(O)NH.sub.2 -pyridazin-3-yl                                         2175   4-C(S)NH.sub.2 -pyridazin-3-yl                                         2176   6-C(S)NH.sub.2 -pyridazin-3-yl                                         2177   4-CO.sub.2 CH.sub.3 -pyridazin-3-yl                                    2178   6-CO.sub.2 CH.sub.3 -pyridazin-3-yl                                    2179   4-ON═C(CH.sub.3).sub.2 -pyridazin-3-yl                             2180   6-ON═C(CH.sub.3).sub.2 -pyridazin-3-yl                             2181   4- O-cyclopropyl!pyridazin-3-yl                                        2182   6- O-cyclopropyl!pyridazin-3-yl                                        2183   4- O-cyclobutyl!pyridazin-3-yl                                         2184   6- O-cyclobutyl!pyridazin-3-yl                                         2185   4- O-cyclopentyl!pyridazin-3-yl                                        2186   6- O-cyclopentyl!pyridazin-3-yl                                        2187   4- O-cyclohexyl!pyridazin-3-yl                                         2188   6- O-cyclohexyl!pyridazin-3-yl                                         2189   4- OCH.sub.2 -cyclopropyl!pyridazin-3-yl                               2190   6- OCH.sub.2 -cyclopropyl!pyridazin-3-yl                               2191   6-F, 4- OCH.sub.2 -cyclopropyl!pyridazin-3-yl                          2192   4-F, 6- OCH.sub.2 -cyclopropyl!pyridazin-3-yl                          2193   6-CH.sub.3, 4- OCH.sub.2 -cyclopropyl!pyridazin-3-yl                   2194   4-CH.sub.3, 6- OCH.sub.2 -cyclopropyl!pyridazin-3-yl                   2195   6-CF.sub.3, 4- OCH.sub.2 -cyclopropyl!pyridazin-3-yl                   2196   4-CH.sub.3, 6- OCH.sub.2 -cyclopropyl!pyridazin-3-yl                   2197   4- OCH(CH.sub.3)-cyclopropyl!pyridazin-3-yl                            2198   6- OCH(CH.sub.3)-cyclopropyl!pyridazin-3-yl                            2199   6-F, 4- OCH(CH.sub.3)-cyclopropyl!pyridazin-3-yl                       2200   4-F, 6- OCH(CH.sub.3)-cyclopropyl!pyridazin-3-yl                       2201   6-CH.sub.3, 4- OCH(CH.sub.3)-cyclopropyl!pyridazin-3-yl                2202   4-CH.sub.3, 6- OCH(CH.sub.3)-cyclopropyl!pyridazin-3-yl                2203   6-CF.sub.3, 4- OCH(CH.sub.3)-cyclopropyl!pyridazin-3-yl                2204   4-CF.sub.3, 4- OCH(CH.sub.3)-cyclopropyl!pyridazin-3-yl                2205   4- O-(1-CH.sub.3 -cyclopropyl)!pyridazin-3-yl                          2206   6- O-(1-CH.sub.3 -cyclopropyl)!pyridazin-3-yl                          2207   6-F, 4- O-(1-CH.sub.3 -cyclopropyl)!pyridazin-3-yl                     2208   4-F, 4- O-(1-CH.sub.3 -cyclopropyl)!pyridazin-3-yl                     2209   6-CH.sub.3, 4- O-(1-CH.sub.3 -cyclopropyl)!pyridazin-3-yl              2210   4-CH.sub.3, 6- O-(1-CH.sub.3 -cyclopropyl)!pyridazin-3-yl              2211   6-CF.sub.3, 4- O-(1-CH.sub.3 -cyclopropyl)!pyridazin-3-yl              2212   4-CF.sub.3, 6- O-(1-CH.sub.3 -cyclopropyl)!pyridazin-3-yl              2213   4- OCH.sub.2 -(1-CH.sub.3 -cyclopropyl)!pyridazin-3-yl                 2214   6- OCH.sub.2 -(1-CH.sub.3 -cyclopropyl)!pyridazin-3-yl                 2215   6-F, 4- OCH.sub.2 -(1-CH.sub.3 -cyclopropyl)!pyridazin-3-yl            2216   4-F, 6- OCH.sub.2 -(1-CH.sub.3 -cyclopropyl)!pyridazin-3-yl            2217   6-CH.sub.3, 4- OCH.sub.2 -(1-CH.sub.3 -cyclopropyl)!pyridazin-3-yl            N                                                                      2218   4-CH.sub.3, 4- OCH.sub.2 -(1-CH.sub.3 -cyclopropyl)!pyridazin-3-yl            O                                                                      2219   6-CF.sub.3, 4- OCH.sub.2 -(1-CH.sub.3 -cyclopropyl)!pyridazin-3-yl            O                                                                      2220   4-CF.sub.3, 4- OCH.sub.2 -(1-CH.sub.3 -cyclopropyl)!pyridazin-3-yl     2221   4- OCH.sub.2 -(2-CH.sub.3 -cyclopropyl)!pyridazin-3-yl                 2222   6- OCH.sub.2 -(2-CH.sub.3 -cyclopropyl)!pyridazin-3-yl                 2223   6-F, 4- OCH.sub.2 -(2-CH.sub.3 -cyclopropyl)!pyridazin-3-yl            2224   4-F, 6- OCH.sub.2 -(2-CH.sub.3 -cyclopropyl)!pyridazin-3-yl            2225   6-CH.sub.3, 4- OCH.sub.2 -(2-CH.sub.3 -cyclopropyl)!pyridazin-1-yl     2226   4-CH.sub.3, 6- OCH.sub.2 -(2-CH.sub.3 -cyclopropyl)!pyridazin-1-yl     2227   6-CF.sub.3, 4- OCH.sub.2 -(2-CH.sub.3 -cyclopropyl)!pyridazin-1-yl     2228   4-CF.sub.3, 6- OCH.sub.2 -(2-CH.sub.3 -cyclopropyl)!pyridazin-1-yl     2229   4- OCH.sub.2 -(tetrahydropyran-2-yl)!pyridazin-3-yl                    2230   6- OCH.sub.2 -(tetrahydropyran-2-yl)!pyridazin-3-yl                    2231   6-F, 4- OCH.sub.2 -(tetrahydropyran-2-yl)!pyridazin-3-yl               2232   4-F, 6- OCH.sub.2 -(tetrahydropyran-2-yl)!pyridazin-3-yl               2233   6-CH.sub.3, 4- OCH.sub.2 -(tetrahydropyran-2-yl)!pyridazin-3-yl        2234   4-CH.sub.3, 6- OCH.sub.2 -(tetrahydropyran-2-yl)!pyridazin-3-yl        2235   6-CF.sub.3, 4- OCH.sub.2 -(tetrahydropyran-2-yl)!pyridazin-3-yl        2236   4-CF.sub.3, 6- OCH.sub.2 -(tetrahydropyran-2-yl)!pyridazin-3-yl        2237   4- OCH.sub.2 -(furan-2-yl)!pyridazin-3-yl                              2238   6- OCH.sub.2 -(furan-2-yl)!pyridazin-3-yl                              2239   6-F, 4- OCH.sub.2 -(furan-2-yl)!pyridazin-3-yl                         2240   4-F, 6- OCH.sub.2 -(furan-2-yl)!pyridazin-3-yl                         2241   6-CH.sub.3, 4- OCH.sub.2 -(furan-2-yl)!pyridazin-3-yl                  2242   4-CH.sub.3, 6- OCH.sub.2 -(furan-2-yl)!pyridazin-3-yl                  2243   6-CF.sub.3, 4- OCH.sub.2 -(furan-2-yl)!pyridazin-3-yl                  2244   4-CF.sub.3, 6- OCH.sub.2 -(furan-2-yl)!pyridazin-3-yl                  2245   4- OCH.sub.2 -(furan-3-yl)!pyridazin-3-yl                              2246   6- OCH.sub.2 -(furan-3-yl)!pyridazin-3-yl                              2247   6-F, 4- OCH.sub.2 -(furan-3-yl)!pyridazin-3-yl                         2248   4-F, 6- OCH.sub.2 -(furan-3-yl)!pyridazin-3-yl                         2249   6-CH.sub.3, 4- OCH.sub.2 -(furan-3-yl)!pyridazin-1-yl                  2250   4-CH.sub.3, 6- OCH.sub.2 -(furan-3-yl)!pyridazin-1-yl                  2251   6-CF.sub.3, 4- OCH.sub.2 -(furan-3-yl)!pyridazin-1-yl                  2252   4-CF.sub.3, 6- OCH.sub.2 -(furan-3-yl)!pyridazin-1-yl                  2253   4- OCH.sub.2 -(tetrahydrofuran-3-yl)!pyridazin-3-yl                    2254   6- OCH.sub.2 -(tetrahydrofuran-3-yl)!pyridazin-3-yl                    2255   6-F, 4- OCH.sub.2 -(tetrahydrofuran-3-yl)!pyridazin-3-yl               2256   4-F, 6- OCH.sub.2 -(tetrahydrofuran-3-yl)!pyridazin-3-yl               2257   6-CH.sub.3, 4- OCH.sub.2 -(tetrahydrofuran-3-yl)!pyridazin-3-yl        2258   4-CH.sub.3, 6- OCH.sub.2 -(tetrahydrofuran-3-yl)!pyridazin-3-yl        2259   6-CF.sub.3, 4- OCH.sub.2 -(tetrahydrofuran-3-yl)!pyridazin-3-yl        2260   4-CF.sub.3, 6- OCH.sub.2 -(tetrahydrofuran-3-yl)!pyridazin-3-yl        2261   4- OCH.sub.2 -(tetrahydrofuran-2-yl)!pyridazin-3-yl                    2262   6- OCH.sub.2 -(tetrahydrofuran-2-yl)!pyridazin-3-yl                    2263   6-F, 4- OCH.sub.2 -(tetrahydrofuran-2-yl)!pyridazin-3-yl               2264   4-F, 6- OCH.sub.2 -(tetrahydrofuran-2-yl)!pyridazin-3-yl               2265   6-CH.sub.3, 4- OCH.sub.2 -(tetrahydrofuran-2-yl)!pyridazin-3-yl        2266   4-CH.sub.3, 6- OCH.sub.2 -(tetrahydrofuran-2-yl)!pyridazin-3-yl        2267   6-CF.sub.3, 4- OCH.sub.2 -(tetrahydrofuran-2-yl)!pyridazin-3-yl        2268   4-CF.sub.3, 6- OCH.sub.2 -(tetrahydrofuran-2-yl)!pyridazin-3-yl        2269   4- O-(tetrahydropyran-4-yl)!pyridazin-3-yl                             2270   6- O-(tetrahydropyran-4-yl)!pyridazin-3-yl                             2271   6-F, 4- O-(tetrahydropyran-4-yl)!pyridazin-3-yl                        2272   4-F, 6- O-(tetrahydropyran-4-yl)!pyridazin-3-yl                        2273   6-CH.sub.3, 4- O-(tetrahydropyran-4-yl)!pyridazin-3-yl                 2274   4-CH.sub.3, 6- O-(tetrahydropyran-4-yl)!pyridazin-3-yl                 2275   6-CF.sub.3, 4- O-(tetrahydropyran-4-yl)!pyridazin-3-yl                 2276   4-CF.sub.3, 6- O-(tetrahydropyran-4-yl)!pyridazin-3-yl                 2277   4- 2-Cl--C.sub.5 H.sub.4 !pyridazin-3-yl                               2278   6- 2-Cl--C.sub.5 H.sub.4 !pyridazin-3-yl                               2279   6-F, 4- 2-Cl--C.sub.5 H.sub.4 !pyridazin-3-yl                          2280   4-F, 6- 2-Cl--C.sub.5 H.sub.4 !pyridazin-3-yl                          2281   6-CH.sub.3, 4- 2-Cl--C.sub.5 H.sub.4 !pyridazin-3-yl                   2282   4-CH.sub.3, 6- 2-Cl--C.sub.5 H.sub.4 !pyridazin-3-yl                   2283   6-CF.sub.3, 4- 2-Cl--C.sub.5 H.sub.4 !pyridazin-3-yl                   2284   4-CF.sub.3, 6- 2-Cl--C.sub.5 H.sub.4 !pyridazin-3-yl                   2285   4- OCH.sub.2 -(pyridin-2-yl)!pyridazin-3-yl                            2286   6- OCH.sub.2 -(pyridin-2-yl)!pyridazin-3-yl                            2287   6-F, 4- OCH.sub.2 -(pyridin-2-yl)!pyridazin-3-yl                       2288   4-F, 6- OCH.sub.2 -(pyridin-2-yl)!pyridazin-3-yl                       2289   6-CH.sub.3, 4- OCH.sub.2 -(pyridin-2-yl)!pyridazin-3-yl                2290   4-CH.sub.3, 6- OCH.sub.2 -(pyridin-2-yl)!pyridazin-3-yl                2291   6-CF.sub.3, 4- OCH.sub.2 -(pyridin-2-yl)!pyridazin-3-yl                2292   4-CF.sub.3, 6- OCH.sub.2 -(pyridin-2-yl)!pyridazin-3-yl                2293   4- OCH.sub.2 -(pyridin-3-yl)!pyridazin-3-yl                            2294   6- OCH.sub.2 -(pyridin-3-yl)!pyridazin-3-yl                            2295   6-F, 4- OCH.sub.2 -(pyridin-3-yl)!pyridazin-3-yl                       2296   4-F, 6- OCH.sub.2 -(pyridin-3-yl)!pyridazin-3-yl                       2297   6-CH.sub.3, 4- OCH.sub.2 -(pyridin-3-yl)!pyridazin-3-yl                2298   4-CH.sub.3, 6- OCH.sub.2 -(pyridin-3-yl)!pyridazin-3-yl                2299   6-CF.sub.3, 4- OCH.sub.2 -(pyridin-3-yl)!pyridazin-3-yl                2300   4-CF.sub.3, 6- OCH.sub.2 -(pyridin-3-yl)!pyridazin-3-yl                2301   4- morpholin-4-yl!pyridazin-3-yl                                       2302   6- morpholin-4-yl!pyridazin-3-yl                                       2303   4- 1-CH.sub.3 -imidazol-2-yl!pyridazin-3-yl                            2304   6- 1-CH.sub.3 -imidazol-2-yl!pyridazin-3-yl                            2305   6-F, 4- 1-CH.sub.3 -imidazol-2-yl!pyridazin-3-yl                       2306   4-F, 6- 1-CH.sub.3 -imidazol-2-yl!pyridazin-3-yl                       2307   6-CH.sub.3, 4- 1-CH.sub.3 -imidazol-2-yl!pyridazin-1-yl                2308   4-CH.sub.3, 6- 1-CH.sub.3 -imidazol-2-yl!pyridazin-1-yl                2309   6-CF.sub.3, 4- 1-CH.sub.3 -imidazol-2-yl!pyridazin-1-yl                2310   4-CF.sub.3, 6- 1-CH.sub.3 -imidazol-2-yl!pyridazin-1-yl                2311   4- 1,2,4-triazol-1-yl!pyridazin-3-yl                                   2312   6- 1,2,4-triazol-1-yl!pyridazin-3-yl                                   2313   6-F, 4- 1,2,4-triazol-1-yl!pyridazin-3-yl                              2314   4-F, 6- 1,2,4-triazol-1-yl!pyridazin-3-yl                              2315   6-CH.sub.3, 4- 1,2,4-triazol-1-yl!pyridazin-1-yl                       2316   4-CH.sub.3, 6- 1,2,4-triazol-1-yl!pyridazin-1-yl                       2317   6-CF.sub.3, 4- 1,2,4-triazol-1-yl!pyridazin-1-yl                       2318   4-CF.sub.3, 6- 1,2,4-triazol-1-yl!pyridazin-1-yl                       2319   4,6-Cl.sub.2 -pyridazin-3-yl                                           2320   4,5-Cl.sub.2 -pyridazin-3-yl                                           2321   4,6-(CH.sub.3).sub.2 -pyridazin-3-yl                                   2322   4,5-(CH.sub.3).sub.2 -pyridazin-3-yl                                   2323   4,6-(OCH.sub.3).sub.2 -pyridazin-3-yl                                  2324   4,5-(OCH.sub.3).sub.2 -pyridazin-3-yl                                  2325   4,6-(OCH.sub.2 CH.sub.3).sub.2 -pyridazin-3-yl                         2326   4,5-(OCH.sub.2 CH.sub.3).sub.2 -pyridazin-3-yl                         2327   4-F, 6-CH.sub.3 -pyridazin-3-yl                                        2328   4-F, 5-CH.sub.3 -pyridazin-3-yl                                        2329   6-F, 4-CH.sub.3 -pyridazin-3-yl                                        2330   5-F, 4-CH.sub.3 -pyridazin-3-yl                                        2331   4-F, 6-OCH.sub.3 -pyridazin-3-yl                                       2332   4-F, 5-OCH.sub.3 -pyridazin-3-yl                                       2333   6-F, 4-OCH.sub.3 -pyridazin-3-yl                                       2334   5-F, 4-OCH.sub.3 -pyridazin-3-yl                                       2335   4-F, 6-OCH.sub.2 CH.sub.3 -pyridazin-3-yl                              2336   4-F, 5-OCH.sub.2 CH.sub.3 -pyridazin-3-yl                              2337   6-F, 4-OCH.sub.2 CH.sub.3 -pyridazin-3-yl                              2338   5-F, 4-OCH.sub.2 CH.sub.3 -pyridazin-3-yl                              2339   4-F, 6-OCH.sub.2 CF.sub.3 -pyridazin-3-yl                              2340   4-F, 5-OCH.sub.2 CF.sub.3 -pyridazin-3-yl                              2341   6-F, 4-OCH.sub.2 CF.sub.3 -pyridazin-3-yl                              2342   5-F, 4-OCH.sub.2 CF.sub.3 -pyridazin-3-yl                              2343   4-F, 6-OCH(CH.sub.3).sub.2 -pyridazin-3-yl                             2344   4-F, 5-OCH(CH.sub.3).sub.2 -pyridazin-3-yl                             2345   6-F, 4-OCH(CH.sub.3).sub.2 -pyridazin-3-yl                             2346   5-F, 4-OCH(CH.sub.3).sub.2 -pyridazin-3-yl                             2347   4-Cl, 6-CH.sub.3 -pyridazin-3-yl                                       2348   4-Cl, 5-CH.sub.3 -pyridazin-3-yl                                       2349   6-Cl, 4-CH.sub.3 -pyridazin-3-yl                                       2350   5-Cl, 4-CH.sub.3 -pyridazin-3-yl                                       2351   4-Cl, 6-OCH.sub.3 -pyridazin-3-yl                                      2352   4-Cl, 5-OCH.sub.3 -pyridazin-3-yl                                      2353   6-Cl, 4-OCH.sub.3 -pyridazin-3-yl                                      2354   5-Cl, 4-OCH.sub.3 -pyridazin-3-yl                                      2355   4-Cl, 6-OCH.sub.2 CH.sub.3 -pyridazin-3-yl                             2356   4-Cl, 5-OCH.sub.2 CH.sub.3 -pyridazin-3-yl                             2357   6-Cl, 4-OCH.sub.2 CH.sub.3 -pyridazin-3-yl                             2358   5-Cl, 4-OCH.sub.2 CH.sub.3 -pyridazin-3-yl                             2359   4-Cl, 6-OCH.sub.2 CF.sub.3 -pyridazin-3-yl                             2360   4-Cl, 5-OCH.sub.2 CF.sub.3 -pyridazin-3-yl                             2361   6-Cl, 4-OCH.sub.2 CF.sub.3 -pyridazin-3-yl                             2362   5-Cl, 4-OCH.sub.2 CF.sub.3 -pyridazin-3-yl                             2363   4-Cl, 6-OCH(CH.sub.3).sub.2 -pyridazin-3-yl                            2364   4-Cl, 5-OCH(CH.sub.3).sub.2 -pyridazin-3-yl                            2365   6-Cl, 4-OCH(CH.sub.3).sub.2 -pyridazin-3-yl                            2366   5-Cl, 4-OCH(CH.sub.3).sub.2 -pyridazin-3-yl                            2367   4-CH.sub.3, 6-OCH.sub.3 -pyridazin-3-yl                                2368   4-CH.sub.3, 5-OCH.sub.3 -pyridazin-3-yl                                2369   6-CH.sub.3, 4-OCH.sub.3 -pyridazin-3-yl                                2370   5-CH.sub.3, 4-OCH.sub.3 -pyridazin-3-yl                                2371   5-CH.sub.3, 4-OCH.sub.2 CH.sub.3 -pyridazin-3-yl                       2372   6-CH.sub.3, 4-OCH.sub.2 CH.sub.3 -pyridazin-3-yl                       2373   4-CH.sub.3, 6-OCH.sub.2 CH.sub.3 -pyridazin-3-yl                       2374   4-CH.sub.3, 5-OCH.sub.2 CH.sub.3 -pyridazin-3-yl                       2375   4-CH.sub.3, 6-OCH.sub.2 CF.sub.3 -pyridazin-3-yl                       2376   4-CH.sub.3, 5-OCH.sub.2 CH.sub.3 -pyridazin-3-yl                       2377   6-CH.sub.3, 4-OCH.sub.2 CF.sub.3 -pyridazin-3-yl                       2378   5-CH.sub.3, 4-OCH.sub.2 CF.sub.3 -pyridazin-3-yl                       2379   4-CH.sub.3, 6-OCH(CH.sub.3).sub.2 -pyridazin-3-yl                      2380   4-CH.sub.3, 6-OCH(CH.sub.3).sub.2 -pyridazin-3-yl                      2381   6-CH.sub.3, 4-OCH(CH.sub.3).sub.2 -pyridazin-3-yl                      2382   5-CH.sub.3, 4-OCH(CH.sub.3).sub.2 -pyridazin-3-yl                      2383   4-CH.sub.3, 6-OCH.sub.2 CH═CH.sub.2 -pyridazin-3-yl                2384   4-CH.sub.3, 5-OCH.sub.2 CH═CH.sub.2 -pyridazin-3-yl                2385   6-CH.sub.3, 4-OCH.sub.2 CH═CH.sub.2 -pyridazin-3-yl                2386   5-CH.sub.3, 4-OCH.sub.2 CH═CH.sub.2 -pyridazin-3-yl                2387   4-CH.sub.3, 6-CO.sub.2 CH.sub.3 -pyridazin-3-yl                        2388   4-CH.sub.3, 5-CO.sub.2 CH.sub.3 -pyridazin-3-yl                        2389   4-CH.sub.3, 6-CF.sub.3 -pyridazin-3-yl                                 2390   4-CH.sub.3, 5-CF.sub.3 -pyridazin-3-yl                                 2391   6-CH.sub.3, 4-CF.sub.3 -pyridazin-3-yl                                 2392   5-CH.sub.3, 4-CF.sub.3 -pyridazin-3-yl                                 2393   4-CF.sub.3, 6-CH.sub.2 CH.sub.3 -pyridazin-3-yl                        2394   4-CF.sub.3, 5-CH.sub.2 CH.sub.3 -pyridazin-3-yl                        2395   6-CF.sub.3, 4-CH.sub.2 CH.sub.3 -pyridazin-3-yl                        2396   5-CF.sub.3, 4-CH.sub.2 CH.sub.3 -pyridazin-3-yl                        2397   4-CF.sub.3, 6-OCH.sub.3 -pyridazin-3-yl                                2398   4-CF.sub.3, 5-OCH.sub.3 -pyridazin-3-yl                                2399   6-CF.sub.3, 4-OCH.sub.3 -pyridazin-3-yl                                2400   5-CF.sub.3, 4-OCH.sub.3 -pyridazin-3-yl                                2401   4-CF.sub.3, 6-OCH.sub.2 CH.sub.3 -pyridazin-3-yl                       2402   4-CF.sub.3, 5-OCH.sub.2 CH.sub.3 -pyridazin-3-yl                       2403   6-CF.sub.3, 4-OCH.sub.2 CH.sub.3 -pyridazin-3-yl                       2404   5-CF.sub.3, 4-OCH.sub.2 CH.sub.3 -pyridazin-3-yl                       2405   4-CF.sub.3, 6-OCH.sub.2 CF.sub.3 -pyridazin-3-yl                       2406   4-CF.sub.3, 5-OCH.sub.2 CF.sub.3 -pyridazin-3-yl                       2407   6-CF.sub.3, 4-OCH.sub.2 CF.sub.3 -pyridazin-3-yl                       2408   5-CF.sub.3, 4-OCH.sub.2 CF.sub.3 -pyridazin-3-yl                       2409   4-OCH.sub.3, 6-OCH.sub.2 CH.sub.3 -pyridazin-3-yl                      2410   4-OCH.sub.3, 5-OCH.sub.2 CH.sub.3 -pyridazin-3-yl                      2411   6-OCH.sub.3, 4-OCH.sub.2 CH.sub.3 -pyridazin-3-yl                      2412   5-OCH.sub.3, 4-OCH.sub.2 CH.sub.3 -pyridazin-3-yl                      2413   4-OCH.sub.3, 6-OCH.sub.2 CF.sub.3 -pyridazin-3-yl                      2414   4-OCH.sub.3, 6-OCH.sub.2 CF.sub.3 -pyridazin-3-yl                      2415   6-OCH.sub.3, 4-OCH.sub.2 CF.sub.3 -pyridazin-3-yl                      2416   5-OCH.sub.3, 4-OCH.sub.2 CF.sub.3 -pyridazin-3-yl                      2417   4-OCH.sub.3, 6-OCH(CH.sub.3)pyridazin-3-yl                             2418   4-OCH.sub.3, 5-OCH(CH.sub.3)pyridazin-3-yl                             2419   6-OCH.sub.3, 4-OCH(CH.sub.3)pyridazin-3-yl                             2420   5-OCH.sub.3, 4-OCH(CH.sub.3)pyridazin-3-yl                             2421   4-OCH.sub.2 CH.sub.3, 6-CH.sub.2 OCH.sub.2 CH.sub.3 -pyridazin-3-yl           N                                                                      2422   4-OCH.sub.2 CH.sub.3, 5-CH.sub.2 OCH.sub.2 CH.sub.3 -pyridazin-3-yl           O                                                                      2423   6-OCH.sub.2 CH.sub.3, 4-CH.sub.2 OCH.sub.2 CH.sub.3 -pyridazin-3-yl           N                                                                      2424   5-OCH.sub.2 CH.sub.3, 4-CH.sub.2 OCH.sub.2 CH.sub.3 -pyridazin-3-yl           O                                                                      2425   4-NO.sub.2, 6-CH.sub.3 -pyridazin-3-yl                                 2426   4-NO.sub.2, 5-CH.sub.3 -pyridazin-3-yl                                 2427   6-NO.sub.2, 4-CH.sub.3 -pyridazin-3-yl                                 2428   5-NO.sub.2, 4-CH.sub.3 -pyridazin-3-yl                                 2429   4-NO.sub.2, 6-OCH.sub.3 -pyridazin-3-yl                                2430   4-NO.sub.2, 5-OCH.sub.3 -pyridazin-3-yl                                2431   6-NO.sub.2, 4-OCH.sub.3 -pyridazin-3-yl                                2432   5-NO.sub.2, 4-OCH.sub.3 -pyridazin-3-yl                                2433   4-NO.sub.2, 6-OCH.sub.2 CH.sub.3 -pyridazin-3-yl                       2434   4-NO.sub.2, 5-OCH.sub.2 CH.sub.3 -pyridazin-3-yl                       2435   6-NO.sub.2, 4-OCH.sub.2 CH.sub.3 -pyridazin-3-yl                       2436   5-NO.sub.2, 4-OCH.sub.2 CH.sub.3 -pyridazin-3-yl                       2437   4-NO.sub.2, 6-OCH(CH.sub.3).sub.2 -pyridazin-3-yl                      2438   4-NO.sub.2, 5-OCH(CH.sub.3).sub.2 -pyridazin-3-yl                      2439   6-NO.sub.2, 4-OCH(CH.sub.3).sub.2 -pyridazin-3-yl                      2440   5-NO.sub.2, 4-OCH(CH.sub.3).sub.2 -pyridazin-3-yl                      2441   4-NO.sub.2, 6-OCH.sub.2 CF.sub.3 -pyridazin-3-yl                       2442   4-NO.sub.2, 5-OCH.sub.2 CF.sub.3 -pyridazin-3-yl                       2443   6-NO.sub.2, 4-OCH.sub.2 CF.sub.3 -pyridazin-3-yl                       2444   5-NO.sub.2, 4-OCH.sub.2 CF.sub.3 -pyridazin-3-yl                       2445   4-CN, 6-CH.sub.3 -pyridazin-3-yl                                       2446   4-CN, 5-CH.sub.3 -pyridazin-3-yl                                       2447   6-CN, 4-CH.sub.3 -pyridazin-3-yl                                       2448   5-CN, 4-CH.sub.3 -pyridazin-3-yl                                       2449   4-CN, 6-OCH.sub.3 -pyridazin-3-yl                                      2450   4-CN, 5-OCH.sub.3 -pyridazin-3-yl                                      2451   6-CN, 4-OCH.sub.3 -pyridazin-3-yl                                      2452   5-CN, 4-OCH.sub.3 -pyridazin-3-yl                                      2453   4-CN, 6-OCH.sub.2 CH.sub.3 -pyridazin-3-yl                             2454   4-CN, 5-OCH.sub.2 CH.sub.3 -pyridazin-3-yl                             2455   6-CN, 4-OCH.sub.2 CH.sub.3 -pyridazin-3-yl                             2456   5-CN, 4-OCH.sub.2 CH.sub.3 -pyridazin-3-yl                             2457   4-CN, 6-OCH(CH.sub.3).sub.2 -pyridazin-3-yl                            2458   4-CN, 5-OCH(CH.sub.3).sub.2 -pyridazin-3-yl                            2459   6-CN, 4-OCH(CH.sub.3).sub.2 -pyridazin-3-yl                            2460   5-CN, 4-OCH(CH.sub.3).sub.2 -pyridazin-3-yl                            2461   4-CN, 6-OCH.sub.2 CF.sub.3 -pyridazin-3-yl                             2462   4-CN, 5-OCH.sub.2 CF.sub.3 -pyridazin-3-yl                             2463   6-CN, 4-OCH.sub.2 CF.sub.3 -pyridazin-3-yl                             2464   5-CN, 4-OCH.sub.2 CF.sub.3 -pyridazin-3-yl                             2465   5,6-(CH.sub.3).sub.2, 4-OCH.sub.3 -pyridazin-3-yl                      2466   3-CH.sub.3 -pyridazin-4-yl                                             2467   6-CH.sub.3 -pyridazin-4-yl                                             2468   3-CH.sub.2 CH.sub.3 -pyridazin-4-yl                                    2469   6-CH.sub.2 CH.sub.3 -pyridazin-4-yl                                    2470   3-CH(CH.sub.3).sub.2 -pyridazin-4-yl                                   2471   6-CH(CH.sub.3).sub.2 -pyridazin-4-yl                                   2472   3-CH(CH.sub.3)CH.sub.2 CH.sub.3 -pyridazin-4-yl                        2473   6-CH(CH.sub.3)CH.sub.2 CH.sub.3 -pyridazin-4-yl                        2474   3-CF.sub.3 -pyridazin-4-yl                                             2475   6-CF.sub.3 -pyridazin-4-yl                                             2476   3-CH═CH.sub.2 -pyridazin-4-yl                                      2477   6-CH═CH.sub.2 -pyridazin-4-yl                                      2478   3-CH═CHCH.sub.3 -pyridazin-4-yl                                    2479   6-CH═CHCH.sub.3 -pyridazin-4-yl                                    2480   3-CH═CHCl-pyridazin-4-yl                                           2481   6-CH═CHCl-pyridazin-4-yl                                           2482   3-C.tbd.CH-pyridazin-4-yl                                              2483   6-C.tbd.CH-pyridazin-4-yl                                              2484   3-CH.sub.2 C.tbd.CH-pyridazin-4-yl                                     2485   6-CH.sub.2 C.tbd.CH-pyridazin-4-yl                                     2486   3-CH.sub.2 C.tbd.CCH.sub.3 -pyridazin-4-yl                             2487   6-CH.sub.2 C.tbd.CCH.sub.3 -pyridazin-4-yl                             2488   3-cyclopropyl-pyridazin-4-yl                                           2489   6-cyclopropyl-pyridazin-4-yl                                           2490   3-cyclopentyl-pyridazin-4-yl                                           2491   6-cyclopentyl-pyridazin-4-yl                                           2492   3-OCH.sub.3 -pyridazin-4-yl                                            2493   6-OCH.sub.3 -pyridazin-4-yl                                            2494   3-OCH.sub.2 CH.sub.3 -pyridazin-4-yl                                   2495   6-OCH.sub.2 CH.sub.3 -pyridazin-4-yl                                   2496   3-OCH.sub.2 CH.sub.2 CH.sub.3 -pyridazin-4-yl                          2497   6-OCH.sub.2 CH.sub.2 CH.sub.3 -pyridazin-4-yl                          2498   3-OCH(CH.sub.3).sub.2 -pyridazin-4-yl                                  2499   6-OCH(CH.sub.3).sub.2 -pyridazin-4-yl                                  2500   3-OCH.sub.2 CH.sub.2 CH.sub.2 CH.sub.3 -pyridazin-4-yl                 2501   6-OCH.sub.2 CH.sub.2 CH.sub.2 CH.sub.3 -pyridazin-4-yl                 2502   3-OCH(CH.sub.3)CH.sub.2 CH.sub.3 -pyridazin-4-yl                       2503   6-OCH(CH.sub.3)CH.sub.2 CH.sub.3 -pyridazin-4-yl                       2504   3-OCH.sub.2 CH(CH.sub.3).sub.2 -pyridazin-4-yl                         2505   6-OCH.sub.2 CH(CH.sub.3).sub.2 -pyridazin-4-yl                         2506   3-OC(CH.sub.3).sub.3 -pyridazin-4-yl                                   2507   6-OC(CH.sub.3).sub.3 -pyridazin-4-yl                                   2508   3-OCH(CH.sub.3)CH.sub.2 CH.sub.2 CH.sub.3 -pyridazin-4-yl              2509   6-OCH(CH.sub.3)CH.sub.2 CH.sub.2 CH.sub.3 -pyridazin-4-yl              2510   3-OCH.sub.2 OCH.sub.3 -pyridazin-4-yl                                  2511   6-OCH.sub.2 OCH.sub.3 -pyridazin-4-yl                                  2512   3-OCH.sub.2 OCH.sub.2 CH.sub.3 -pyridazin-4-yl                         2513   6-OCH.sub.2 OCH.sub.2 CH.sub.3 -pyridazin-4-yl                         2514   3-OCH(CH.sub.3)OCH.sub.3 -pyridazin-4-yl                               2515   6-OCH(CH.sub.3)OCH.sub.3 -pyridazin-4-yl                               2516   3-OCH(CH.sub.3)OCH.sub.2 CH.sub.3 -pyridazin-4-yl                      2517   6-OCH(CH.sub.3)OCH.sub.2 CH.sub.3 -pyridazin-4-yl                      2518   3-OCH.sub.2 CH.sub.2 OCH.sub.3 -pyridazin-4-yl                         2519   6-OCH.sub.2 CH.sub.2 OCH.sub.3 -pyridazin-4-yl                         2520   3-OCH.sub.2 CH.sub.2 OCH.sub.2 CH.sub.3 -pyridazin-4-yl                2521   6-OCH.sub.2 CH.sub.2 OCH.sub.2 CH.sub.3 -pyridazin-4-yl                2522   3-OCH.sub.2 CH.sub.2 OCH(CH.sub.3).sub.2 -pyridazin-4-yl               2523   6-OCH.sub.2 CH.sub.2 OCH(CH.sub.3).sub.2 -pyridazin-4-yl               2524   3-OCH.sub.2 CH.sub.2 SCH.sub.3 -pyridazin-4-yl                         2525   6-OCH.sub.2 CH.sub.2 SCH.sub.3 -pyridazin-4-yl                         2526   3-OCH.sub.2 CH.sub.2 SO.sub.2 CH.sub.3 -pyridazin-4-yl                 2527   6-OCH.sub.2 CH.sub.2 SO.sub.2 CH.sub.3 -pyridazin-4-yl                 2528   3-OCH.sub.2 CH.sub.2 SCH(CH.sub.3).sub.2 -pyridazin-4-yl               2529   6-OCH.sub.2 CH.sub.2 SCH(CH.sub.3).sub.2 -pyridazin-4-yl               2530   3-OCH.sub.2 CH.sub.2 CN-pyridazin-4-yl                                 2531   6-OCH.sub.2 CH.sub.2 CN-pyridazin-4-yl                                 2532   3-OCH.sub.2 CH.sub.2 SCH.sub.2 CH.sub.2 CN-pyridazin-4-yl              2533   6-OCH.sub.2 CH.sub.2 SCH.sub.2 CH.sub.2 CN-pyridazin-4-yl              2534   3-OCH.sub.2 CH.sub.2 OC.sub.5 H.sub.6 -pyridazin-4-yl                  2535   6-OCH.sub.2 CH.sub.2 OC.sub.5 H.sub.6 -pyridazin-4-yl                  2536   3-OCH.sub.2 CH.sub.2 OCH.sub.2 C.sub.5 H.sub.6 -pyridazin-4-yl         2537   6-OCH.sub.2 CH.sub.2 OCH.sub.2 C.sub.5 H.sub.6 -pyridazin-4-yl         2538   3-OCH.sub.2 CH.sub.2 N(CH.sub.3).sub.2 -pyridazin-4-yl                 2539   6-OCH.sub.2 CH.sub.2 N(CH.sub.3).sub.2 -pyridazin-4-yl                 2540   3-OCH.sub.2 CH.sub.2 CONH.sub.2 -pyridazin-4-yl                        2541   6-OCH.sub.2 CH.sub.2 CONH.sub.2 -pyridazin-4-yl                        2542   3-OCH.sub.2 CH.sub.2 CO.sub.2 CH.sub.2 CH.sub.2 CH.sub.3 -pyridazin           -4-yl                                                                  2543   6-OCH.sub.2 CH.sub.2 CO.sub.2 CH.sub.2 CH.sub.2 CH.sub.3 -pyridazin           -4-yl                                                                  2544   3-OCH(CH.sub.3)CH.sub.2 OCH.sub.3 -pyridazin-4-yl                      2545   6-OCH(CH.sub.3)CH.sub.2 OCH.sub.3 -pyridazin-4-yl                      2546   3-OCH(CH.sub.3)CH.sub.2 CO.sub.2 CH.sub.3 -pyridazin-4-yl              2547   6-OCH(CH.sub.3)CH.sub.2 CO.sub.2 CH.sub.3 -pyridazin-4-yl              2548   3-OCH(CH.sub.3)CH.sub.2 CO.sub.2 CH.sub.2 CH.sub.3 -pyridazin-4-yl     2549   6-OCH(CH.sub.3)CH.sub.2 CO.sub.2 CH.sub.2 CH.sub.3 -pyridazin-4-yl     2550   3-OCH.sub.2 CH(CH.sub.3)CO.sub.2 CH.sub.3 -pyridazin-4-yl              2551   6-OCH.sub.2 CH(CH.sub.3)CO.sub.2 CH.sub.3 -pyridazin-4-yl              2552   3-OCH.sub.2 C(═O)CH.sub.3 -pyridazin-4-yl                          2553   6-OCH.sub.2 C(═O)CH.sub.3 -pyridazin-4-yl                          2554   3-OCH.sub.2 C(═O)CH.sub.2 CH.sub.3 -pyridazin-4-yl                 2555   6-OCH.sub.2 C(═O)CH.sub.2 CH.sub.3 -pyridazin-4-yl                 2556   3-OCH.sub.2 CO.sub.2 CH.sub.3 -pyridazin-4-yl                          2557   6-OCH.sub.2 CO.sub.2 CH.sub.3 -pyridazin-4-yl                          2558   3-OCH.sub.2 CO.sub.2 CH.sub.2 CH.sub.3 -pyridazin-4-yl                 2559   6-OCH.sub.2 CO.sub.2 CH.sub.2 CH.sub.3 -pyridazin-4-yl                 2560   3-OCH.sub.2 C(═O)NH.sub.2 -pyridazin-4-yl                          2561   6-OCH.sub.2 C(═O)NH.sub.2 -pyridazin-4-yl                          2562   3-OCH.sub.2 C(═O)NHCH.sub.3 -pyridazin-4-yl                        2563   6-OCH.sub.2 C(═O)NHCH.sub.3 -pyridazin-4-yl                        2564   3-OCH.sub.2 C(═O)SCH.sub.3 -pyridazin-4-yl                         2565   6-OCH.sub.2 C(═O)SCH.sub.3 -pyridazin-4-yl                         2566   3-OCH(CH.sub.3)C(═O)NH.sub.2 -pyridazin-4-yl                       2567   6-OCH(CH.sub.3)C(═O)NH.sub.2 -pyridazin-4-yl                       2568   3-OCH(CH.sub.3)C(═O)NHCH.sub.3 -pyridazin-4-yl                     2569   6-OCH(CH.sub.3)C(═O)NHCH.sub.3 -pyridazin-4-yl                     2570   3-OCH(CH.sub.3)C(═O)NHNH.sub.2 -pyridazin-4-yl                     2571   6-OCH(CH.sub.3)C(═O)NHNH.sub.2 -pyridazin-4-yl                     2572   3-OCH(CH.sub.3)CO.sub.2 CH.sub.3 -pyridazin-4-yl                       2573   6-OCH(CH.sub.3)CO.sub.2 CH.sub.3 -pyridazin-4-yl                       2574   3-OCH(CH.sub.3)CO.sub.2 CH.sub.2 CH.sub.3 -pyridazin-4-yl              2575   6-OCH(CH.sub.3)CO.sub.2 CH.sub.2 CH.sub.3 -pyridazin-4-yl              2576   3-OCH(CH.sub.3)C(═O)CH.sub.3 -pyridazin-4-yl                       2577   6-OCH(CH.sub.3)C(═O)CH.sub.3 -pyridazin-4-yl                       2578   3-OCH(CH.sub.3)C(═O)CH.sub.2 CH.sub.3 -pyridazin-4-yl              2579   6-OCH(CH.sub.3)C(═O)CH.sub.2 CH.sub.3 -pyridazin-4-yl              2580   3-OCH(CH.sub.3)CH.sub.2 C(═O)CH.sub.3 -pyridazin-4-yl              2581   6-OCH(CH.sub.3)CH.sub.2 C(═O)CH.sub.3 -pyridazin-4-yl              2582   3-OCH(CH.sub.3)CH.sub.2 OC(CH.sub.3).sub.3 -pyridazin-4-yl             2583   6-OCH(CH.sub.3)CH.sub.2 OC(CH.sub.3).sub.3 -pyridazin-4-yl             2584   3-OCH(CH.sub.3)CH.sub.2 OCH.sub.2 CH.sub.3 -pyridazin-4-yl             2585   6-OCH(CH.sub.3)CH.sub.2 OCH.sub.2 CH.sub.3 -pyridazin-4-yl             2586   3-OCH(CH.sub.3)CH.sub.2 O(CH.sub.3).sub.2 CH.sub.3 -pyridazin-4-yl     2587   6-OCH(CH.sub.3)CH.sub.2 O(CH.sub.3).sub.2 CH.sub.3 -pyridazin-4-yl     2588   3-OCH(CH.sub.3)CH.sub.2 OCH.sub.2 CH═CH.sub.2 -pyridazin-4-yl      2589   6-OCH(CH.sub.3)CH.sub.2 OCH.sub.2 CH═CH.sub.2 -pyridazin-4-yl      2590   3-O(CH.sub.2).sub.3 OCH.sub.3 -pyridazin-4-yl                          2591   6-O(CH.sub.2).sub.3 OCH.sub.3 -pyridazin-4-yl                          2592   3-O(CH.sub.2).sub.3 OCH.sub.2 CH.sub.3 -pyridazin-4-yl                 2593   6-O(CH.sub.2).sub.3 OCH.sub.2 CH.sub.3 -pyridazin-4-yl                 2594   3-O(CH.sub.2).sub.3 OCH(CH.sub.3).sub.2 -pyridazin-4-yl                2595   6-O(CH.sub.2).sub.3 OCH(CH.sub.3).sub.2 -pyridazin-4-yl                2596   3-O(CH.sub.2).sub.3 OC.sub.5 H.sub.6 -pyridazin-4-yl                   2597   6-O(CH.sub.2).sub.3 OC.sub.5 H.sub.6 -pyridazin-4-yl                   2598   3-O(CH.sub.2).sub.3 OCH.sub.2 C.sub.5 H.sub.6 -pyridazin-4-yl          2599   6-O(CH.sub.2).sub.3 OCH.sub.2 C.sub.5 H.sub.6 -pyridazin-4-yl          2600   3-OCH(CH.sub.2 CH.sub.3)CH.sub.2 OCH.sub.3 -pyridazin-4-yl             2601   6-OCH(CH.sub.2 CH.sub.3)CH.sub.2 OCH.sub.3 -pyridazin-4-yl             2602   3-OCH(CH.sub.2 CH.sub.3)CH.sub.2 CH.sub.2 OCH.sub.3 -pyridazin-4-yl           N                                                                      2603   6-OCH(CH.sub.2 CH.sub.3)CH.sub.2 CH.sub.2 OCH.sub.3 -pyridazin-4-yl           O                                                                      2604   3-OCH(CH.sub.2 CH.sub.3)CH.sub.2 CH.sub.2 OCH.sub.2 CH.sub.3                  -pyridazin-4-yl                                                        2605   6-OCH(CH.sub.2 CH.sub.3)CH.sub.2 CH.sub.2 OCH.sub.2 CH.sub.3                  -pyridazin-4-yl                                                        2606   3-O (CH.sub.2).sub.3 O!.sub.2 CH.sub.3 -pyridazin-4-yl                 2607   6-O (CH.sub.2).sub.3 O!.sub.2 CH.sub.3 -pyridazin-4-yl                 2608   3-OCH.sub.2 CH(CH.sub.3)CH.sub.2 OCH.sub.3 -pyridazin-4-yl             2609   6-OCH.sub.2 CH(CH.sub.3)CH.sub.2 OCH.sub.3 -pyridazin-4-yl             2610   3-OCH.sub.2 CH(CH.sub.3)CH.sub.2 OCH.sub.2 CH.sub.3 -pyridazin-4-yl    2611   6-OCH.sub.2 CH(CH.sub.3)CH.sub.2 OCH.sub.2 CH.sub.3 -pyridazin-4-yl           M                                                                      2612   3-OCH(CH.sub.2 Cl)CH.sub.2 OCH.sub.3 -pyridazin-4-yl                   2613   6-OCH(CH.sub.2 Cl)CH.sub.2 OCH.sub.3 -pyridazin-4-yl                   2614   3-OCH(CH.sub.2 Cl)CH.sub.2 OCH.sub.2 CH.sub.3 -pyridazin-4-yl          2615   6-OCH(CH.sub.2 Cl)CH.sub.2 OCH.sub.2 CH.sub.3 -pyridazin-4-yl          2616   3-OCH(CH.sub.2 Cl)CH.sub.2 OCH(CH.sub.3).sub.2 -pyridazin-4-yl         2617   6-OCH(CH.sub.2 Cl)CH.sub.2 OCH(CH.sub.3).sub.2 -pyridazin-4-yl         2618   3-OCH(CH.sub.2 Cl)CH.sub.2 OCH.sub.2 CH═CH.sub.2 -pyridazin-4-y           l                                                                      2619   6-OCH(CH.sub.2 Cl)CH.sub.2 OCH.sub.2 CH═CH.sub.2 -pyridazin-4-y           l                                                                      2620   3-OCH CH.sub.2 OCH.sub.3 !.sub.2 -pyridazin-4-yl                       2621   6-OCH CH.sub.2 OCH.sub.3 !.sub.2 -pyridazin-4-yl                       2622   3-OCH CH.sub.2 OCH.sub.2 CH.sub.3 !.sub.2 -pyridazin-4-yl              2623   6-OCH CH.sub.2 OCH.sub.2 CH.sub.3 !.sub.2 -pyridazin-4-yl              2624   3-OCCl.sub.3 -pyridazin-4-yl                                           2625   6-OCCl.sub.3 -pyridazin-4-yl                                           2626   3-OCHF.sub.2 -pyridazin-4-yl                                           2627   6-OCHF.sub.2 -pyridazin-4-yl                                           2628   3-OCF.sub.3 -pyridazin-4-yl                                            2629   6-OCF.sub.3 -pyridazin-4-yl                                            2630   3-OCF.sub.2 CHF.sub.2 -pyridazin-4-yl                                  2631   6-OCF.sub.2 CHF.sub.2 -pyridazin-4-yl                                  2632   3-OCH.sub.2 CF.sub.3 -pyridazin-4-yl                                   2633   6-OCH.sub.2 CF.sub.3 -pyridazin-4-yl                                   2634   3-OCH.sub.2 CHF.sub.2 -pyridazin-4-yl                                  2635   6-OCH.sub.2 CHF.sub.2 -pyridazin-4-yl                                  2636   3-O(CH.sub.2).sub.3 F-pyridazin-4-yl                                   2637   6-O(CH.sub.2).sub.3 F-pyridazin-4-yl                                   2638   3-OCH(CH.sub.3)CF.sub.3 -pyridazin-4-yl                                2639   6-OCH(CH.sub.3)CF.sub.3 -pyridazin-4-yl                                2640   3-O(CH.sub.2).sub.4 F-pyridazin-4-yl                                   2641   6-O(CH.sub.2).sub.4 F-pyridazin-4-yl                                   2642   3-O(CH.sub.2).sub.3 CF.sub.3 -pyridazin-4-yl                           2643   6-O(CH.sub.2).sub.3 CF.sub.3 -pyridazin-4-yl                           2644   3-OCH(CH.sub.3)CF.sub.2 CF.sub.3 -pyridazin-4-yl                       2645   6-OCH(CH.sub.3)CF.sub.2 CF.sub.3 -pyridazin-4-yl                       2646   3-OCH(CH.sub.3)CF.sub.2 CHF.sub.2 -pyridazin-4-yl                      2647   6-OCH(CH.sub.3)CF.sub.2 CHF.sub.2 -pyridazin-4-yl                      2648   3-OCH.sub.2 CF.sub.2 CHFCH.sub.3 -pyridazin-4-yl                       2649   6-OCH.sub.2 CF.sub.2 CHFCH.sub.3 -pyridazin-4-yl                       2650   3-OCH.sub.2 (CF.sub.2).sub.2 CF.sub.3 -pyridazin-4-yl                  2651   6-OCH.sub.2 (CF.sub.2).sub.2 CF.sub.3 -pyridazin-4-yl                  2652   3-O(CF.sub.2).sub.3 CF.sub.3 -pyridazin-4-yl                           2653   6-O(CF.sub.2).sub.3 CF.sub.3 -pyridazin-4-yl                           2654   3-OCH.sub.2 CF.sub.2 CHF.sub.2 -pyridazin-4-yl                         2655   6-OCH.sub.2 CF.sub.2 CHF.sub.2 -pyridazin-4-yl                         2656   3-CH.sub.2 CH═CH.sub.2 -pyridazin-4-yl                             2657   6-CH.sub.2 CH═CH.sub.2 -pyridazin-4-yl                             2658   3-CH.sub.2 C(CH.sub.3)═CH.sub.2 -pyridazin-4-yl                    2659   6-CH.sub.2 C(CH.sub.3)═CH.sub.2 -pyridazin-4-yl                    2660   3-OCH.sub.2 CH═CHCH.sub.3 -pyridazin-4-yl                          2661   6-OCH.sub.2 CH═CHCH.sub.3 -pyridazin-4-yl                          2662   3-O(CH.sub.2).sub.2 CH═CH.sub.2 -pyridazin-4-yl                    2663   6-O(CH.sub.2).sub.2 CH═CH.sub.2 -pyridazin-4-yl                    2664   3-OCH.sub.2 C(CH.sub.3)═CH.sub.2 -pyridazin-4-yl                   2665   6-OCH.sub.2 C(CH.sub.3)═CH.sub.2 -pyridazin-4-yl                   2666   3-OCH(CH.sub.3)CH═CH.sub.2 -pyridazin-4-yl                         2667   6-OCH(CH.sub.3)CH═CH.sub.2 -pyridazin-4-yl                         2668   3-OCH.sub.2 C.tbd.CH-pyridazin-4-yl                                    2669   6-OCH.sub.2 C.tbd.CH-pyridazin-4-yl                                    2670   3-OCH.sub.2 C.tbd.CCH.sub.3 -pyridazin-4-yl                            2671   6-OCH.sub.2 C.tbd.CCH.sub.3 -pyridazin-4-yl                            2672   3-O(CH.sub.2).sub.2 C.tbd.CH-pyridazin-4-yl                            2673   6-O(CH.sub.2).sub.2 C.tbd.CH-pyridazin-4-yl                            2674   3-SCH.sub.3 -pyridazin-4-yl                                            2675   6-SCH.sub.3 -pyridazin-4-yl                                            2676   3-SCH.sub.2 CH.sub.3 -pyridazin-4-yl                                   2677   6-SCH.sub.2 CH.sub.3 -pyridazin-4-yl                                   2678   3-OC.sub.5 H.sub.6 -pyridazin-4-yl                                     2679   6-OC.sub.5 H.sub.6 -pyridazin-4-yl                                     2680   3-OCH.sub.2 C.sub.5 H.sub.6 -pyridazin-4-yl                            2681   6-OCH.sub.2 C.sub.5 H.sub.6 -pyridazin-4-yl                            2682   3-NO.sub.2 -pyridazin-4-yl                                             2683   6-NO.sub.2 -pyridazin-4-yl                                             2684   3-NHCH.sub.3 -pyridazin-4-yl                                           2685   6-NHCH.sub.3 -pyridazin-4-yl                                           2686   3-N(CH.sub.3).sub.2 -pyridazin-4-yl                                    2687   6-N(CH.sub.3).sub.2 -pyridazin-4-yl                                    2688   3-N(CH.sub.3)C.sub.2 H.sub.6 -pyridazin-4-yl                           2689   6-N(CH.sub.3)C.sub.2 H.sub.6 -pyridazin-4-yl                           2690   3-NHCH.sub.2 CF.sub.3 -pyridazin-4-yl                                  2691   6-NHCH.sub.2 CF.sub.3 -pyridazin-4-yl                                  2692   3-F-pyridazin-4-yl                                                     2693   6-F-pyridazin-4-yl                                                     2694   3-Cl-pyridazin-4-yl                                                    2695   6-Cl-pyridazin-4-yl                                                    2696   3-OH-pyridazin-4-yl                                                    2697   6-OH-pyridazin-4-yl                                                    2698   3-CN-pyridazin-4-yl                                                    2699   6-CN-pyridazin-4-yl                                                    2700   3-C(O)NH.sub.2 -pyridazin-4-yl                                         2701   6-C(O)NH.sub.2 -pyridazin-4-yl                                         2702   3-C(S)NH.sub.2 -pyridazin-4-yl                                         2703   6-C(S)NH.sub.2 -pyridazin-4-yl                                         2704   3-CO.sub.2 CH.sub.3 -pyridazin-4-yl                                    2705   6-CO.sub.2 CH.sub.3 -pyridazin-4-yl                                    2706   3-ON═C(CH.sub.3).sub.2 -pyridazin-4-yl                             2707   6-ON═C(CH.sub.3).sub.2 -pyridazin-4-yl                             2708   3- O-cyclopropyl!pyridazin-4-yl                                        2709   6- O-cyclopropyl!pyridazin-4-yl                                        2710   3- O-cyclobutyl!pyridazin-4-yl                                         2711   6- O-cyclobutyl!pyridazin-4-yl                                         2712   3- O-cyclopentyl!pyridazin-4-yl                                        2713   6- O-cyclopentyl!pyridazin-4-yl                                        2714   3- O-cyclohexyl!pyridazin-4-yl                                         2715   6- O-cyclohexyl!pyridazin-4-yl                                         2716   3- OCH.sub.2 -cyclopropyl!pyridazin-4-yl                               2717   6- OCH.sub.2 -cyclopropyl!pyridazin-4-yl                               2718   6-F, 3- OCH.sub.2 -cyclopropyl!pyridazin-4-yl                          2719   3-F, 6- OCH.sub.2 -cyclopropyl!pyridazin-4-yl                          2720   6-CH.sub.3, 3- OCH.sub.2 -cyclopropyl!pyridazin-4-yl                   2721   3-CH.sub.3, 6- OCH.sub.2 -cyclopropyl!pyridazin-4-yl                   2722   6-CF.sub.3, 3- OCH.sub.2 -cyclopropyl!pyridazin-4-yl                   2723   3-CF.sub.3, 6- OCH.sub.2 -cyclopropyl!pyridazin-4-yl                   2724   3- OCH(CH.sub.3)-cyclopropyl!pyridazin-4-yl                            2725   6- OCH(CH.sub.3)-cyclopropyl!pyridazin-4-yl                            2726   6-F, 3- OCH(CH.sub.3)cyclopropyl!pyridazin-4-yl                        2727   3-F, 6- OCH(CH.sub.3)cyclopropyl!pyridazin-4-yl                        2728   6-CH.sub.3, 3- OCH(CH.sub.3)cyclopropyl!pyridazin-4-yl                 2729   3-CH.sub.3, 6- OCH(CH.sub.3)cyclopropyl!pyridazin-4-yl                 2730   4-CF.sub.3, 3- OCH(CH.sub.3)cyclopropyl!pyridazin-4-yl                 2731   3-CF.sub.3, 6- OCH(CH.sub.3)cyclopropyl!pyridazin-4-yl                 2732   3- O-(1-CH.sub.3 -cyclopropyl)!pyridazin-4-yl                          2733   6- O-(1-CH.sub.3 -cyclopropyl)!pyridazin-4-yl                          2734   6-F, 3- O-(1-CH.sub.3 -cyclopropyl)!pyridazin-4-yl                     2735   3-F, 6- O-(1-CH.sub.3 -cyclopropyl)!pyridazin-4-yl                     2736   6-CH.sub.3, 3- O-(1-CH.sub.3 -cyclopropyl)!pyridazin-4-yl              2737   3-CH.sub.3, 6- O-(1-CH.sub.3 -cyclopropyl)!pyridazin-4-yl              2738   6-CF.sub.3, 3- O-(1-CH.sub.3 -cyclopropyl)!pyridazin-4-yl              2739   3-CF.sub.3, 6- O-(1-CH.sub.3 -cyclopropyl)!pyridazin-4-yl              2740   3- OCH.sub.2 -(1-CH.sub.3 -cyclopropyl)!pyridazin-4-yl                 2741   6- OCH.sub.2 -(1-CH.sub.3 -cyclopropyl)!pyridazin-4-yl                 2742   6-F, 3- OCH.sub.2 -(1-CH.sub.3 -cyclopropyl)!pyridazin-4-yl            2743   3-F, 6- OCH.sub.2 -(1-CH.sub.3 -cyclopropyl)!pyridazin-4-yl            2744   6-CH.sub.3, 3- OCH.sub.2 -(1-CH.sub.3 -cyclopropyl)!pyridazin-4-yl            N                                                                      2745   3-CH.sub.3, 6- OCH.sub.2 -(1-CH.sub.3 -cyclopropyl)!pyridazin-4-yl            O                                                                      2746   6-CF.sub.3, 3- OCH.sub.2 -(1-CH.sub.3 -cyclopropyl)!pyridazin-4-yl            3                                                                      2747   3-CF.sub.3, 6- OCH.sub.2 -(1-CH.sub.3 -cyclopropyl)!pyridazin-4-yl            0                                                                      2748   3- OCH.sub.2 -(2-CH.sub.3 -cyclopropyl)!pyridazin-4-yl                 2749   6- OCH.sub.2 -(2-CH.sub.3 -cyclopropyl)!pyridazin-4-yl                 2750   6-F, 3- OCH.sub.2 -(2-CH.sub.3 -cyclopropyl)!pyridazin-4-yl            2751   3-F, 6- OCH.sub.2 -(2-CH.sub.3 -cyclopropyl)!pyridazin-4-yl            2752   6-CH.sub.3, 3- OCH.sub.2 -(2-CH.sub.3 -cyclopropyl)!pyridazin-4-yl            ,                                                                      2753   3-CH.sub.3, 6- OCH.sub.2 -(2-CH.sub.3 -cyclopropyl)!pyridazin-4-yl            1                                                                      2754   6-CF.sub.3, 3- OCH.sub.2 -(2-CH.sub.3 -cyclopropyl)!pyridazin-4-yl            9                                                                      2755   3-CF.sub.3, 6- OCH.sub.2 -(2-CH.sub.3 -cyclopropyl)!pyridazin-4-yl            9                                                                      2756   3- OCH.sub.2 -(tetrahydropyran-2-yl)!pyridazin-4-yl                    2757   6- OCH.sub.2 -(tetrahydropyran-2-yl)!pyridazin-4-yl                    2758   6-F, 3- OCH.sub.2 -(tetrahydropyran-2-yl)!pyridazin-4-yl               2759   3-F, 6- OCH.sub.2 -(tetrahydropyran-2-yl)!pyridazin-4-yl               2760   6-CH.sub.3, 3- OCH.sub.2 -(tetrahydropyran-2-yl)!pyridazin-4-yl        2761   3-CH.sub.3, 6- OCH.sub.2 -(tetrahydropyran-2-yl)!pyridazin-4-yl        2762   6-CF.sub.3, 3- OCH.sub.2 -(tetrahydropyran-2-yl)!pyridazin-4-yl        2763   3-CF.sub.3, 6- OCH.sub.2 -(tetrahydropyran-2-yl)!pyridazin-4-yl        2764   3- OCH.sub.2 -(furan-2-yl)!pyridazin-4-yl                              2765   6- OCH.sub.2 -(furan-2-yl)!pyridazin-4-yl                              2766   6-F, 3- OCH.sub.2 -(furan-2-yl)!pyridazin-4-yl                         2767   3-F, 6- OCH.sub.2 -(furan-2-yl)!pyridazin-4-yl                         2768   6-CH.sub.3, 3- OCH.sub.2 -(furan-2-yl)!pyridazin-4-yl                  2769   3-CH.sub.3, 6- OCH.sub.2 -(furan-2-yl)!pyridazin-4-yl                  2770   6-CF.sub.3, 3- OCH.sub.2 -(furan-2-yl)!pyridazin-4-yl                  2771   3-CF.sub.3, 6- OCH.sub.2 -(furan-2-yl)!pyridazin-4-yl                  2772   3- OCH.sub.2 -(furan-3-yl)!pyridazin-4-yl                              2773   6- OCH.sub.2 -(furan-3-yl)!pyridazin-4-yl                              2774   6-F, 3- OCH.sub.2 -(furan-3-yl)!pyridazin-4-yl                         2775   3-F, 3- OCH.sub.2 -(furan-3-yl)!pyridazin-4-yl                         2776   6-CH.sub.3, 3- OCH.sub.2 -(furan-3-yl)!pyridazin-4-yl                  2777   3-CH.sub.3, 6- OCH.sub.2 -(furan-3-yl)!pyridazin-4-yl                  2778   6-CF.sub.3, 3- OCH.sub.2 -(furan-3-yl)!pyridazin-4-yl                  2779   3-CF.sub.3, 6- OCH.sub.2 -(furan-3-yl)!pyridazin-4-yl                  2780   3- OCH.sub.2 -(tetrahydrofuran-3-yl)!pyridazin-4-yl                    2781   6- OCH.sub.2 -(tetrahydrofuran-3-yl)!pyridazin-4-yl                    2782   6-F, 3- OCH.sub.2 -(tetrahydrofuran-3-yl)!pyridazin-4-yl               2783   3-F, 6- OCH.sub.2 -(tetrahydrofuran-3-yl)!pyridazin-4-yl               2784   6-CH.sub.3, 3- OCH.sub.2 -(tetrahydrofuran-3-yl)!pyridazin-4-yl        2785   3-CH.sub.3, 6- OCH.sub.2 -(tetrahydrofuran-3-yl)!pyridazin-4-yl        2786   6-CF.sub.3, 3- OCH.sub.2 -(tetrahydrofuran-3-yl)!pyridazin-4-yl        2787   3-CF.sub.3, 6- OCH.sub.2 -(tetrahydrofuran-3-yl)!pyridazin-4-yl        2788   3- OCH.sub.2 -(tetrahydrofuran-2-yl)!pyridazin-4-yl                    2789   6- OCH.sub.2 -(tetrahydrofuran-2-yl)!pyridazin-4-yl                    2790   6-F, 3- OCH.sub.2 -(tetrahydrofuran-2-yl)!pyridazin-4-yl               2791   3-F, 6- OCH.sub.2 -(tetrahydrofuran-2-yl)!pyridazin-4-yl               2792   6-CH.sub.3, 3- OCH.sub.2 -(tetrahydrofuran-2-yl)!pyridazin-4-yl        2793   3-CH.sub.3, 6- OCH.sub.2 -(tetrahydrofuran-2-yl)!pyridazin-4-yl        2794   6-CF.sub.3, 3- OCH.sub.2 -(tetrahydrofuran-2-yl)!pyridazin-4-yl        2795   3-CF.sub.3, 6- OCH.sub.2 -(tetrahydrofuran-2-yl)!pyridazin-4-yl        2796   3- O-(tetrahydropyran-3-yl)!pyridazin-4-yl                             2797   6- O-(tetrahydropyran-3-yl)!pyridazin-4-yl                             2798   6-F, 3- O-(tetrahydropyran-3-yl)!pyridazin-4-yl                        2799   3-F, 6- O-(tetrahydropyran-3-yl)!pyridazin-4-yl                        2800   6-CH.sub.3, 3- O-(tetrahydropyran-3-yl)!pyridazin-4-yl                 2801   3-CH.sub.3, 6- O-(tetrahydropyran-3-yl)!pyridazin-4-yl                 2802   6-CF.sub.3, 3- O-(tetrahydropyran-3-yl)!pyridazin-4-yl                 2803   3-CF.sub.3, 6- O-(tetrahydropyran-3-yl)!pyridazin-4-yl                 2804   3- 2-Cl--C.sub.5 H.sub.4 !pyridazin-4-yl                               2805   6- 2-Cl--C.sub.5 H.sub.4 !pyridazin-4-yl                               2806   6-F, 3- 2-Cl--C.sub.5 H.sub.4 !pyridazin-4-yl                          2807   3-F, 6- 2-Cl--C.sub.5 H.sub.4 !pyridazin-4-yl                          2808   6-CH.sub.3, 3- 2-Cl--C.sub.5 H.sub.4 !pyridazin-4-yl                   2809   3-CH.sub.3, 6- 2-Cl--C.sub.5 H.sub.4 !pyridazin-4-yl                   2810   6-CF.sub.3, 3- 2-Cl--C.sub.5 H.sub.4 !pyridazin-4-yl                   2811   3-CF.sub.3, 6- 2-Cl--C.sub.5 H.sub.4 !pyridazin-4-yl                   2812   3- OCH.sub.2 -(pyridin-2-yl)!pyridazin-4-yl                            2813   6- OCH.sub.2 -(pyridin-2-yl)!pyridazin-4-yl                            2814   6-F, 3- OCH.sub.2 -(pyridin-2-yl)!pyridazin-4-yl                       2815   3-F, 6- OCH.sub.2 -(pyridin-2-yl)!pyridazin-4-yl                       2816   6-CH.sub.3, 3- OCH.sub.2 -(pyridin-2-yl)!pyridazin-4-yl                2817   3-CH.sub.3, 6- OCH.sub.2 -(pyridin-2-yl)!pyridazin-4-yl                2818   6-CF.sub.3, 3- OCH.sub.2 -(pyridin-2-yl)!pyridazin-4-yl                2819   3-CH.sub.3, 6- OCH.sub.2 -(pyridin-2-yl)!pyridazin-4-yl                2820   3- OCH.sub.2 -(pyridin-4-yl)!pyridazin-4-yl                            2821   6- OCH.sub.2 -(pyridin-4-yl)!pyridazin-4-yl                            2822   6-F, 3- OCH.sub.2 -(pyridin-4-yl)!pyridazin-4-yl                       2823   3-F, 6- OCH.sub.2 -(pyridin-4-yl)!pyridazin-4-yl                       2824   6-CH.sub.3, 3- OCH.sub.2 -(pyridin-4-yl)!pyridazin-4-yl                2825   3-CH.sub.3, 6- OCH.sub.2 -(pyridin-4-yl)!pyridazin-4-yl                2826   6-CF.sub.3, 3- OCH.sub.2 -(pyridin-4-yl)!pyridazin-4-yl                2827   3-CF.sub.3, 6- OCH.sub.2 -(pyridin-4-yl)!pyridazin-4-yl                2828   3- morpholin-4-yl!pyridazin-4-yl                                       2829   6- morpholin-4-yl!pyridazin-4-yl                                       2830   3- 1-CH.sub.3 -imidazol-2-yl!pyridazin-4-yl                            2831   6- 1-CH.sub.3 -imidazol-2-yl!pyridazin-4-yl                            2832   6-F, 3- 1-CH.sub.3 -imidazol-2-yl!pyridazin-4-yl                       2833   3-F, 6- 1-CH.sub.3 -imidazol-2-yl!pyridazin-4-yl                       2834   6-CH.sub.3, 3- 1-CH.sub.3 -imidazol-2-yl!pyridazin-4-yl                2835   3-CH.sub.3, 6- 1-CH.sub.3 -imidazol-2-yl!pyridazin-4-yl                2836   6-CF.sub.3, 3- 1-CH.sub.3 -imidazol-2-yl!pyridazin-4-yl                2837   3-CF.sub.3, 6- 1-CH.sub.3 -imidazol-2-yl!pyridazin-4-yl                2838   3- 1,2,3-triazol-1-yl!pyridazin-4-yl                                   2839   6- 1,2,3-triazol-1-yl!pyridazin-4-yl                                   2840   6-F, 3- 1,2,3-triazol-1-yl!pyridazin-4-yl                              2841   3-F, 6- 1,2,3-triazol-1-yl!pyridazin-4-yl                              2842   6-CH.sub.3, 3- 1,2,3-triazol-1-yl!pyridazin-4-yl                       2843   3-CH.sub.3, 3- 1,2,3-triazol-1-yl!pyridazin-4-yl                       2844   6-CF.sub.3, 3- 1,2,3-triazol-1-yl!pyridazin-4-yl                       2845   3-CF.sub.3, 6- 1,2,3-triazol-1-yl!pyridazin-4-yl                       2846   3,6-Cl.sub.2 -pyridazin-4-yl                                           2847   3,5-Cl.sub.2 -pyridazin-4-yl                                           2848   3,6-(CH.sub.3).sub.2 -pyridazin-4-yl                                   2849   3,5-(CH.sub.3).sub.2 -pyridazin-4-yl                                   2850   3,6-(OCH.sub.3).sub.2 -pyridazin-4-yl                                  2851   3,5-(OCH.sub.3).sub.2 -pyridazin-4-yl                                  2852   3,6-(OCH.sub.2 CH.sub.3).sub.2 -pyridazin-4-yl                         2853   3,5-(OCH.sub.2 CH.sub.3).sub.2 -pyridazin-4-yl                         2854   3-F, 6-CH.sub.3 -pyridazin-4-yl                                        2855   3-F, 5-CH.sub.3 -pyridazin-4-yl                                        2856   6-F, 3-CH.sub.3 -pyridazin-4-yl                                        2857   5-F, 3-CH.sub.3 -pyridazin-4-yl                                        2858   3-F, 6-OCH.sub.3 -pyridazin-4-yl                                       2859   3-F, 5-OCH.sub.3 -pyridazin-4-yl                                       2860   6-F, 3-OCH.sub.3 -pyridazin-4-yl                                       2861   5-F, 3-OCH.sub.3 -pyridazin-4-yl                                       2862   3-F, 6-OCH.sub.2 CH.sub.3 -pyridazin-4-yl                              2863   3-F, 5-OCH.sub.2 CH.sub.3 -pyridazin-4-yl                              2864   6-F, 3-OCH.sub.2 CH.sub.3 -pyridazin-4-yl                              2865   5-F, 3-OCH.sub.2 CH.sub.3 -pyridazin-4-yl                              2866   3-F, 6-OCH.sub.2 CF.sub.3 -pyridazin-4-yl                              2867   3-F, 5-OCH.sub.2 CF.sub.3 -pyridazin-4-yl                              2868   6-F, 3-OCH.sub.2 CF.sub.3 -pyridazin-4-yl                              2869   5-F, 3-OCH.sub.2 CF.sub.3 -pyridazin-4-yl                              2870   3-F, 6-OCH(CH.sub.3).sub.2 -pyridazin-4-yl                             2871   3-F, 5-OCH(CH.sub.3).sub.2 -pyridazin-4-yl                             2872   6-F, 3-OCH(CH.sub.3).sub.2 -pyridazin-4-yl                             2873   5-F, 3-OCH(CH.sub.3).sub.2 -pyridazin-4-yl                             2874   3-Cl, 6-CH.sub.3 -pyridazin-4-yl                                       2875   3-Cl, 5-CH.sub.3 -pyridazin-4-yl                                       2876   6-Cl, 3-CH.sub.3 -pyridazin-4-yl                                       2877   5-Cl, 3-CH.sub.3 -pyridazin-4-yl                                       2878   3-Cl, 6-OCH.sub.3 -pyridazin-4-yl                                      2879   3-Cl, 5-OCH.sub.3 -pyridazin-4-yl                                      2880   6-Cl, 3-OCH.sub.3 -pyridazin-4-yl                                      2881   5-Cl, 3-OCH.sub.3 -pyridazin-4-yl                                      2882   3-Cl, 6-OCH.sub.2 CH.sub.3 -pyridazin-4-yl                             2883   3-Cl, 5-OCH.sub.2 CH.sub.3 -pyridazin-4-yl                             2884   6-Cl, 6-OCH.sub.3 CH.sub.3 -pyridazin-4-yl                             2885   5-Cl, 3-OCH.sub.2 CH.sub.3 -pyridazin-4-yl                             2886   3-Cl, 6-OCH.sub.2 CF.sub.3 -pyridazin-4-yl                             2887   3-Cl, 5-OCH.sub.2 CF.sub.3 -pyridazin-4-yl                             2888   6-Cl, 3-OCH.sub.2 CF.sub.3 -pyridazin-4-yl                             2889   5-Cl, 3-OCH.sub.2 CF.sub.3 -pyridazin-4-yl                             2890   3-Cl, 6-OCH(CH.sub.3).sub.2 -pyridazin-4-yl                            2891   3-Cl, 5-OCH(CH.sub.3).sub.2 -pyridazin-4-yl                            2892   6-Cl, 3-OCH(CH.sub.3).sub.2 -pyridazin-4-yl                            2893   5-Cl, 3-OCH(CH.sub.3).sub.2 -pyridazin-4-yl                            2894   3-CH.sub.3, 6-OCH.sub.3 -pyridazin-4-yl                                2895   3-CH.sub.3, 5-OCH.sub.3 -pyridazin-4-yl                                2896   6-CH.sub.3, 3-OCH.sub.3 -pyridazin-4-yl                                2897   5-CH.sub.3, 3-OCH.sub.3 -pyridazin-4-yl                                2898   5-CH.sub.3, 3-OCH.sub.2 CH.sub.3 -pyridazin-4-yl                       2899   6-CH.sub.3, 3-OCH.sub.2 CH.sub.3 -pyridazin-4-yl                       2900   3-CH.sub.3, 6-OCH.sub.2 CH.sub.3 -pyridazin-4-yl                       2901   3-CH.sub.3, 5-OCH.sub.2 CH.sub.3 -pyridazin-4-yl                       2902   3-CH.sub.3, 6-OCH.sub.2 CF.sub.3 -pyridazin-4-yl                       2903   3-CH.sub.3, 5-OCH.sub.2 CF.sub.3 -pyridazin-4-yl                       2904   6-CH.sub.3, 3-OCH.sub.2 CF.sub.3 -pyridazin-4-yl                       2905   5-CH.sub.3, 3-OCH.sub.2 CF.sub.3 -pyridazin-4-yl                       2906   3-CH.sub.3, 6-OCH(CH.sub.3).sub.2 -pyridazin-4-yl                      2907   3-CH.sub.3, 6-OCH(CH.sub.3).sub.2 -pyridazin-4-yl                      2908   6-CH.sub.3, 3-OCH(CH.sub.3).sub.2 -pyridazin-4-yl                      2909   5-CH.sub.3, 3-OCH(CH.sub.3).sub.2 -pyridazin-4-yl                      2910   3-CH.sub.3, 6-OCH.sub.2 CH═CH.sub.2 -pyridazin-4-yl                2911   3-CH.sub.3, 5-OCH(CH.sub.3).sub.2 -pyridazin-4-yl                      2912   6-CH.sub.3, 3-OCH(CH.sub.3).sub.2 -pyridazin-4-yl                      2913   5-CH.sub.3, 3-OCH(CH.sub.3).sub.2 -pyridazin-4-yl                      2914   3-CH.sub.3, 6-CO.sub.2 CH.sub.3 -pyridazin-4-yl                        2915   3-CH.sub.3, 5-CO.sub.2 CH.sub.3 -pyridazin-4-yl                        2916   3-CH.sub.3, 6-CF.sub.3 -pyridazin-4-yl                                 2917   3-CH.sub.3, 5-CF.sub.3 -pyridazin-4-yl                                 2918   6-CH.sub.3, 3-CF.sub.3 -pyridazin-4-yl                                 2919   5-CH.sub.3, 3-CF.sub.3 -pyridazin-4-yl                                 2920   3-CF.sub.3, 6-CH.sub.2 CH.sub.3 -pyridazin-4-yl                        2921   3-CF.sub.3, 5-CH.sub.2 CH.sub.3 -pyridazin-4-yl                        2922   6-CF.sub.3, 3-CH.sub.2 CH.sub.3 -pyridazin-4-yl                        2923   5-CF.sub.3, 3-CH.sub.2 CH.sub.3 -pyridazin-4-yl                        2924   3-CF.sub.3, 6-OCH.sub.3 -pyridazin-4-yl                                2925   3-CF.sub.3, 5-OCH.sub.3 -pyridazin-4-yl                                2926   6-CF.sub.3, 3-OCH.sub.3 -pyridazin-4-yl                                2927   5-CF.sub.3, 3-OCH.sub.3 -pyridazin-4-yl                                2928   3-CF.sub.3, 3-OCH.sub.2 CH.sub.3 -pyridazin-4-yl                       2929   3-CF.sub.3, 5-OCH.sub.2 CH.sub.3 -pyridazin-4-yl                       2930   6-CF.sub.3, 3-OCH.sub.2 CH.sub.3 -pyridazin-4-yl                       2931   5-CF.sub.3, 3-OCH.sub.2 CH.sub.3 -pyridazin-4-yl                       2932   3-CF.sub.3, 6-OCH.sub.2 CF.sub.3 -pyridazin-4-yl                       2933   3-CF.sub.3, 5-OCH.sub.2 CF.sub.3 -pyridazin-4-yl                       2934   6-CF.sub.3, 3-OCH.sub.2 CH.sub.3 -pyridazin-4-yl                       2935   5-CF.sub.3, 3-OCH.sub.2 CH.sub.3 -pyridazin-4-yl                       2936   3-OCH.sub.3, 6-OCH.sub.2 CH.sub.3 -pyridazin-4-yl                      2937   3-OCH.sub.3, 5-OCH.sub.2 CH.sub.3 -pyridazin-4-yl                      2938   6-OCH.sub.3, 3-OCH.sub.2 CH.sub.3 -pyridazin-4-yl                      2939   5-OCH.sub.3, 3-OCH.sub.2 CH.sub.3 -pyridazin-4-yl                      2940   3-OCH.sub.3, 6-OCH.sub.2 CF.sub.3 -pyridazin-4-yl                      2941   3-OCH.sub.3, 5-OCH.sub.2 CF.sub.3 -pyridazin-4-yl                      2942   6-OCH.sub.3, 3-OCH.sub.2 CF.sub.3 -pyridazin-4-yl                      2943   5-OCH.sub.3, 3-OCH.sub.2 CF.sub.3 -pyridazin-4-yl                      2944   3-OCH.sub.3, 6-OCH(CH.sub.3)-pyridazin-4-yl                            2945   3-OCH.sub.3, 5-OCH(CH.sub.3)-pyridazin-4-yl                            2946   6-OCH.sub.3, 3-OCH(CH.sub.3)-pyridazin-4-yl                            2947   5-OCH.sub.3, 3-OCH(CH.sub.3)-pyridazin-4-yl                            2948   3-OCH.sub.2 CH.sub.3, 6-CH.sub.2 OCH.sub.2 CH.sub.3 -pyridazin-4-yl           N                                                                      2949   3-OCH.sub.2 CH.sub.3, 5-CH.sub.2 OCH.sub.2 CH.sub.3 -pyridazin-4-yl           O                                                                      2950   6-OCH.sub.2 CH.sub.3, 3-CH.sub.2 OCH.sub.2 CH.sub.3 -pyridazin-4-yl           6                                                                      2951   5-OCH.sub.2 CH.sub.3, 6-CH.sub.2 OCH.sub.2 CH.sub.3 -pyridazin-4-yl    2952   3-NO.sub.2, 6-CH.sub.3 -pyridazin-4-yl                                 2953   3-NO.sub.2, 5-CH.sub.3 -pyridazin-4-yl                                 2954   6-NO.sub.2, 3-CH.sub.3 -pyridazin-4-yl                                 2955   5-NO.sub.2, 3-CH.sub.3 -pyridazin-4-yl                                 2956   3-NO.sub.2, 6-OCH.sub.3 -pyridazin-4-yl                                2957   3-NO.sub.2, 5-OCH.sub.3 -pyridazin-4-yl                                2958   6-NO.sub.2, 3-OCH.sub.3 -pyridazin-4-yl                                2959   5-NO.sub.2, 3-OCH.sub.3 -pyridazin-4-yl                                2960   3-NO.sub.2, 6-OCH.sub.2 CH.sub.3 -pyridazin-4-yl                       2961   3-NO.sub.2, 5-OCH.sub.2 CH.sub.3 -pyridazin-4-yl                       2962   6-NO.sub.2, 3-OCH.sub.2 CH.sub.3 -pyridazin-4-yl                       2963   5-NO.sub.2, 6-OCH.sub.2 CH.sub.3 -pyridazin-4-yl                       2964   3-NO.sub.2, 6-OCH(CH.sub.3).sub.2 -pyridazin-4-yl                      2965   3-NO.sub.2, 5-OCH(CH.sub.3).sub.2 -pyridazin-4-yl                      2966   6-NO.sub.2, 3-OCH(CH.sub.3).sub.2 -pyridazin-4-yl                      2967   5-NO.sub.2, 3-OCH(CH.sub.3).sub.2 -pyridazin-4-yl                      2968   3-NO.sub.2, 6-OCH.sub.2 CF.sub.3 -pyridazin-4-yl                       2969   3-NO.sub.2, 5-OCH.sub.2 CF.sub.3 -pyridazin-4-yl                       2970   6-NO.sub.2, 3-OCH.sub.2 CF.sub.3 -pyridazin-4-yl                       2971   5-NO.sub.2, 3-OCH.sub.2 CF.sub.3 -pyridazin-4-yl                       2972   3-CN, 6-CH.sub.3 -pyridazin-4-yl                                       2973   3-CN, 5-CH.sub.3 -pyridazin-4-yl                                       2974   6-CN, 3-CH.sub.3 -pyridazin-4-yl                                       2975   5-CN, 3-CH.sub.3 -pyridazin-4-yl                                       2976   3-CN, 6-OCH.sub.3 -pyridazin-4-yl                                      2977   3-CN, 5-OCH.sub.3 -pyridazin-4-yl                                      2978   6-CN, 3-OCH.sub.3 -pyridazin-4-yl                                      2979   5-CN, 3-OCH.sub.3 -pyridazin-4-yl                                      2980   3-CN, 6-OCH.sub.2 CH.sub.3 -pyridazin-4-yl                             2981   3-CN, 5-OCH.sub.2 CH.sub.3 -pyridazin-4-yl                             2982   6-CN, 3-OCH.sub.2 CH.sub.3 -pyridazin-4-yl                             2983   5-CN, 3-OCH.sub.2 CH.sub.3 -pyridazin-4-yl                             2984   3-CN, 6-OCH(CH.sub.3).sub.2 -pyridazin-4-yl                            2985   3-CN, 5-OCH(CH.sub.3).sub.2 -pyridazin-4-yl                            2986   6-CN, 3-OCH(CH.sub.3).sub.2 -pyridazin-4-yl                            2987   5-CN, 3-OCH(CH.sub.3).sub.2 -pyridazin-4-yl                            2988   3-CN, 6-OCH.sub.2 CF.sub.3 -pyridazin-4-yl                             2989   3-CN, 5-OCH.sub.2 CF.sub.3 -pyridazin-4-yl                             2990   6-CN, 3-OCH.sub.2 CF.sub.3 -pyridazin-4-yl                             2991   5-CN, 3-OCH.sub.2 CF.sub.3 -pyridazin-4-yl                             2992   5,6-(CH.sub.3).sub.2, 3-OCH.sub.3 -pyridazin-4-yl                      2993   3-CH.sub.3 -pyrazin-2-yl                                               2994   6-CH.sub.3 -pyrazin-2-yl                                               2995   3-CH.sub.2 CH.sub.3 -pyrazin-2-yl                                      2996   6-CH.sub.2 CH.sub.3 -pyrazin-2-yl                                      2997   3-CH(CH.sub.3).sub.2 -pyrazin-2-yl                                     2998   3-CH(CH.sub.3).sub.2 -pyrazin-2-yl                                     2999   3-CH(CH.sub.3)CH.sub.2 CH.sub.3 -pyrazin-2-yl                          3000   6-CH(CH.sub.3)CH.sub.2 CH.sub.3 -pyrazin-2-yl                          3001   3-CF.sub.3 -pyrazin-2-yl                                               3002   6-CF.sub.3 -pyrazin-2-yl                                               3003   3-CH═CH.sub.2 -pyrazin-2-yl                                        3004   6-CH═CH.sub.2 -pyrazin-2-yl                                        3005   3-CH═CHCH.sub.3 -pyrazin-2-yl                                      3006   6-CH═CHCH.sub.3 -pyrazin-2-yl                                      3007   3-CH═CHCl-pyrazin-2-yl                                             3008   6-CH═CHCl-pyrazin-2-yl                                             3009   3-C.tbd.CH-pyrazin-2-yl                                                3010   6-C.tbd.CH-pyrazin-2-yl                                                3011   3-CH.sub.2 C.tbd.CH-pyrazin-2-yl                                       3012   6-CH.sub.2 C.tbd.CH-pyrazin-2-yl                                       3013   3-CH.sub.2 C.tbd.CCH.sub.3 -pyrazin-2-yl                               3014   6-CH.sub.2 C.tbd.CCH.sub.3 -pyrazin-2-yl                               3015   3-cyclopropyl-pyrazin-2-yl                                             3016   6-cyclopropyl-pyrazin-2-yl                                             3017   3-cyclopentyl-pyrazin-2-yl                                             3018   6-cyclopentyl-pyrazin-2-yl                                             3019   3-OCH.sub.3 -pyrazin-2-yl                                              3020   6-OCH.sub.3 -pyrazin-2-yl                                              3021   3-OCH.sub.2 CH.sub.3 -pyrazin-2-yl                                     3022   6-OCH.sub.2 CH.sub.3 -pyrazin-2-yl                                     3023   3-OCH.sub.2 CH.sub.2 CH.sub.3 -pyrazin-2-yl                            3024   6-OCH.sub.2 CH.sub.2 CH.sub.3 -pyrazin-2-yl                            3025   3-OCH(CH.sub.3).sub.2 -pyrazin-2-yl                                    3026   6-OCH(CH.sub.3).sub.2 -pyrazin-2-yl                                    3027   3-OCH.sub.2 CH.sub.2 CH.sub.2 CH.sub.3 -pyrazin-2-yl                   3028   6-OCH.sub.2 CH.sub.2 CH.sub.2 CH.sub.3 -pyrazin-2-yl                   3029   3-OCH(CH.sub.3)CH.sub.2 CH.sub.3 -pyrazin-2-yl                         3030   6-OCH(CH.sub.3)CH.sub.2 CH.sub.3 -pyrazin-2-yl                         3031   3-OCH.sub.2 CH(CH.sub.3).sub.2 -pyrazin-2-yl                           3032   6-OCH.sub.2 CH(CH.sub.3).sub.2 -pyrazin-2-yl                           3033   3-OC(CH.sub.3).sub.3 -pyrazin-2-yl                                     3034   6-OC(CH.sub.3).sub.3 -pyrazin-2-yl                                     3035   3-OCH(CH.sub.3)CH.sub.2 CH.sub.2 CH.sub.3 -pyrazin-2-yl                3036   6-OCH(CH.sub.3)CH.sub.2 CH.sub.2 CH.sub.3 -pyrazin-2-yl                3037   3-OCH.sub.2 OCH.sub.3 -pyrazin-2-yl                                    3038   6-OCH.sub.2 OCH.sub.3 -pyrazin-2-yl                                    3039   3-OCH.sub.2 OCH.sub.2 CH.sub.3 -pyrazin-2-yl                           3040   6-OCH.sub.2 OCH.sub.2 CH.sub.3 -pyrazin-2-yl                           3041   3-OCH(CH.sub.3)OCH.sub.3 -pyrazin-2-yl                                 3042   6-OCH(CH.sub.3)OCH.sub.3 -pyrazin-2-yl                                 3043   3-OCH(CH.sub.3)OCH.sub.2 CH.sub.3 -pyrazin-2-yl                        3044   6-OCH(CH.sub.3)OCH.sub.2 CH.sub.3 -pyrazin-2-yl                        3045   3-OCH.sub.2 CH.sub.2 OCH.sub.3 -pyrazin-2-yl                           3046   6-OCH.sub.2 CH.sub.2 OCH.sub.3 -pyrazin-2-yl                           3047   3-OCH.sub.2 CH.sub.2 OCH.sub.2 CH.sub.3 -pyrazin-2-yl                  3048   6-OCH.sub.2 CH.sub.2 OCH.sub.2 CH.sub.3 -pyrazin-2-yl                  3049   3-OCH.sub.2 CH.sub.2 OCH(CH.sub.3).sub.2 -pyrazin-2-yl                 3050   6-OCH.sub.2 CH.sub.2 OCH(CH.sub.3).sub.2 -pyrazin-2-yl                 3051   3-OCH.sub.2 CH.sub.2 SCH.sub.3 -pyrazin-2-yl                           3052   6-OCH.sub.2 CH.sub.2 SCH.sub.3 -pyrazin-2-yl                           3053   3-OCH.sub.2 CH.sub.2 SO.sub.2 CH.sub.3 -pyrazin-2-yl                   3054   6-OCH.sub.2 CH.sub.2 SO.sub.2 CH.sub.3 -pyrazin-2-yl                   3055   3-OCH.sub.2 CH.sub.2 SCH(CH.sub.3).sub.2 -pyrazin-2-yl                 3056   6-OCH.sub.2 CH.sub.2 SCH(CH.sub.3).sub.2 -pyrazin-2-yl                 3057   3-OCH.sub.2 CH.sub.2 CN-pyrazin-2-yl                                   3058   6-OCH.sub.2 CH.sub.2 CN-pyrazin-2-yl                                   3059   3-OCH.sub.2 CH.sub.2 SCH.sub.2 CH.sub.2 CN-pyrazin-2-yl                3060   6-OCH.sub.2 CH.sub.2 SCH.sub.2 CH.sub.2 CN-pyrazin-2-yl                3061   3-OCH.sub.2 CH.sub.2 OC.sub.5 H.sub.6 -pyrazin-2-yl                    3062   6-OCH.sub.2 CH.sub.2 OC.sub.5 H.sub.6 -pyrazin-2-yl                    3063   3-OCH.sub.2 CH.sub.2 OCH.sub.2 C.sub.5 H.sub.6 -pyrazin-2-yl           3064   6-OCH.sub.2 CH.sub.2 OCH.sub.2 C.sub.5 H.sub.6 -pyrazin-2-yl           3065   3-OCH.sub.2 CH.sub.2 N(CH.sub.3).sub.2 -pyrazin-2-yl                   3066   6-OCH.sub.2 CH.sub.2 N(CH.sub.3).sub.2 -pyrazin-2-yl                   3067   3-OCH.sub.2 CH.sub.2 CONH.sub.2 -pyrazin-2-yl                          3068   6-OCH.sub.2 CH.sub.2 CONH.sub.2 -pyrazin-2-yl                          3069   3-OCH.sub.2 CH.sub.2 CO.sub.2 CH.sub.2 CH.sub.2 CH.sub.3 -pyrazin-2           -yl                                                                    3070   6-OCH.sub.2 CH.sub.2 CO.sub.2 CH.sub.2 CH.sub.2 CH.sub.3 -pyrazin-2           -yl                                                                    3071   3-OCH(CH.sub.3)CH.sub.2 OCH.sub.3 -pyrazin-2-yl                        3072   6-OCH(CH.sub.3)CH.sub.2 OCH.sub.3 -pyrazin-2-yl                        3073   3-OCH(CH.sub.3)CH.sub.2 CO.sub.2 CH.sub.3 -pyrazin-2-yl                3074   6-OCH(CH.sub.3)CH.sub.2 CO.sub.2 CH.sub.3 -pyrazin-2-yl                3075   3-OCH(CH.sub.3)CH.sub.2 CO.sub.2 CH.sub.2 CH.sub.3 -pyrazin-2-yl       3076   6-OCH(CH.sub.3)CH.sub.2 CO.sub.2 CH.sub.2 CH.sub.3 -pyrazin-2-yl       3077   3-OCH.sub.2 CH(CH.sub.3)CO.sub.2 CH.sub.3 -pyrazin-2-yl                3078   6-OCH.sub.2 CH(CH.sub.3)CO.sub.2 CH.sub.3 -pyrazin-2-yl                3079   3-OCH.sub.2 C(═O)CH.sub.3 -pyrazin-2-yl                            3080   6-OCH.sub.2 C(═O)CH.sub.3 -pyrazin-2-yl                            3081   3-OCH.sub.2 C(═O)CH.sub.2 CH.sub.3 -pyrazin-2-yl                   3082   6-OCH.sub.2 C(═O)CH.sub.2 CH.sub.3 -pyrazin-2-yl                   3083   3-OCH.sub.2 CO.sub.2 CH.sub.3 -pyrazin-2-yl                            3084   6-OCH.sub.2 CO.sub.2 CH.sub.3 -pyrazin-2-yl                            3085   3-OCH.sub.2 CO.sub.2 CH.sub.2 CH.sub.3 -pyrazin-2-yl                   3086   6-OCH.sub.2 CO.sub.2 CH.sub.2 CH.sub.3 -pyrazin-2-yl                   3087   3-OCH.sub.2 C(═O)NH.sub.2 -pyrazin-2-yl                            3088   6-OCH.sub.2 C(═O)NH.sub.2 -pyrazin-2-yl                            3089   3-OCH.sub.2 C(═O)NHCH.sub.3 -pyrazin-2-yl                          3090   6-OCH.sub.2 C(═O)NHCH.sub.3 -pyrazin-2-yl                          3091   3-OCH.sub.2 C(═O)SCH.sub.3 -pyrazin-2-yl                           3092   6-OCH.sub.2 C(═O)SCH.sub.3 -pyrazin-2-yl                           3093   3-OCH(CH.sub.3)C(═O)NH.sub.2 -pyrazin-2-yl                         3094   6-OCH(CH.sub.3)C(═O)NH.sub.2 -pyrazin-2-yl                         3095   3-OCH(CH.sub.3)C(═O)NHCH.sub.3 -pyrazin-2-yl                       3096   6-OCH(CH.sub.3)C(═O)NHCH.sub.3 -pyrazin-2-yl                       3097   3-OCH(CH.sub.3)C(═O)NHNH.sub.2 -pyrazin-2-yl                       3098   6-OCH(CH.sub.3)C(═O)NHNH.sub.2 -pyrazin-2-yl                       3099   3-OCH(CH.sub.3)CO.sub.2 CH.sub.3 -pyrazin-2-yl                         3100   6-OCH(CH.sub.3)CO.sub.2 CH.sub.3 -pyrazin-2-yl                         3101   3-OCH(CH.sub.3)CO.sub.2 CH.sub.2 CH.sub.3 -pyrazin-2-yl                3102   6-OCH(CH.sub.3)CO.sub.2 CH.sub.2 CH.sub.3 -pyrazin-2-yl                3103   3-OCH(CH.sub.3)C(═O)CH.sub.3 -pyrazin-2-yl                         3104   6-OCH(CH.sub.3)C(═O)CH.sub.3 -pyrazin-2-yl                         3105   3-OCH(CH.sub.3)C(═O)CH.sub.2 CH.sub.3 -pyrazin-2-yl                3106   6-OCH(CH.sub.3)C(═O)CH.sub.2 CH.sub.3 -pyrazin-2-yl                3107   3-OCH(CH.sub.3)CH.sub.2 C(═O)CH.sub.3 -pyrazin-2-yl                3108   6-OCH(CH.sub.3)CH.sub.2 C(═O)CH.sub.3 -pyrazin-2-yl                3109   3-OCH(CH.sub.3)CH.sub.2 OC(CH.sub.3).sub.3 -pyrazin-2-yl               3110   6-OCH(CH.sub.3)CH.sub.2 OC(CH.sub.3).sub.3 -pyrazin-2-yl               3111   3-OCH(CH.sub.3)CH.sub.2 OCH.sub.2 CH.sub.3 -pyrazin-2-yl               3112   6-OCH(CH.sub.3)CH.sub.2 OCH.sub.2 CH.sub.3 -pyrazin-2-yl               3113   3-OCH(CH.sub.3)CH.sub.2 O(CH.sub.3).sub.2 CH.sub.3 -pyrazin-2-yl       3114   6-OCH(CH.sub.3)CH.sub.2 O(CH.sub.3).sub.2 CH.sub.3 -pyrazin-2-yl       3115   3-OCH(CH.sub.3)CH.sub.2 OCH.sub.2 CH═CH.sub.2 -pyrazin-2-yl        3116   6-OCH(CH.sub.3)CH.sub.2 OCH.sub.2 CH═CH.sub.2 -pyrazin-2-yl        3117   3-O(CH.sub.2).sub.3 OCH.sub.3 -pyrazin-2-yl                            3118   6-O(CH.sub.2).sub.3 OCH.sub.3 -pyrazin-2-yl                            3119   3-O(CH.sub.2).sub.3 OCH.sub.2 CH.sub.3 -pyrazin-2-yl                   3120   6-O(CH.sub.2).sub.3 OCH.sub.2 CH.sub.3 -pyrazin-2-yl                   3121   3-O(CH.sub.2).sub.3 OCH(CH.sub.3).sub.2 -pyrazin-2-yl                  3122   6-O(CH.sub.2).sub.3 OCH(CH.sub.3).sub.2 -pyrazin-2-yl                  3123   3-O(CH.sub.2).sub.3 OC.sub.5 H.sub.6 -pyrazin-2-yl                     3124   6-O(CH.sub.2).sub.3 OC.sub.5 H.sub.6 -pyrazin-2-yl                     3125   3-O(CH.sub.2).sub.3 OCH.sub.2 C.sub.5 H.sub.6 -pyrazin-2-yl            3126   6-O(CH.sub.2).sub.3 OCH.sub.2 C.sub.5 H.sub.6 -pyrazin-2-yl            3127   3-OCH(CH.sub.2 CH.sub.3)CH.sub.2 OCH.sub.3 -pyrazin-2-yl               3128   6-OCH(CH.sub.2 CH.sub.3)CH.sub.2 OCH.sub.3 -pyrazin-2-yl               3129   3-OCH(CH.sub.2 CH.sub.3)CH.sub.2 CH.sub.2 OCH.sub.3 -pyrazin-2-yl      3130   6-OCH(CH.sub.2 CH.sub.3)CH.sub.2 CH.sub.2 OCH.sub.3 -pyrazin-2-yl      3131   3-OCH(CH.sub.2 CH.sub.3)CH.sub.2 CH.sub.2 OCH.sub.2 CH.sub.3                  -pyrazin-2-yl                                                          3132   6-OCH(CH.sub.2 CH.sub.3)CH.sub.2 CH.sub.2 OCH.sub.2 CH.sub.3                  -pyrazin-2-yl                                                          3133   3-O (CH.sub.2).sub.3 O!.sub.2 CH.sub.3 -pyrazin-2-yl                   3134   6-O (CH.sub.2).sub.3 O!.sub.2 CH.sub.3 -pyrazin-2-yl                   3135   3-OCH.sub.2 CH(CH.sub.3)CH.sub.2 OCH.sub.3 -pyrazin-2-yl               3136   6-OCH.sub.2 CH(CH.sub.3)CH.sub.2 OCH.sub.3 -pyrazin-2-yl               3137   3-OCH.sub.2 CH(CH.sub.3)CH.sub.2 OCH.sub.2 CH.sub.3 -pyrazin-2-yl      3138   6-OCH.sub.2 CH(CH.sub.3)CH.sub.2 OCH.sub.2 CH.sub.3 -pyrazin-2-yl      3139   3-OCH(CH.sub.2 Cl)CH.sub.2 OCH.sub.3 -pyrazin-2-yl                     3140   6-OCH(CH.sub.2 Cl)CH.sub.2 OCH.sub.3 -pyrazin-2-yl                     3141   3-OCH(CH.sub.2 Cl)CH.sub.2 OCH.sub.2 CH.sub.3 -pyrazin-2-yl            3142   6-OCH(CH.sub.2 Cl)CH.sub.2 OCH.sub.2 CH.sub.3 -pyrazin-2-yl            3143   3-OCH(CH.sub.2 Cl)CH.sub.2 OCH(CH.sub.3).sub.2 -pyrazin-2-yl           3144   6-OCH(CH.sub.2 Cl)CH.sub.2 OCH(CH.sub.3).sub.2 -pyrazin-2-yl           3145   3-OCH(CH.sub.2 Cl)CH.sub.2 OCH.sub.2 CH═CH.sub.2 -pyrazin-2-yl            N                                                                      3146   6-OCH(CH.sub.2 Cl)CH.sub.2 OCH.sub.2 CH═CH.sub.2 -pyrazin-2-yl            O                                                                      3147   3-OCH CH.sub.2 OCH.sub.3 !.sub.2 -pyrazin-2-yl                         3148   6-OCH CH.sub.2 OCH.sub.3 !.sub.2 -pyrazin-2-yl                         3149   3-OCH CH.sub.2 OCH.sub.2 CH.sub.3 !.sub.2 -pyrazin-2-yl                3150   6-OCH CH.sub.2 OCH.sub.2 CH.sub.3 !.sub.2 -pyrazin-2-yl                3151   3-OCCl.sub.3 -pyrazin-2-yl                                             3152   6-OCCl.sub.3 -pyrazin-2-yl                                             3153   3-OCHF.sub.2 -pyrazin-2-yl                                             3154   6-OCHF.sub.2 -pyrazin-2-yl                                             3155   3-OCF.sub.3 -pyrazin-2-yl                                              3156   6-OCF.sub.3 -pyrazin-2-yl                                              3157   3-OCF.sub.2 CHF.sub.2 -pyrazin-2-yl                                    3158   6-OCF.sub.2 CHF.sub.2 -pyrazin-2-yl                                    3159   3-OCH.sub.2 CF.sub.3 -pyrazin-2-yl                                     3160   6-OCH.sub.2 CF.sub.3 -pyrazin-2-yl                                     3161   3-OCH.sub.2 CHF.sub.2 -pyrazin-2-yl                                    3162   6-OCH.sub.2 CHF.sub.2 -pyrazin-2-yl                                    3163   3-O(CH.sub.2).sub.3 F-pyrazin-2-yl                                     3164   6-O(CH.sub.2).sub.3 F-pyrazin-2-yl                                     3165   3-OCH(CH.sub.3)CF.sub.3 -pyrazin-2-yl                                  3166   6-OCH(CH.sub.3)CF.sub.3 -pyrazin-2-yl                                  3167   3-O(CH.sub.2).sub.4 F-pyrazin-2-yl                                     3168   6-O(CH.sub.2).sub.4 F-pyrazin-2-yl                                     3169   3-O(CH.sub.2).sub.3 CF.sub.3 -pyrazin-2-yl                             3170   6-O(CH.sub.2).sub.3 CF.sub.3 -pyrazin-2-yl                             3171   3-OCH(CH.sub.3)CF.sub.2 CF.sub.3 -pyrazin-2-yl                         3172   6-OCH(CH.sub.3)CF.sub.2 CF.sub.3 -pyrazin-2-yl                         3173   3-OCH(CH.sub.3)CF.sub.2 CH.sub.2 -pyrazin-2-yl                         3174   6-OCH(CH.sub.3)CF.sub.2 CH.sub.2 -pyrazin-2-yl                         3175   3-OCH.sub.2 CF.sub.2 CHFCH.sub.3 -pyrazin-2-yl                         3176   6-OCH.sub.2 CF.sub.2 CHFCH.sub.3 -pyrazin-2-yl                         3177   3-OCH.sub.2 (CF.sub.2).sub.2 CF.sub.3 -pyrazin-2-yl                    3178   6-OCH.sub.2 (CF.sub.2).sub.2 CF.sub.3 -pyrazin-2-yl                    3179   3-O(CF.sub.2).sub.3 CF.sub.3 -pyrazin-2-yl                             3180   6-O(CF.sub.2).sub.3 CF.sub.3 -pyrazin-2-yl                             3181   3-OCH.sub.2 CF.sub.2 CHF.sub.2 -pyrazin-2-yl                           3182   6-OCH.sub.2 CF.sub.2 CHF.sub.2 -pyrazin-2-yl                           3183   3-CH.sub.2 CH═CH.sub.2 -pyrazin-2-yl                               3184   6-CH.sub.2 CH═CH.sub.2 -pyrazin-2-yl                               3185   3-CH.sub.2 C(CH.sub.3)═CH.sub.2 -pyrazin-2-yl                      3186   6-CH.sub.2 C(CH.sub.3)═CH.sub.2 -pyrazin-2-yl                      3187   3-OCH.sub.2 CH═CHCH.sub.3 -pyrazin-2-yl                            3188   6-OCH.sub.2 CH═CHCH.sub.3 -pyrazin-2-yl                            3189   3-O(CH.sub.2).sub.2 CH═CH.sub.2 -pyrazin-2-yl                      3190   6-O(CH.sub.2).sub.2 CH═CH.sub.2 -pyrazin-2-yl                      3191   3-OCH.sub.2 C(CH.sub.3)═CH.sub.2 -pyrazin-2-yl                     3192   6-OCH.sub.2 C(CH.sub.3)═CH.sub.2 -pyrazin-2-yl                     3193   3-OCH(CH.sub.3)CH═CH.sub.2 -pyrazin-2-yl                           3194   6-OCH(CH.sub.3)CH═CH.sub.2 -pyrazin-2-yl                           3195   3-OCH.sub.2 C.tbd.CH-pyrazin-2-yl                                      3196   6-OCH.sub.2 C.tbd.CH-pyrazin-2-yl                                      3197   3-OCH.sub.2 C.tbd.CCH.sub.3 -pyrazin-2-yl                              3198   6-OCH.sub.2 C.tbd.CCH.sub.3 -pyrazin-2-yl                              3199   3-O(CH.sub.2).sub.2 C.tbd.CH-pyrazin-2-yl                              3200   6-O(CH.sub.2).sub.2 C.tbd.CH-pyrazin-2-yl                              3201   3-SCH.sub.3 -pyrazin-2-yl                                              3202   6-SCH.sub.3 -pyrazin-2-yl                                              3203   3-SCH.sub.2 CH.sub.3 -pyrazin-2-yl                                     3204   6-SCH.sub.2 CH.sub.3 -pyrazin-2-yl                                     3205   3-OC.sub.5 H.sub.6 -pyrazin-2-yl                                       3206   6-OC.sub.5 H.sub.6 -pyrazin-2-yl                                       3207   3-OCH.sub.2 C.sub.5 H.sub.6 -pyrazin-2-yl                              3208   6-OCH.sub.2 C.sub.5 H.sub.6 -pyrazin-2-yl                              3209   3-NO.sub.2 -pyrazin-2-yl                                               3210   6-NO.sub.2 -pyrazin-2-yl                                               3211   3-NHCH.sub.3 -pyrazin-2-yl                                             3212   6-NHCH.sub.3 -pyrazin-2-yl                                             3213   3-N(CH.sub.3).sub.2 -pyrazin-2-yl                                      3214   6-N(CH.sub.3).sub.2 -pyrazin-2-yl                                      3215   3-N(CH.sub.3)C.sub.2 H.sub.6 -pyrazin-2-yl                             3216   6-N(CH.sub.3)C.sub.2 H.sub.6 -pyrazin-2-yl                             3217   3-NHCH.sub.2 CF.sub.3 -pyrazin-2-yl                                    3218   6-NHCH.sub.2 CF.sub.3 -pyrazin-2-yl                                    3219   3-F-pyrazin-2-yl                                                       3220   6-F-pyrazin-2-yl                                                       3221   3-Cl-pyrazin-2-yl                                                      3222   6-Cl-pyrazin-2-yl                                                      3223   3-OH-pyrazin-2-yl                                                      3224   6-OH-pyrazin-2-yl                                                      3225   3-CN-pyrazin-2-yl                                                      3226   6-CN-pyrazin-2-yl                                                      3227   3-C(O)NH.sub.2 -pyrazin-2-yl                                           3228   6-C(O)NH.sub.2 -pyrazin-2-yl                                           3229   3-C(S)NH.sub.2 -pyrazin-2-yl                                           3230   6-C(S)NH.sub.2 -pyrazin-2-yl                                           3231   3-CO.sub.2 CH.sub.3 -pyrazin-2-yl                                      3232   6-CO.sub.2 CH.sub.3 -pyrazin-2-yl                                      3233   3-ON═C(CH.sub.3).sub.2 -pyrazin-2-yl                               3234   6-ON═C(CH.sub.3).sub.2 -pyrazin-2-yl                               3235   3- O-cyclopropyl!pyrazin-2-yl                                          3236   6- O-cyclopropyl!pyrazin-2-yl                                          3237   3- O-cyclobutyl!pyrazin-2-yl                                           3238   6- O-cyclobutyl!pyrazin-2-yl                                           3239   3- O-cyclopentyl!pyrazin-2-yl                                          3240   6- O-cyclopentyl!pyrazin-2-yl                                          3241   3- O-cyclohexyl!pyrazin-2-yl                                           3242   6- O-cyclohexyl!pyrazin-2-yl                                           3243   3- OCH.sub.2 -cyclopropyl!pyrazin-2-yl                                 3244   6- OCH.sub.2 -cyclopropyl!pyrazin-2-yl                                 3245   6-F, 3- OCH.sub.2 -cyclopropyl!pyrazin-2-yl                            3246   3-F, 6- OCH.sub.2 -cyclopropyl!pyrazin-2-yl                            3247   6-CH.sub.3, 3- OCH.sub.2 -cyclopropyl!pyrazin-2-yl                     3248   3-CH.sub.3, 6- OCH.sub.2 -cyclopropyl!pyrazin-2-yl                     3249   6-CH.sub.3, 3- OCH.sub.2 -cyclopropyl!pyrazin-2-yl                     3250   3-CH.sub.3, 6- OCH.sub.2 -cyclopropyl!pyrazin-2-yl                     3251   3- OCH(CH.sub.3)-cyclopropyl!pyrazin-2-yl                              3252   6- OCH(CH.sub.3)-cyclopropyl!pyrazin-2-yl                              3253   6-F, 3- OCH(CH.sub.3)-cyclopropyl!pyrazin-2-yl                         3254   3-F, 6- OCH(CH.sub.3)-cyclopropyl!pyrazin-2-yl                         3255   6-CH.sub.3, 3- OCH(CH.sub.3)-cyclopropyl!pyrazin-2-yl                  3256   3-CH.sub.3, 6- OCH(CH.sub.3)-cyclopropyl!pyrazin-2-yl                  3257   6-CF.sub.3, 3- OCH(CH.sub.3)-cyclopropyl!pyrazin-2-yl                  3258   3-CF.sub.3, 6- OCH(CH.sub.3)-cyclopropyl!pyrazin-2-yl                  3259   3- O-(1-CH.sub.3 -cyclopropyl)!pyrazin-2-yl                            3260   6- O-(1-CH.sub.3 -cyclopropyl)!pyrazin-2-yl                            3261   6-F, 3- O-(1-CH.sub.3 -cyclopropyl)!pyrazin-2-yl                       3262   3-F, 6- O-(1-CH.sub.3 -cyclopropyl)!pyrazin-2-yl                       3263   6-CH.sub.3, 3- O-(1-CH.sub.3 -cyclopropyl)!pyrazin-2-yl                3264   3-CH.sub.3, 6- O-(1-CH.sub.3 -cyclopropyl)!pyrazin-2-yl                3265   6-CF.sub.3, 3- O-(1-CH.sub.3 -cyclopropyl)!pyrazin-2-yl                3266   3-CF.sub.3, 6- O-(1-CH.sub.3 -cyclopropyl)!pyrazin-2-yl                3267   3- OCH.sub.2 -(1-CH.sub.3 -cyclopropyl)!pyrazin-2-yl                   3268   6- OCH.sub.2 -(1-CH.sub.3 -cyclopropyl)!pyrazin-2-yl                   3269   6-F, 3- OCH.sub.2 -(1-CH.sub.3 -cyclopropyl)!pyrazin-2-yl              3270   3-F, 6- OCH.sub.2 -(1-CH.sub.3 -cyclopropyl)!pyrazin-2-yl              3271   6-CH.sub.3, 3- OCH.sub.2 -(1-CH.sub.3 -cyclopropyl)!pyrazin-2-yl       3272   3-CH.sub.3, 6- OCH.sub.2 -(1-CH.sub.3 -cyclopropyl)!pyrazin-2-yl       3273   6-CF.sub.3, 3- OCH.sub.2 -(1-CH.sub.3 -cyclopropyl)!pyrazin-2-yl       3274   3-CF.sub.3, 6- OCH.sub.2 -(1-CH.sub.3 -cyclopropyl)!pyrazin-2-yl       3275   3- OCH.sub.2 -(2-CH.sub.3 -cyclopropyl)!pyrazin-2-yl                   3276   6- OCH.sub.2 -(2-CH.sub.3 -cyclopropyl)!pyrazin-2-yl                   3277   6-F, 3- OCH.sub.2 -(2-CH.sub.3 -cyclopropyl)!pyrazin-2-yl              3278   3-F, 6- OCH.sub.2 -(2-CH.sub.3 -cyclopropyl)!pyrazin-2-yl              3279   6-CH.sub.3, 3- OCH.sub.2 -(2-CH.sub.3 -cyclopropyl)!pyrazin-2-yl       3280   3-CH.sub.3, 6- OCH.sub.2 -(2-CH.sub.3 -cyclopropyl)!pyrazin-2-yl       3281   6-CF.sub.3, 3- OCH.sub.2 -(2-CH.sub.3 -cyclopropyl)!pyrazin-2-yl       3282   3-CF.sub.3, 6- OCH.sub.2 -(2-CH.sub.3 -cyclopropyl)!pyrazin-2-yl       3283   3- OCH.sub.2 -(tetrahydropyran-2-yl)!pyrazin-2-yl                      3284   6- OCH.sub.2 -(tetrahydropyran-2-yl)!pyrazin-2-yl                      3285   6-F, 3- OCH.sub.2 -(tetrahydropyran-2-yl)!pyrazin-2-yl                 3286   3-F, 6- OCH.sub.2 -(tetrahydropyran-2-yl)!pyrazin-2-yl                 3287   6-CH.sub.3, 3- OCH.sub.2 -(tetrahydropyran-2-yl)!pyrazin-2-yl          3288   3-CH.sub.3, 6- OCH.sub.2 -(tetrahydropyran-2-yl)!pyrazin-2-yl          3289   6-CF.sub.3, 3- OCH.sub.2 -(tetrahydropyran-2-yl)!pyrazin-2-yl          3290   3-CF.sub.3, 6- OCH.sub.2 -(tetrahydropyran-2-yl)!pyrazin-2-yl          3291   3- OCH.sub.2 -(furan-2-yl)!pyrazin-2-yl                                3292   6- OCH.sub.2 -(furan-2-yl)!pyrazin-2-yl                                3293   6-F, 3- OCH.sub.2 -(furan-2-yl)!pyrazin-2-yl                           3294   3-F, 6- OCH.sub.2 -(furan-2-yl)!pyrazin-2-yl                           3295   6-CH.sub.3, 3- OCH.sub.2 -(furan-2-yl)!pyrazin-2-yl                    3296   3-CH.sub.3, 6- OCH.sub.2 -(furan-2-yl)!pyrazin-2-yl                    3297   6-CF.sub.3, 3- OCH.sub.2 -(furan-2-yl)!pyrazin-2-yl                    3298   3-CF.sub.3, 6- OCH.sub.2 -(furan-2-yl)!pyrazin-2-yl                    3299   3- OCH.sub.2 -(furan-3-yl)!pyrazin-2-yl                                3300   6- OCH.sub.2 -(furan-3-yl)!pyrazin-2-yl                                3301   6-F, 3- OCH.sub.2 -(furan-3-yl)!pyrazin-2-yl                           3302   3-F, 6- OCH.sub.2 -(furan-3-yl)!pyrazin-2-yl                           3303   6-CH.sub.3, 3- OCH.sub.2 -(furan-3-yl)!pyrazin-2-yl                    3304   3-CH.sub.3, 6- OCH.sub.2 -(furan-3-yl)!pyrazin-2-yl                    3305   6-CF.sub.3, 3- OCH.sub.2 -(furan-3-yl)!pyrazin-2-yl                    3306   3-CF.sub.3, 6- OCH.sub.2 -(furan-3-yl)!pyrazin-2-yl                    3307   3- OCH.sub.2 -(tetrahydrofuran-3-yl)!pyrazin-2-yl                      3308   6- OCH.sub.2 -(tetrahydrofuran-3-yl)!pyrazin-2-yl                      3309   6-F, 3- OCH.sub.2 -(tetrahydrofuran-3-yl)!pyrazin-2-yl                 3310   3-F, 6- OCH.sub.2 -(tetrahydrofuran-3-yl)!pyrazin-2-yl                 3311   6-CH.sub.3, 3- OCH.sub.2 -(tetrahydrofuran-3-yl)!pyrazin-2-yl          3312   3-CH.sub.3, 6- OCH.sub.2 -(tetrahydrofuran-3-yl)!pyrazin-2-yl          3313   6-CF.sub.3, 3- OCH.sub.2 -(tetrahydrofuran-3-yl)!pyrazin-2-yl          3314   3-CF.sub.3, 6- OCH.sub.2 -(tetrahydrofuran-3-yl)!pyrazin-2-yl          3315   3- OCH.sub.2 -(tetrahydrofuran-2-yl)!pyrazin-2-yl                      3316   6- OCH.sub.2 -(tetrahydrofuran-2-yl)!pyrazin-2-yl                      3317   6-F, 3- OCH.sub.2 -(tetrahydrofuran-2-yl)!pyrazin-2-yl                 3318   3-F, 6- OCH.sub.2 -(tetrahydrofuran-2-yl)!pyrazin-2-yl                 3319   6-CH.sub.3, 3- OCH.sub.2 -(tetrahydrofuran-2-yl)!pyrazin-2-yl          3320   3-CH.sub.3, 6- OCH.sub.2 -(tetrahydrofuran-2-yl)!pyrazin-2-yl          3321   6-CF.sub.3, 3- OCH.sub.2 -(tetrahydrofuran-2-yl)!pyrazin-2-yl          3322   3-CF.sub.3, 6- OCH.sub.2 -(tetrahydrofuran-2-yl)!pyrazin-2-yl          3323   3- O-(tetrahydropyran-3-yl)!pyrazin-2-yl                               3324   6- O-(tetrahydropyran-3-yl)!pyrazin-2-yl                               3325   6-F, 3- O-(tetrahydropyran-3-yl)!pyrazin-2-yl                          3326   3-F, 6- O-(tetrahydropyran-3-yl)!pyrazin-2-yl                          3327   6-CH.sub.3, 3- O-(tetrahydropyran-3-yl)!pyrazin-2-yl                   3328   3-CH.sub.3, 6- O-(tetrahydropyran-3-yl)!pyrazin-2-yl                   3329   6-CF.sub.3, 3- O-(tetrahydropyran-3-yl)!pyrazin-2-yl                   3330   3-CF.sub.3, 6- O-(tetrahydropyran-3-yl)!pyrazin-2-yl                   3331   3- 2-Cl--C.sub.5 H.sub.4 !pyrazin-2-yl                                 3332   6- 2-Cl--C.sub.5 H.sub.4 !pyrazin-2-yl                                 3333   6-F, 3- 2-Cl--C.sub.5 H.sub.4 !pyrazin-2-yl                            3334   3-F, 6- 2-Cl--C.sub.5 H.sub.4 !pyrazin-2-yl                            3335   6-CH.sub.3, 3- 2-Cl--C.sub.5 H.sub.4 !pyrazin-2-yl                     3336   3-CH.sub.3, 6- 2-Cl--C.sub.5 H.sub.4 !pyrazin-2-yl                     3337   6-CF.sub.3, 3- 2-Cl--C.sub.5 H.sub.4 !pyrazin-2-yl                     3338   3-CF.sub.3, 6- 2-Cl--C.sub.5 H.sub.4 !pyrazin-2-yl                     3339   3- OCH.sub.2 -(pyridin-2-yl)!pyrazin-2-yl                              3340   6- OCH.sub.2 -(pyridin-2-yl)!pyrazin-2-yl                              3341   6-F, 3- OCH.sub.2 -(pyridin-2-yl)!pyrazin-2-yl                         3342   3-F, 6- OCH.sub.2 -(pyridin-2-yl)!pyrazin-2-yl                         3343   6-CH.sub.3, 3- OCH.sub.2 -(pyridin-2-yl)!pyrazin-2-yl                  3344   3-CH.sub.3, 6- OCH.sub.2 -(pyridin-2-yl)!pyrazin-2-yl                  3345   6-CF.sub.3, 3- OCH.sub.2 -(pyridin-2-yl)!pyrazin-2-yl                  3346   3-CF.sub.3, 6- OCH.sub.2 -(pyridin-2-yl)!pyrazin-2-yl                  3347   3- OCH.sub.2 -(pyridin-4-yl)!pyrazin-2-yl                              3348   6- OCH.sub.2 -(pyridin-4-yl)!pyrazin-2-yl                              3349   6-F, 3- OCH.sub.2 -(pyridin-4-yl)!pyrazin-2-yl                         3350   3-F, 6- OCH.sub.2 -(pyridin-4-yl)!pyrazin-2-yl                         3351   6-CH.sub.3, 3- OCH.sub.2 -(pyridin-4-yl)!pyrazin-2-yl                  3352   3-CH.sub.3, 6- OCH.sub.2 -(pyridin-4-yl)!pyrazin-2-yl                  3353   6-CF.sub.3, 3- OCH.sub.2 -(pyridin-4-yl)!pyrazin-2-yl                  3354   3-CF.sub.3, 6- OCH.sub.2 -(pyridin-4-yl)!pyrazin-2-yl                  3355   3- morpholin-4-yl!pyrazin-2-yl                                         3356   6- morpholin-4-yl!pyrazin-2-yl                                         3357   3- 1-CH.sub.3 -imidazol-2-yl!pyrazin-2-yl                              3358   6- 1-CH.sub.3 -imidazol-2-yl!pyrazin-2-yl                              3359   6-F, 3- 1-CH.sub.3 -imidazol-2-yl!pyrazin-2-yl                         3360   3-F, 6- 1-CH.sub.3 -imidazol-2-yl!pyrazin-2-yl                         3361   6-CH.sub.3, 3- 1-CH.sub.3 -imidazol-2-yl!pyrazin-2-yl                  3362   3-CH.sub.3, 6- 1-CH.sub.3 -imidazol-2-yl!pyrazin-2-yl                  3363   6-CF.sub.3, 3- 1-CH.sub.3 -imidazol-2-yl!pyrazin-2-yl                  3364   3-CF.sub.3, 6- 1-CH.sub.3 -imidazol-2-yl!pyrazin-2-yl                  3365   3- 1,2,3-triazol-1-yl!pyrazin-2-yl                                     3366   6- 1,2,3-triazol-1-yl!pyrazin-2-yl                                     3367   6-F, 3- 1,2,3-triazol-1-yl!pyrazin-2-yl                                3368   3-F, 3- 1,2,3-triazol-1-yl!pyrazin-2-yl                                3369   6-CH.sub.3, 3- 1,2,3-triazol-1-yl!pyrazin-2-yl                         3370   3-CH.sub.3, 3- 1,2,3-triazol-1-yl!pyrazin-2-yl                         3371   6-CF.sub.3, 3- 1,2,3-triazol-1-yl!pyrazin-2-yl                         3372   3-CF.sub.3, 6- 1,2,3-triazol-1-yl!pyrazin-2-yl                         3373   3,6-Cl.sub.2 -pyrazin-2-yl                                             3374   3,5-Cl.sub.2 -pyrazin-2-yl                                             3375   3,6-(CH.sub.3).sub.2 -pyrazin-2-yl                                     3376   3,5-(CH.sub.3).sub.2 -pyrazin-2-yl                                     3377   3,6-(OCH.sub.3).sub.2 -pyrazin-2-yl                                    3378   3,5-(OCH.sub.3).sub.2 -pyrazin-2-yl                                    3379   3,6-(OCH.sub.2 CH.sub.3).sub.2 -pyrazin-2-yl                           3380   3,5-(OCH.sub.2 CH.sub.3).sub.2 -pyrazin-2-yl                           3381   3-F, 6-CH.sub.3 -pyrazin-2-yl                                          3382   3-F, 5-CH.sub.3 -pyrazin-2-yl                                          3383   6-F, 3-CH.sub.3 -pyrazin-2-yl                                          3384   5-F, 3-CH.sub.3 -pyrazin-2-yl                                          3385   3-F, 6-OCH.sub.3 -pyrazin-2-yl                                         3386   3-F, 5-OCH.sub.3 -pyrazin-2-yl                                         3387   6-F, 3-OCH.sub.3 -pyrazin-2-yl                                         3388   5-F, 3-OCH.sub.3 -pyrazin-2-yl                                         3389   3-F, 6-OCH.sub.2 CH.sub.3 -pyrazin-2-yl                                3390   3-F, 5-OCH.sub.2 CH.sub.3 -pyrazin-2-yl                                3391   6-F, 3-OCH.sub.2 CH.sub.3 -pyrazin-2-yl                                3392   5-F, 3-OCH.sub.2 CH.sub.3 -pyrazin-2-yl                                3393   3-F, 6-OCH.sub.2 CF.sub.3 -pyrazin-2-yl                                3394   3-F, 5-OCH.sub.2 CF.sub.3 -pyrazin-2-yl                                3395   6-F, 3-OCH.sub.2 CF.sub.3 -pyrazin-2-yl                                3396   5-F, 3-OCH.sub.2 CF.sub.3 -pyrazin-2-yl                                3397   3-F, 6-OCH(CH.sub.3).sub.2 -pyrazin-2-yl                               3398   3-F, 5-OCH(CH.sub.3).sub.2 -pyrazin-2-yl                               3399   6-F, 3-OCH(CH.sub.3).sub.2 -pyrazin-2-yl                               3400   5-F, 3-OCH(CH.sub.3).sub.2 -pyrazin-2-yl                               3401   3-Cl, 6-CH.sub.3 -pyrazin-2-yl                                         3402   3-Cl, 5-CH.sub.3 -pyrazin-2-yl                                         3403   6-Cl, 3-CH.sub.3 -pyrazin-2-yl                                         3404   5-Cl, 3-CH.sub.3 -pyrazin-2-yl                                         3405   3-Cl, 6-OCH.sub.3 -pyrazin-2-yl                                        3406   3-Cl, 5-OCH.sub.3 -pyrazin-2-yl                                        3407   6-Cl, 3-OCH.sub.3 -pyrazin-2-yl                                        3408   5-Cl, 3-OCH.sub.3 -pyrazin-2-yl                                        3409   3-Cl, 6-OCH.sub.2 CH.sub.3 -pyrazin-2-yl                               3410   3-Cl, 5-OCH.sub.2 CH.sub.3 -pyrazin-2-yl                               3411   6-Cl, 3-OCH.sub.2 CH.sub.3 -pyrazin-2-yl                               3412   5-Cl, 3-OCH.sub.2 CH.sub.3 -pyrazin-2-yl                               3413   3-Cl, 6-OCH.sub.2 CF.sub.3 -pyrazin-2-yl                               3414   3-Cl, 5-OCH.sub.2 CF.sub.3 -pyrazin-2-yl                               3415   6-Cl, 3-OCH.sub.2 CF.sub.3 -pyrazin-2-yl                               3416   5-Cl, 3-OCH.sub.2 CF.sub.3 -pyrazin-2-yl                               3417   3-Cl, 6-OCH(CH.sub.3).sub.2 -pyrazin-2-yl                              3418   3-Cl, 5-OCH(CH.sub.3).sub.2 -pyrazin-2-yl                              3419   6-Cl, 3-OCH(CH.sub.3).sub.2 -pyrazin-2-yl                              3420   5-Cl, 3-OCH(CH.sub.3).sub.2 -pyrazin-2-yl                              3421   3-CH.sub.3, 6-OCH.sub.3 -pyrazin-2-yl                                  3422   3-CH.sub.3, 5-OCH.sub.3 -pyrazin-2-yl                                  3423   6-CH.sub.3, 3-OCH.sub.3 -pyrazin-2-yl                                  3424   5-CH.sub.3, 3-OCH.sub.3 -pyrazin-2-yl                                  3425   5-CH.sub.3, 3-OCH.sub.2 CH.sub.3 -pyrazin-2-yl                         3426   6-CH.sub.3, 3-OCH.sub.2 CH.sub.3 -pyrazin-2-yl                         3427   3-CH.sub.3, 6-OCH.sub.2 CH.sub.3 -pyrazin-2-yl                         3428   3-CH.sub.3, 5-OCH.sub.2 CH.sub.3 -pyrazin-2-yl                         3429   3-CH.sub.3, 6-OCH.sub.2 CF.sub.3 -pyrazin-2-yl                         3430   3-CH.sub.3, 5-OCH.sub.2 CF.sub.3 -pyrazin-2-yl                         3431   6-CH.sub.3, 3-OCH.sub.2 CF.sub.3 -pyrazin-2-yl                         3432   5-CH.sub.3, 3-OCH.sub.2 CF.sub.3 -pyrazin-2-yl                         3433   3-CH.sub.3, 6-OCH(CH.sub.3).sub.2 -pyrazin-2-yl                        3434   3-CH.sub.3, 6-OCH(CH.sub.3).sub.2 -pyrazin-2-yl                        3435   6-CH.sub.3, 3-OCH(CH.sub.3).sub.2 -pyrazin-2-yl                        3436   5-CH.sub.3, 3-OCH(CH.sub.3).sub.2 -pyrazin-2-yl                        3437   3-CH.sub.3, 6-OCH.sub.2 CH═CH.sub.2 -pyrazin-2-yl                  3438   3-CH.sub.3, 5-OCH.sub.2 CH═CH.sub.2 -pyrazin-2-yl                  3439   6-CH.sub.3, 3-OCH.sub.2 CH═CH.sub.2 -pyrazin-2-yl                  3440   5-CH.sub.3, 3-OCH.sub.2 CH═CH.sub.2 -pyrazin-2-yl                  3441   3-CH.sub.3, 6-CO.sub.2 CH.sub.3 -pyrazin-2-yl                          3442   3-CH.sub.3, 5-CO.sub.2 CH.sub.3 -pyrazin-2-yl                          3443   3-CH.sub.3, 6-CF.sub.3 -pyrazin-2-yl                                   3444   3-CH.sub.3, 5-CF.sub.3 -pyrazin-2-yl                                   3445   6-CH.sub.3, 3-CF.sub.3 -pyrazin-2-yl                                   3446   5-CH.sub.3, 3-CF.sub.3 -pyrazin-2-yl                                   3447   3-CF.sub.3, 6-CH.sub.2 CH.sub.3 -pyrazin-2-yl                          3448   3-CF.sub.3, 5-CH.sub.2 CH.sub.3 -pyrazin-2-yl                          3449   6-CF.sub.3, 3-CH.sub.2 CH.sub.3 -pyrazin-2-yl                          3450   5-CF.sub.3, 3-CH.sub.2 CH.sub.3 -pyrazin-2-yl                          3451   3-CF.sub.3, 6-OCH.sub.3 -pyrazin-2-yl                                  3452   3-CF.sub.3, 5-OCH.sub.3 -pyrazin-2-yl                                  3453   6-CF.sub.3, 3-OCH.sub.3 -pyrazin-2-yl                                  3454   5-CF.sub.3, 3-OCH.sub.3 -pyrazin-2-yl                                  3455   3-CF.sub.3, 6-OCH.sub.2 CH.sub.3 -pyrazin-2-yl                         3456   3-CF.sub.3, 5-OCH.sub.2 CH.sub.3 -pyrazin-2-yl                         3457   5-CF.sub.3, 3-OCH.sub.2 CH.sub.3 -pyrazin-2-yl                         3458   5-CF.sub.3, 3-OCH.sub.2 CH.sub.3 -pyrazin-2-yl                         3459   3-CF.sub.3, 6-OCH.sub.2 CF.sub.3 -pyrazin-2-yl                         3460   3-CF.sub.3, 5-OCH.sub.2 CF.sub.3 -pyrazin-2-yl                         3461   6-CF.sub.3, 3-OCH.sub.2 CF.sub.3 -pyrazin-2-yl                         3462   5-CF.sub.3, 3-OCH.sub.2 CF.sub.3 -pyrazin-2-yl                         3463   3-OCH.sub.3, 6-OCH.sub.2 CH.sub.3 -pyrazin-2-yl                        3464   3-OCH.sub.3, 5-OCH.sub.2 CH.sub.3 -pyrazin-2-yl                        3465   6-OCH.sub.3, 3-OCH.sub.2 CH.sub.3 -pyrazin-2-yl                        3466   5-OCH.sub.3, 3-OCH.sub.2 CH.sub.3 -pyrazin-2-yl                        3467   3-OCH.sub.3, 6-OCH.sub.2 CF.sub.3 -pyrazin-2-yl                        3468   3-OCH.sub.3, 5-OCH.sub.2 CF.sub.3 -pyrazin-2-yl                        3469   6-OCH.sub.3, 3-OCH.sub.2 CF.sub.3 -pyrazin-2-yl                        3470   5-OCH.sub.3, 3-OCH.sub.2 CF.sub.3 -pyrazin-2-yl                        3471   3-OCH.sub.3, 6-OCH(CH.sub.3)-pyrazin-2-yl                              3472   3-OCH.sub.3, 5-OCH(CH.sub.3)-pyrazin-2-yl                              3473   6-OCH.sub.3, 3-OCH(CH.sub.3)-pyrazin-2-yl                              3474   5-OCH.sub.3, 3-OCH(CH.sub.3)-pyrazin-2-yl                              3475   3-OCH.sub.2 CH.sub.3, 6-CH.sub.2 OCH.sub.2 CH.sub.3 -pyrazin-2-yl      3476   3-OCH.sub.2 CH.sub.3, 5-CH.sub.2 OCH.sub.2 CH.sub.3 -pyrazin-2-yl      3477   6-OCH.sub.2 CH.sub.3, 3-CH.sub.2 OCH.sub.2 CH.sub.3 -pyrazin-2-yl      3478   5-OCH.sub.2 CH.sub.3, 3-CH.sub.2 OCH.sub.2 CH.sub.3 -pyrazin-2-yl      3479   3-NO.sub.2, 6-CH.sub.3 -pyrazin-2-yl                                   3480   3-NO.sub.2, 5-CH.sub.3 -pyrazin-2-yl                                   3481   6-NO.sub.2, 3-CH.sub.3 -pyrazin-2-yl                                   3482   5-NO.sub.2, 3-CH.sub.3 -pyrazin-2-yl                                   3483   3-NO.sub.2, 6-OCH.sub.3 -pyrazin-2-yl                                  3484   3-NO.sub.2, 5-OCH.sub.3 -pyrazin-2-yl                                  3485   6-NO.sub.2, 3-OCH.sub.3 -pyrazin-2-yl                                  3486   5-NO.sub.2, 3-OCH.sub.3 -pyrazin-2-yl                                  3487   3-NO.sub.2, 6-OCH.sub.2 CH.sub.3 -pyrazin-2-yl                         3488   3-NO.sub.2, 5-OCH.sub.2 CH.sub.3 -pyrazin-2-yl                         3489   6-NO.sub.2, 3-OCH.sub.2 CH.sub.3 -pyrazin-2-yl                         3490   5-NO.sub.2, 3-OCH.sub.2 CH.sub.3 -pyrazin-2-yl                         3491   3-NO.sub.2, 6-OCH(CH.sub.3).sub.2 -pyrazin-2-yl                        3492   3-NO.sub.2, 5-OCH(CH.sub.3).sub.2 -pyrazin-2-yl                        3493   6-NO.sub.2, 3-OCH(CH.sub.3).sub.2 -pyrazin-2-yl                        3494   5-NO.sub.2, 3-OCH(CH.sub.3).sub.2 -pyrazin-2-yl                        3495   3-NO.sub.2, 6-OCH.sub.2 CF.sub.3 -pyrazin-2-yl                         3496   3-NO.sub.2, 5-OCH.sub.2 CF.sub.3 -pyrazin-2-yl                         3497   6-NO.sub.2, 3-OCH.sub.2 CF.sub.3 -pyrazin-2-yl                         3498   5-NO.sub.2, 3-OCH.sub.2 CF.sub.3 -pyrazin-2-yl                         3499   3-CN, 6-CH.sub.3 -pyrazin-2-yl                                         3500   3-CN, 5-CH.sub.3 -pyrazin-2-yl                                         3501   6-CN, 3-CH.sub.3 -pyrazin-2-yl                                         3502   5-CN, 3-CH.sub.3 -pyrazin-2-yl                                         3503   3-CN, 6-OCH.sub.3 -pyrazin-2-yl                                        3504   3-CN, 5-OCH.sub.3 -pyrazin-2-yl                                        3505   6-CN, 3-OCH.sub.3 -pyrazin-2-yl                                        3506   5-CN, 3-OCH.sub.3 -pyrazin-2-yl                                        3507   3-CN, 6-OCH.sub.2 CH.sub.3 -pyrazin-2-yl                               3508   3-CN, 5-OCH.sub.2 CH.sub.3 -pyrazin-2-yl                               3509   6-CN, 3-OCH.sub.2 CH.sub.3 -pyrazin-2-yl                               3510   5-CN, 3-OCH.sub.2 CH.sub.3 -pyrazin-2-yl                               3511   3-CN, 6-OCH(CH.sub.3).sub.2 -pyrazin-2-yl                              3512   3-CN, 5-OCH(CH.sub.3).sub.2 -pyrazin-2-yl                              3513   6-CN, 3-OCH(CH.sub.3).sub.2 -pyrazin-2-yl                              3514   5-CN, 3-OCH(CH.sub.3).sub.2 -pyrazin-2-yl                              3515   3-CN, 6-OCH.sub.2 CF.sub.3 -pyrazin-2-yl                               3516   3-CN, 5-OCH.sub.2 CF.sub.3 -pyrazin-2-yl                               3517   6-CN, 3-OCH.sub.2 CF.sub.3 -pyrazin-2-yl                               3518   5-CN, 3-OCH.sub.2 CF.sub.3 -pyrazin-2-yl                               3519   5,6-(CH.sub.3).sub.2, 3-OCH.sub.3 -pyrazin-2-yl                        3520   4-CH.sub.3 -1,3,5-triazin-2-yl                                         3521   4-CH.sub.2 CH.sub.3 -1,3,5-triazin-2-yl                                3522   4-CH(CH.sub.3).sub.2 -1,3,5-triazin-2-yl                               3523   4-CH(CH.sub.3)CH.sub.2 CH.sub.3 -1,3,5-triazin-2-yl                    3524   4-CF.sub.3 -1,3,5-triazin-2-yl                                         3525   4-CH═CH.sub.2 -1,3,5-triazin-2-yl                                  3526   4-CH═CHCH.sub.3 -1,3,5-triazin-2-yl                                3527   4-CH═CHCl-1,3,5-triazin-2-yl                                       3528   4-C.tbd.CH-1,3,5-triazin-2-yl                                          3529   4-CH.sub.2 C.tbd.CH-1,3,5-triazin-2-yl                                 3530   4-CH.sub.2 C.tbd.CCH.sub.3 -1,3,5-triazin-2-yl                         3531   4-cyclopropyl-1,3,5-triazin-2-yl                                       3532   4-cyclopentyl-1,3,5-triazin-2-yl                                       3533   4-OCH.sub.3 -1,3,5-triazin-2-yl                                        3534   4-OCH.sub.2 CH.sub.3 -1,3,5-triazin-2-yl                               3535   4-OCH.sub.2 CH.sub.2 CH.sub.3 -1,3,5-triazin-2-yl                      3536   4-OCH(CH.sub.3).sub.2 -1,3,5-triazin-2-yl                              3537   4-OCH.sub.2 CH.sub.2 CH.sub.2 CH.sub.3 -1,3,5-triazin-2-yl             3538   4-OCH(CH.sub.3)CH.sub.2 CH.sub.3 -1,3,5-triazin-2-yl                   3539   4-OCH.sub.2 CH(CH.sub.3).sub.2 -1,3,5-triazin-2-yl                     3540   4-OC(CH.sub.3).sub.4 -1,3,5-triazin-2-yl                               3541   4-OCH(CH.sub.3)CH.sub.2 CH.sub.2 CH.sub.3 -1,3,5-triazin-2-yl          3542   4-OCH.sub.2 OCH.sub.3 -1,3,5-triazin-2-yl                              3543   4-OCH.sub.2 OCH.sub.2 CH.sub.3 -1,3,5-triazin-2-yl                     3544   4-OCH(CH.sub.3)OCH.sub.3 -1,3,5-triazin-2-yl                           3545   4-OCH(CH.sub.3 OCH.sub.2 CH.sub.3 -1,3,5-triazin-2-yl                  3546   4-OCH.sub.2 CH.sub.2 OCH.sub.3 -1,3,5-triazin-2-yl                     3547   4-OCH.sub.2 CH.sub.2 OCH.sub.2 CH.sub.3 -1,3,5-triazin-2-yl            3548   4-OCH.sub.2 CH.sub.2 OCH(CH.sub.3).sub.2 -1,3,5-triazin-2-yl           3549   4-OCH.sub.2 CH.sub.2 SCH.sub.3 -1,3,5-triazin-2-yl                     3550   4-OCH.sub.2 CH.sub.2 SO.sub.2 CH.sub.3 -1,3,5-triazin-2-yl             3551   4-OCH.sub.2 CH.sub.2 SCH(CH.sub.3).sub.2 -1,3,5-triazin-2-yl           3552   4-OCH.sub.2 CH.sub.2 CN-1,3,5-triazin-2-yl                             3553   4-OCH.sub.2 CH.sub.2 SCH.sub.2 CH.sub.2 CN-1,3,5-triazin-2-yl          3554   4-OCH.sub.2 CH.sub.2 OC.sub.6 H.sub.5 -1,3,5-triazin-2-yl              3555   4-OCH.sub.2 CH.sub.2 OCH.sub.2 C.sub.6 H.sub.5 -1,3,5-triazin-2-yl            N                                                                      3556   4-OCH.sub.2 CH.sub.2 N(CH.sub.3).sub.2 -1,3,5-triazin-2-yl             3557   4-OCH.sub.2 CH.sub.2 CONH.sub.2 -1,3,5-triazin-2-yl                    3558   4-OCH.sub.2 CH.sub.2 CO.sub.2 CH.sub.2 CH.sub.2 CH.sub.3 -1,3,5-tri           azin-2-yl                                                              3559   4-OCH(CH.sub.3)CH.sub.2 OCH.sub.3 -1,3,5-triazin-2-yl                  3560   4-OCH(CH.sub.3)CH.sub.2 CO.sub.2 CH.sub.3 -1,3,5-triazin-2-yl          3561   4-OCH(CH.sub.3)CH.sub.2 CO.sub.2 CH.sub.2 CH.sub.3 -1,3,5-triazin-2           -yl                                                                    3562   4-OCH.sub.2 CH(CH.sub.3)CO.sub.2 CH.sub.3 -1,3,5-triazin-2-yl          3563   4-OCH.sub.2 C(═O)CH.sub.3 -1,3,5-triazin-2-yl                      3564   4-OCH.sub.2 C(═O)CH.sub.2 CH.sub.3 -1,3,5-triazin-2-yl             3565   4-OCH.sub.2 CO.sub.2 CH.sub.3 -1,3,5-triazin-2-yl                      3566   4-OCH.sub.2 CO.sub.2 CH.sub.2 CH.sub.3 -1,3-5-triazin-2-yl             3567   4-OCH.sub.2 C(═O)NH.sub.2 -1,3,5-triazin-2-yl                      3568   4-OCH.sub.2 C(═)NHCH.sub.3 -1,3,5-triazin-2-yl                     3569   4-OCH.sub.2 C(═O)SCH.sub.3 -1,3,5-triazin-2-yl                     3570   4-OCH(CH.sub.3)C(═O)NH.sub.2 -1,3,5-triazin-2-yl                   3571   4-OCH(CH.sub.3)C(═O)NHCH.sub.3 -1,3,5-triazin-2-yl                 3572   4-OCH(CH.sub.3)C(═O)NHNH.sub.2 -1,3,5-triazin-2-yl                 3573   4-OCH(CH.sub.3)CO.sub.2 CH.sub.3 -1,3,5-triazin-2-yl                   3574   4-OCH(CH.sub.3)CO.sub.2 CH.sub.2 CH.sub.3 -1,3,5-triazin-2-yl          3575   4-OCH(CH.sub.3)C(═O)CH.sub.2 CH.sub.3 -1,3,5-triazin-2-yl          3576   4-OCH(CH.sub.3)C(═O)CH.sub.2 CH.sub.3 -1,3,5-triazin-2-yl          3577   4-OCH(CH.sub.3)CH.sub.2 C(═O)CH.sub.3 -1,3,5-triazin-2-yl          3578   4-OCH(CH.sub.3)CH.sub.2 OC(CH.sub.3).sub.4 -1,3,5-triazin-2-yl         3579   4-OCH(CH.sub.3)CH.sub.2 OCH.sub.2 CH.sub.3 -1,3,5-triazin-2-yl         3580   4-OCH(CH.sub.3)CH.sub.2 O(CH.sub.3).sub.2 CH.sub.3 -1,3,5-triazin-2           -yl                                                                    3581   4-OCH(CH.sub.3)CH.sub.2 OCH.sub.2 CH═CH.sub.2 -1,3,5-triazin-2-           yl                                                                     3582   4-O(CH.sub.2).sub.3 OCH.sub.3 -1,3,5-triazin-2-yl                      3583   4-O(CH.sub.2).sub.3 OCH.sub.2 CH.sub.3 -1,3,5-triazin-2-yl             3584   4-O(CH.sub.2).sub.3 OCH(CH.sub.3).sub.2 -1,3,5-triazin-2-yl            3585   4-O(CH.sub.2).sub.3 OC.sub.6 H.sub.5 -1,3,5-triazin-2-yl               3586   4-O(CH.sub.2).sub.3 OCH.sub.2 C.sub.6 H.sub.5 -1,3,5-triazin-2-yl      3587   4-OCH(CH.sub.2 CH.sub.3)CH.sub.2 OCH.sub.3 -1,3,5-triazin-2-yl         3588   4-OCH(CH.sub.2 CH.sub.3)CH.sub.2 CH.sub.2 OCH.sub.3 -1,3,5-triazin-           2-yl                                                                   3589   4-OCH(CH.sub.2 CH.sub.3)CH.sub.2 CH.sub.2 OCH.sub.2 CH.sub.3                  -1,3,5-triazin-2-yl                                                    3590   4-O (CH.sub.2).sub.3 O!.sub.2 CH.sub.3 -1,3,5-triazin-2-yl             3591   4-OCH.sub.2 CH(CH.sub.3)CH.sub.2 OCH.sub.3 -1,3,5-triazin-2-yl         3592   4-OCH.sub.2 CH(CH.sub.3)CH.sub.2 OCH.sub.2 CH.sub.3 -1,3,5-triazin-           2-yl                                                                   3593   4-OCH(CH.sub.2 Cl)CH.sub.2 OCH.sub.3 -1,3,5-triazin-2-yl               3594   4-OCH(CH.sub.2 Cl)CH.sub.2 OCH.sub.2 CH.sub.3 -1,3,5-triazin-2-yl      3595   4-OCH(CH.sub.2 Cl)CH.sub.2 OCH(CH.sub.3).sub.2 -1,3,5-triazin-2-yl            a                                                                      3596   4-OCH(CH.sub.2 Cl)CH.sub.2 OCH.sub.2 CH═CH.sub.2 -1,3,5-triazin           -2-yl                                                                  3597   4-OCH CH.sub.2 OCH.sub.3 !.sub.2 -1,3,5-triazin-2-yl                   3598   4-OCH CH.sub.2 OCH.sub.2 CH.sub.3 !.sub.2 -1,3,5-triazin-2-yl          3599   4-OCCl.sub.4 -1,3,5-triazin-2-yl                                       3600   4-OCHF.sub.2 -1,3,5-triazin-2-yl                                       3601   4-OCF.sub.3 -1,3,5-triazin-2-yl                                        3602   4-OCF.sub.2 CHF.sub.2 -1,3,5-triazin-2-yl                              3603   4-OCH.sub.2 CF.sub.3 -1,3,5-triazin-2-yl                               3604   4-OCH.sub.2 CHF.sub.2 -1,3,5-triazin-2-yl                              3605   4-O(CH.sub.2).sub.3 F-1,3,5-triazin-2-yl                               3606   4-OCH(CH.sub.3)CF.sub.3 -1,3,5-triazin-2-yl                            3607   4-O(CH.sub.2).sub.4 F-1,3,5-triazin-2-yl                               3608   4-O(CH.sub.2).sub.3 CF.sub.3 -1,3,5-triazin-2-yl                       3609   4-OCH(CH.sub.3)CF.sub.2 CF.sub.3 -1,3,5-triazin-2-yl                   3610   4-OCH(CH.sub.3)CF.sub.2 CHF.sub.2 -1,3,5-triazin-2-yl                  3611   4-OCH.sub.2 CF.sub.2 CHFCH.sub.3 -1,3,5-triazin-2-yl                   3612   4-OCH.sub.2 (CF.sub.2).sub.2 CF.sub.3 -1,3,5-triazin-2-yl              3613   4-O(CF.sub.2).sub.3 CF.sub.3 -1,3,5-triazin-2-yl                       3614   4-OCH.sub.2 CF.sub.2 CHF.sub.2 -1,3,5-triazin-2-yl                     3615   4-CH.sub.2 CH═CH.sub.2 -1,3,5-triazin-2-yl                         3616   4-CH.sub.2 C(CH.sub.3)═CH.sub.2 -1,3,5-triazin-2-yl                3617   4-OCH.sub.2 CH═CHCH.sub.3 -1,3,5-triazin-2-yl                      3618   4-O(CH.sub.2).sub.2 CH═CH.sub.2 -1,3,5-triazin-2-yl                3619   4-OCH.sub.2 C(CH.sub.3)═CH.sub.2 -1,3,5-triazin-2-yl               3620   4-OCH(CH.sub.3)CH═CH.sub.2 -1,3,5-triazin-2-yl                     3621   4-OCH.sub.2 C.tbd.CH-1,3,5-triazin-2-yl                                3622   4-OCH.sub.2 C.tbd.CCH.sub.3 -1,3,5-triazin-2-yl                        3623   4-O(CH.sub.2).sub.2 C.tbd.CH-1,3,5-triazin-2-yl                        3624   4-SCH.sub.3 -1,3,5-triazin-2-yl                                        3625   4-SCH.sub.2 CH.sub.3 -1,3,5-triazin-2-yl                               3626   4-OC.sub.6 H.sub.5 -1,3,5-triazin-2-yl                                 3627   4-OCH.sub.2 C.sub.6 H.sub.5 -1,3,5-triazin-2-yl                        3628   4-NO.sub.2 -1,3,5-triazin-2-yl                                         3629   4-NHCH.sub.3 -1,3,5-triazin-2-yl                                       3630   4-N(CH.sub.3).sub.2 -1,3,5-triazin-2-yl                                3631   4-N(CH.sub.3)C.sub.2 H.sub.6 -1,3,5-triazin-2-yl                       3632   4-NHCH.sub.2 CF.sub.3 -1,3,5-triazin-2-yl                              3633   4-F-1,3,5-triazin-2-yl                                                 3635   4-Cl-1,3,5-triazin-2-yl                                                3636   4-CN-1,3,5-triazin-2-yl                                                3637   4-C(O)NH.sub.2 -1,3,5-triazin-2-yl                                     3638   4-C(S)NH.sub.2 -1,3,5-triazin-2-yl                                     3639   4-CO.sub.2 CH.sub.3 -1,3,5-triazin-2-yl                                3640   4-ON═C(CH.sub.3).sub.2 -1,3,5-triazin-2-yl                         3641   4- O-cyclopropyl!-1,3,5-triazin-2-yl                                   3642   4- O-cyclobutyl!-1,3,5-triazin-2-yl                                    3643   4- O-cyclopentyl!-1,3,5-triazin-2-yl                                   3644   4- O-cyclohexyl!-1,3,5-triazin-2-yl                                    3645   4- OCH.sub.2 -cyclopropyl!-1,3,5-triazin-2-yl                          3646   6-F, 4- OCH.sub.2 -cyclopropyl!-1,3,5-triazin-2-yl                     3647   6-CH.sub.3, 4- OCH.sub.2 -cyclopropyl!-1,3,5-triazin-2-yl              3648   6-CF.sub.3, 4- OCH.sub.2 -cyclopropyl!-1,3,5-triazin-2-yl              3649   4- OCH(CH.sub.3)-cyclopropyl!-1,3,5-triazin-2-yl                       3650   6-F, 4- OCH(CH.sub.3)-cyclopropyl!-1,3,5-triazin-2-yl                  3651   6-CH.sub.3, 4- OCH(CH.sub.3)-cyclopropyl!-1,3,5-triazin-2-yl           3652   6-CF.sub.3, 4- OCH(CH.sub.3)-cyclopropyl!-1,3,5-triazin-2-yl           3653   4- O-(1-CH.sub.3 -cyclopropyl)!-1,3,5-triazin-2-yl                     3654   6-F, 4- O-(1-CH.sub.3 -cyclopropyl)!-1,3,5-triazin-2-yl                3655   6-CH.sub.3, 4- O-(1-CH.sub.3 -cyclopropyl)!-1,3,5-triazin-2-yl         3656   6-CF.sub.3, 4- O-(1-CH.sub.3 -cyclopropyl)!-1,3,5-triazin-2-yl         3657   4- OCH.sub.2 -(1-CH.sub.3 -cyclopropyl)!-1,3,5-triazin-2-yl            3658   6-F, 4- OCH.sub.2 -(1-CH.sub.3 -cyclopropyl)!-1,3,5-triazin-2-yl       3659   6-CH.sub.3, 4- OCH.sub.2 -(1-CH.sub.3 -cyclopropyl)!-1,3,5-triazin-           2-yl                                                                   3660   6-CF.sub.3, 4- OCH.sub.2 -(1-CH.sub.3 -cyclopropyl)!-1,3,5-triazin-           2-yl                                                                   3661   4- OCH.sub.2 -(2-CH.sub.3 -cyclopropyl)!-1,3,5-triazin-2-yl            3662   6-F, 4- OCH.sub.2 -(2-CH.sub.3 -cyclopropyl)!-1,3,5-triazin-2-yl       3663   6-CH.sub.3, 4- OCH.sub.2 -(2-CH.sub.3 -cyclopropyl)!-1,3,5-triazin-           2-yl                                                                   3664   6-CF.sub.3, 4- OCH.sub.2 -(2-CH.sub.3 -cyclopropyl)!-1,3,5-triazin-           2-yl                                                                   3665   4- OCH.sub.2 -(tetrahydropyran-2-yl)!-1,3,5-triazin-2-yl               3666   6-F, 4- OCH.sub.2 -(tetrahydropyran-2-yl)!-1,3,5-triazin-2-yl          3667   6-CH.sub.3, 4- OCH.sub.2 -(tetrahydropyran-2-yl)!-1,3,5-triazin-2-y           l                                                                      3668   6-CF.sub.3, 4- OCH.sub.2 -(tetrahydropyran-2-yl)!-1,3,5-triazin-2-y           l                                                                      3669   4- OCH.sub.2 -(furan-2-yl)!-1,3,5-triazin-2-yl                         3670   6-F, 4- OCH.sub.2 -(furan-2-yl)!-1,3,5-triazin-2-yl                    3671   6-CH.sub.3, 4- OCH.sub.2 -(furan-2-yl)!-1,3,5-triazin-2-yl             3672   6-CF.sub.3, 4- OCH.sub.2 -(furan-2-yl)!-1,3,5-triazin-2-yl             3673   4- OCH.sub.2 -(furan-4-yl)!-1,3,5-triazin-2-yl                         3674   6-F, 4- OCH.sub.2 -(furan-4-yl)!-1,3,5-triazin-2-yl                    3675   6-CH.sub.3, 4- OCH.sub.2 -(furan-4-yl)!-1,3,5-triazin-2-yl             3676   6-CF.sub.3, 4- OCH.sub.2 -(furan-4-yl)!-1,3,5-triazin-2-yl             3677   4- OCH.sub.2 -(tetrahydrofuran-4-yl)!-1,3,5-triazin-2-yl               3678   6-F, 4 OCH.sub.2 -(tetrahydrofuran-4-yl)!-1,3,5-triazin-2-yl           3679   6-CH.sub.3, 4- OCH.sub.2 -(tetrahydrofuran-4-yl)!-1,3,5-triazin-2-y           l                                                                      3680   6-CF.sub.3, 4- OCH.sub.2 -(tetrahydrofuran-4-yl)!-1,3,5-triazin-2-y           l                                                                      3681   4- OCH.sub.2 -(tetrahydrofuran-2-yl)!-1,3,5-triazin-2-yl               3682   6-F, 4- OCH.sub.2 -(tetrahydrofuran-2-yl)!-1,3,5-triazin-2-yl          3683   6-CH.sub.3, 4- OCH.sub.2 -(tetrahydrofuran-2-yl)!-1,3,5-triazin-2-y           l                                                                      3684   6-CF.sub.3, 4- OCH.sub.2 -(tetrahydrofuran-2-yl)!-1,3,5-triazin-2-y           l                                                                      3685   4- O-(tetrahydropyran-4-yl)!-1,3,5-triazin-2-yl                        3686   6-F, 4- O-(tetrahydropyran-4-yl)!-1,3,5-triazin-2-yl                   3687   6-CH.sub.3, 4- O-(tetrahydropyran-4-yl)!-1,3,5-triazin-2-yl            3688   6-CF.sub.3, 4- O-(tetrahydropyran-4-yl)!-1,3,5-triazin-2-yl            3689   4- 2-Cl--C.sub.5 H.sub.4 !-1,3,5-triazin-2-yl                          3690   6-F, 4- 2-Cl--C.sub.5 H.sub.4 !-1,3,5-triazin-2-yl                     3691   6-CH.sub.3, 4- 2-Cl--C.sub.5 H.sub.4 !-1,3,5-triazin-2-yl              3692   6-CF.sub.3, 4- 2-Cl--C.sub.5 H.sub.4 !-1,3,5-triazin-2-yl              3693   4- OCH.sub.2 -(pyridin-2-yl)!-1,3,5-triazin-2-yl                       3694   6-F, 4- OCH.sub.2 -(pyridin-2-yl)!-1,3,5-triazin-2-yl                  3695   6-CH.sub.3, 4- OCH.sub.2 -(pyridin-2-yl)!-1,3,5-triazin-2-yl           3696   6-CF.sub.3, 4- OCH.sub.2 -(pyridin-2-yl)!-1,3,5-triazin-2-yl           3697   4- OCH.sub.2 -(pyridin-4-yl)!-1,3,5-triazin-2-yl                       3698   6-F, 4- OCH.sub.2 -(pyridin-4-yl)!-1,3,5-triazin-2-yl                  3699   6-CH.sub.3, 4- OCH.sub.2 -(pyridin-4-yl)!-1,3,5-triazin-2-yl           3700   6-CF.sub.3, 4- OCH.sub.2 -(pyridin-4-yl)!-1,3,5-triazin-2-yl           3701   4- morpholin-4-yl!-1,3,5-triazin-2-yl                                  3702   4- 1-CH.sub.3 -imidazol-2-yl!-1,3,5-triazin-2-yl                       3703   6-F, 4- 1-CH.sub.3 -imidazol-2-yl!-1,3,5-triazin-2-yl                  3704   6-CH.sub.3, 4- 1-CH.sub.3 -imidazol-2-yl!-1,3,5-triazin-2-yl           3705   6-CF.sub.3, 4- 1-CH.sub.3 -imidazol-2-yl!-1,3,5-triazin-2-yl           3706   4- 1,2,4-triazol-1-yl!-1,3,5-triazin-2-yl                              3707   6-F, 4- 1,2,4-triazol-1-yl!-1,3,5-triazin-2-yl                         3708   6-CH.sub.3, 4- 1,2,4-triazol-1-yl!-1,3,5-triazin-2-yl                  3709   6-CF.sub.3, 4- 1,2,4-triazol-1-yl!-1,3,5-triazin-2-yl                  3710   4,6-Cl.sub.2 -1,3,5-triazin-2-yl                                       3711   4,6-(CH.sub.3).sub.2 -1,3,5-triazin-2-yl                               3712   4,6-(OCH.sub.3).sub.2 -1,3,5-triazin-2-yl                              3713   4,6-(OCH.sub.2 CH.sub.3).sub.2 -1,3,5-triazin-2-yl                     3714   4-F, 6-CH.sub.3 -1,3,5-triazin-2-yl                                    3715   4-F, 6-OCH.sub.3 -1,3,5-triazin-2-yl                                   3716   4-F, 6-OCH.sub.2 CH.sub.3 -1,3,5-triazin-2-yl                          3717   4-F, 6-OCH.sub.2 CF.sub.3 -1,3,5-triazin-2-yl                          3718   4-F, 6-OCH(CH.sub.3).sub.2 -1,3,5-triazin-2-yl                         3719   4-Cl, 6-CH.sub.3 -1,3,5-triazin-2-yl                                   3720   4-Cl, 6-OCH.sub.3 -1,3,5-triazin-2-yl                                  3721   4-Cl, 6-OCH.sub.2 CH.sub.3 -1,3,5-triazin-2-yl                         3722   4-Cl, 6-OCH.sub.2 CF.sub.3 -1,3,5-triazin-2-yl                         3723   4-Cl, 6-OCH(CH.sub.3).sub.2 -1,3,5-triazin-2-yl                        3724   4-CH.sub.3, 6-OCH.sub.3 -1,3,5-triazin-2-yl                            3725   4-CH.sub.3, 6-OCH.sub.2 CH.sub.3 -1,3,5-triazin-2-yl                   3726   4-CH.sub.3, 6-OCH.sub.2 CF.sub.3 -1,3,5-triazin-2-yl                   3727   4-CH.sub.3, 6-OCH(CH.sub.3).sub.2 -1,3,5-triazin-2-yl                  3728   4-CH.sub.3, 6-OCH.sub.2 CH═CH.sub.2 -1,3,5-triazin-2-yl            3729   4-CH.sub.3, 6-CO.sub.2 CH.sub.3 -1,3,5-triazin-2-yl                    3730   4-CH.sub.3, 6-CF.sub.3 -1,3,5-triazin-2-yl                             3731   4-CF.sub.3, 6-CH.sub.2 CH.sub.3 -1,3,5-triazin-2-yl                    3732   4-CF.sub.3, 6-OCH.sub.3 -1,3,5-triazin-2-yl                            3733   4-CF.sub.3, 6-OCH.sub.2 CH.sub.3 -1,3,5-triazin-2-yl                   3734   4-CF.sub.3, 6-OCH.sub.2 CF.sub.3 -1,3,5-triazin-2-yl                   3735   4-OCH.sub.3, 6-OCH.sub.2 CH.sub.3 -1,3,5-triazin-2-yl                  3736   4-OCF.sub.3, 6-OCH.sub.2 CH.sub.3 -1,3,5-triazin-2-yl                  3737   4-OCH.sub.3, 6-OCH(CH.sub.3)-1,3,5-triazin-2-yl                        3738   4-OCH.sub.2 CH.sub.3, 6-CH.sub.2 OCH.sub.2 CH.sub.3 -1,3,5-triazin-           2-yl                                                                   3739   4-NO.sub.2, 6-CH.sub.3 -1,3,5-triazin-2-yl                             3740   4-NO.sub.2, 6-OCH.sub.3 -1,3,5-triazin-2-yl                            3741   4-NO.sub.2, 6-OCH.sub.2 CH.sub.3 -1,3,5-triazin-2-yl                   3742   4-NO.sub.2, 6-OCH(CH.sub.3).sub.2 -1,3,5-triazin-2-yl                  3743   4-NO.sub.2, 6-OCH.sub.2 CF.sub.3 -1,3,5-triazin-2-yl                   3744   4-CN, 6-CH.sub.3 -1,3,5-triazin-2-yl                                   3745   4-CN, 6-OCH.sub.3 -1,3,5-triazin-2-yl                                  3746   4-CN, 6-OCH.sub.2 CH.sub.3 -1,3,5-triazin-2-yl                         3747   4-CN, 6-OCH(CH.sub.3).sub.2 -1,3,5-triazin-2-yl                        3748   4-CN, 6-OCH.sub.2 CF.sub.3 -1,3,5-triazin-2-yl                         3749   1-CH.sub.3, 4-CH.sub.3 -indol-2-yl                                     3750   1-CH.sub.3, 4-CH.sub.2 CH.sub.3 -indol-2-yl                            3751   1-CH.sub.3, 4-CH(CH.sub.3).sub.2 -indol-2-yl                           3752   1-CH.sub.3, 4-CH(CH.sub.3)CH.sub.2 CH.sub.3 -indol-2-yl                3753   1-CH.sub.3, 4-CF.sub.3 -indol-2-yl                                     3754   1-CH.sub.3, 4-CH═CH.sub.2 -indol-2-yl                              3755   1-CH.sub.3, 4-CH═CHCH.sub.3 -indol-2-yl                            3756   1-CH.sub.3, 4-CH═CHCl-indol-2-yl                                   3757   1-CH.sub.3, 4-C.tbd.CH-indol-2-yl                                      3758   1-CH.sub.3, 4-CH.sub.2 C.tbd.CH-indol-2-yl                             3759   1-CH.sub.3, 4-CH.sub.2 C.tbd.CCH.sub.3 -indol-2-yl                     3760   1-CH.sub.3, 4-cyclopropyl-indol-2-yl                                   3761   1-CH.sub.3, 4-cyclopentyl-indol-2-yl                                   3762   1-CH.sub.3, 4-OCH.sub.3 -indol-2-yl                                    3763   1-CH.sub.3, 4-OCH.sub.2 CH.sub.3 -indol-2-yl                           3764   1-CH.sub.3, 4-OCH.sub.2 CH.sub.2 CH.sub.3 -indol-2-yl                  3765   1-CH.sub.3, 4-OCH(CH.sub.3).sub.2 -indol-2-yl                          3766   1-CH.sub.3, 4-OCH.sub.2 CH.sub.2 CH.sub.2 CH.sub.3 -indol-2-yl         3767   1-CH.sub.3, 4-OCH(CH.sub.3)CH.sub.2 CH.sub.3 -indol-2-yl               3768   1-CH.sub.3, 4-OCH.sub.2 CH(CH.sub.3).sub.2 -indol-2-yl                 3769   1-CH.sub.3, 4-OC(CH.sub.3).sub.4 -indol-2-yl                           3770   1-CH.sub.3, 4-OCH(CH.sub.3)CH.sub.2 CH.sub.2 CH.sub.3 -indol-2-yl      3771   1-CH.sub.3, 4-OCH.sub.2 OCH.sub.3 -indol-2-yl                          3772   1-CH.sub.3, 4-OCH.sub.2 OCH.sub.2 CH.sub.3 -indol-2-yl                 3773   1-CH.sub.3, 4-OCH(CH.sub.3)OCH.sub.3 -indol-2-yl                       3774   1-CH.sub.3, 4-OCH(CH.sub.3)OCH.sub.2 CH.sub.3 -indol-2-yl              3775   1-CH.sub.3, 4-OCH.sub.2 CH.sub.2 OCH.sub.3 -indol-2-yl                 3776   1-CH.sub.3, 4-OCH.sub.2 CH.sub.2 OCH.sub.2 CH.sub.3 -indol-2-yl        3777   1-CH.sub.3, 4-OCH.sub.2 CH.sub.2 OCH(CH.sub.3).sub.2 -indol-2-yl       3778   1-CH.sub.3, 4-OCH.sub.2 CH.sub.2 SCH.sub.3 -indol-2-yl                 3779   1-CH.sub.3, 4-OCH.sub.2 CH.sub.2 SO.sub.2 CH.sub.3 -indol-2-yl         3780   1-CH.sub.3, 4-OCH.sub.2 CH.sub.2 SCH(CH.sub.3).sub.2 -indol-2-yl       3781   1-CH.sub.3, 4-OCH.sub.2 CH.sub.2 CN-indol-2-yl                         3782   1-CH.sub.3, 4-OCH.sub.2 CH.sub.2 SCH.sub.2 CH.sub.2 CN-indol-2-yl      3783   1-CH.sub.3, 4-OCH.sub.2 CH.sub.2 OC.sub.6 H.sub.5 -indol-2-yl          3784   1-CH.sub.3, 4-OCH.sub.2 CH.sub.2 OCH.sub.2 C.sub.6 H.sub.5                    -indol-2-yl                                                            3785   1-CH.sub.3, 4-OCH.sub.2 CH.sub.2 N(CH.sub.3).sub.2 -indol-2-yl         3786   1-CH.sub.3, 4-OCH.sub.2 CH.sub.2 CONH.sub.2 -indol-2-yl                3787   1-CH.sub.3, 4-OCH.sub.2 CH.sub.2 CO.sub.2 CH.sub.2 CH.sub.2                   CH.sub.3 -indol-2-yl                                                   3788   1-CH.sub.3, 4-OCH(CH.sub.3)CH.sub.2 OCH.sub.3 -indol-2-yl              3789   1-CH.sub.3, 4-OCH(CH.sub.3)CH.sub.2 CO.sub.2 CH.sub.3 -indol-2-yl      3790   1-CH.sub.3, 4-OCH(CH.sub.3 (CH.sub.2 CO.sub.2 CH.sub.2 CH.sub.3               -indol-2-yl                                                            3791   1-CH.sub.3, 4-OCH.sub.2 CH(CH.sub.3)CO.sub.2 CH.sub.3 -indol-2-yl      3792   1-CH.sub.3, 4-OCH.sub.2 C(═O)CH.sub.3 -indol-2-yl                  3793   1-CH.sub.3, 4-OCH.sub.2 C(═O)CH.sub.2 CH.sub.3 -indol-2-yl         3794   1-CH.sub.3, 4-OCH.sub.2 CO.sub.2 CH.sub.3 -indol-2-yl                  3795   1-CH.sub.3, 4-OCH.sub.2 CO.sub.2 CH.sub.2 CH.sub.3 -indol-2-yl         3796   1-CH.sub.3, 4-OCH.sub.2 C(═O)NH.sub.2 -indol-2-yl                  3797   1-CH.sub.3, 4-OCH.sub.2 C(═O)NHCH.sub.3 -indol-2-yl                3798   1-CH.sub.3, 4-OCH.sub.2 C(═)SCH.sub.3 -indol-2-yl                  3799   1-CH.sub.3, 4-OCH(CH.sub.3)C(═O)NH.sub.2 -indol-2-yl               3800   1-CH.sub.3, 4-OCH(CH.sub.3)C(═O)NHCH.sub.3 -indol-2-yl             3801   1-CH.sub.3, 4-OCH(CH.sub.3)C(═O)NHNH.sub.2 -indol-2-yl             3802   1-CH.sub.3, 4-OCH(CH.sub.3)CO.sub.2 CH.sub.3 -indol-2-yl               3803   1-CH.sub.3, 4-OCH(CH.sub.3)CO.sub.2 CH.sub.2 CH.sub.3 -indol-2-yl      3804   1-CH.sub.3, 4-OCH(CH.sub.3)C(═O)CH.sub.3 -indol-2-yl               3805   1-CH.sub.3, 4-OCH(CH.sub.3)C(═O)CH.sub.2 CH.sub.3 -indol-2-yl      3806   1-CH.sub.3, 4-OCH(CH.sub.3)CH.sub.2 C(═O)CH.sub.3 -indol-2-yl      3807   1-CH.sub.3, 4-OCH(CH.sub.3)CH.sub.2 OC(CH.sub.3).sub.4 -indol-2-yl            N                                                                      3808   1-CH.sub.3, 4-OCH(CH.sub.3)CH.sub.2 OCH.sub.2 CH.sub.3 -indol-2-yl            N                                                                      3809   1-CH.sub.3, 4-OCH(CH.sub.3)CH.sub.2 O(CH.sub.3).sub.2 CH.sub.3                -indol-2-yl                                                            3810   1-CH.sub.3, 4-OCH(CH.sub.3)CH.sub.2 OCH.sub.2 CH═CH.sub.2                 -indol-2-yl                                                            3811   1-CH.sub.3, 4-O(CH.sub.2).sub.3 OCH.sub.3 -indol-2-yl                  3812   1-CH.sub.3, 4-O(CH.sub.2).sub.3 OCH.sub.2 CH.sub.3 -indol-2-yl         3813   1-CH.sub.3, 4-O(CH.sub.2).sub.3 OCH(CH.sub.3).sub.2 -indol-2-yl        3814   1-CH.sub.3, 4-O(CH.sub.2).sub.3 OC.sub.6 H.sub.5 -indol-2-yl           3815   1-CH.sub.3, 4-O(CH.sub.2).sub.3 OCH.sub.2 C.sub.6 H.sub.5 -indol-2-           yl                                                                     3816   1-CH.sub.3, 4-OCH(CH.sub.2 CH.sub.3)CH.sub.2 OCH.sub.3 -indol-2-yl            a                                                                      3817   1-CH.sub.3, 4-OCH(CH.sub.2 CH.sub.3)CH.sub.2 CH.sub.2 OCH.sub.3               -indol-2-yl                                                            3818   1-CH.sub.3, 4-OCH(CH.sub.2 CH.sub.3)CH.sub.2 CH.sub.2 OCH.sub.2               CH.sub.3 -indol-2-yl                                                   3819   1-CH.sub.3, 4-O (CH.sub.2).sub.3 O!.sub.2 CH.sub.3 -indol-2-yl         3820   1-CH.sub.3, 4-OCH.sub.2 CH(CH.sub.3)CH.sub.2 OCH.sub.3 -indol-2-yl            r                                                                      3821   1-CH.sub.3, 4-OCH.sub.2 CH(CH.sub.3)CH.sub.2 OCH.sub.2 CH.sub.3               -indol-2-yl                                                            3822   1-CH.sub.3, 4-OCH(CH.sub.2 Cl)CH.sub.2 OCH.sub.3 -indol-2-yl           3823   1-CH.sub.3, 4-OCH(CH.sub.2 Cl)CH.sub.2 OCH.sub.2 CH.sub.3 -indol-2-           yl                                                                     3824   1-CH.sub.3, 4-OCH(CH.sub.2 Cl)CH.sub.2 OCH(CH.sub.3).sub.2                    -indol-2-yl                                                            3825   1-CH.sub.3, 4-OCH(CH.sub.2 Cl)CH.sub.2 OCH.sub.2 CH═CH.sub.2              -indol-2-yl                                                            3826   1-CH.sub.3, 4-OCH CH.sub.2 OCH.sub.3 !.sub.2 -indol-2-yl               3827   1-CH.sub.3, 4-OCH CH.sub.2 OCH.sub.2 CH.sub.3 !.sub.2 -indol-2-yl      3828   1-CH.sub.3, 4-OCCl.sub.4 -indol-2-yl                                   3829   1-CH.sub.3, 4-OCHF.sub.2 -indol-2-yl                                   3830   1-CH.sub.3, 4-OCF.sub.3 -indol-2-yl                                    3831   1-CH.sub.3, 4-OCF.sub.2 CHF.sub.2 -indol-2-yl                          3832   1-CH.sub.3, 4-OCH.sub.2 CF.sub.3 -indol-2-yl                           3833   1-CH.sub.3, 4-OCH.sub.2 CHF.sub.2 -indol-2-yl                          3834   1-CH.sub.3, 4-O(CH.sub.2).sub.3 F-indol-2-yl                           3835   1-CH.sub.3, 4-OCH(CH.sub.3)CF.sub.3 -indol-2-yl                        3836   1-CH.sub.3, 4-O(CH.sub.2).sub.4 F-indol-2-yl                           3837   1-CH.sub.3, 4-O(CH.sub.2).sub.3 CF.sub.3 -indol-2-yl                   3838   1-CH.sub.3, 4-OCH(CH.sub.3)CF.sub.2 CF.sub.3 -indol-2-yl               3839   1-CH.sub.3, 4-OCH(CH.sub.3)CF.sub.2 CHF.sub.2 -indol-2-yl              3840   1-CH.sub.3, 4-OCH.sub.2 CF.sub.2 CHFCH.sub.3 -indol-2-yl               3841   1-CH.sub.3, 4-OCH.sub.2 (CF.sub.2).sub.2 CF.sub.3 -indol-2-yl          3842   1-CH.sub.3, 4-O(CF.sub.2).sub.3 CF.sub.3 -indol-2-yl                   3843   1-CH.sub.3, 4-OCH.sub.2 CF.sub.2 CHF.sub.2 -indol-2-yl                 3844   1-CH.sub.3, 4-CH.sub.2 CH═CH.sub.2 -indol-2-yl                     3845   1-CH.sub.3, 4-CH.sub.2 C(CH.sub.3)═CH.sub.2 -indol-2-yl            3846   1-CH.sub.3, 4-OCH.sub.2 CH═CHCH.sub.3 -indol-2-yl                  3847   1-CH.sub.3, 4-O(CH.sub.2).sub.2 CH═CH.sub.2 -indol-2-yl            3848   1-CH.sub.3, 4-OCH.sub.2 C(CH.sub.3)═CH.sub.2 -indol-2-yl           3849   1-CH.sub.3, 4-OCH(CH.sub.3)CH═CH.sub.2 -indol-2-yl                 3850   1-CH.sub.3, 4-OCH.sub.2 C.tbd.CH-indol-2-yl                            3851   1-CH.sub.3, 4-OCH.sub.2 C.tbd.CH-indol-2-yl                            3852   1-CH.sub.3, 4-O(CH.sub.2).sub.2 C.tbd.CH-indol-2-yl                    3853   1-CH.sub.3, 4-SCH.sub.3 -indol-2-yl                                    3854   1-CH.sub.3, 4-SCH.sub.2 CH.sub.3 -indol-2-yl                           3855   1-CH.sub.3, 4-OC.sub.6 H.sub.5 -indol-2-yl                             3856   1-CH.sub.3, 4-OCH.sub.2 C.sub.6 H.sub.5 -indol-2-yl                    3857   1-CH.sub.3, 4-NO.sub.2 -indol-2-yl                                     3858   1-CH.sub.3, 4-NHCH.sub.3 -indol-2-yl                                   3859   1-CH.sub.3, 4-N(CH.sub.3).sub.2 -indol-2-yl                            3860   1-CH.sub.3, 4-N(CH.sub.3)C.sub.2 H.sub.6 -indol-2-yl                   3861   1-CH.sub.3, 4-NHCH.sub.2 CF.sub.3 -indol-2-yl                          3862   1-CH.sub.3, 4-F-indol-2-yl                                             3863   1-CH.sub.3, 4-Cl-indol-2-yl                                            3864   1-CH.sub.3, 4-OH-indol-2-yl                                            3865   1-CH.sub.3, 4-CN-indol-2-yl                                            3866   1-CH.sub.3, 4-C(O)NH.sub.2 -indol-2-yl                                 3867   1-CH.sub.3, 4-C(S)NH.sub.2 -indol-2-yl                                 3868   1-CH.sub.3, 4-CO.sub.2 CH.sub.3 -indol-2-yl                            3869   1-CH.sub.3, 4-ON═C(CH.sub.3).sub.2 -indol-2-yl                     3870   1-CH.sub.3, 4- O-cyclopropyl!indol-2-yl                                3871   1-CH.sub.3, 4- O-cyclobutyl!indol-2-yl                                 3872   1-CH.sub.3, 4- O-cyclopentyl!indol-2-yl                                3873   1-CH.sub.3, 4- O-cyclohexyl!indol-2-yl                                 3874   1-CH.sub.3, 4- OCH.sub.2 -cyclopropyl!indol-2-yl                       3875   1-CH.sub.3, 6-F, 4- OCH.sub.2 -cyclopropyl!indol-2-yl                  3876   1-CH.sub.3, 6-CH.sub.3, 4- OCH.sub.2 -cyclopropyl!indol-2-yl           3877   1-CH.sub.3, 6-CF.sub.3, 4- OCH.sub.2 -cyclopropyl!indol-2-yl           3878   1-CH.sub.3, 4- OCH(CH.sub.3)-cyclopropyl!indol-2-yl                    3879   1-CH.sub.3, 6-F, 4- OCH(CH.sub.3)-cyclopropyl!indol-2-yl               3880   1-CH.sub.3, 6-CH.sub.3, 4- OCH(CH.sub.3)-cyclopropyl!indol-2-yl        3881   1-CF.sub.3, 6-CH.sub.3, 4- OCH(CH.sub.3)-cyclopropyl!indol-2-yl        3882   1-CH.sub.3, 4- O-(1-CH.sub.3 -cyclopropyl)!indol-2-yl                  3883   1-CH.sub.3, 6-F, 4- O-(1-CH.sub.3 -cyclopropyl)!indol-2-yl             3884   1-CH.sub.3, 6-CH.sub.3, 4- O-(1-CH.sub.3 -cyclopropyl)!indol-2-yl      3885   1-CH.sub.3, 6-CF.sub.3, 4- O-(1-CH.sub.3 -cyclopropyl)!indol-2-yl      3886   1-CH.sub.3, 4- OCH.sub.2 -(1-CH.sub.3 -cyclopropyl)!indol-2-yl         3887   1-CH.sub.3, 6-F, 4- OCH.sub.2 -(1-CH.sub.3 -cyclopropyl)!indol-2-yl           N                                                                      3888   1-CH.sub.3, 6-CH.sub.3, 4- OCH.sub.2 -(1-CH.sub.3 -cyclopropyl)!ind           ol-2-yl                                                                3889   1-CH.sub.3, 6-CF.sub.3, 4- OCH.sub.2 -(1-CH.sub.3 -cyclopropyl)!ind           ol-2-yl                                                                3890   1-CH.sub.3, 4- OCH.sub.2 -(2-CH.sub.3 -cyclopropyl)!indol-2-yl         3891   1-CH.sub.3, 6-F, 4- OCH.sub.2 -(2-CH.sub.3 -cyclopropyl)!indol-2-yl           A                                                                      3892   1-CH.sub.3, 6-CH.sub.3, 4- OCH.sub.2 -(2-CH.sub.3 -cyclopropyl)!ind           ol-2-yl                                                                3893   1-CH.sub.3, 6-CF.sub.3, 4- OCH.sub.2 -(2-CH.sub.3 -cyclopropyl)!ind           ol-2-yl                                                                3894   1-CH.sub.3, 4- OCH.sub.2 -(tetrahydropyran-2-yl)!indol-2-yl            3895   1-CH.sub.3, 6-F, 4- OCH.sub.2 -(tetrahydropyran-2-yl)!indol-2-yl       3896   1-CH.sub.3, 6-CH.sub.3, 4- OCH.sub.2 -(tetrahydropyran-2-yl)!indol-           2-yl                                                                   3897   1-CH.sub.3, 6-CF.sub.3, 4- OCH.sub.2 -(tetrahydropyran-2-yl)!indol-           2-yl                                                                   3898   1-CH.sub.3, 4- OCH.sub.2 -(furan-2-yl)!indol-2-yl                      3899   1-CH.sub.3, 6-F, 4- OCH.sub.2 -(furan-2-yl)!indol-2-yl                 3900   1-CH.sub.3, 6-CH.sub.3, 4- OCH.sub.2 -(furan-2-yl)!indol-2-yl          3901   1-CH.sub.3, 6-CF.sub.3, 4- OCH.sub.2 -(furan-2-yl)!indol-2-yl          3902   1-CH.sub.3, 4- OCH.sub.2 -(furan-4-yl)!indol-2-yl                      3903   1-CH.sub.3, 6-F, 4- OCH.sub.2 -(furan-4-yl)!indol-2-yl                 3904   1-CH.sub.3, 6-CH.sub.3, 4- OCH.sub.2 -(furan-4-yl)!indol-2-yl          3905   1-CH.sub.3, 6-CF.sub.3, 4- OCH.sub.2 -(furan-4-yl)!indol-2-yl          3906   1-CH.sub.3, 4- OCH.sub.2 -(tetrahydrofuran-4-yl)!indol-2-yl            3907   1-CH.sub.3, 6-F, 4- OCH.sub.2 -(tetrahydrofuran-4-yl)!indol-2-yl       3908   1-CH.sub.3, 6-CH.sub.3, 4- OCH.sub.2 -(tetrahydrofuran-4-yl)!indol-           2-yl                                                                   3909   1-CH.sub.3, 6-CF.sub.3, 4- OCH.sub.2 -(tetrahydrofuran-4-yl)!indol-           2-yl                                                                   3910   1-CH.sub.3, 4- OCH.sub.2 -(tetrahydrofuran-2-yl)!indol-2-yl            3911   1-CH.sub.3, 6-F, 4- OCH.sub.2 -(tetrahydrofuran-2-yl)!indol-2-yl       3912   1-CH.sub.3, 6-CH.sub.3, 4- OCH.sub.2 -(tetrahydrofuran-2-yl)!indol-           2-yl                                                                   3913   1-CH.sub.3, 6-CF.sub.3, 4- OCH.sub.2 -(tetrahydrofuran-2-yl)!indol-           2-yl                                                                   3914   1-CH.sub.3, 4- O-(tetrahydropyran-4-yl)!indol-2-yl                     3915   1-CH.sub.3, 6-F, 4- O-(tetrahydropyran-4-yl)!indol-2-yl                3916   1-CH.sub.3, 6-CH.sub.3, 4- O-(tetrahydropyran-4-yl)!indol-2-yl         3917   1-CH.sub.3, 6-CF.sub.3, 4- O-(tetrahydropyran-4-yl)!indol-2-yl         3918   1-CH.sub.3, 4- 2-Cl--C.sub.5 H.sub.4 !indol-2-yl                       3919   1-CH.sub.3, 6-F, 4- 2-Cl--C.sub.5 H.sub.4 !indol-2-yl                  3920   1-CH.sub.3, 6-CH.sub.3, 4- 2-Cl--C.sub.5 H.sub.4 !indol-2-yl           3921   1-CH.sub.3, 6-CF.sub.3, 4- 2-Cl--C.sub.5 H.sub.4 !indol-2-yl           3922   1-CH.sub.3, 4- OCH.sub.2 -(pyridin-2-yl)!indol-2-yl                    3923   1-CH.sub.3, 6-F, 4- OCH.sub.2 -(pyridin-2-yl)!indol-2-yl               3924   1-CH.sub.3, 6-CH.sub.3, 4- OCH.sub.2 -(pyridin-2-yl)!indol-2-yl        3925   1-CH.sub.3, 6-CF.sub.3, 4- OCH.sub.2 -(pyridin-2-yl)!indol-2-yl        3926   1-CH.sub.3, 4- OCH.sub.2 -(pyridin-4-yl)!indol-2-yl                    3927   1-CH.sub.3, 6-F, 4- OCH.sub.2 -(pyridin-4-yl)!indol-2-yl               3928   1-CH.sub.3, 6-CH.sub.3, 4- OCH.sub.2 -(pyridin-4-yl)!indol-2-yl        3929   1-CH.sub.3, 6-CF.sub.3, 4- OCH.sub.2 -(pyridin-4-yl)!indol-2-yl        3930   1-CH.sub.3, 4- morpholin-4-yl!indol-2-yl                               3931   1-CH.sub.3, 4- 1-CH.sub.3 -imidazol-2-yl!indol-2-yl                    3932   1-CH.sub.3, 6-F, 4- 1-CH.sub.3 -imidazol-2-yl!indol-2-yl               3933   1-CH.sub.3, 6-CH.sub.3, 4- 1-CH.sub.3 -imidazol-2-yl!indol-2-yl        3934   1-CH.sub.3, 6-CF.sub.3, 4- 1-CH.sub.3 -imidazol-2-yl!indol-2-yl        3935   1-CH.sub.3, 4- 1,2,4-triazol-1-yl!indol-2-yl                           3936   1-CH.sub.3, 6-F, 4- 1,2,4-triazol-1-yl!indol-2-yl                      3937   1-CH.sub.3, 6-CH.sub.3, 4- 1,2,4-triazol-1-yl!indol-2-yl               3938   1-CH.sub.3, 6-CF.sub.3, 4- 1,2,4-triazol-1-yl!indol-2-yl               3939   1-CH.sub.3, 4,6-Cl.sub.2 -indol-2-yl                                   3940   1-CH.sub.3, 4,6-(CH.sub.3).sub.2 -indol-2-yl                           3941   1-CH.sub.3, 4,6-(OCH.sub.3).sub.2 -indol-2-yl                          3942   1-CH.sub.3, 4,6-(OCH.sub.2 CH.sub.3).sub.2 -indol-2-yl                 3943   1-CH.sub.3, 4-F, 6-CH.sub.3 -indol-2-yl                                3944   1-CH.sub.3, 4-F, 6-OCH.sub.3 -indol-2-yl                               3945   1-CH.sub.3, 4-F, 6-OCH.sub.2 CH.sub.3 -indol-2-yl                      3946   1-CH.sub.3, 4-F, 6-OCH.sub.2 CF.sub.3 -indol-2-yl                      3947   1-CH.sub.3, 4-F, 6-OCH(CH.sub.3).sub.2 -indol-2-yl                     3948   1-CH.sub.3, 4-Cl, 6-CH.sub.3 -indol-2-yl                               3949   1-CH.sub.3, 4-Cl, 6-OCH.sub.3 -indol-2-yl                              3950   1-CH.sub.3, 4-Cl, 6-OCH.sub.2 CH.sub.3 -indol-2-yl                     3951   1-CH.sub.3, 4-Cl, 6-OCH.sub.2 CF.sub.3 -indol-2-yl                     3952   1-CH.sub.3, 4-Cl, 6-OCH(CH.sub.3).sub.2 -indol-2-yl                    3953   1-CH.sub.3, 4-CH.sub.3, 6-OCH.sub.3 -indol-2-yl                        3954   1-CH.sub.3, 4-CH.sub.3, 6-OCH.sub.2 CH.sub.3 -indol-2-yl               3955   1-CH.sub.3, 4-CH.sub.3, 6-OCH.sub.2 CF.sub.3 -indol-2-yl               3956   1-CH.sub.3, 4-CH.sub.3, 6-OCH(CH.sub.3).sub.2 -indol-2-yl              3957   1-CH.sub.3, 4-CH.sub.3, 6-OCH.sub.2 CH═CH.sub.2 -indol-2-yl        3958   1-CH.sub.3, 4-CH.sub.3, 6-CO.sub.2 CH.sub.3 -indol-2-yl                3959   1-CH.sub.3, 4-CH.sub.3, 6-CF.sub.3 -indol-2-yl                         3960   1-CH.sub.3, 4-CF.sub.3, 6-CH.sub.2 CH.sub.3 -indol-2-yl                3961   1-CH.sub.3, 4-CF.sub.3, 6-OCH.sub.3 -indol-2-yl                        3962   1-CH.sub.3, 4-CF.sub.3, 6-OCH.sub.2 CH.sub.3 -indol-2-yl               3963   1-CH.sub.3, 4-CF.sub.3, 6-OCH.sub.2 CF.sub.3 -indol-2-yl               3964   1-CH.sub.3, 4-OCH.sub.3, 6-OCH.sub.2 CH.sub.3 -indol-2-yl              3965   1-CH.sub.3, 4-OCH.sub.3, 6-OCH.sub.2 CF.sub.3 -indol-2-yl              3966   1-CH.sub.3, 4-OCH.sub.3, 6-OCH(CH.sub.3)-indol-2-yl                    3967   1-CH.sub.3, 4-OCH.sub.2 CH.sub.3, 6-CH.sub.2 OCH.sub.2 CH.sub.3               -indol-2-yl                                                            3968   1-CH.sub.3, 4-NO.sub.2, 6-CH.sub.3 -indol-2-yl                         3969   1-CH.sub.3, 4-NO.sub.2, 6-OCH.sub.3 -indol-2-yl                        3970   1-CH.sub.3, 4-NO.sub.2, 6-OCH.sub.2 CH.sub.3 -indol-2-yl               3971   1-CH.sub.3, 4-NO.sub.2, 6-OCH(CH.sub.3).sub.2 -indol-2-yl              3972   1-CH.sub.3, 4-NO.sub.2, 6-OCH.sub.2 CF.sub.3 -indol-2-yl               3973   1-CH.sub.3, 4-CN, 6-CH.sub.3 -indol-2-yl                               3974   1-CH.sub.3, 4-CN, 6-OCH.sub.3 -indol-2-yl                              3975   1-CH.sub.3, 4-CN, 6-OCH.sub.2 CH.sub.3 -indol-2-yl                     3976   1-CH.sub.3, 4-CN, 6-OCH(CH.sub.3).sub.2 -indol-2-yl                    3977   1-CH.sub.3, 4-CN, 6-OCH.sub.2 CF.sub.3 -indol-2-yl                     3978   1-CH.sub.3, 4-CH.sub.3 -indol-3-yl                                     3979   1-CH.sub.3, 4-CH.sub.2 CH.sub.3 -indol-3-yl                            3980   1-CH.sub.3, 4-CH(CH.sub.3).sub.2 -indol-3-yl                           3981   1-CH.sub.3, 4-CH(CH.sub.3)CH.sub.2 CH.sub.3 -indol-3-yl                3982   1-CH.sub.3, 4-CF.sub.3 -indol-3-yl                                     3983   1-CH.sub.3, 4-CH═CH.sub.2 -indol-3-yl                              3984   1-CH.sub.3, 4-CH═CHCH.sub.3 -indol-3-yl                            3985   1-CH.sub.3, 4-CH═CHCl-indol-3-yl                                   3986   1-CH.sub.3, 4-C.tbd.CH-indol-3-yl                                      3987   1-CH.sub.3, 4-CH.sub.2 C.tbd.CH-indol-3-yl                             3988   1-CH.sub.3, 4-CH.sub.2 C.tbd.CCH.sub.3 -indol-3-yl                     3989   1-CH.sub.3, 4-cyclopropyl-indol-3-yl                                   3990   1-CH.sub.3, 4-cyclopentyl-indol-3-yl                                   3991   1-CH.sub.3, 4-OCH.sub.3 -indol-3-yl                                    3992   1-CH.sub.3, 4-OCH.sub.2 CH.sub.3 -indol-3-yl                           3993   1-CH.sub.3, 4-OCH.sub.2 CH.sub.2 CH.sub.3 -indol-3-yl                  3994   1-CH.sub.3, 4-OCH(CH.sub.3).sub.2 -indol-3-yl                          3995   1-CH.sub.3, 4-OCH.sub.2 CH.sub.2 CH.sub.2 CH.sub.3 -indol-3-yl         3996   1-CH.sub.3, 4-OCH(CH.sub.3)CH.sub.2 CH.sub.3 -indol-3-yl               3997   1-CH.sub.3, 4-OCH.sub.2 CH(CH.sub.3).sub.2 -indol-3-yl                 3998   1-CH.sub.3, 4-OC(CH.sub.3).sub.4 -indol-3-yl                           3999   1-CH.sub.3, 4-OCH(CH.sub.3)CH.sub.2 CH.sub.2 CH.sub.3 -indol-3-yl      4000   1-CH.sub.3, 4-OCH.sub.2 OCH.sub.3 -indol-3-yl                          4001   1-CH.sub.3, 4-OCH.sub.2 OCH.sub.2 CH.sub.3 -indol-3-yl                 4002   1-CH.sub.3, 4-OCH(CH.sub.3)OCH.sub.3 -indol-3-yl                       4003   1-CH.sub.3, 4-OCH(CH.sub.3)OCH.sub.2 CH.sub.3 -indol-3-yl              4004   1-CH.sub.3, 4-OCH.sub.2 CH.sub.2 OCH.sub.3 -indol-3-yl                 4005   1-CH.sub.3, 4-OCH.sub.2 CH.sub.2 OCH.sub.2 CH.sub.3 -indol-3-yl        4006   1-CH.sub.3, 4-OCH.sub.2 CH.sub.2 OCH(CH.sub.3).sub.2 -indol-3-yl       4007   1-CH.sub.3, 4-OCH.sub.2 CH.sub.2 SCH.sub.3 -indol-3-yl                 4008   1-CH.sub.3, 4-OCH.sub.2 SO.sub.2 CH.sub.3 -indol-3-yl                  4009   1-CH.sub.3, 4-OCH.sub.2 CH.sub.2 SCH(CH.sub.3).sub.2 -indol-3-yl       4010   1-CH.sub.3, 4-OCH.sub.2 CH.sub.2 CN-indol-3-yl                         4011   1-CH.sub.3, 4-OCH.sub.2 CH.sub.2 SCH.sub.2 CH.sub.2 CN-indol-3-yl      4012   1-CH.sub.3, 4-OCH.sub.2 CH.sub.2 OC.sub.6 H.sub.5 -indol-3-yl          4013   1-CH.sub.3, 4-OCH.sub.2 CH.sub.2 OCH.sub.2 C.sub.6 H.sub.5                    -indol-3-yl                                                            4014   1-CH.sub.3, 4-OCH.sub.2 CH.sub.2 N(CH.sub.3).sub.2 -indol-3-yl         4015   1-CH.sub.3, 4-OCH.sub.2 CH.sub.2 CONH.sub.2 -indol-3-yl                4016   1-CH.sub.3, 4-OCH.sub.2 CH.sub.2 CO.sub.2 CH.sub.2 CH.sub.2                   CH.sub.3 -indol-3-yl                                                   4017   1-CH.sub.3, 4-OCH(CH.sub.3)CH.sub.2 OCH.sub.3 -indol-3-yl              4018   1-CH.sub.3, 4-OCH(CH.sub.3)CH.sub.2 CO.sub.2 CH.sub.3 -indol-3-yl      4019   1-CH.sub.3, 4-OCH(CH.sub.3)CH.sub.2 CO.sub.2 CH.sub.2 CH.sub.3                -indol-3-yl                                                            4020   1-CH.sub.3, 4-OCH.sub.2 CH(CH.sub.3)CO.sub.2 CH.sub.3 -indol-3-yl      4021   1-CH.sub.3, 4-OCH.sub.2 C(═O)CH.sub.3 -indol-3-yl                  4022   1-CH.sub.3, 4-OCH.sub.2 C(═O)CH.sub.2 CH.sub.3 -indol-3-yl         4023   1-CH.sub.3, 4-OCH.sub.2 CO.sub.2 CH.sub.3 -indol-3-yl                  4024   1-CH.sub.3, 4-OCH.sub.2 CO.sub.2 CH.sub.2 CH.sub.3 -indol-3-yl         4025   1-CH.sub.3, 4-OCH.sub.2 C(═O)NH.sub.2 -indol-3-yl                  4026   1-CH.sub.3, 4-OCH.sub.2 C(═O)NHCH.sub.3 -indol-3-yl                4027   1-CH.sub.3, 4-OCH.sub.2 C(═O)SCH.sub.3 -indol-3-yl                 4028   1-CH.sub.3, 4-OCH(CH.sub.3)C(═O)NH.sub.2 -indol-3-yl               4029   1-CH.sub.3, 4-OCH(CH.sub.3)C(═O)NHCH.sub.3 -indol-3-yl             4030   1-CH.sub.3, 4-OCH(CH.sub.3)C(═O)NHNH.sub.2 -indol-3-yl             4031   1-CH.sub.3, 4-OCH(CH.sub.3)CO.sub.2 CH.sub.3 -indol-3-yl               4032   1-CH.sub.3, 4-OCH(CH.sub.3)CO.sub.2 CH.sub.2 CH.sub.3 -indol-3-yl      4033   1-CH.sub.3, 4-OCH(CH.sub.3)C(═O)CH.sub.3 -indol-3-yl               4034   1-CH.sub.3, 4-OCH(CH.sub.3)C(═O)CH.sub.2 CH.sub.3 -indol-3-yl      4035   1-CH.sub.3, 4-OCH(CH.sub.3)CH.sub.2 C(═O)CH.sub.3 -indol-3-yl      4036   1-CH.sub.3, 4-OCH(CH.sub.3)CH.sub.2 OC(CH.sub.3).sub.4 -indol-3-yl            N                                                                      4037   1-CH.sub.3, 4-OCH(CH.sub.3)CH.sub.2 OCH.sub.2 CH.sub.3 -indol-3-yl            O                                                                      4038   1-CH.sub.3, 4-OCH(CH.sub.3)CH.sub.2 O(CH.sub.3).sub.2 CH.sub.3                -indol-3-yl                                                            4039   1-CH.sub.3, 4-OCH(CH.sub.3)CH.sub.2 OCH.sub.2 CH═CH.sub.2                 -indol-3-yl                                                            4040   1-CH.sub.3, 4-O(CH.sub.2).sub.3 OCH.sub.3 -indol-3-yl                  4041   1-CH.sub.3, 4-O(CH.sub.2).sub.3 OCH.sub.2 CH.sub.3 -indol-3-yl         4042   1-CH.sub.3, 4-O(CH.sub.2).sub.3 OCH(CH.sub.3).sub.2 -indol-3-yl        4043   1-CH.sub.3, 4-O(CH.sub.2).sub.3 OC.sub.6 H.sub.5 -indol-3-yl           4044   1-CH.sub.3, 4-O(CH.sub.2).sub.3 OCH.sub.2 C.sub.6 H.sub.5 -indol-3-           yl                                                                     4045   1-CH.sub.3, 4-OCH(CH.sub.2 CH.sub.3)CH.sub.2 OCH.sub.3 -indol-3-yl            O                                                                      4046   1-CH.sub.3, 4-OCH(CH.sub.2 CH.sub.3)CH.sub.2 CH.sub.2 OCH.sub.3               -indol-3-yl                                                            4047   1-CH.sub.3, 4-OCH(CH.sub.2 CH.sub.3)CH.sub.2 CH.sub.2 OCH.sub.2               CH.sub.3 -indol-3-yl                                                   4048   1-CH.sub.3, 4-O (CH.sub.2).sub.3 O!.sub.2 CH.sub.3 -indol-3-yl         4049   1-CH.sub.3, 4-OCH.sub.2 CH(CH.sub.3)CH.sub.2 OCH.sub.3 -indol-3-yl            5                                                                      4050   1-CH.sub.3, 4-OCH.sub.2 CH(CH.sub.3)CH.sub.2 OCH.sub.2 CH.sub.3               -indol-3-yl                                                            4051   1-CH.sub.3, 4-OCH(CH.sub.2 Cl)CH.sub.2 OCH.sub.3 -indol-3-yl           4052   1-CH.sub.3, 4-OCH(CH.sub.2 Cl)CH.sub.2 OCH.sub.2 CH.sub.3 -indol-3-           yl                                                                     4053   1-CH.sub.3, 4-OCH(CH.sub.2 Cl)CH.sub.2 OCH(CH.sub.3).sub.2                    -indol-3-yl                                                            4054   1-CH.sub.3, 4-OCH(CH.sub.2 Cl)CH.sub.2 OCH.sub.2 CH═CH.sub.2              -indol-3-yl                                                            4055   1-CH.sub.3, 4-OCH CH.sub.2 OCH.sub.3 !.sub.2 -indol-3-yl               4056   1-CH.sub.3, 4-OCH CH.sub.2 OCH.sub.2 CH.sub.3 !.sub.2 -indol-3-yl      4057   1-CH.sub.3, 4-OCCl.sub.4 -indol-3-yl                                   4058   1-CH.sub.3, 4-OCHF.sub.2 -indol-3-yl                                   4059   1-CH.sub.3, 4-OCF.sub.3 -indol-3-yl                                    4060   1-CH.sub.3, 4-OCF.sub.2 CHF.sub.2 -indol-3-yl                          4061   1-CH.sub.3, 4-OCH.sub.2 CF.sub.3 -indol-3-yl                           4062   1-CH.sub.3, 4-OCH.sub.2 CHF.sub.2 -indol-3-yl                          4063   1-CH.sub.3, 4-O(CH.sub.2).sub.3 F-indol-3-yl                           4064   1-CH.sub.3, 4-OCH(CH.sub.3)CF.sub.3 -indol-3-yl                        4065   1-CH.sub.3, 4-O(CH.sub.2).sub.4 F-indol-3-yl                           4066   1-CH.sub.3, 4-O(CH.sub.2).sub.3 CF.sub.3 -indol-3-yl                   4067   1-CH.sub.3, 4-OCH(CH.sub.3)CF.sub.2 CF.sub.3 -indol-3-yl               4068   1-CH.sub.3, 4-OCH(CH.sub.3)CF.sub.2 CHF.sub.2 -indol-3-yl              4069   1-CH.sub.3, 4-OCH.sub.2 CF.sub.2 CHFCH.sub.3 -indol-3-yl               4070   1-CH.sub.3, 4-OCH.sub.2 (CF.sub.2).sub.2 CF.sub.3 -indol-3-yl          4071   1-CH.sub.3, 4-O(CF.sub.2).sub.3 CF.sub.3 -indol-3-yl                   4072   1-CH.sub.3, 4-OCH.sub.2 CF.sub.2 CHF.sub.2 -indol-3-yl                 4073   1-CH.sub.3, 4-CH.sub.2 CH═CH.sub.2 -indol-3-yl                     4074   1-CH.sub.3, 4-CH.sub.2 C(CH.sub.3 ═CH.sub.2 -indol-3-yl            4075   1-CH.sub.3, 4-OCH.sub.2 CH═CHCH.sub.3 -indol-3-yl                  4076   1-CH.sub.3, 4-O(CH.sub.2).sub.2 CH═CH.sub.2 -indol-3-yl            4077   1-CH.sub.3, 4-OCH.sub.2 C(CH.sub.3)═CH.sub.2 -indol-3-yl           4078   1-CH.sub.3, 4-OCH(CH.sub.3)CH═CH.sub.2 -indol-3-yl                 4079   1-CH.sub.3, 4-OCH.sub.2 C.tbd.CH-indol-3-yl                            4080   1-CH.sub.3, 4-OCH.sub.2 C.tbd.CCH.sub.3 -indol-3-yl                    4081   1-CH.sub.3, 4-O(CH.sub.2).sub.2 C.tbd.CH-indol-3-yl                    4082   1-CH.sub.3, 4-SCH.sub.3 -indol-3-yl                                    4083   1-CH.sub.3, 4-SCH.sub.2 CH.sub.3 -indol-3-yl                           4084   1-CH.sub.3, 4-OC.sub.6 H.sub.5 -indol-3-yl                             4085   1-CH.sub.3, 4-OCH.sub.2 C.sub.6 H.sub.5 -indol-3-yl                    4086   1-CH.sub.3, 4-NO.sub.2 -indol-3-yl                                     4087   1-CH.sub.3, 4-NHCH.sub.3 -indol-3-yl                                   4088   1-CH.sub.3, 4-N(CH.sub.3).sub.2 -indol-3-yl                            4089   1-CH.sub.3, 4-NHCH.sub.2 CF.sub.3 -indol-3-yl                          4090   1-CH.sub.3, 4-NHCH.sub.2 CF.sub.3 -indol-3-yl                          4091   1-CH.sub.3, 4-F-indol-3-yl                                             4092   1-CH.sub.3, 4-Cl-indol-3-yl                                            4093   1-CH.sub.3, 4-OH-indol-3-yl                                            4094   1-CH.sub.3, 4-CN-indol-3-yl                                            4095   1-CH.sub.3, 4-C(O)NH.sub.2 -indol-3-yl                                 4096   1-CH.sub.3, 4-C(S)NH.sub.2 -indol-3-yl                                 4097   1-CH.sub.3, 4-CO.sub.2 CH.sub.3 -indol-3-yl                            4098   1-CH.sub.3, 4-ON═C(CH.sub.3).sub.2 -indol-3-yl                     4099   1-CH.sub.3, 4- O-cyclopropyl!indol-3-yl                                4100   1-CH.sub.3, 4- O-cyclobutyl!indol-3-yl                                 4101   1-CH.sub.3, 4- O-cyclopentyl!indol-3-yl                                4102   1-CH.sub.3, 4- O-cyclohexyl!indol-3-yl                                 4103   1-CH.sub.3, 4- OCH.sub.2 -cyclopropyl!indol-3-yl                       4104   1-CH.sub.3, 6-F, 4- OCH.sub.2 -cyclopropyl!indol-3-yl                  4105   1-CH.sub.3, 6-CH.sub.3, 4- OCH.sub.2 -cyclopropyl!indol-3-yl           4106   1-CH.sub.3, 6-CF.sub.3, 4- OCH.sub.2 -cyclopropyl!indol-3-yl           4107   1-CH.sub.3, 4- OCH(CH.sub.3)-cyclopropyl!indol-3-yl                    4108   1-CH.sub.3, 6-F, 4- OCH(CH.sub.3)-cyclopropyl!indol-3-yl               4109   1-CH.sub.3, 6-CH.sub.3, 4- OCH(CH.sub.3)-cyclopropyl!indol-3-yl        4110   1-CH.sub.3, 6-CF.sub.3, 4- OCH(CH.sub.3)-cyclopropyl!indol-3-yl        4111   1-CH.sub.3, 4- O-(1-CH.sub.3 -cyclopropyl)!indol-3-yl                  4112   1-CH.sub.3, 6-F, 4- O-(1-CH.sub.3 -cyclopropyl)!indol-3-yl             4113   1-CH.sub.3, 6-CH.sub.3, 4- O-(1-CH.sub.3 -cyclopropyl)!indol-3-yl      4114   1-CH.sub.3, 6-CF.sub.3, 4- O-(1-CH.sub.3 -cyclopropyl)!indol-3-yl      4115   1-CH.sub.3, 4- OCH.sub.2 -(1-CH.sub.3 -cyclopropyl)!indol-3-yl         4116   1-CH.sub.3, 6-F, 4- OCH.sub.2 -(1-CH.sub.3 -cyclopropyl)!indol-3-yl           N                                                                      4117   1-CH.sub.3, 6-CH.sub.3, 4- OCH.sub.2 -(1-CH.sub.3 -cyclopropyl)!ind           ol-3-yl                                                                4118   1-CH.sub.3, 6-CF.sub.3, 4- OCH.sub.2 -(1-CH.sub.3 -cyclopropyl)!ind           ol-3-yl                                                                4119   1-CH.sub.3, 4- OCH.sub.2 -(2-CH.sub.3 -cyclopropyl)!indol-3-yl         4120   1-CH.sub.3, 6-F, 4- OCH.sub.2 -(2-CH.sub.3 -cyclopropyl)!indol-3-yl           n                                                                      4121   1-CH.sub.3, 6-CH.sub.3, 4- OCH.sub.2 -(2-CH.sub.3 -cyclopropyl)!ind           ol-3-yl                                                                4122   1-CH.sub.3, 6-CF.sub.3, 4- OCH.sub.2 -(2-CH.sub.3 -cyclopropyl)!ind           ol-3-yl                                                                4123   1-CH.sub.3, 4- OCH.sub.2 -(tetrahydropyran-2-yl)!indol-3-yl            4124   1-CH.sub.3, 6-F, 4- OCH.sub.2 -(tetrahydropyran-2-yl)!indol-3-yl       4125   1-CH.sub.3, 6-CH.sub.3, 4- OCH.sub.2 -(tetrahydropyran-2-yl)!indol-           3-yl                                                                   4126   1-CH.sub.3, 6-CF.sub.3, 4- OCH.sub.2 -(tetrahydropyran-2-yl)!indol-           3-yl                                                                   4127   1-CH.sub.3, 4- OCH.sub.2 -(furan-2-yl)!indol-3-yl                      4128   1-CH.sub.3, 6-F, 4- OCH.sub.2 -(furan-2-yl)!indol-3-yl                 4129   1-CH.sub.3, 6-CH.sub.3, 4- OCH.sub.2 -(furan-2-yl)!indol-3-yl          4130   1-CH.sub.3, 6-CF.sub.3, 4- OCH.sub.2 -(furan-2-yl)!indol-3-yl          4131   1-CH.sub.3, 4- OCH.sub.2 -(furan-4-yl)!indol-3-yl                      4132   1-CH.sub.3, 6-F, 4- OCH.sub.2 -(furan-4-yl)!indol-3-yl                 4133   1-CH.sub.3, 6-CH.sub.3, 4- OCH.sub.2 -(furan-4-yl)!indol-3-yl          4134   1-CH.sub.3, 6-CF.sub.3, 4- OCH.sub.2 -(furan-4-yl)!indol-3-yl          4135   1-CH.sub.3, 4- OCH.sub.2 -(tetrahydrofuran-4-yl)!indol-3-yl            4136   1-CH.sub.3, 6-F, 4- OCH.sub.2 -(tetrahydrofuran-4-yl)!indol-3-yl       4137   1-CH.sub.3, 6-CH.sub.3, 4- OCH.sub.2 -(tetrahydrofuran-4-yl)!indol-           3-yl                                                                   4138   1-CH.sub.3, 6-CF.sub.3, 4- OCH.sub.2 -(tetrahydrofuran-4-yl)!indol-           3-yl                                                                   4139   1-CH.sub.3, 4- OCH.sub.2 -(tetrahydrofuran-2-yl)!indol-3-yl            4140   1-CH.sub.3, 6-F, 4- OCH.sub.2 -(tetrahydrofuran-2-yl)!indol-3-yl       4141   1-CH.sub.3, 6-CH.sub.3, 4- OCH.sub.2 -(tetrahydrofuran-2-yl)!indol-           3-yl                                                                   4142   1-CH.sub.3, 6-CF.sub.3, 4- OCH.sub.2 -(tetrahydrofuran-2-yl)!indol-           3-yl                                                                   4143   1-CH.sub.3, 4- O-tetrahydropyran-4-yl)!indol-3-yl                      4144   1-CH.sub.3, 6-F, 4- O-(tetrahydropyran-4-yl)!indol-3-yl                4145   1-CH.sub.3, 6-CH.sub.3, 4- O-(tetrahydropyran-4-yl)!indol-3-yl         4146   1-CH.sub.3, 6-CF.sub.3, 4- O-(tetrahydropyran-4-yl)!indol-3-yl         4147   1-CH.sub.3, 4- 2-Cl--C.sub.5 H.sub.4 !indol-3-yl                       4148   1-CH.sub.3, 6-F, 4- 2-Cl--C.sub.5 H.sub.4 !indol-3-yl                  4149   1-CH.sub.3, 6-CH.sub.3, 4- 2-Cl--C.sub.5 H.sub.4 !indol-3-yl           4150   1-CH.sub.3, 6-CF.sub.3, 4- 2-Cl--C.sub.5 H.sub.4 !indol-3-yl           4151   1-CH.sub.3, 4- OCH.sub.2 -(pyridin-2-yl)!indol-3-yl                    4152   1-CH.sub.3, 6-F, 4- OCH.sub.2 -(pyridin-2-yl)!indol-3-yl               4153   1-CH.sub.3, 6-CH.sub.3, 4- OCH.sub.2 -(pyridin-2-yl)!indol-3-yl        4154   1-CH.sub.3, 6-CF.sub.3, 4- OCH.sub.2 -(pyridin-2-yl)!indol-3-yl        4155   1-CH.sub.3, 4- OCH.sub.2 -(pyridin-4-yl)!indol-3-yl                    4156   1-CH.sub.3, 6-F, 4- OCH.sub.2 -(pyridin-4-yl)!indol-3-yl               4157   1-CH.sub.3, 6-CH.sub.3, 4- OCH.sub.2 -(pyridin-4-yl)!indol-3-yl        4158   1-CH.sub.3, 6-CF.sub.3, 4- OCH.sub.2 -(pyridin-4-yl)!indol-3-yl        4159   1-CH.sub.3, 4- morpholin-4-yl!indol-3-yl                               4160   1-CH.sub.3, 4- 1-CH.sub.3 -imidazol-2-yl!indol-3-yl                    4161   1-CH.sub.3, 6-F, 4- 1-CH.sub.3 -imidazol-2-yl!indol-3-yl               4162   1-CH.sub.3, 6-CH.sub.3, 4- 1-CH.sub.3 -imidazol-2-yl!indol-3-yl        4163   1-CH.sub.3, 6-CF.sub.3, 4- 1-CH.sub.3 -imidazol-2-yl!indol-3-yl        4164   1-CH.sub.3, 4- 1,2,4-triazol-1-yl)indol-3-yl                           4165   1-CH.sub.3, 6-F, 4- 1,2,4-triazol-1-yl!indol-3-yl                      4166   1-CH.sub.3, 6-CH.sub.3, 4- 1,2,4-triazol-1-yl!indol-3-yl               4167   1-CH.sub.3, 6-CF.sub.3, 4- 1,2,4-triazol-1-yl!indol-3-yl               4168   1-CH.sub.3, 4,6-Cl.sub.2 -indol-3-yl                                   4169   1-CH.sub.3, 4,6-(CH.sub.3).sub.2 -indol-3-yl                           4170   1-CH.sub.3, 4,6-(OCH.sub.3).sub.2 -indol-3-yl                          4171   1-CH.sub.3, 4,6-(OCH.sub.2 CH.sub.3).sub.2 -indol-3-yl                 4172   1-CH.sub.3, 4-F, 6-CH.sub.3 -indol-3-yl                                4173   1-CH.sub.3, 4-F, 6-OCH.sub.3 -indol-3-yl                               4174   1-CH.sub.3, 4-F, 6-OCH.sub.2 CH.sub.3 -indol-3-yl                      4175   1-CH.sub.3, 4-F, 6-OCH.sub.2 CF.sub.3 -indol-3-yl                      4176   1-CH.sub.3, 4-F, 6-OCH(CH.sub.3).sub.2 -indol-3-yl                     4177   1-CH.sub.3, 4-Cl, 6-CH.sub.3 -indol-3-yl                               4178   1-CH.sub.3, 4-Cl, 6-OCH.sub.3 -indol-3-yl                              4179   1-CH.sub.3, 4-Cl, 6-OCH.sub.2 CH.sub.3 -indol-3-yl                     4180   1-CH.sub.3, 4-Cl, 6-OCH.sub.2 CF.sub.3 -indol-3-yl                     4181   1-CH.sub.3, 4-Cl, 6-OCH(CH.sub.3).sub.2 -indol-3-yl                    4182   1-CH.sub.3, 4-CH.sub.3, 6-OCH.sub.3 -indol-3-yl                        4183   1-CH.sub.3, 4-CH.sub.3, 6-OCH.sub.2 CH.sub.3 -indol-3-yl               4184   1-CH.sub.3, 4-CH.sub.3, 6-OCH.sub.2 CF.sub.3 -indol-3-yl               4185   1-CH.sub.3, 4-CH.sub.3, 6-OCH(CH.sub.3).sub.2 -indol-3-yl              4186   1-CH.sub.3, 4-CH.sub.3, 6-OCH.sub.2 CH═CH.sub.2 -indol-3-yl        4187   1-CH.sub.3, 4-CH.sub.3, 6-CO.sub.2 CH.sub.3 -indol-3-yl                4188   1-CH.sub.3, 4-CH.sub.3, 6-CF.sub.3 -indol-3-yl                         4189   1-CH.sub.3, 4-CH.sub.3, 6-CH.sub.2 CH.sub.3 -indol-3-yl                4190   1-CH.sub.3, 4-CH.sub.3, 6-OCH.sub.3 -indol-3-yl                        4191   1-CH.sub.3, 4-CH.sub.3, 6-OCH.sub.2 CH.sub.3 -indol-3-yl               4192   1-CH.sub.3, 4-CH.sub.3, 6-OCH.sub.2 CF.sub.3 -indol-3-yl               4193   1-CH.sub.3, 4-OCH.sub.3, 6-OCH.sub.2 CH.sub.3 -indol-3-yl              4194   1-CH.sub.3, 4-OCH.sub.3, 6-OCH.sub.2 CF.sub.3 -indol-3-yl              4195   1-CH.sub.3, 4-OCH.sub.3, 6-OCH(CH.sub.3)-indol-3-yl                    4196   1-CH.sub.3, 4-OCH.sub.2 CH.sub.3, 6-CH.sub.2 OCH.sub.2 CH.sub.3               -indol-3-yl                                                            4197   1-CH.sub.3, 4-NO.sub.2, 6-CH.sub.3 -indol-3-yl                         4198   1-CH.sub.3, 4-NO.sub.2, 6-OCH.sub.3 -indol-3-yl                        4199   1-CH.sub.3, 4-NO.sub.2, 6-OCH.sub.2 CH.sub.3 -indol-3-yl               4200   1-CH.sub.3, 4-NO.sub.2, 6-OCH(CH.sub.3).sub.2 -indol-3-yl              4201   1-CH.sub.3, 4-NO.sub.2, 6-OCH.sub.2 CF.sub.3 -indol-3-yl               4202   1-CH.sub.3, 4-CN, 6-CH.sub.3 -indol-3-yl                               4203   1-CH.sub.3, 4-CN, 6-OCH.sub.3 -indol-3-yl                              4204   1-CH.sub.3, 4-CN, 6-OCH.sub.2 CH.sub.3 -indol-3-yl                     4205   1-CH.sub.3, 4-CN, 6-OCH(CH.sub.3).sub.2 -indol-3-yl                    4206   1-CH.sub.3, 4-CN, 6-OCH.sub.2 CF.sub.3 -indol-3-yl                     4207   4-CH.sub.3 -quinolin-2-yl                                              4208   4-CH.sub.2 CH.sub.3 -quinolin-2-yl                                     4209   4-CH(CH.sub.3).sub.2 -quinolin-2-yl                                    4210   4-CH(CH.sub.3)CH.sub.2 CH.sub.3 -quinolin-2-yl                         4211   4-CF.sub.3 -quinolin-2-yl                                              4212   4-CH═CH.sub.2 -quinolin-2-yl                                       4213   4-CH═CHCH.sub.3 -quinolin-2-yl                                     4214   4-CH═CHCl-quinolin-2-yl                                            4215   4-C.tbd.CH-quinolin-2-yl                                               4216   4-CH.sub.2 C.tbd.CH-quinolin-2-yl                                      4217   4-CH.sub.2 C.tbd.CCH.sub.3 -quinolin-2-yl                              4218   4-cyclopropyl-quinolin-2-yl                                            4219   4-cyclopentyl-quinolin-2-yl                                            4220   4-OCH.sub.3 -quinolin-2-yl                                             4221   4-OCH.sub.2 CH.sub.3 -quinolin-2-yl                                    4222   4-OCH.sub.2 CH.sub.2 CH.sub.3 -quinolin-2-yl                           4223   4-OCH(CH.sub.3).sub.2 -quinolin-2-yl                                   4224   4-OCH.sub.2 CH.sub.2 CH.sub.2 CH.sub.3 -quinolin-2-yl                  4225   4-OCH(CH.sub.3)CH.sub.2 CH.sub.3 -quinolin-2-yl                        4226   4-OCH.sub.2 CH(CH.sub.3).sub.2 -quinolin-2-yl                          4227   4-OC(CH.sub.3).sub.4 -quinolin-2-yl                                    4228   4-OCH(CH.sub.3)CH.sub.2 CH.sub.2 CH.sub.3 -quinolin-2-yl               4229   4-OCH.sub.2 OCH.sub.3 -quinolin-2-yl                                   4230   4-OCH.sub.2 OCH.sub.2 CH.sub.3 -quinolin-2-yl                          4231   4-OCH(CH.sub.3)OCH.sub.3 -quinolin-2-yl                                4232   4-OCH(CH.sub.3)OCH.sub.2 CH.sub.3 -quinolin-2-yl                       4233   4-OCH.sub.2 CH.sub.2 OCH.sub.3 -quinolin-2-yl                          4234   4-OCH.sub.2 CH.sub.2 OCH.sub.2 CH.sub.3 -quinolin-2-yl                 4235   4-OCH.sub.2 CH.sub.2 OCH(CH.sub.3).sub.2 -quinolin-2-yl                4236   4-OCH.sub.2 CH.sub.2 SCH.sub.3 -quinolin-2-yl                          4237   4-OCH.sub.2 CH.sub.2 SO.sub.2 CH.sub.3 -quinolin-2-yl                  4238   4-OCH.sub.2 CH.sub.2 SCH(CH.sub.3).sub.2 -quinolin-2-yl                4239   4-OCH.sub.2 CH.sub.2 CN-quinolin-2-yl                                  4240   4-OCH.sub.2 CH.sub.2 SCH.sub.2 CH.sub.2 CN-quinolin-2-yl               4241   4-OCH.sub.2 CH.sub.2 OC.sub.6 H.sub.5 -quinolin-2-yl                   4242   4-OCH.sub.2 CH.sub.2 OCH.sub.2 C.sub.6 H.sub.5 -quinolin-2-yl          4243   4-OCH.sub.2 CH.sub.2 N(CH.sub.3).sub.2 -quinolin-2-yl                  4244   4-OCH.sub.2 CH.sub.2 CONH.sub.2 -quinolin-2-yl                         4245   4-OCH.sub.2 CH.sub.2 CO.sub.2 CH.sub.2 CH.sub.2 CH.sub.3 -quinolin-           2-yl                                                                   4246   4-OCH(CH.sub.3)CH.sub.2 OCH.sub.3 -quinolin-2-yl                       4247   4-OCH(CH.sub.3)CH.sub.2 CO.sub.2 CH.sub.3 -quinolin-2-yl               4248   4-OCH(CH.sub.3)CH.sub.2 CO.sub.2 CH.sub.2 CH.sub.3 -quinolin-2-yl      4249   4-OCH.sub.2 CH(CH.sub.3)CO.sub.2 CH.sub.3 -quinolin-2-yl               4250   4-OCH.sub.2 C(═O)CH.sub.3 -quinolin-2-yl                           4251   4-OCH.sub.2 C(═O)CH.sub.3 -quinolin-2-yl                           4252   4-OCH.sub.2 CO.sub.2 CH.sub.3 -quinolin-2-yl                           4253   4-OCH.sub.2 CO.sub.2 CH.sub.2 CH.sub.3 -quinolin-2-yl                  4254   4-OCH.sub.2 C(═O)NH.sub.2 -quinolin-2-yl                           4255   4-OCH.sub.2 C(═O)NHCH.sub.3 -quinolin-2-yl                         4256   4-OCH.sub.2 C(═O)SCH.sub.3 -quinolin-2-yl                          4257   4-OCH(CH.sub.3)C(═O)NH.sub.2 -quinolin-2-yl                        4258   4-OCH(CH.sub.3)C(═O)NHCH.sub.3 -quinolin-2-yl                      4259   4-OCH(CH.sub.3)C(═O)NHNH.sub.2 -quinolin-2-yl                      4260   4-OCH(CH.sub.3)CO.sub.2 CH.sub.3 -quinolin-2-yl                        4261   4-OCH(CH.sub.3)CO.sub.2 CH.sub.2 CH.sub.3 -quinolin-2-yl               4263   4-OCH(CH.sub.3)C(═O)CH.sub.2 CH.sub.3 -quinolin-2-yl               4264   4-OCH(CH.sub.3)CH.sub.2 C(═O)CH.sub.3 -quinolin-2-yl               4265   4-OCH(CH.sub.3)CH.sub.2 OC(CH.sub.3).sub.4 -quinolin-2-yl              4266   4-OCH(CH.sub.3)CH.sub.2 OCH.sub.2 CH.sub.3 -quinolin-2-yl              4267   4-OCH(CH.sub.3)CH.sub.2 O(CH.sub.3).sub.2 CH.sub.3 -quinolin-2-yl      4268   4-OCH(CH.sub.3)CH.sub.2 OCH.sub.2 CH═CH.sub.2 -quinolin-2-yl       4269   4-O(CH.sub.2).sub.3 OCH.sub.3 -quinolin-2-yl                           4270   4-O(CH.sub.2).sub.3 OCH.sub.2 CH.sub.3 -quinolin-2-yl                  4271   4-O(CH.sub.3).sub.3 OCH(CH.sub.3).sub.2 -quinolin-2-yl                 4272   4-O(CH.sub.2).sub.3 OC.sub.6 H.sub.5 -quinolin-2-yl                    4273   4-O(CH.sub.2).sub.3 OCH.sub.2 C.sub.6 H.sub.5 -quinolin-2-yl           4274   4-OCH(CH.sub.2 CH.sub.3)CH.sub.2 OCH.sub.3 -quinolin-2-yl              4275   4-OCH(CH.sub.2 CH.sub.3)CH.sub.2 CH.sub.2 OCH.sub.3 -quinolin-2-yl            O                                                                      4276   4-OCH(CH.sub.2 CH.sub.3)CH.sub.2 CH.sub.2 OCH.sub.2 CH.sub.3                  -quinolin-2-yl                                                         4277   4-O (CH.sub.2).sub.3 O!.sub.2 CH.sub.3 -quinolin-2-yl                  4278   4-OCH.sub.2 CH(CH.sub.3)CH.sub.2 OCH.sub.3 -quinolin-2-yl              4279   4-OCH.sub.2 CH(CH.sub.3)CH.sub.2 OCH.sub.2 CH.sub.3 -quinolin-2-yl            u                                                                      4280   4-OCH(CH.sub.2 Cl)CH.sub.2 OCH.sub.3 -quinolin-2-yl                    4281   4-OCH(CH.sub.2 Cl)CH.sub.2 OCH.sub.2 CH.sub.3 -quinolin-2-yl           4282   4-OCH(CH.sub.2 Cl)CH.sub.2 OCH(CH.sub.3).sub.2 -quinolin-2-yl          4283   4-OCH(CH.sub.2 Cl)CH.sub.2 OCH.sub.2 CH═CH.sub.2 -quinolin-2-yl           N                                                                      4284   4-OCH CH.sub.2 OCH.sub.3 !.sub.2 -quinolin-2-yl                        4285   4-OCH CH.sub.2 OCH.sub.2 CH.sub.3 !.sub.2 -quinolin-2-yl               4286   4-OCCl.sub.4 -quinolin-2-yl                                            4287   4-OCHF.sub.2 -quinolin-2-yl                                            4288   4-OCF.sub.3 -quinolin-2-yl                                             4289   4-OCF.sub.2 CHF.sub.2 -quinolin-2-yl                                   4290   4-OCH.sub.2 CF.sub.3 -quinolin-2-yl                                    4291   4-OCH.sub.2 CHF.sub.2 -quinolin-2-yl                                   4292   4-O(CH.sub.2).sub.3 F-quinolin-2-yl                                    4293   4-OCH(CH.sub.3)CF.sub.3 -quinolin-2-yl                                 4294   4-O(CH.sub.2).sub.4 F-quinolin-2-yl                                    4295   4-O(CH.sub.2).sub.3 CF.sub.3 -quinolin-2-yl                            4296   4-OCH(CH.sub.3)CF.sub.2 CF.sub.3 -quinolin-2-yl                        4297   4-OCH(CH.sub.3)CF.sub.2 CHF.sub.2 -quinolin-2-yl                       4298   4-OCH.sub.2 CF.sub.2 CHFCH.sub.3 -quinolin-2-yl                        4299   4-OCH.sub.2 (CF.sub.2).sub.2 CF.sub.3 -quinolin-2-yl                   4300   4-O(CF.sub.2).sub.3 CF.sub.3 -quinolin-2-yl                            4301   4-OCH.sub.2 CF.sub.2 CHF.sub.2 -quinolin-2-yl                          4302   4-CH.sub.2 CH═CH.sub.2 -quinolin-2-yl                              4303   4-CH.sub.2 C(CH.sub.3)═CH.sub.2 -quinolin-2-yl                     4304   4-OCH.sub.2 CH═CHCH.sub.3 -quinolin-2-yl                           4305   4-O(CH.sub.2).sub.2 CH═CH.sub.2 -quinolin-2-yl                     4306   4-OCH.sub.2 C(CH.sub.3)═CH.sub.2 -quinolin-2-yl                    4307   4-OCH(CH.sub.3)CH═CH.sub.2 -quinolin-2-yl                          4308   4-OCH.sub.2 C.tbd.CH-quinolin-2-yl                                     4309   4-OCH.sub.2 C.tbd.CCH.sub.3 -quinolin-2-yl                             4310   4-O(CH.sub.2).sub.2 C.tbd.CH-quinolin-2-yl                             4311   4-SCH.sub.3 -quinolin-2-yl                                             4312   4-SCH.sub.2 CH.sub.3 -quinolin-2-yl                                    4313   4-OC.sub.6 H.sub.5 -quinolin-2-yl                                      4314   4-OCH.sub.2 C.sub.6 H.sub.5 -quinolin-2-yl                             4315   4-NO.sub.2 -quinolin-2-yl                                              4316   4-NHCH.sub.3 -quinolin-2-yl                                            4317   4-N(CH.sub.3).sub.2 -quinolin-2-yl                                     4318   4-N(CH.sub.3)C.sub.2 H.sub.6 -quinolin-2-yl                            4319   4-NHCH.sub.2 CF.sub.3 -quinolin-2-yl                                   4320   4-F-quinolin-2-yl                                                      4321   4-Cl-quinolin-2-yl                                                     4322   4-OH-quinolin-2-yl                                                     4323   4-CN-quinolin-2-yl                                                     4324   4-C(O)NH.sub.2 -quinolin-2-yl                                          4325   4-C(S)NH.sub.2 -quinolin-2-yl                                          4326   4-CO.sub.2 CH.sub.3 -quinolin-2-yl                                     4327   4-ON═C(CH.sub.3).sub.2 -quinolin-2-yl                              4328   4- O-cyclopropyl!quinolin-2-yl                                         4329   4- O-cyclobutyl!quinolin-2-yl                                          4330   4- O-cyclopentyl!quinolin-2-yl                                         4331   4- O-cyclohexyl!quinolin-2-yl                                          4332   4- OCH.sub.2 -cyclopropyl!quinolin-2-yl                                4333   6-F, 4- OCH.sub.2 -cyclopropyl!quinolin-2-yl                           4334   6-CH.sub.3, 4- OCH.sub.2 -cyclopropyl!quinolin-2-yl                    4335   6-CF.sub.3, 4- OCH.sub.2 -cyclopropyl!quinolin-2-yl                    4336   4- OCH(CH.sub.3)-cyclopropyl!quinolin-2-yl                             4337   6-F, 4- OCH(CH.sub.3)-cyclopropyl!quinolin-2-yl                        4338   6-CH.sub.3, 4- OCH(CH.sub.3)-cyclopropyl!quinolin-2-yl                 4339   6-CF.sub.3, 4- OCH(CH.sub.3)-cyclopropyl!quinolin-2-yl                 4340   4- O-(1-CH.sub.3 -cyclopropyl)!quinolin-2-yl                           4341   6-F, 4- O-(1-CH.sub.3 -cyclopropyl)!quinolin-2-yl                      4342   6-CH.sub.3, 4- O-(1-CH.sub.3 -cyclopropyl)!quinolin-2-yl               4343   6-CF.sub.3, 4- O-(1-CH.sub.3 -cyclopropyl)!quinolin-2-yl               4344   4- OCH.sub.2 -(1-CH.sub.3 -cyclopropyl)!quinolin-2-yl                  4345   6-F, 4- OCH.sub.2 -(1-CH.sub.3 -cyclopropyl)!quinolin-2-yl             4346   6-CH.sub.3, 4- OCH.sub.2 -(1-CH.sub.3 -cyclopropyl)!quinolin-2-yl      4347   6-CF.sub.3, 4- OCH.sub.2 -(1-CH.sub.3 -cyclopropyl!quinolin-2-yl       4348   4- OCH.sub.2 -(2-CH.sub.3 -cyclopropyl)!quinolin-2-yl                  4349   6-F, 4- OCH.sub.2 -(2-CH.sub.3 -cyclopropyl)!quinolin-2-yl             4350   6-CH.sub.3, 4- OCH.sub.2 -(2-CH.sub.3 -cyclopropyl)!quinolin-2-yl      4351   6-CF.sub.3, 4- OCH.sub.2 -(2-CH.sub.3 -cyclopropyl)!quinolin-2-yl      4352   4- OCH.sub.2 -(tetrahydropyran-2-yl)!quinolin-2-yl                     4353   6-F, 4- OCH.sub.2 -(tetrahydropyran-2-yl)!quinolin-2-yl                4354   6-CH.sub.3, 4- OCH.sub.2 -(tetrahydropyran-2-yl)!quinolin-2-yl         4355   6-CF.sub.3, 4- OCH.sub.2 -(tetrahydropyran-2-yl)!quinolin-2-yl         4356   4- OCH.sub.2 -(furan-2-yl)!quinolin-2-yl                               4357   6-F, 4- OCH.sub.2 -(furan-2-yl)!quinolin-2-yl                          4358   6-CH.sub.3, 4- OCH.sub.2 -(furan-2-yl)!quinolin-2-yl                   4359   6-CF.sub.3, 4- OCH.sub.2 -(furan-2-yl)!quinolin-2-yl                   4360   4- OCH.sub.2 -(furan-4-yl)!quinolin-2-yl                               4361   6-F, 4- OCH.sub.2 -(furan-4-yl)!quinolin-2-yl                          4362   6-CH.sub.3, 4- OCH.sub.2 -(furan-4-yl)!quinolin-2-yl                   4363   6-CF.sub.3, 4- OCH.sub.2 -(furan-4-yl)!quinolin-2-yl                   4364   4- OCH.sub.2 -(tetrahydrofuran-4-yl)!quinolin-2-yl                     4365   6-F, 4- OCH.sub.2 -(tetrahydrofuran-4-yl)!quinolin-2-yl                4366   6-CH.sub.3, 4- OCH.sub.2 -(tetrahydrofuran-4-yl)!quinolin-2-yl         4367   6-CF.sub.3, 4- OCH.sub.2 -(tetrahydrofuran-4-yl)!quinolin-2-yl         4368   4- OCH.sub.2 -(tetrahydrofuran-2-yl)!quinolin-2-yl                     4369   6-F, 4- OCH.sub.2 -(tetrahydrofuran-2-yl)!quinolin-2-yl                4370   6-CH.sub.3, 4- OCH.sub.2 -(tetrahydrofuran-2-yl)!quinolin-2-yl         4371   6-CF.sub.3, 4- OCH.sub.2 -(tetrahydrofuran-2-yl)!quinolin-2-yl         4372   4- O-(tetrahydropyran-4-yl)!quinolin-2-yl                              4373   6-F, 4- O-(tetrahydropyran-4-yl)!quinolin-2-yl                         4374   6-CH.sub.3, 4- O-(tetrahydropyran-4-yl)!quinolin-2-yl                  4375   6-CF.sub.3, 4- O-(tetrahydropyran-4-yl)!quinolin-2-yl                  4376   4- 2-Cl--C.sub.5 H.sub.4 !quinolin-2-yl                                4377   6-F, 4- 2-Cl--C.sub.5 H.sub.4 !quinolin-2-yl                           4378   6-CH.sub.3, 4- 2-Cl--C.sub.5 H.sub.4 !quinolin-2-yl                    4379   6-CF.sub.3, 4- 2-Cl--C.sub.5 H.sub.4 !quinolin-2-yl                    4380   4- OCH.sub.2 -(pyridin-2-yl)!quinolin-2-yl                             4381   6-F, 4 OCH.sub.2 -(pyridin-2-yl)!quinolin-2-yl                         4382   6-CH.sub.3, 4- OCH.sub.2 -(pyridin-2-yl)!quinolin-2-yl                 4383   6-CF.sub.3, 4- OCH.sub.2 -(pyridin-2-yl)!quinolin-2-yl                 4384   4- OCH.sub.2 -(pyridin-4-yl)!quinolin-2-yl                             4385   6-F, 4- OCH.sub.2 -(pyridin-4-yl)!quinolin-2-yl                        4386   6-CH.sub.3, 4- OCH.sub.2 -(pyridin-4-yl)!quinolin-2-yl                 4387   6-CH.sub.3, 4- OCH.sub.2 -(pyridin-4-yl)!quinolin-2-yl                 4388   4- morpholin-4-yl!quinolin-2-yl                                        4389   4- 1-CH.sub.3 -imidazol-2-yl!quinolin-2-yl                             4390   6-F, 4- 1-CH.sub.3 -imidazol-2-yl!quinolin-2-yl                        4391   6-CH.sub.3, 4- 1-CH.sub.3 -imidazol-2-yl!quinolin-2-yl                 4392   6-CF.sub.3, 4- 1-CH.sub.3 -imidazol-2-yl!quinolin-2-yl                 4393   4- 1,2,4-triazol-1-yl!quinolin-2-yl                                    4394   6-F, 4- 1,2,4-triazol-1-yl!quinolin-2-yl                               4395   6-CH.sub.3, 4- 1,2,4-triazol-1-yl!quinolin-2-yl                        4396   6-CF.sub.3, 4- 1,2,4-triazol-1-yl!quinolin-2-yl                        4397   4,6-Cl.sub.2 -quinolin-2-yl                                            4398   4,6-(CH.sub.3).sub.2 -quinolin-2-yl                                    4399   4,6-OCH.sub.3).sub.2 -quinolin-2-yl                                    4400   4,6-(OCH.sub.2 CH.sub.3).sub.2 -quinolin-2-yl                          4401   4-F, 6-CH.sub.3 -quinolin-2-yl                                         4402   4-F, 6-OCH.sub.3 -quinolin-2-yl                                        4403   4-F, 6-OCH.sub.2 CH.sub.3 -quinolin-2-yl                               4404   4-F, 6-OCH.sub.2 CF.sub.3 -quinolin-2-yl                               4405   4-F, 6-OCH(CH.sub.3).sub.2 -quinolin-2-yl                              4406   4-Cl, 6-CH.sub.3 -quinolin-2-yl                                        4407   4-Cl, 6-OCH.sub.3 -quinolin-2-yl                                       4408   4-Cl, 6-OCH.sub.2 CH.sub.3 -quinolin-2-yl                              4409   4-Cl, 6-OCH.sub.2 CF.sub.3 -quinolin-2-yl                              4410   4-Cl, 6-OCH(CH.sub.3).sub.2 -quinolin-2-yl                             4411   4-CH.sub.3, 6-OCH.sub.3 -quinolin-2-yl                                 4412   4-CH.sub.3, 6-OCH.sub.2 CH.sub.3 -quinolin-2-yl                        4413   4-CH.sub.3, 6-OCH.sub.2 CF.sub.3 -quinolin-2-yl                        4414   4-CH.sub.3, 6-OCH(CH.sub.3).sub.2 -quinolin-2-yl                       4415   4-CH.sub.3, 6-OCH.sub.2 CH═CH.sub.2 -quinolin-2-yl                 4416   4-CH.sub.3, 6-CO.sub.2 CH.sub.3 -quinolin-2-yl                         4417   4-CH.sub.3, 6-CF.sub.3 -quinolin-2-yl                                  4418   4-CF.sub.3, 6-CH.sub.2 CH.sub.3 -quinolin-2-yl                         4419   4-CF.sub.3, 6-OCH.sub.3 -quinolin-2-yl                                 4420   4-CF.sub.3, 6-OCH.sub.2 CH.sub.3 -quinolin-2-yl                        4421   4-CF.sub.3, 6-OCH.sub.2 CF.sub.3 -quinolin-2-yl                        4422   4-OCH.sub.3, 6-OCH.sub.2 CH.sub.3 -quinolin-2-yl                       4423   4-OCH.sub.3, 6-OCH.sub.2 CF.sub.3 -quinolin-2-yl                       4424   4-OCH.sub.3, 6-OCH(CH.sub.3)-quinolin-2-yl                             4425   4-OCH.sub.2 CH.sub.3, 6-CH.sub.2 OCH.sub.2 CH.sub.3 -quinolin-2-yl            N                                                                      4426   4-NO.sub.2, 6-CH.sub.3 -quinolin-2-yl                                  4427   4-NO.sub.2, 6-OCH.sub.3 -quinolin-2-yl                                 4428   4-NO.sub.2, 6-OCH.sub.2 CH.sub.3 -quinolin-2-yl                        4429   4-NO.sub.2, 6-OCH(CH.sub.3).sub.2 -quinolin-2-yl                       4430   4-NO.sub.2, 6-OCH.sub.2 CF.sub.3 -quinolin-2-yl                        4431   4-CN, 6-CH.sub.3 -quinolin-2-yl                                        4432   4-CN, 6-OCH.sub.3 -quinolin-2-yl                                       4433   4-CN, 6-OCH.sub.2 CH.sub.3 -quinolin-2-yl                              4434   4-CN, 6-OCH(CH.sub.3).sub.2 -quinolin-2-yl                             4435   4-CN, 6-OCH.sub.2 CF.sub.3 -quinolin-2-yl                              4436   4-CH.sub.3 -isoquinolin-3-yl                                           4437   4-CH.sub.2 CH.sub.3 -isoquinolin-3-yl                                  4438   4-CH(CH.sub.3).sub.2 -isoquinolin-3-yl                                 4439   4-CH(CH.sub.3)CH.sub.2 CH.sub.3 -isoquinolin-3-yl                      4440   4-CF.sub.3 -isoquinolin-3-yl                                           4441   4-CH═CH.sub.2 -isoquinolin-3-yl                                    4442   4-CH═CHCH.sub.3 -isoquinolin-3-yl                                  4443   4-CH═CHCl-isoquinolin-3-yl                                         4444   4-C.tbd.CH-isoquinolin-3-yl                                            4445   4-CH.sub.2 C.tbd.CH-isoquinolin-3-yl                                   4446   4-CH.sub.2 C.tbd.CCH.sub.3 -isoquinolin-3-yl                           4447   4-cyclopropyl-isoquinolin-3-yl                                         4448   4-cyclopentyl-isoquinolin-3-yl                                         4449   4-OCH.sub.3 -isoquinolin-3-yl                                          4450   4-OCH.sub.2 CH.sub.3 -isoquinolin-3-yl                                 4451   4-OCH.sub.2 CH.sub.2 CH.sub.3 -isoquinolin-3-yl                        4452   4-OCH(CH.sub.3).sub.2 -isoquinolin-3-yl                                4453   4-OCH.sub.2 CH.sub.2 CH.sub.2 CH.sub.3 -isoquinolin-3-yl               4454   4-OCH(CH.sub.3)CH.sub.2 CH.sub.3 -isoquinolin-3-yl                     4455   4-OCH.sub.2 CH(CH.sub.3).sub.2 -isoquinolin-3-yl                       4456   4-OC(CH.sub.3).sub.4 -isoquinolin-3-yl                                 4457   4-OCH(CH.sub.3)CH.sub.2 CH.sub.2 CH.sub.3 -isoquinolin-3-yl            4458   4-OCH.sub.2 OCH.sub.3 -isoquinolin-3-yl                                4459   4-OCH.sub.2 OCH.sub.2 CH.sub.3 -isoquinolin-3-yl                       4460   4-OCH(CH.sub.3)OCH.sub.3 -isoquinolin-3-yl                             4461   4-OCH(CH.sub.3)OCH.sub.2 CH.sub.3 -isoquinolin-3-yl                    4462   4-OCH.sub.2 CH.sub.2 OCH.sub.3 -isoquinolin-3-yl                       4463   4-OCH.sub.2 CH.sub.2 OCH.sub.2 CH.sub.3 -isoquinolin-3-yl              4464   4-OCH.sub.2 CH.sub.2 OCH(CH.sub.3).sub.2 -isoquinolin-3-yl             4465   4-OCH.sub.2 CH.sub.2 SCH.sub.3 -isoquinolin-3-yl                       4466   4-OCH.sub.2 CH.sub.2 SO.sub.2 CH.sub.3 -isoquinolin-3-yl               4467   4-OCH.sub.2 CH.sub.2 SCH(CH.sub.3).sub.2 -isoquinolin-3-yl             4468   4-OCH.sub.2 CH.sub.2 CN-isoquinolin-3-yl                               4469   4-OCH.sub.2 CH.sub.2 SCH.sub.2 CH.sub.2 CN-isoquinolin-3-yl            4470   4-OCH.sub.2 CH.sub.2 OC.sub.6 H.sub.5 -isoquinolin-3-yl                4471   4-OCH.sub.2 CH.sub.2 OCH.sub.2 C.sub.6 H.sub.5 -isoquinolin-3-yl       4472   4-OCH.sub.2 CH.sub.2 N(CH.sub.3).sub.2 -isoquinolin-3-yl               4473   4-OCH.sub.2 CH.sub.2 CONH.sub.2 -isoquinolin-3-yl                      4474   4-OCH.sub.2 CH.sub.2 CO.sub.2 CH.sub.2 CH.sub.2 CH.sub.3 -isoquinol           in-3-yl                                                                4475   4-OCH(CH.sub.3)CH.sub.2 OCH.sub.3 -isoquinolin-3-yl                    4476   4-OCH(CH.sub.3)CH.sub.2 CO.sub.2 CH.sub.3 -isoquinolin-3-yl            4477   4-OCH(CH.sub.3)CH.sub.2 CO.sub.2 CH.sub.2 CH.sub.3 -isoquinolin-3-y           l                                                                      4478   4-OCH.sub.2 CH(CH.sub.3)CO.sub.2 CH.sub.3 -isoquinolin-3-yl            4479   4-OCH.sub.2 C(═O)CH.sub.3 -isoquinolin-3-yl                        4480   4-OCH.sub.2 C(═O)CH.sub.2 CH.sub.3 -isoquinolin-3-yl               4481   4-OCH.sub.2 CO.sub.2 CH.sub.3 -isoquinolin-3-yl                        4482   4-OCH.sub.2 CO.sub.2 CH.sub.2 CH.sub.3 -isoquinolin-3-yl               4483   4-OCH.sub.2 C(═O)NH.sub.2 -isoquinolin-3-yl                        4484   4-OCH.sub.2 C(═O)NHCH.sub.3 -isoquinolin-3-yl                      4485   4-OCH.sub.2 C(═O)SCH.sub.3 -isoquinolin-3-yl                       4486   4-OCH(CH.sub.3)C(═O)NH.sub.2 -isoquinolin-3-yl                     4487   4-OCH(CH.sub.3)C(═O)NHCH.sub.3 -isoquinolin-3-yl                   4488   4-OCH(CH.sub.3)C(═O)NHNH.sub.3 -isoquinolin-3-yl                   4489   4-OCH(CH.sub.3)CO.sub.2 CH.sub.3 -isoquinolin-3-yl                     4490   4-OCH(CH.sub.3)CO.sub.2 CH.sub.2 CH.sub.3 -isoquinolin-3-yl            4491   4-OCH(CH.sub.3)C(═O)CH.sub.3 -isoquinolin-3-yl                     4492   4-OCH(CH.sub.3)C(═O)CH.sub.2 CH.sub.3 -isoquinolin-3-yl            4493   4-OCH(CH.sub.3)CH.sub.2 C(═O)CH.sub.3 -isoquinolin-3-yl            4494   4-OCH(CH.sub.3)CH.sub.2 OC(CH.sub.3).sub.4 -isoquinolin-3-yl           4495   4-OCH(CH.sub.3)CH.sub.2 OCH.sub.2 CH.sub.3 -isoquinolin-3-yl           4496   4-OCH(CH.sub.3)CH.sub.2 O(CH.sub.3).sub.2 CH.sub.3 -isoquinolin-3-y           l                                                                      4497   4-OCH(CH.sub.3)CH.sub.2 OCH.sub.2 CH═CH.sub.2 -isoquinolin-3-yl           O                                                                      4498   4-O(CH.sub.2).sub.3 OCH.sub.3 -isoquinolin-3-yl                        4499   4-O(CH.sub.2).sub.3 OCH.sub.2 CH.sub.3 -isoquinolin-3-yl               4500   4-O(CH.sub.2).sub.3 OCH(CH.sub.3).sub.2 -isoquinolin-3-yl              4501   4-O(CH.sub.2).sub.3 OC.sub.6 H.sub.5 -isoquinolin-3-yl                 4502   4-O(CH.sub.2).sub.3 OCH.sub.2 C.sub.6 H.sub.5 -isoquinolin-3-yl        4503   4-OCH(CH.sub.2 CH.sub.3)CH.sub.2 OCH.sub.3 -isoquinolin-3-yl           4504   4-OCH(CH.sub.2 CH.sub.3)CH.sub.2 CH.sub.2 OCH.sub.3 -isoquinolin-3-           yl                                                                     4505   4-OCH(CH.sub.2 CH.sub.3)CH.sub.2 CH.sub.2 OCH.sub.2 CH.sub.3                  -isoquinolin-3-yl                                                      4506   4-O (CH.sub.2).sub.3 O!.sub.2 CH.sub.3 -isoquinolin-3-yl               4507   4-OCH.sub.2 CH(CH.sub.3)CH.sub.2 OCH.sub.3 -isoquinolin-3-yl           4508   4-OCH.sub.2 CH(CH.sub.3)CH.sub.2 OCH.sub.2 CH.sub.3 -isoquinolin-3-           yl                                                                     4509   4-OCH(CH.sub.2 Cl)CH.sub.2 OCH.sub.3 -isoquinolin-3-yl                 4510   4-OCH(CH.sub.2 Cl)CH.sub.2 OCH.sub.2 CH.sub.3 -isoquinolin-3-yl        4511   4-OCH(CH.sub.2 Cl)CH.sub.2 OCH(CH.sub.3).sub.2 -isoquinolin-3-yl       4512   4-OCH(CH.sub.2 Cl)CH.sub.2 OCH.sub.2 CH═CH.sub.2 -isoquinolin-3           -yl                                                                    4513   4-OCH CH.sub.2 OCH.sub.3 !.sub.2 -isoquinolin-3-yl                     4514   4-OCH CH.sub.2 OCH.sub.2 CH.sub.3 !.sub.2 -isoquinolin-3-yl            4515   4-OCCl.sub.4 -isoquinolin-3-yl                                         4516   4-OCHF.sub.2 -isoquinolin-3-yl                                         4517   4-OCF.sub.3 -isoquinolin-3-yl                                          4518   4-OCF.sub.2 CHF.sub.2 -isoquinolin-3-yl                                4519   4-OCH.sub.2 CF.sub.3 -isoquinolin-3-yl                                 4520   4-OCH.sub.2 CHF.sub.2 -isoquinolin-3-yl                                4521   4-O(CH.sub.2).sub.3 F-isoquinolin-3-yl                                 4522   4-OCH(CH.sub.3)CF.sub.3 -isoquinolin-3-yl                              4523   4-O(CH.sub.2).sub.4 F-isoquinolin-3-yl                                 4524   4-O(CH.sub.2).sub.3 CF.sub.3 -isoquinolin-3-yl                         4525   4-OCH(CH.sub.3)CF.sub.2 CF.sub.3 -isoquinolin-3-yl                     4526   4-OCH(CH.sub.3)CF.sub.2 CHF.sub.2 -isoquinolin-3-yl                    4527   4-OCH.sub.2 CF.sub.2 CHFCH.sub.3 -isoquinolin-3-yl                     4528   4-OCH.sub.2 (CF.sub.2).sub.2 CF.sub.3 -isoquinolin-3-yl                4529   4-O(CF.sub.2).sub.3 CF.sub.3 -isoquinolin-3-yl                         4530   4-OCH.sub.2 CF.sub.2 CHF.sub.2 -isoquinolin-3-yl                       4531   4-CH.sub.2 CH═CH.sub.2 -isoquinolin-3-yl                           4532   4-CH.sub.2 C(CH.sub.3)═CH.sub.2 -isoquinolin-3-yl                  4533   4-OCH.sub.2 CH═CHCH.sub.3 -isoquinolin-3-yl                        4534   4-O(CH.sub.2).sub.2 CH═CH.sub.2 -isoquinolin-3-yl                  4535   4-OCH.sub.2 C(CH.sub.3)═CH.sub.2 -isoquinolin-3-yl                 4536   4-OCH(CH.sub.3)CH═CH.sub.2 -isoquinolin-3-yl                       4537   4-OCH.sub.2 C.tbd.CH-isoquinolin-3-yl                                  4538   4-OCH.sub.2 C.tbd.CCH.sub.3 -isoquinolin-3-yl                          4539   4-O(CH.sub.2).sub.2 C.tbd.CH-isoquinolin-3-yl                          4540   4-SCH.sub.3 -isoquinolin-3-yl                                          4541   4-SCH.sub.2 CH.sub.3 -isoquinolin-3-yl                                 4542   4-OC.sub.6 H.sub.5 -isoquinolin-3-yl                                   4543   4-OCH.sub.2 C.sub.6 H.sub.5 -isoquinolin-3-yl                          4544   4-NO.sub.2 -isoquinolin-3-yl                                           4545   4-NHCH.sub.3 -isoquinolin-3-yl                                         4546   4-N(CH.sub.3).sub.2 -isoquinolin-3-yl                                  4547   4-N(CH.sub.3)C.sub.2 H.sub.6 -isoquinolin-3-yl                         4548   4-NHCH.sub.2 CF.sub.3 -isoquinolin-3-yl                                4549   4-F-isoquinolin-3-yl                                                   4550   4-Cl-isoquinolin-3-yl                                                  4551   4-OH-isoquinolin-3-yl                                                  4552   4-CN-isoquinolin-3-yl                                                  4553   4-C(O)NH.sub.2 -isoquinolin-3-yl                                       4554   4-C(S)NH.sub.2 -isoquinolin-3-yl                                       4555   4-CO.sub.2 CH.sub.3 -isoquinolin-3-yl                                  4556   4-ON═C(CH.sub.3).sub.2 -isoquinolin-3-yl                           4557   4- O-cyclopropyl!isoquinolin-3-yl                                      4558   4- O-cyclobutyl!isoquinolin-3-yl                                       4559   4- O-cyclopentyl!isoquinolin-3-yl                                      4560   4- O-cyclohexyl!isoquinolin-3-yl                                       4561   4- OCH.sub.2 -cyclopropyl!isoquinolin-3-yl                             4562   6-F, 4- OCH.sub.2 -cyclopropyl!isoquinolin-3-yl                        4563   6-CH.sub.3, 4- OCH.sub.2 -cyclopropyl!isoquinolin-3-yl                 4564   6-CF.sub.3, 4- OCH.sub.2 -cyclopropyl!isoquinolin-3-yl                 4565   4- OCH(CH.sub.3)-cyclopropyl!isoquinolin-3-yl                          4566   6-F, 4- OCH(CH.sub.3)-cyclopropyl!isoquinolin-3-yl                     4567   6-CH.sub.3, 4- OCH(CH.sub.3)-cyclopropyl!isoquinolin-3-yl              4568   6-CF.sub.3, 4- OCH(CH.sub.3)-cyclopropyl!isoquinolin-3-yl              4569   4- O-(1-CH.sub.3 -cyclopropyl)!isoquinolin-3-yl                        4570   6-F, 4- O-(1-CH.sub.3 -cyclopropyl)!isoquinolin-3-yl                   4571   6-CH.sub.3, 4- O(1-CH.sub.3 -cyclopropyl)!isoquinolin-3-yl             4572   6-CF.sub.3, 4- O(1-CH.sub.3 -cyclopropyl)!isoquinolin-3-yl             4573   4- OCH.sub.2 -(1-CH.sub.3 -cyclopropyl)!isoquinolin-3-yl               4574   6-F, 4- OCH.sub.2 -(1-CH.sub.3 -cyclopropyl)!isoquinolin-3-yl          4575   6-CH.sub.3, 4- OCH.sub.2 -(1-CH.sub.3 -cyclopropyl)!isoquinolin-3-y           l                                                                      4576   6-CF.sub.3, 4- OCH.sub.2 -(1-CH.sub.3 -cyclopropyl)!isoquinolin-3-y           l                                                                      4577   4- OCH.sub.2 -(2-CH.sub.3 cyclopropyl)!isoquinolin-3-yl                4578   6-F, 4- OCH.sub.2 -(2-CH.sub.3 -cyclopropyl)!isoquinolin-3-yl          4579   6-CH.sub.3, 4- OCH.sub.2 -(2-CH.sub.3 -cyclopropyl)!isoquinolin-3-y           l                                                                      4580   6-CF.sub.3, 4- OCH.sub.2 -(2-CH.sub.3 -cyclopropyl)!isoquinolin-3-y           l                                                                      4581   4- OCH.sub.2 -(tetrahydropyran-2-yl)!isoquinolin-3-yl                  4582   6-F, 4- OCH.sub.2 -(tetrahydropyran-2-yl)!isoquinolin-3-yl             4583   6-CH.sub.3, 4- OCH.sub.2 -(tetrahydropyran-2-yl)!isoquinolin-3-yl      4584   6-CF.sub.3, 4- OCH.sub.2 -(tetrahydropyran-2-yl)!isoquinolin-3-yl      4585   4- OCH.sub.2 -(furan-2-yl)!isoquinolin-3-yl                            4586   6-F, 4- OCH.sub.2 -(furan-2-yl)!isoquinolin-3-yl                       4587   6-CH.sub.3, 4- OCH.sub.2 -(furan-2-yl)!isoquinolin-3-yl                4588   6-CF.sub.3, 4- OCH.sub.2 -(furan-2-yl)!isoquinolin-3-yl                4589   4- OCH.sub.2 -(furan-4-yl)!isoquinolin-3-yl                            4590   6-F, 4- OCH.sub.2 -(furan-4-yl)!isoquinolin-3-yl                       4591   6-CH.sub.3, 4- OCH.sub.2 -(furan-4-yl)!isoquinolin-3-yl                4592   6-CF.sub.3, 4- OCH.sub.2 -(furan-4-yl)!isoquinolin-3-yl                4593   4- OCH.sub.2 -(tetrahydrofuran-4-yl)!isoquinolin-3-yl                  4594   6-F, 4- OCH.sub.2 -(tetrahydrofuran-4-yl)!isoquinolin-3-yl             4595   6-CH.sub.3, 4- OCH.sub.2 (tetrahydrofuran-4-yl)!isoquinolin-3-yl       4596   6-CF.sub.3, 4- OCH.sub.2 (tetrahydrofuran-4-yl)!isoquinolin-3-yl       4597   4- OCH.sub.2 -(tetrahydrofuran-2-yl)!isoquinolin-3-yl                  4598   6-F, 4- OCH.sub.2 -(tetrahydrofuran-2-yl)!isoquinolin-3-yl             4599   6-CH.sub.3, 4- OCH.sub.2 -(tetrahydrofuran-2-yl)!isoquinolin-3-yl      4600   6-CF.sub.3, 4- OCH.sub.2 -(tetrahydrofuran-2-yl)!isoquinolin-3-yl      4601   4- O-(tetrahydropyran-4-yl)!isoquinolin-3-yl                           4602   6-F, 4- O-(tetrahydropyran-4-yl)!isoquinolin-3-yl                      4603   6-CH.sub.3, 4- O-(tetrahydropyran-4-yl)!isoquinolin-3-yl               4604   6-CF.sub.3, 4- O-(tetrahydropyran-4-yl)!isoquinolin-3-yl               4605   4- 2-Cl--C.sub.5 H.sub.4 !isoquinolin-3-yl                             4606   6-F, 4- 2-Cl--C.sub.5 H.sub.4 !isoquinolin-3-yl                        4607   6-CH.sub.3, 4- 2-Cl--C.sub.5 H.sub.4 !isoquinolin-3-yl                 4608   6-CF.sub.3, 4- 2-Cl--C.sub.5 H.sub.4 !isoquinolin-3-yl                 4609   4- OCH.sub.2 -(pyridin-2-yl)!isoquinolin-3-yl                          4610   6-F, 4- OCH.sub.2 -(pyridin-2-yl)!isoquinolin-3-yl                     4611   6-CH.sub.3, 4- OCH.sub.2 -(pyridin-2-yl)!isoquinolin-3-yl              4612   6-CF.sub.3, 4- OCH.sub.2 -(pyridin-2-yl)!isoquinolin-3-yl              4613   4- OCH.sub.2 -(pyridin-4-yl)!isoquinolin-3-yl                          4614   6-F, 4- OCH.sub.2 -(pyridin-4-yl)!isoquinolin-3-yl                     4615   6-CH.sub.3, 4- OCH.sub.2 -(pyridin-4-yl)!isoquinolin-3-yl              4616   6-CF.sub.3, 4- OCH.sub.2 -(pyridin-4-yl)!isoquinolin-3-yl              4617   4- morpholin-4-yl!isoquinolin-3-yl                                     4618   4- 1-CH.sub.3 -imidazol-2-yl!isoquinolin-3-yl                          4619   6-F, 4- 1-CH.sub.3 -imidazol-2-yl!isoquinolin-3-yl                     4620   6-CH.sub.3, 4- 1-CH.sub.3 -imidazol-2-yl!isoquinolin-3-yl              4621   6-CF.sub.3, 4- 1-CH.sub.3 -imidazol-2-yl!isoquinolin-3-yl              4622   4- 1,2,4-triazol-1-yl!isoquinolin-3-yl                                 4623   6-F, 4- 1,2,4-triazol-1-yl!isoquinolin-3-yl                            4624   6-CH.sub.3, 4- 1,2,4-triazol-1-yl!isoquinolin-3-yl                     4625   6-CF.sub.3, 4- 1,2,4-triazol-1-yl!isoquinolin-3-yl                     4626   4,6-Cl.sub.2 -isoquinolin-3-yl                                         4627   4,6-(CH.sub.3).sub.2 -isoquinolin-3-yl                                 4628   4,6-(OCH.sub.3).sub.2 -isoquinolin-3-yl                                4629   4,6-(OCH.sub.2 CH.sub.3).sub.2 -isoquinolin-3-yl                       4630   4-F, 6-CH.sub.3 -isoquinolin-3-yl                                      4631   4-F, 6-OCH.sub.3 -isoquinolin-3-yl                                     4632   4-F, 6-OCH.sub.2 CH.sub.3 -isoquinolin-3-yl                            4633   4-F, 6-OCH.sub.2 CF.sub.3 -isoquinolin-3-yl                            4634   4-F, 6-OCH(CH.sub.3).sub.2 -isoquinolin-3-yl                           4635   4-Cl, 6-CH.sub.3 -isoquinolin-3-yl                                     4636   4-Cl, 6-OCH.sub.3 -isoquinolin-3-yl                                    4637   4-Cl, 6-OCH.sub.2 CH.sub.3 -isoquinolin-3-yl                           4638   4-Cl, 6-OCH.sub.2 CF.sub.3 -isoquinolin-3-yl                           4639   4-Cl, 6-OCH(CH.sub.3).sub.2 -isoquinolin-3-yl                          4640   4-CH.sub.3, 6-OCH.sub.3 -isoquinolin-3-yl                              4641   4-CH.sub.3, 6-OCH.sub.2 CH.sub.3 -isoquinolin-3-yl                     4642   4-CH.sub.3, 6-OCH.sub.2 CF.sub.3 -isoquinolin-3-yl                     4643   4-CH.sub.3, 6-OCH(CH.sub.3).sub.2 -isoquinolin-3-yl                    4644   4-CH.sub.3, 6-OCH.sub.2 CH═CH.sub.2 -isoquinolin-3-yl              4645   4-CH.sub.3, 6-CO.sub.2 CH.sub.3 -isoquinolin-3-yl                      4646   4-CH.sub.3, 6-CF.sub.3 -isoquinolin-3-yl                               4647   4-CF.sub.3, 6-CH.sub.2 CH.sub.3 -isoquinolin-3-yl                      4648   4-CF.sub.3, 6-OCH.sub.3 -isoquinolin-3-yl                              4649   4-CF.sub.3, 6-OCH.sub.2 CH.sub.3 -isoquinolin-3-yl                     4650   4-CF.sub.3, 6-OCH.sub.2 CF.sub.3 -isoquinolin-3-yl                     4651   4-OCH.sub.3, 6-OCH.sub.2 CH.sub.3 -isoquinolin-3-yl                    4652   4-OCH.sub.3, 6-OCH.sub.2 CF.sub.3 -isoquinolin-3-yl                    4653   4-OCH.sub.3, 6-OCH(CH.sub.3)-isoquinolin-3-yl                          4654   4-OCH.sub.2 CH.sub.3, 6-CH.sub.2 OCH.sub.2 CH.sub.3 -isoquinolin-3-           yl                                                                     4655   4-NO.sub.2, 6-CH.sub.3 -isoquinolin-3-yl                               4656   4-NO.sub.2, 6-OCH.sub.3 -isoquinolin-3-yl                              4657   4-NO.sub.2, 6-OCH.sub.2 CH.sub.3 -isoquinolin-3-yl                     4658   4-NO.sub.2, 6-OCH(CH.sub.3).sub.2 -isoquinolin-3-yl                    4659   4-NO.sub.2, 6-OCH.sub.2 CF.sub.3 -isoquinolin-3-yl                     4660   4-CN, 6-CH.sub.3 -isoquinolin-3-yl                                     4661   4-CN, 6-OCH.sub.3 -isoquinolin-3-yl                                    4662   4-CN, 6-OCH.sub.2 CH.sub.3 -isoquinolin-3-yl                           4663   4-CN, 6-OCH(CH.sub.3).sub.2 -isoquinolin-3-yl                          4664   4-CN, 6-OCH.sub.2 CF.sub.3 -isoquinolin-3-yl                           4665   7-CH.sub.3, 2-CH.sub.3 -purin-8-yl                                     4666   7-CH.sub.3, 2-CH.sub.2 CH.sub.3 -purin-8-yl                            4667   7-CH.sub.3, 2-CH(CH.sub.3).sub.2 -purin-8-yl                           4668   7-CH.sub.3, 2-CH(CH.sub.3)CH.sub.2 CH.sub.3 -purin-8-yl                4669   7-CH.sub.3, 2-CF.sub.3 -purin-8-yl                                     4670   7-CH.sub.3, 2-CH═CH.sub.2 -purin-8-yl                              4671   7-CH.sub.3, 2-CH═CHCH.sub.3 -purin-8-yl                            4672   7-CH.sub.3, 2-CH═CHCl-purin-8-yl                                   4673   7-CH.sub.3, 2-C.tbd.CH-purin-8-yl                                      4674   7-CH.sub.3, 2-CH.sub.2 C.tbd.CH-purin-8-yl                             4675   7-CH.sub.3, 2-CH.sub.2 C.tbd.CCH.sub.3 -purin-8-yl                     4676   7-CH.sub.3, 2-cyclopropyl-purin-8-yl                                   4677   7-CH.sub.3, 2-cyclopentyl-purin-8-yl                                   4678   7-CH.sub.3, 2-OCH.sub.3 -purin-8-yl                                    4679   7-CH.sub.3, 2-OCH.sub.2 CH.sub.3 -purin-8-yl                           4680   7-CH.sub.3, 2-OCH.sub.2 CH.sub.2 CH.sub.3 -purin-8-yl                  4681   7-CH.sub.3, 2-OCH(CH.sub.3).sub.2 -purin-8-yl                          4682   7-CH.sub.3, 2-OCH.sub.2 CH.sub.2 CH.sub.2 CH.sub.3 -purin-8-yl         4683   7-CH.sub.3, 2-OCH(CH.sub.3)CH.sub.2 CH.sub.3 -purin-8-yl               4684   7-CH.sub.3, 2-OCH.sub.2 CH(CH.sub.3).sub.2 -purin-8-yl                 4685   7-CH.sub.3, 2-OC(CH.sub.3).sub.2 -purin-8-yl                           4686   7-CH.sub.3, 2-OCH(CH.sub.3)CH.sub.2 CH.sub.2 CH.sub.3 -purin-8-yl      4687   7-CH.sub.3, 2-OCH.sub.2 OCH.sub.3 -purin-8-yl                          4688   7-CH.sub.3, 2-OCH.sub.2 OCH.sub.2 CH.sub.3 -purin-8-yl                 4689   7-CH.sub.3, 2-OCH(CH.sub.3)OCH.sub.3 -purin-8-yl                       4690   7-CH.sub.3, 2-OCH(CH.sub.3)OCH.sub.2 CH.sub.3 -purin-8-yl              4691   7-CH.sub.3, 2-OCH.sub.2 CH.sub.2 OCH.sub.3 -purin-8-yl                 4692   7-CH.sub.3, 2-OCH.sub.2 CH.sub.2 OCH.sub.2 CH.sub.3 -purin-8-yl        4693   7-CH.sub.3, 2-OCH.sub.2 CH.sub.2 OCH(CH.sub.3).sub.2 -purin-8-yl       4694   7-CH.sub.3, 2-OCH.sub.2 CH.sub.2 SCH.sub.3 -purin-8-yl                 4695   7-CH.sub.3, 2-OCH.sub.2 CH.sub.2 SO.sub.2 CH.sub.3 -purin-8-yl         4696   7-CH.sub.3, 2-OCH.sub.2 CH.sub.2 SCH(CH.sub.3).sub.2 -purin-8-yl       4697   7-CH.sub.3, 2-OCH.sub.2 CH.sub.2 CN-purin-8-yl                         4698   7-CH.sub.3, 2-OCH.sub.2 CH.sub.2 SCH.sub.2 CH.sub.2 CN-purin-8-yl      4699   7-CH.sub.3 , 2-OCH.sub.2 CH.sub.2 OC.sub.6 H.sub.5 -purin-8-yl         4700   7-CH.sub.3, 2-OCH.sub.2 CH.sub.2 OCH.sub.2 C.sub.6 H.sub.5                    -purin-8-yl                                                            4701   7-CH.sub.3, 2-OCH.sub.2 CH.sub.2 N(CH.sub.3).sub.2 -purin-8-yl         4702   7-CH.sub.3, 2-OCH.sub.2 CH.sub.2 CONH.sub.2 -purin-8-yl                4703   7-CH.sub.3, 2-OCH.sub.2 CH.sub.2 CO.sub.2 CH.sub.2 CH.sub.2                   CH.sub.3 -purin-8-yl                                                   4704   7-CH.sub.3, 2-OCH(CH.sub.3)CH.sub.2 OCH.sub.3 -purin-8-yl              4705   7-CH.sub.3, 2-OCH(CH.sub.3)CH.sub.2 CO.sub.2 CH.sub.3 -purin-8-yl      4706   7-CH.sub.3, 2-OCH(CH.sub.3)CH.sub.2 CO.sub.2 CH.sub.2 CH.sub.3                -purin-8-yl                                                            4707   7-CH.sub.3, 2-OCH.sub.2 CH(CH.sub.3)CO.sub.2 CH.sub.3 -purin-8-yl      4708   7-CH.sub.3, 2-OCH.sub.2 C(═O)CH.sub.3 -purin-8-yl                  4709   7-CH.sub.3, 2-OCH.sub.2 C(═O)CH.sub.2 CH.sub.3 -purin-8-yl         4710   7-CH.sub.3, 2-OCH.sub.2 CO.sub.2 CH.sub.3 -purin-8-yl                  4711   7-CH.sub.3, 2-OCH.sub.2 CO.sub.2 CH.sub.2 CH.sub.3 -purin-8-yl         4712   7-CH.sub.3, 2-OCH.sub.2 C(═O)NH.sub.2 -purin-8-yl                  4713   7-CH.sub.3, 2-OCH.sub.2 C(═O)NHCH.sub.3 -purin-8-yl                4714   7-CH.sub.3, 2-OCH.sub.2 C(═O)SCH.sub.3 -purin-8-yl                 4715   7-CH.sub.3, 2-OCH(CH.sub.3)C(═O)NH.sub.2 -purin-8-yl               4716   7-CH.sub.3, 2-OCH(CH.sub.3)C(═O)NHCH.sub.3 -purin-8-yl             4717   7-CH.sub.3, 2-OCH(CH.sub.3)C(═O)NHNH.sub.3 -purin-8-yl             4718   7-CH.sub.3, 2-OCH(CH.sub.3)CO.sub.2 CH.sub.3 -purin-8-yl               4719   7-CH.sub.3, 2-OCH(CH.sub.3)CO.sub.2 CH.sub.2 CH.sub.3 -purin-8-yl      4720   7-CH.sub.3, 2-OCH(CH.sub.3)C(═O)CH.sub.3 -purin-8-yl               4721   7-CH.sub.3, 2-OCH(CH.sub.3)C(═O)CH.sub.2 CH.sub.3 -purin-8-yl      4722   7-CH.sub.3, 2-OCH(CH.sub.3)CH.sub.2 C(═O)CH.sub.3 -purin-8-yl      4723   7-CH.sub.3, 2-OCH(CH.sub.3)CH.sub.2 OC(CH.sub.3).sub.2 -purin-8-yl            N                                                                      4724   7-CH.sub.3, 2-OCH(CH.sub.3)CH.sub.2 OCH.sub.2 CH.sub.3 -purin-8-yl            O                                                                      4725   7-CH.sub.3, 2-OCH(CH.sub.3)CH.sub.2 O(CH.sub.3).sub.2 CH.sub.3                -purin-8-yl                                                            4726   7-CH.sub.3, 2-OCH(CH.sub.3)CH.sub.2 OCH.sub.2 CH═CH.sub.2                 -purin-8-yl                                                            4727   7-CH.sub.3, 2-O(CH.sub.2).sub.3 OCH.sub.3 -purin-8-yl                  4728   7-CH.sub.3, 2-O(CH.sub.2).sub.3 OCH.sub.2 CH.sub.3 -purin-8-yl         4729   7-CH.sub.3, 2-O(CH.sub.2).sub.3 OCH(CH.sub.3).sub.2 -purin-8-yl        4730   7-CH.sub.3, 2-O(CH.sub.2).sub.3 OC.sub.6 H.sub.5 -purin-8-yl           4731   7-CH.sub.3, 2-O(CH.sub.2).sub.3 OCH.sub.2 C.sub.6 H.sub.4 -purin-8-           yl                                                                     4732   7-CH.sub.3, 2-OCH(CH.sub.2 CH.sub.3)CH.sub.2 OCH.sub.3 -purin-8-yl            9                                                                      4733   7-CH.sub.3, 2-OCH(CH.sub.2 CH.sub.3)CH.sub.2 CH.sub.2 OCH.sub.3               -purin-8-yl                                                            4734   7-CH.sub.3, 2-OCH(CH.sub.2 CH.sub.3)CH.sub.2 CH.sub.2 OCH.sub.2               CH.sub.3 -purin-8-yl                                                   4735   7-CH.sub.3, 2-O (CH.sub.2).sub.3 O!.sub.2 CH.sub.3 -purin-8-yl         4736   7-CH.sub.3, 2-OCH.sub.2 CH(CH.sub.3)CH.sub.2 OCH.sub.3 -purin-8-yl            N                                                                      4737   7-CH.sub.3, 2-OCH.sub.2 CH(CH.sub.3)CH.sub.2 OCH.sub.2 CH.sub.3               -purin-8-yl                                                            4738   7-CH.sub.3, 2-OCH(CH.sub.2 Cl)CH.sub.2 OCH.sub.3 -purin-8-yl           4739   7-CH.sub.3, 2-OCH(CH.sub.2 Cl)CH.sub.2 OCH.sub.2 CH.sub.3 -purin-8-           yl                                                                     4740   7-CH.sub.3, 2-OCH(CH.sub.2 Cl)CH.sub.2 OCH(CH.sub.3).sub.2                    -purin-8-yl                                                            4741   7-CH.sub.3, 2-OCH(CH.sub.2 Cl)CH.sub.2 OCH.sub.2 CH═CH.sub.2              -purin-8-yl                                                            4742   7-CH.sub.3, 2-OCH CH.sub.2 OCH.sub.3 !.sub.2 -purin-8-yl               4743   7-CH.sub.3, 2-OCH CH.sub.2 OCH.sub.2 CH.sub.3 !.sub.2 -purin-8-yl      4744   7-CH.sub.3, 2-OCCl.sub.2 -purin-8-yl                                   4745   7-CH.sub.3, 2-OCHF.sub.2 -purin-8-yl                                   4746   7-CH.sub.3, 2-OCF.sub.3 -purin-8-yl                                    4747   7-CH.sub.3, 2-OCF.sub.2 CHF.sub.2 -purin-8-yl                          4748   7-CH.sub.3, 2-OCH.sub.2 CF.sub.3 -purin-8-yl                           4749   7-CH.sub.3, 2-OCH.sub.2 CHF.sub.2 -purin-8-yl                          4750   7-CH.sub.3, 2-O(CH.sub.2).sub.3 F-purin-8-yl                           4751   7-CH.sub.3, 2-OCH(CH.sub.3)CF.sub.3 -purin-8-yl                        4752   7-CH.sub.3, 2-O(CH.sub.2).sub.4 F-purin-8-yl                           4753   7-CH.sub.3, 2-O(CH.sub.2).sub.3 CF.sub.3 -purin-8-yl                   4754   7-CH.sub.3, 2-OCH(CH.sub.3)CF.sub.2 CF.sub.3 -purin-8-yl               4755   7-CH.sub.3, 2-OCH(CH.sub.3)CF.sub.2 CHF.sub.2 -purin-8-yl              4756   7-CH.sub.3, 2-OCH.sub.2 CF.sub.2 CHFCH.sub.3 -purin-8-yl               4757   7-CH.sub.3, 2-OCH.sub.2 (CF.sub.2).sub.2 CF.sub.3 -purin-8-yl          4758   7-CH.sub.3, 2-O(CF.sub.2).sub.3 CF.sub.3 -purin-8-yl                   4759   7-CH.sub.3, 2-OCH.sub.2 CF.sub.2 CHF.sub.2 -purin-8-yl                 4760   7-CH.sub.3, 2-CH.sub.2 CH═CH.sub.2 -purin-8-yl                     4761   7-CH.sub.3, 2-CH.sub.2 C(CH.sub.3)═CH.sub.2 -purin-8-yl            4762   7-CH.sub.3, 2-OCH.sub.2 CH═CHCH.sub.3 -purin-8-yl                  4763   7-CH.sub.3, 2-O(CH.sub.2).sub.2 CH═CH.sub.2 -purin-8-yl            4764   7-CH.sub.3, 2-OCH.sub.2 C(CH.sub.3)═CH.sub.2 -purin-8-yl           4765   7-CH.sub.3, 2-OCH(CH.sub.3)CH═CH.sub.2 -purin-8-yl                 4766   7-CH.sub.3, 2-OCH.sub.2 C.tbd.CH-purin-8-yl                            4767   7-CH.sub.3, 2-OCH.sub.2 C.tbd.CCH.sub.3 -purin-8-yl                    4768   7-CH.sub.3, 2-O(CH.sub.2).sub.2 C.tbd.CH-purin-8-yl                    4769   7-CH.sub.3, 2-SCH.sub.3 -purin-8-yl                                    4770   7-CH.sub.3, 2-SCH.sub.2 CH.sub.3 -purin-8-yl                           4771   7-CH.sub.3, 2-OC.sub.6 H.sub.5 -purin-8-yl                             4772   7-CH.sub.3, 2-OCH.sub.2 C.sub.6 H.sub.5 -purin-8-yl                    4773   7-CH.sub.3, 2-NO.sub.2 -purin-8-yl                                     4774   7-CH.sub.3, 2-NHCH.sub.3 -purin-8-yl                                   4775   7-CH.sub.3, 2-N(CH.sub.3).sub.2 -purin-8-yl                            4776   7-CH.sub.3, 2-N(CH.sub.3)C.sub.2 H.sub.6 -purin-8-yl                   4777   7-CH.sub.3, 2-NHCH.sub.2 CF.sub.3 -purin-8-yl                          4778   7-CH.sub.3, 2-F-purin-8-yl                                             4779   7-CH.sub.3, 2-Cl-purin-8-yl                                            4780   7-CH.sub.3, 2-OH-purin-8-yl                                            4781   7-CH.sub.3, 2-CN-purin-8-yl                                            4782   7-CH.sub.3, 2-C(O)NH.sub.2 -purin-8-yl                                 4783   7-CH.sub.3, 2-C(S)NH.sub.2 -purin-8-yl                                 4784   7-CH.sub.3, 2-CO.sub.2 CH.sub.3 -purin-8-yl                            4785   7-CH.sub.3, 2-ON═C(CH.sub.3).sub.2 -purin-8-yl                     4786   7-CH.sub.3, 2- O-cyclopropyl!purin-8-yl                                4787   7-CH.sub.3, 2- O-cyclobutyl!purin-8-yl                                 4788   7-CH.sub.3, 2- O-cyclopentyl!purin-8-yl                                4789   7-CH.sub.3, 2- O-cyclohexyl!purin-8-yl                                 4790   7-CH.sub.3, 2- OCH.sub.2 -cyclopropyl!purin-8-yl                       4791   7-CH.sub.3, 6-F, 2- OCH.sub.2 -cyclopropyl!purin-8-yl                  4792   7-CH.sub.3, 6-CH.sub.3, 2- OCH.sub.2 -cyclopropyl!purin-8-yl           4793   7-CH.sub.3, 6-CF.sub.3, 2- OCH.sub.2 -cyclopropyl!purin-8-yl           4794   7-CH.sub.3, 2- OCH(CH.sub.3)-cyclopropyl!purin-8-yl                    4795   7-CH.sub.3, 6-F, 2- OCH(CH.sub.3)-cyclopropyl!purin-8-yl               4796   7-CH.sub.3, 6-CH.sub.3, 2- OCH(CH.sub.3)-cyclopropyl!purin-8-yl        4797   7-CH.sub.3, 6-CF.sub.3, 2- OCH(CH.sub.3)-cyclopropyl!purin-8-yl        4798   7-CH.sub.3, 2- O-(7-CH.sub.3 -cyclopropyl)!purin-8-yl                  4799   7-CH.sub.3, 6-F, 2- O-(7-CH.sub.3 -cyclopropyl!purin-8-yl              4800   7-CH.sub.3, 6-CH.sub.3, 2- O-(7-CH.sub.3 -cyclopropyl)!purin-8-yl      4801   7-CH.sub.3, 6-CF.sub.3, 2- O-(7-CH.sub.3 -cyclopropyl)!purin-8-yl      4802   7-CH.sub.3, 2- OCH.sub.2 -(7-CH.sub.3 -cyclopropyl)!purin-8-yl         4803   7-CH.sub.3, 6-F, 2- OCH.sub.2 -(7-CH.sub.3 -cyclopropyl)!purin-8-yl           N                                                                      4804   7-CH.sub.3, 6-CH.sub.3, 2- OCH.sub.2 -(7-CH.sub.3 -cyclopropyl)!pur           in-8-yl                                                                4805   7-CH.sub.3, 6-CF.sub.3, 2- OCH.sub.2 -(7-CH.sub.3 -cyclopropyl)!pur           in-8-yl                                                                4806   7-CH.sub.3, 2- OCH.sub.2 -(2-CH.sub.3 -cyclopropyl)!purin-8-yl         4807   7-CH.sub.3, 6-F, 2- OCH.sub.2 -(2-CH.sub.3 -cyclopropyl)!purin-8-yl           c                                                                      4808   7-CH.sub.3, 6-CH.sub.3, 2- OCH.sub.2 -(2-CH.sub.3 -cyclopropyl)!pur           in-8-yl                                                                4809   7-CH.sub.3, 6-CF.sub.3, 2- OCH.sub.2 -(2-CH.sub.3 -cyclopropyl)!pur           in-8-yl                                                                4810   7-CH.sub.3, 2- OCH.sub.2 -(tetrahydropyran-2-yl)!purin-8-yl            4811   7-CH.sub.3, 6-F, 2- OCH.sub.2 -(tetrahydropyran-2-yl)!purin-8-yl       4812   7-CH.sub.3, 6-CH.sub.3, 2- OCH.sub.2 -(tetrahydropyran-2-yl)!purin-           8-yl                                                                   4813   7-CH.sub.3, 6-CF.sub.3, 2- OCH.sub.2 -(tetrahydropyran-2-yl)!purin-           8-yl                                                                   4814   7-CH.sub.3, 2- OCH.sub.2 -(furan-2-yl)!purin-8-yl                      4815   7-CH.sub.3, 6-F, 2- OCH.sub.2 -(furan-2-yl)!purin-8-yl                 4816   7-CH.sub.3, 6-CH.sub.3, 2- OCH.sub.2 -(furan-2-yl)!purin-8-yl          4817   7-CH.sub.3, 6-CF.sub.3, 2- OCH.sub.2 -(furan-2-yl)!purin-8-yl          4818   7-CH.sub.3, 2- OCH.sub.2 -(furan-2-yl)!purin-8-yl                      4819   7-CH.sub.3, 6-F, 2- OCH.sub.2 -(furan-2-yl)!purin-8-yl                 4820   7-CH.sub.3, 6-CH.sub.3, 2- OCH.sub.2 -(furan-2-yl)!purin-8-yl          4821   7-CH.sub.3, 6-CF.sub.3, 2- OCH.sub.2 -(furan-2-yl)!purin-8-yl          4822   7-CH.sub.3, 2- OCH.sub.2 -(tetrahydrofuran-2-yl)!purin-8-yl            4823   7-CH.sub.3, 6-F, 2- OCH.sub.2 -(tetrahydrofuran-2-yl)!purin-8-yl       4824   7-CH.sub.3, 6-CH.sub.3, 2- OCH.sub.2 -(tetrahydrofuran-2-yl)!purin-           8-yl                                                                   4825   7-CH.sub.3, 6-CF.sub.3, 2- OCH.sub.2 -(tetrahydrofuran-2-yl)!purin-           8-yl                                                                   4826   7-CH.sub.3, 2- OCH.sub.2 -(tetrahydrofuran-2-yl)!purin-8-yl            4827   7-CH.sub.3, 6-F, 2- OCH.sub.2 -(tetrahydrofuran-2-yl)!purin-8-yl       4828   7-CH.sub.3, 6-CH.sub.3, 2- OCH.sub.2 -(tetrahydrofuran-2-yl)!purin-           8-yl                                                                   4829   7-CH.sub.3, 6-CF.sub.3, 2- OCH.sub.2 -(tetrahydrofuran-2-yl)!purin-           8-yl                                                                   4830   7-CH.sub.3, 2- O-tetrahydropyran-2-yl)!purin-8-yl                      4831   7-CH.sub.3, 6-F, 2- O-(tetrahydropyran-2-yl)!purin-8-yl                4832   7-CH.sub.3, 6-CH.sub.3, 2- O-tetrahydropyran-2-yl)!purin-8-yl          4833   7-CH.sub.3, 6-CF.sub.3, 2- O-tetrahydropyran-2-yl)!purin-8-yl          4834   7-CH.sub.3, 2- 2-Cl--C.sub.5 H.sub.4 !-purin-8-yl                      4835   7-CH.sub.3, 6-F, 2- 2-ClC.sub.5 H.sub.4 !purin-8-yl                    4836   7-CH.sub.3, 6-CH.sub.3, 2- 2-Cl--C.sub.5 H.sub.4 !purin-8-yl           4837   7-CH.sub.3, 6-CF.sub.3, 2- 2-Cl--C.sub.5 H.sub.4 !purin-8-yl           4838   7-CH.sub.3, 2- OCH.sub.2 -(pyridin-2-yl)!purin-8-yl                    4839   7-CH.sub.3, 6-F, 2- OCH.sub.2 -(pyridin-2-yl)!purin-8-yl               4840   7-CH.sub.3, 6-CH.sub.3, 2- OCH.sub.2 -(pyridin-2-yl)!purin-8-yl        4841   7-CH.sub.3, 6-CF.sub.3, 2- OCH.sub.2 -(pyridin-2-yl)!purin-8-yl        4842   7-CH.sub.3, 2- OCH.sub.2 -(pyridin-2-yl)!purin-8-yl                    4843   7-CH.sub.3, 6-F, 2- OCH.sub.2 -(pyridin-2-yl)!purin-8-yl               4844   7-CH.sub.3, 6-CH.sub.3, 2- OCH.sub.2 -(pyridin-2-yl)!purin-8-yl        4845   7-CH.sub.3, 6-CF.sub.3, 2- OCH.sub.2 -(pyridin-2-yl)!purin-8-yl        4846   7-CH.sub.3, 2- morpholin-2-yl!purin-8-yl                               4847   7-CH.sub.3, 2- 7-CH.sub.3 -imidazol-2-yl!purin-8-yl                    4848   7-CH.sub.3, 6-F, 2- 7-CH.sub.3 -imidazol-2-yl!purin-8-yl               4849   7-CH.sub.3, 6-CH.sub.3, 2- 7-CH.sub.3 -imidazol-2-yl!purin-8-yl        4850   7-CH.sub.3, 6-CF.sub.3, 2- 7-CH.sub.3 -imidazol-2-yl!purin-8-yl        4851   7-CH.sub.3, 2- 1,2,2-triazol-1-yl!purin-8-yl                           4852   7-CH.sub.3, 6-F, 2- 1,2,2-triazol-1-yl!purin-8-yl                      4853   7-CH.sub.3, 6-CH.sub.3, 2- 1,2,2-triazol-1-yl!purin-8-yl               4854   7-CH.sub.3, 6-CF.sub.3, 2- 1,2,2-triazol-1-yl!purin-8-yl               4855   7-CH.sub.3, 4,6-Cl.sub.2 -purin-8-yl                                   4856   7-CH.sub.3, 4,6-(CH.sub.3).sub.2 -purin-8-yl                           4857   7-CH.sub.3, 4,6-(OCH.sub.3).sub.2 -purin-8-yl                          4858   7-CH.sub.3, 4,6-(OCH.sub.2 CH.sub.3).sub.2 -purin-8-yl                 4859   7-CH.sub.3, 2-F, 6-CH.sub.3 -purin-8-yl                                4860   7-CH.sub.3, 2-F, 6-OCH.sub.3 -purin-8-yl                               4861   7-CH.sub.3, 2-F, 6-OCH.sub.2 CH.sub.3 -purin-8-yl                      4862   7-CH.sub.3, 2-F, 6-OCH.sub.2 CF.sub.3 -purin-8-yl                      4863   7-CH.sub.3, 2-F, 6-OCH(CH.sub.3).sub.2 -purin-8-yl                     4864   7-CH.sub.3, 2-Cl, 6-CH.sub.3 -purin-8-yl                               4865   7-CH.sub.3, 2-Cl, 6-OCH.sub.3 -purin-8-yl                              4866   7-CH.sub.3, 2-Cl, 6-OCH.sub.2 CH.sub.3 -purin-8-yl                     4867   7-CH.sub.3, 2-Cl, 6-OCH.sub.2 CF.sub.3 -purin-8-yl                     4868   7-CH.sub.3, 2-Cl, 6-OCH(CH.sub.3).sub.2 -purin-8-yl                    4869   7-CH.sub.3, 2-CH.sub.3, 6-OCH.sub.3 -purin-8-yl                        4870   7-CH.sub.3, 2-CH.sub.3, 6-OCH.sub.2 CH.sub.3 -purin-8-yl               4871   7-CH.sub.3, 2-CH.sub.3, 6-OCH.sub.2 CF.sub.3 -purin-8-yl               4872   7-CH.sub.3, 2-CH.sub.3, 6-OCH(CH.sub.3).sub.2 -purin-8-yl              4873   7-CH.sub.3, 2-CH.sub.3, 6-OCH.sub.2 CH═CH.sub.2 -purin-8-yl        4874   7-CH.sub.3, 2-CH.sub.3, 6-CO.sub.2 CH.sub.3 -purin-8-yl                4875   7-CH.sub.3, 2-CH.sub.3, 6-CF.sub.3 -purin-8-yl                         4876   7-CH.sub.3, 2-CF.sub.3, 6-CH.sub.2 CH.sub.3 -purin-8-yl                4877   7-CH.sub.3, 2-CF.sub.3, 6-OCH.sub.3 -purin-8-yl                        4878   7-CH.sub.3, 2-CF.sub.3, 6-OCH.sub.2 CH.sub.3 -purin-8-yl               4879   7-CH.sub.3, 2-CF.sub.3, 6-OCH.sub.2 CF.sub.3 -purin-8-yl               4880   7-CH.sub.3, 2-OCH.sub.3, 6-OCH.sub.2 CH.sub.3 -purin-8-yl              4881   7-CH.sub.3, 2-OCH.sub.3, 6-OCH.sub.2 CF.sub.3 -purin-8-yl              4882   7-CH.sub.3, 2-OCH.sub.3, 6-OCH(CH.sub.3)-purin-8-yl                    4883   7-CH.sub.3, 2-OCH.sub.2 CH.sub.3, 6-CH.sub.2 OCH.sub.2 CH.sub.3               -purin-8-yl                                                            4884   7-CH.sub.3, 2-NO.sub.2, 6-CH.sub.3 -purin-8-yl                         4885   7-CH.sub.3, 2-NO.sub.2, 6-OCH.sub.3 -purin-8-yl                        4886   7-CH.sub.3, 2-NO.sub.2, 6-OCH.sub.2 CH.sub.3 -purin-8-yl               4887   7-CH.sub.3, 2-NO.sub.2, 6-OCH(CH.sub.3).sub.2 -purin-8-yl              4888   7-CH.sub.3, 2-NO.sub.2, 6-OCH.sub.2 CF.sub.3 -purin-8-yl               4889   7-CH.sub.3, 2-CN, 6-CH.sub.3 -purin-8-yl                               4890   7-CH.sub.3, 2-CN, 6-OCH.sub.3 -purin-8-yl                              4891   7-CH.sub.3, 2-CN, 6-OCH.sub.2 CH.sub.3 -purin-8-yl                     4892   7-CH.sub.3, 2-CN, 6-OCH(CH.sub.3).sub.2 -purin-8-yl                    4893   7-CH.sub.3, 2-CN, 6-OCH.sub.2 CF.sub.3 -purin-8-yl                     4894   3-CH.sub.2 CH.sub.2 CH.sub.3 -pyridin-2-yl                             4895   4-CH.sub.2 CH.sub.2 CH.sub.3 -pyridin-2-yl                             4896   5-CH.sub.2 CH.sub.2 CH.sub.3 -pyridin-2-yl                             4897   6-CH.sub.2 CH.sub.2 CH.sub.3 -pyridin-2-yl                             4898   3-CH(CH.sub.3).sub.2 -pyridin-2-yl                                     4899   4-CH(CH.sub.3).sub.2 -pyridin-2-yl                                     4900   5-CH(CH.sub.3).sub.2 -pyridin-2-yl                                     4901   6-CH(CH.sub.3).sub.2 -pyridin-2-yl                                     4902   3-CH.sub.2 (CH.sub.2).sub.2 CH.sub.3 -pyridin-2-yl                     4903   4-CH.sub.2 (CH.sub.2).sub.2 CH.sub.3 -pyridin-2-yl                     4904   5-CH.sub.2 (CH.sub.2).sub.2 CH.sub.3 -pyridin-2-yl                     4905   6-CH.sub.2 (CH.sub.2).sub.2 CH.sub.3 -pyridin-2-yl                     4906   3-CH(CH.sub.3)CH.sub.2 CH.sub.3 -pyridin-2-yl                          4907   4-CH(CH.sub.3)CH.sub.2 CH.sub.3 -pyridin-2-yl                          4908   5-CH(CH.sub.3)CH.sub.2 CH.sub.3 -pyridin-2-yl                          4909   6-CH(CH.sub.3)CH.sub.2 CH.sub.3 -pyridin-2-yl                          4910   3-CH.sub.2 CH(CH.sub.3).sub.2 -pyridin-2-yl                            4911   4-CH.sub.2 -H(CH.sub.3).sub.2 -pyridin-2-yl                            4912   5-CH.sub.2 CH(CH.sub.3).sub.2 -pyridin-2-yl                            4913   6-CH.sub.2 CH(CH.sub.3).sub.2 -pyridin-2-yl                            4914   3-C(CH.sub.3).sub.3 -pyridin-2-yl                                      4915   4-C(CH.sub.3).sub.3 -pyridin-2-yl                                      4916   5-C(CH.sub.3).sub.3 -pyridin-2-yl                                      4917   6-C(CH.sub.3).sub.3 -pyridin-2-yl                                      4918   3-C.sub.2 F.sub.5 -pyridin-2-yl                                        4919   4-C.sub.2 F.sub.5 -pyridin-2-yl                                        4920   5-C.sub.2 F.sub.5 -pyridin-2-yl                                        4921   6-C.sub.2 F.sub.5 -pyridin-2-yl                                        4922   4-CH.sub.2 CH(CH.sub.3).sub.2 -pyrimidin-2-yl                          4923   5-CH.sub.2 CH(CH.sub.3).sub.2 -pyrimidin-2-yl                          4924   4-C(CH.sub.3).sub.3 -pyrimidin-2-yl                                    4925   5-C(CH.sub.3).sub.3 -pyrimidin-2-yl                                    4926   3-Cl-pyridin-2-yl                                                      4927   4-Cl-pyridin-2-yl                                                      4928   5-Cl-pyridin-2-yl                                                      4929   6-Cl-pyridin-2-yl                                                      4930   3-F-pyridin-2-yl                                                       4931   4-F-pyridin-2-yl                                                       4932   5-F-pyridin-2-yl                                                       4933   6-F-pyridin-2-yl                                                       4934   3-Br-pyridin-2-yl                                                      4935   4-Br-pyridin-2-yl                                                      4936   5-Br-pyridin-2-yl                                                      4937   6-Br-pyridin-2-yl                                                      ______________________________________                                    

The compounds of the formula I according to the invention are suitablefor controlling harmful fungi and animal pests of the insects, arachnidsand nematodes classes. They can be employed as fungicides and pesticidesin crop protection and in the hygiene, stored material protection andveterinary sectors.

The harmful insects include:

from the order of the butterflies (Lepidoptera), for example, Adoxophyesorana, Agrotis ypsilon, Agrotis segetum, Alabama argillacea, Anticarsiagemmatalis, Argyresthia conjugella, Autographa gamma, Cacoecia murinana,Capua reticulana, Choristoneura fumiferana, Chilo partellus,Choristoneura occidentalis, Cirphis unipuncta, Cnaphalocrocis medinalis,Crocidolomia binotalis, Cydia pomonella, Dendrolimus pini, Diaphanianitidalis, Diatraea grandiosella, Earias insulana, Elasmopalpuslignosellus, Eupoecilia ambiguella, Feltia subterranea, Grapholithafunebrana, Grapholitha molesta, Heliothis armigera, Heliothis virescens,Heliothis zea, Hellula undalis, Hibernia defoliaria, Hyphantria cunea,Hyponomeuta malinellus, Keiferia lycopersicella, Lambdina fiscellaria,Laphygma exigua, Leucoptera scitella, Lithocolletis blancardella,Lobesia botrana, Loxostege sticticalis, Lymantria dispar, Lymantriamonacha, Lyonetia clerkella, Manduca sexta, Malacosoma neustria,Mamestra brassicae, Mocis repanda, Operophthera brumata, Orgyiapseudotsugata, Ostrinia nubilalis, Pandemis heparana, Panolis flammea,Pectinophora gossypiella, Phthorimaea operculella, Phyllocnistiscitrella, Pieris brassicae, Plathypena scabra, Platynota stultana,Plutella xylostella, Prays citri, Prays oleae, Prodenia sunia, Prodeniaornithogalli, Pseudoplusia includens, Rhyacionia frustrana,Scrobipalpula absoluta, Sesamia inferens, Sparganothis pilleriana,Spodoptera frugiperda, Spodoptera littoralis, Spodoptera litura,Syllepta derogata, Synanthedon myopaeformis, Thaumatopoea pityocampa,Tortrix viridana, Trichoplusia ni, Tryporyza incertulas, Zeirapheracanadensis, further Galleria mellonella and Sitotroga cerealella,Ephestia cautella, Tineola bisselliella;

from the order of the beetles (Coleoptera), for example, Agrioteslineatus, Agriotes obscurus, Anthonomus grandis, Anthonomus pomorum,Apion vorax, Atomaria linearis, Blastophagus piniperda, Cassidanebulosa, Cerotoma trifurcata, Ceuthorhynchus assimilis, Ceuthorhynchusnapi, Chaetocnema tibialis, Conoderus vespertinus, Crioceris asparagi,Dendroctonus refipennis, Diabrotica longicornis, Diabrotica 12-punctata,Diabrotica virgifera, Epilachna varivestis, Epitrix hirtipennis,Eutinobothrus brasiliensis, Hylobius abietis, Hypera brunneipennis,Hypera postica, Ips typographus, Lema bilineata, Lema melanopus,Leptinotarsa decemlineata, Limonius californicus, Lissorhoptrusoryzophilus, Melanotus communis, Meligethes aeneus, Melolonthahippocastani, Melolontha melolontha, Oulema oryzae, Ortiorrhynchussulcatus, Otiorrhynchus ovatus, Phaedon cochleariae, Phylloperthahorticola, Phyllophaga sp., Phyllotreta chrysocephala, Phyllotretanemorum, Phyllotreta striolata, Popillia japonica, Psylliodes napi,Scolytus intricatus, Sitona lineatus, further Bruchus rufimanus, Bruchuspisorum, Bruchus lentis, Sitophilus granaria, Lasioderma serricorne,Oryzaephilus surinamensis, Rhyzopertha dominica, Sitophilus oryzae,Tribolium castaneum, Trogoderma granarium, Zabrotes subfasciatus;

from the order of the dipterous insects (Diptera), for example,Anastrepha ludens, Ceratitis capitata, Contarinia sorghicola, Dacuscucurbitae, Dacus oleae, Dasineura brassicae, Delia coarctata, Deliaradicum, Hydrellia griseola, Hylemyia platura, Liriomyza sativae,Liriomyza trifolii, Mayetiola destructor, Orseolia oryzae, Oscinellafrit, Pegomya hyoscyami, Phorbia antiqua, Phorbia brassicae, Phorbiacoarctata, Rhagoletis cerasi, Rhagoletis pomonella, Tipula oleracea,Tipula paludosa, further Aedes aegypti, Aedes vexans, Anophelesmaculipennis, Chrysomya bezziana, Chrysomya hominivorax, Chrysomyamacellaria, Cordylobia anthropophaga, Culex pipiens, Fannia canicularis,Gasterophilus intestinalis, Glossina morsitans, Haematobia irritans,Haplodiplosis equestris, Hypoderma lineata, Lucilia cuprina, Luciliasericata, Musca domestica, Muscina stabulans, Oestrus ovis, Tabanusbovinus, Simulium damnosum;

from the order of the thrips (Thysanoptera), for example, Frankliniellafusca, Frankliniella occidentalis, Frankliniella tritici, Haplothripstritici, Scirtothrips citri, Thrips oryzae, Thrips palmi, Thrips tabaci;

from the order of the hymenopterous insects (Hymenoptera), for example,Athalia rosae, Atta cephalotes, Atta sexdens, Atta texana, Hoplocampaminuta, Hoplocampa testudinea, Iridomyrmes humilis, Iridomyrmexpurpureus, Monomorium pharaonis, Solenopsis geminata, Solenopsisinvicta, Solenopsis richteri;

from the order of the bugs (Heteroptera), for example, Acrosternumhilare, Blissus leucopterus, Cyrtopeltis notatus, Dysdercus cingulatus,Dysdercus intermedius, Eurygaster integriceps, Euschistusimpictiventris, Leptoglossus phyllopus, Lygus hesperus, Lyguslineolaris, Lygus pratensis, Nezara viridula, Piesma quadrata, Solubeainsularism Thyanta perditor;

from the order of the plant-sucking insects (Homoptera), for example,Acyrthosiphon onobrychis, Acyrthosiphon pisum, Adelges laricis,Aonidiella aurantii, Aphidula nasturtii, Aphis fabae, Aphis gossypii,Aphis pomi, Aulacorthum solani, Bemisia tabaci, Brachycaudus cardui,Brevicoryne brassicae, Dalbulus maidis, Dreyfusia nordmannianae,Dreyfusia piceae, Dysaphis radicola, Empoasca fabae, Eriosoma lanigerum,Laodelphax striatella, Macrosiphum avenae, Macrosiphum euphorbiae,Macrosiphon rosae, Megoura viciae, Metopolophium dirhodum, Myzuspersicae, Myzus cerasi, Nephotettix cincticeps, Nilaparvata lugens,Perkinsiella saccharicida, Phorodon humuli, Planococcus citri, Psyllamali, Psylla piri, Psylla pyricol, Quadraspidiotus perniciosus,Rhopalosiphum maidis, Saissetia oleae, Schizaphis graminum, Selenaspidusarticulatus, Sitobion avenae, Sogatella furcifera, Toxoptera citricida,Trialeurodes abutilonea, Trialeurodes vaporariorum, Viteus vitifolii;

from the order of the termites (Isoptera), for example, Calotermesflavicollis, Leucotermes flavipes, Macrotermes subhyalinus, Odontotermesformosanus, Reticulitermes lucifugus, Termes natalensis;

from the order of the orthopterous insects (Orthoptera), for example,Gryllotalpa gryllotalpa, Locusta migratoria, Melanoplus bivittatus,Melanoplus femur-rubrum, Melanoplus mexicanus, Melanoplus sanguinipes,Melanoplus spretus, Nomadacris septemfasciata, Schistocerca americana,Schistocerca peregrina, Stauronotus maroccanus, Schistocerca gregaria,further Acheta domestica, Blatta orientalis, Blattella germanica,Periplaneta americana;

from the order of the Arachnoidea, for example, phytophagous mites suchas Aculops lycopersicae, Aculops pelekassi, Aculus schlechtendali,Brevipalpus phoenicis, Bryobia praetiosa, Eotetranychus carpini,Eutetranychus banksii, Eriophyes sheldoni, Oligonychus pratensis,Panonychus ulmi, Panonychus citri, Phyllocoptruta oleivora,Polyphagotarsonemus latus, Tarsonemus pallidus, Tetranychuscinnabarinus, Tetranychus kanzawai, Tetranychus pacificus, Tetranychusurticae, ticks such as Amblyomma americanum, Amblyomma variegatum, Argaspersicus, Boophilus annulatus, Boophilus decoloratus, Boophilusmicroplus, Dermacentor silvarum, Hyalomma truncatum, Ixodes ricinus,Ixodes rubicundus, Ornithodorus moubata, Otobius megnini, Rhipicephalusappendiculatus and Rhipicephalus evertsi as well as animal-parasiticmites such as Dermanyssus gallinae, Psoroptes ovis and Sarcoptesscabiei;

from the class of the nematodes, for example, root gall nematodes, eg.Meloidogyne hapla, Meloidogyne incognita, Meloidogyne javanica,cyst-forming nematodes, eg. Globodera pallida, Globodera rostochiensis,Heterodera avenae, Heterodera glycines, Heterodera schachtii, migratoryendoparasites and semiendoparasitic nematodes, eg. Heliocotylenchusmulticinctus, Hirschmanniella oryzae, Hoplolaimus spp, Pratylenchusbrachyurus, Pratylenchus fallax, Pratylenchus penetrans, Pratylenchusvulnus, Radopholus similis, Rotylenchus reniformis, Scutellonema bradys,Tylenchulus semipenetrans, stem and leaf nematodes eg. Anguina tritici,Aphelenchoides besseyi, Ditylenchus angustus, Ditylenchus dipsaci, virusvectors, eg. Longidorus spp., Trichodorus christei, Trichodorusviruliferus, Xiphinema index, Xiphinema mediterraneum.

The compounds I can be applied as such, in the form of theirformulations or the application forms prepared therefrom, eg. in theform of directly sprayable solutions, powders, suspensions ordispersions, emulsions, oil dispersions, pastes, dust compositions,scattering compositions or granules, by spraying, atomizing, dusting,scattering or watering. The application forms depend entirely on theintended uses; in each case they should if possible guarantee the finestdispersion of the active compounds according to the invention.

The compounds of the formula I are in some cases systemically active asfungicides. They can be employed as foliar and soil fungicides against abroad spectrum of phytopathogenic fungi, in particular from theAscomycetes, Deuteromycetes, Phycomycetes and Basidiomycetes classes.

They are of particular importance for controlling a multiplicity offungi on various crop plants such as wheat, rye, barley, oats, rice,corn, grass, cotton, soybeans, coffee, sugar cane, grapes, fruit anddecorative plants and vegetable plants such as cucumbers, beans andcucurbits, and on the seeds of these plants.

The compounds I are specifically suitable for controlling the followingplant diseases:

Erysiphe graminis (powdery mildew) in cereals,

Erysiphe cichoracearum and Sphaerotheca fuliginea on cucurbits,

Podosphaera leucotricha on apples,

Uncinula necator on vines,

Puccinia species on cereals,

Rhizoctonia species on cotton and grass,

Ustilago species on cereals and sugar cane,

Venturia inaequalis (scab) on apples,

Helminthosporium species on cereals,

Septoria nodorum on wheat,

Botrytis cinerea (gray mold) on strawberries, vines,

Cercospora arachidicola on groundnuts,

Pseudocercosporella herpotrichoides on wheat, barley,

Pyricularia oryzae on rice,

Phytophthora infestans on potatoes and tomatoes,

Fusarium and Verticillium species on various plants,

Plasmopara viticola on vines,

Alternaria species on vegetables and fruit.

The novel compounds can also be employed in the protection of materials,eg. for the protection of wood, paper and textiles eg. againstPaecilomyces variotii.

They can be converted into the customary formulations, such assolutions, emulsions, suspensions, dusts, powders, pastes or granules.The use forms here depend on the particular intended use; in each casethey should if possible guarantee the finest dispersion of the activecompounds.

The formulations are prepared in a known manner, eg. by extending theactive compound with solvents and/or carriers, if desired usingemulsifiers and dispersants, where if water is used as a diluent otherorganic solvents can also be used as auxiliary solvents.

Suitable auxiliaries for this purpose are mainly:

solvents such as aromatics (eg. xylene), chlorinated aromatics (eg.chlorobenzenes), paraffins (eg. petroleum fractions), alcohols (eg.methanol, butanol), ketones (eg. cyclohexanone), amines (eg.ethanolamine, dimethylformamide) and water;

carriers such as ground natural minerals (eg. kaolins, argillaceousearths, talc, chalk) and ground synthetic minerals (eg. highly dispersesilica, silicates);

emulsifiers such as nonionic and anionic emulsifiers (eg.polyoxyethylene fatty alcohol ethers, alkylsulfonates andarylsulfonates) and

dispersants such as lignin-sulfite waste liquors and methylcellulose.

Suitable surface-active substances are the alkali metal, alkaline earthmetal and ammonium salts of aromatic sulfonic acids, eg. lignosulfonic,phenolsulfonic, naphthalenesulfonic and dibutylnaphthalenesulfonic acid,and also of fatty acids, alkyl- and alkylarylsulfonates, alkyl, laurylether and fatty alcohol sulfates, as well as salts of sulfated hexa-,hepta- and octadecanols, and also of fatty alcohol glycol ethers,condensation products of sulfonated naphthalene and its derivatives withformaldehyde, condensation products of naphthalene or of thenaphthalenesulfonic acids with phenol and formaldehyde, polyoxyethyleneoctylphenol ether, ethoxylated isooctyl-, octyl- or nonylphenol,alkylphenol or tributylphenylpolyglycol ether, alkylaryl polyetheralcohols, isotridecyl alcohol, fatty alcohol ethylene oxide condensates,ethoxylated castor oil, polyoxyethylene or polyoxypropylene alkylethers, lauryl alcohol polyglycol ether acetate, sorbitol esters,lignin-sulfite waste liquors or methylcellulose.

Aqueous use forms can be prepared from emulsion concentrates,dispersions, pastes, wettable powders or water-dispersible granules byaddition of water. To prepare emulsions, pastes or oil dispersions, thesubstrates can be homogenized in water as such or dissolved in an oil orsolvent, by means of wetting agents, adhesives, dispersants oremulsifiers. However, concentrates consisting of active substance,wetting agent, adhesive, dispersant or emulsifier and possibly solventor oil can also be prepared which are suitable for dilution with water.

Powder, broadcasting and dusting compositions can be prepared by mixingor joint grinding of the active substances with a solid carrier.

Granules, eg. coated, impregnated and homogeneous granules, can beprepared by binding the active compounds to solid carriers.

Solid carriers are mineral earths such as silica gel, silicic acids,silicates, talc, kaolin, limestone, lime, chalk, bole, loess, clay,dolomite, diatomaceous earth, calcium sulfate and magnesium sulfate,magnesium oxide, ground synthetic materials, fertilizers, such asammonium sulfate, ammonium phosphate, ammonium nitrate, ureas andvegetable products, such as cereal flour, tree bark meal, wood meal andnutshell meal, cellulose powder or other solid carriers. The activecompound concentrations in the ready-to-use preparations can be variedwithin relatively wide ranges.

Very generally, the compositions contain from 0.0001 to 95% by weight ofactive compound.

Formulations containing more than 95% by weight of active compound canbe applied highly successfully in the ultra-low volume process (ULV), iteven being possible to use the active compound without additives.

For use as fungicides, concentrations of from 0.01 to 95% by weight,preferably of from 0.5 to 90% by weight, of active compound arerecommended. For use as insecticides, formulations containing from0.0001 to 10% by weight, preferably from 0.01 to 1% by weight, of activecompound are suitable.

The active compounds are normally employed in a purity of from 90% to100%, preferably from 95% to 100% (according to NMR spectrum).

Examples of such preparations are:

I. a solution of 90 parts by weight of a compound I according to theinvention and 10 parts by weight of N-methylα-pyrrolidone, which issuitable for application in the form of very small drops;

II. a solution of 20 parts by weight of a compound I according to theinvention in a mixture of 80 parts by weight of alkylated benzene, 10parts by weight of the addition product of from 8 to 10 mol of ethyleneoxide to 1 mol of oleic acid N-monoethanolamide, 5 parts by weight ofcalcium salt of dodecylbenzenesulfonic acid, 5 parts by weight of theaddition product of 40 mol of ethylene oxide to 1 mol of castor oil; adispersion is obtained by finely dispersing the formulation in water.

III. a solution of 20 parts by weight of a compound I according to theinvention in a mixture of 40 parts by weight of cyclohexanone, 30 partsby weight of isobutanol, 20 parts by weight of the addition product of 7mol of ethylene oxide to 1 mol of isooctylphenol and 10 parts by weightof the addition product of 40 mol of ethylene oxide to 1 mol of castoroil; a dispersion is obtained by finely dispersing the formulation inwater.

IV. an aqueous dispersion of 20 parts by weight of a compound Iaccording to the invention in a mixture of 25 parts by weight ofcyclohexanone, 65 parts by weight of a mineral oil fraction of boilingpoint from 210° to 280° C. and 10 parts by weight of the additionproduct of 40 mol of ethylene oxide to 1 mol of castor oil; a dispersionis obtained by finely dispersing the formulation in water.

V. a mixture, ground in a hammer mill, of 20 parts by weight of acompound I according to the invention, 3 parts by weight of the sodiumsalt of diisobutylnaphthalene-α-sulfonic acid, 17 parts by weight of thesodium salt of a lignosulfonic acid from a sulfite waste liquor and 60parts by weight of powdered silica gel; a spray mixture is obtained byfinely dispersing the mixture in water;

VI. an intimate mixture of 3 parts by weight of a compound I accordingto the invention and 97 parts by weight of finely divided kaolin; thisdusting composition contains 3% by weight of active compound;

VII. an intimate mixture of 30 parts by weight of a compound I accordingto the invention, 92 parts by weight of powdered silica gel and 8 partsby weight of liquid paraffin which has been sprayed onto the surface ofthis silica gel; this preparation gives the active compound a goodadherence;

VIII. a stable aqueous dispersion of 40 parts by weight of a compound Iaccording to the invention, 10 parts by weight of the sodium salt of aphenolsulfonic acid/urea/formaldehyde condensate, 2 parts by weight ofsilica gel and 48 parts by weight of water, which can be furtherdiluted;

IX. a stable oily dispersion of 20 parts by weight of a compound Iaccording to the invention, 2 parts by weight of the calcium salt ofdodecylbenzenesulfonic acid, 8 parts by weight of fatty alcoholpolyglycol ether, 2 parts by weight of the sodium salt of aphenolsulfonic acid/urea/formaldehyde condensate and 68 parts by weightof a paraffinic mineral oil;

X. a mixture, ground in a hammer mill, of 10 parts by weight of acompound I according to the invention, 4 parts by weight of the sodiumsalt of diisobutylnaphthalene-α-sulfonic acid, 20 parts by weight of thesodium salt of a lignosulfonic acid from a sulfite waste liquor, 38parts by weight of silica gel and 38 parts by weight of kaolin. Byfinely dispersing the mixture in 10,000 parts by weight of water, aspray mixture is obtained which contains 0.1% by weight of the activecompound.

The compounds I are applied by treating the fungi or the seed, plants,materials or the soil to be protected from fungal attack with afungicidally active amount of the active compounds.

They are applied before or after the infection of the materials, plantsor seed by the fungi.

Depending on the type of effect desired, the application rates are from0.02 to 3 kg of active compound per ha, preferably from 0.1 to 1 kg/ha.

In seed treatment, amounts of active compound of from 0.001 to 50 g,preferably from 0.01 to 10 g, per kilogram of seed are in generalneeded.

The application rate of active compound for controlling pests underoutdoor conditions is from 0.02 to 10, preferably from 0.1 to 2.0 kg/haof active compound.

The compounds I, on their own or in combination with herbicides orfungicides, can also be applied jointly mixed with further cropprotection agents, for example with growth regulators or with agents forcontrolling pests or bacteria. Of interest is also the miscibility withfertilizers or with mineral salt solutions which are employed foreliminating nutritional and trace element deficiencies.

The crop protection agents and fertilizers can be added to thecompositions according to the invention in a weight ratio of from 1:10to 10:1, if appropriate even only immediately before use (tank mix). Onmixing with fungicides or insecticides, in many cases an increase in thefungicidal spectrum of action is obtained here.

The following list of fungicides with which the compounds according tothe invention can be applied jointly is intended to illustrate thecombination possibilities, but not to restrict them:

sulfur, dithiocarbamates and their derivatives, such as ferricdimethyldithiocarbamate, zinc dimethyldithiocarbamate, zincethylenebisdithiocarbamate, manganese ethylenebisdithiocarbamate,manganese zinc ethylenediamine bisdithiocarbamate, tetramethylthiuramdisulfides, ammonia complex of zinc N,N-ethylenebisdithiocarbamate,ammonia complex of zinc N,N'-propylenebisdithiocarbamate, zincN,N'-propylenebisdithiocarbamate, N,N'-polypropylenebis(thiocarbamoyl)disulfide; nitro derivatives, such as dinitro-(1-methylheptyl)phenylcrotonate, 2-sec-butyl-4,6-dinitro-phenyl 3,3-dimethylacrylate,2-sec-butyl-4,6-dinitrophenyl isopropyl carbonate, diisopropyl5-nitroisophthalate;

-heterocyclic substances, such as 2-heptadecyl-2-imidazoline acetate,2,4-dichloro-6-(o-chloroanilino)-s-triazine, O,O-diethylphthalimidophosphonothioate, 5-amino-1-β-bis(dimethylamino)-phosphinyl!-3-phenyl-1,2,4-triazole,2,3-dicyano-1,4-dithio-anthraquinone, 2-thio-1,3-dithiolo-β-4,5-b!quinoxaline, methyl 1-(butylcarbamoyl)-2-benzimidazolecarbamate,2-methoxycarbonylaminobenzimidazole, 2-(fur-2-yl)benzimidazole,2-(thiazol-4-yl)-benzimidazole,N-(1,1,2,2-tetrachloroethylthio)tetrahydrophthalimide,N-trichloromethylthiotetrahydrophthalimide,N-trichloromethylthiophthalimide, N-dichlorofluoromethylthio-N',N'-dimethyl-N-phenylsulfamide,5-ethoxy-3-trichloromethyl-1,2,3-thiadiazole,2-thiocyanatomethylthiobenzothiazole, 1,4-dichloro-2,5-dimethoxybenzene,4-(2-chlorophenylhydrazono)-3-methyl-5-isoxazolone, 2-thiopyridine1-oxide, 8-hydroxyquinoline or its copper salt,2,3-dihydro-5-carboxanilido-6-methyl-1,4-oxathiin,2,3-dihydro-5-carboxanilido-6-methyl-1,4-oxathiin 4,4-dioxide,2-methyl-5,6-dihydro-4H-pyran-3-carboxanilide,2-methylfuran-3-carboxanilide, 2,5-dimethylfuran-3-carboxanilide,2,4,5-trimethylfuran-3-carboxanilide,N-cyclohexyl-2,5-dimethylfuran-3-carboxamide,N-cyclohexyl-N-methoxy-2,5-dimethylfuran-3-carboxamide,2-methylbenzanilide, 2-iodobenzanilide,N-formyl-N-morpholine-2,2,2-trichloroethyl acetal,piperazine-1,4-diylbis(1-(2,2,2-trichloroethyl))formamide,1-(3,4-dichloroanilino)-1-formylamino-2,2,2-trichloroethane,2,6-dimethyl-N-tridecylmorpholine or its salts,2,6-dimethyl-N-cyclododecylmorpholine or its salts, N-3-(p-tert-butylphenyl)-2-methylpropyl!-cis-2,6-dimethylmorpholine, N-3-(p-tert-butylphenyl)-2-methylpropyl!piperidine, 1-2-(2,4-dichlorophenyl)-4-ethyl-1,3-dioxolan-2-ylethyl!-1H-1,2,4-triazole, 1-2-(2,4-dichlorophenyl)-4-n-propyl-1,3-dioxolan-2-ylethyl!-1H-1,2,4-triazole,N-(n-propyl)-N-(2,4,6-trichlorophenoxyethyl)-N'-imidazolylurea,1-(4-chloro-phenoxy)-3,3-dimethyl-1-(1H-1,2,4-triazol-1-yl)-2-butanone,1-(4-chlorophenoxy)-3,3-dimethyl-1-(1H-1,2,4-triazol-1-yl)-2-butanol,α-(2-chlorophenyl)-α-(4-chlorophenyl)-5-pyrimidine-methanol,5-butyl-2-dimethylamino-4-hydroxy-6-methylpyrimidine,bis(p-chlorophenyl)-3-pyridinemethanol,1,2-bis(3-ethoxycarbonyl-2-thioureido)benzene,1,2-bis(3-methoxycarbonyl-2-thioureido)benzene,

and also various fungicides, such as dodecylguanidine acetate, 3-3-(3,5-dimethyl-2-oxycyclohexyl)-2-hydroxyethyl!glutarimide,hexachlorobenzene, DL-methyl-N-(2,6-dimethylphenyl)-N-2-furoylalaninate, DL-N-(2,6-dimethylphenyl)-N-(2'-methoxyacetyl)alanine methylester, N-(2,6-dimethylphenyl)-N-chloroacetyl-D,L-2-aminobutyrolactone,DL-N-(2,6-dimethylphenyl)-N-(phenylacetyl)alanine methyl ester,5-methyl-5-vinyl-3-(3,5-dichlorophenyl)-2,4-dioxo-1,3-oxazolidine,3-(3,5-dichlorophenyl)-5-methyl-5-methoxymethyl-1,3-oxazolidine-2,4-dione,3-(3,5-dichlorophenyl)-1-isopropylcarbamoylhydantoin,N-(3,5-dichlorophenyl)-1,2-dimethylcyclopropane-1,2-dicarboximide,2-cyano- N-ethylaminocarbonyl-2-methoximino!-acetamide, 1-2-(2,4-dichlorophenyl)pentyl!-1H-1,2,4-triazole,2,4-difluoro-α-(1H-1,2,4-triazolyl-1-methyl)benzhydryl alcohol,N-(3-chloro-2,6-dinitro-4-trifluoromethylphenyl)-5-trifluoromethyl-3-chloro-2-aminopyridine,1-((bis(4-fluorophenyl)methylsilyl)methyl)-1H-1,2,4-triazole.

SYNTHESIS EXAMPLES

The procedures described in the synthesis examples below were used withappropriate modification of the starting compounds to obtain furthercompounds I. The compounds thus obtained are listed with physical datain the following table.

1. MethylN-methoxy-N-((2-(4-(2,2,2-trifluoroethoxy)pyrimidin-2-yl)acetiminoxymethyl)phenyl)carbamate##STR8##

A mixture of 2.3 g (10 mmol) of4-(2,2,2-trifluoroethoxy)-2-acetylpyrimidine oxime (WO 92/18,487) and0.3 g (12.5 mmol) of sodium hydride in 20 ml of dimethylformamide isstirred at room temperature for 10 minutes. 3.3 g (10 mmol) of methylN-methoxy-N-(2-bromomethylphenyl)carbamate (purity about 80%, WO93/15,046) are then added and the reaction mixture is stirred at roomtemperature for about 1 hour. It is then diluted with water and theaqueous phase is extracted three times with methyl t-butyl ether. Thecombined organic phases are extracted once with water, dried over MgSO₄and concentrated. The residue is purified by column chromatography usingcyclohexane/ethyl acetate mixtures. 2.7 g (63%) of the title compoundare obtained as a pale yellow oil.

¹ H-NMR (CDCl₃ ; δ in ppm): 8.6 (d,1H,pyrimidinyl); 7.6 (m,1H,phenyl);7.4 (m,3H;phenyl); 6.85 (d,1H,pyrimidinyl); 5.45 (s,2H,OCH₂); 4.9(q,2H,O--CH₂ --CF₃); 3.8 (s,3H;OCH₃); 3.75 (s,3H,OCH₃); 2.4 (s,3H,CH₃)

2.N-Methyl-N'-methoxy-N'-((2-(4-(2,2,2-trifluoromethoxy)-pyrimidin-2-yl)acetiminoxymethyl)phenyl)urea##STR9##

A mixture of 2.3 g (10 mmol) of4-(2,2,2-trifluoroethoxy)-2-acetylpyrimidine oxime (WO 92/18,487), 1.8 g(13 mmol) of K₂ CO₃ and 3.4 g (10 mmcol) of phenylN-methoxy-N-(2-bromomethylphenyl)carbamate (prepared in a similar mannerto WO 93/15,046) in 30 ml of dimethylformamide is stirred overnight atroom temperature. The reaction mixture is then diluted with water andthe aqueous phase is extracted three times with methyl t-butyl ether.The combined organic phases are dried over MgSO₄ and concentrated. Theresidue is filtered off with suction through Al₂ O₃ usingcyclohexane/ethyl acetate 4:1. The solvent is then evaporated in vacuo.

The residue is treated with 20 ml of 40% strength aqueous methylaminesolution and the reaction mixture is stirred at room temperature for 3hours. It is then extracted with methylene chloride. The combinedorganic phases are dried over MgSO₄ and concentrated. The residue ispurified by column chromatography using cyclohexane/ethyl acetatemixtures. The product thus obtained crystallizes and is washed withmethyl t-butyl ether/hexane 1:1 with stirring and then sucked dry. 0.4 g(10% of the title compound is obtained as colorless crystals (m.p.:=136°C.).

¹ H-NMR (CDCl₃ ; δ in ppm): 8.6 (d,1H,pyrimidinyl); 7.55 (m,1H,phenyl);7.35 (m,3H;phenyl); 6.8 (d,1H,pyrimidinyl); 6.95 (m, 1H, NH); 5.5(s,2H,OCH₂); 4.85 (q,2H,O--CH₂ --CF₃); 3.7 (s,3H;OCH₃); 2.9 (s,3H,OCH₃);2.4 (s,3H,CH₃)

3. MethylN-methoxy-N-(2-((4-methoxypyrimidin-2-yl)acetiminoxymethyl)-phenyl)carbamatephenyl )carbamate ##STR10##

a) Methyl N-methoxy-N-((2-phthalimidoxymethyl)-phenyl)carbamate##STR11##

A mixture of 15 g (38 mmol) of methylN-methoxy-N-(2-bromomethylphenyl)carbamate (purity about 70%; WO93/15,046), 6.9 g (42 mmol) of N-hydroxyphthalimide and 4.6 g (46 mmol)of triethylamine in 50 ml of dimethylformamide is stirred at 60° C. forabout 2 hours. The reaction mixture is then cooled to room temperatureand diluted with water. During the course of this a solid precipitates,which is washed with water and i-propanol and dried in vacuo. 10.6 g(78%) of the title compound are obtained as colorless crystals(m.p.:=150° C.).

¹ H-NMR (CDCl₃ ; δ in ppm): 7.8 (m,5H,phenyl); 7.4 (m,3H,phenyl); 5.25(s,2H,OCH₂); 4.0 (2s, each 3H,2×OCH₃).

b) Methyl N-methoxy-N-(2-aminoxymethylphenyl)carbamate ##STR12##

A mixture of 6.8 g (19 mmol) of the subst. phthalimide from Example 3aand 0.8 g (16 mmol) of hydrazine hydrate in 30 ml of methanol is stirredat room temperature for 4 hours. The precipitated solid is then filteredoff with suction and the filtrate is concentrated. The partlycrystalline residue is washed with ether with stirring. The solid isfiltered off with suction and the filtrate is concentrated. As aresidue, 4.0 g (99%) of the title compound (purity >90%) are obtained asa yellow oil.

¹ H-NMR (CDCl₃ ; δ in ppm): 7.5 (m,1H,phenyl); 7.35 (m,3H,phenyl); 5.45(s,broad,2H,NH₂); 4.75 (s,2H,OCH₂); 3.8 (s,3H,OCH₃); 3.75 (s,3H,OCH₃)

c) MethylN-methoxy-N-(2-((4-methoxypyrimidin-2-yl)-octiminoxymethyl)phenyl)carbamat##STR13##

A mixture of 1.0 g (6.4 mmol) of 2-acetyl-4-chloropyrimidine (WO92/18,487) and 1.4 g (6.4 mmol) of methylN-methoxy-N-(2-aminoxymethylphenyl)carbamate (Example 3b) in 20 ml ofmethanol is stirred overnight at room temperature. The reaction mixtureis concentrated and the residue is purified by column chromatographyusing cyclohexane/ethyl acetate mixtures. 0.4 g (17%) of the titlecompound is obtained as a pale yellow oil.

¹ H-NMR (CDCl₃ ; δ in ppm): 8.5 (d,1H,pyrimidinyl); 7.6 (m,1H,phenyl);7.4 (m,3H,phenyl); 6.7 (d,1H,pyrimidinyl); 5.45 (s,2H,OCH₂); 4.05(s,3H,OCH₃); 3.8 (s,3H,OCH₃); 3.75 (s,3H,OCH₃); 2.4 (s,3H,CH₃)

MethylN-methoxy-N-(2-((4-chloropyrimidin-2-yl)acetiminoxymethyl)phenyl)carbamate##STR14##

A mixture of 0.7 g (4.4 mmol) of 2-acetyl-4-chloropyrimidine (WO92/18487) and 1 g (4.4 mmol) of methylN-methoxy-N-(2-aminoxymethylphenyl)carbamate (Example 3b) in 15 ml oftetrahydrofuran is stirred at room temperature for 2 hours. The reactionmixture is then concentrated and the residue is purified by columnchromatography using cyclohexane/ethyl acetate mixtures. 1.2 g (74%) ofthe title compound are obtained as a pale yellow oil.

¹ H-NMR (CDCl₃ ; δ in ppm): 8.7 (d,1H,pyrimidinyl); 7.6 (m,1H;phenyl);7.4 (m,3H,phenyl); 7.3 (d,1H,pyrimidinyl); 5.45 (s,2H;OCH₂) 3.8(s,3H,OCH₃); 3.75 (s,3H,OCH₃)

                                      TABLE                                       __________________________________________________________________________    No.                                                                              R.sub.n                                                                         R.sup.1                                                                          X  R.sup.2                                                                          R.sup.3                                                                          R.sup.4       m.p.  °C.!; .sup.1 H-NMR                __________________________________________________________________________    01 H CH.sub.3                                                                         O  CH.sub.3                                                                         CH.sub.3                                                                         4-OC.sub.2 H.sub.5 -pyrimidin-2-yl                                                          3.8(s, 3H); 3.75(s, 3H)                        02 H CH.sub.3                                                                         O  CH.sub.3                                                                         CH.sub.3                                                                         4-OCH.sub.2 CF.sub.3 -pyrimidin-2-yl                                                        3.8(s, 3H); 3.75(s, 3H)                        03 H CH.sub.3                                                                         NH CH.sub.3                                                                         CH.sub.3                                                                         4-OCH.sub.2 CF.sub.3 -pyrimidin-2-yl                                                        136                                            04 H CH.sub.3                                                                         O  CH.sub.3                                                                         CH.sub.3                                                                         4-OCH.sub.3 -pyrimidin-2-yl                                                                 3.8(s, 3H); 3.75(s, 3H)                        05 H CH.sub.3                                                                         O  CH.sub.3                                                                         CH.sub.3                                                                         4-Cl-pyrimidin-2-yl                                                                         3.8(s, 3H); 3.75(s, 3H)                        06 H CH.sub.3                                                                         O  CH.sub.3                                                                         CH.sub.3                                                                         4-OCH(CH.sub.3).sub.2 -pyrimidin-2-yl                                                       3.8(s, 3H); 3.75(s, 3H)                        07 H CH.sub.3                                                                         O  CH.sub.3                                                                         CH.sub.3                                                                         4-O(CH.sub.2).sub.2 CH.sub.3 -pyrimidin-2-yl                                                76                                             08 H CH.sub.3                                                                         O  CH.sub.3                                                                         CH.sub.3                                                                         4-OCH.sub.2 C.tbd.CH-pyrimidin-2-yl                                                         3.8(s, 3H); 3.75(s, 3H)                        09 H CH.sub.3                                                                         O  CH.sub.3                                                                         CH.sub.3                                                                         4-(CH.sub.2).sub.3 -pyrimidin-2-yl                                                          3.8(s, 3H); 3.75(s, 3H)                        10 H CH.sub.3                                                                         O  CH.sub.3                                                                         CH.sub.3                                                                         4-(CH.sub.2).sub.4 CH.sub.3 -pyrimidin-2-yl                                                 3.8(s, 3H); 3.75(s, 3H)                        11 H CH.sub.3                                                                         O  CH.sub.3                                                                         CH.sub.3                                                                         4-C.sub.6 H.sub.5 -pyrimidin-2-yl                                                           3.8(s, 3H); 3.75(s, 3H)                        12 H CH.sub.3                                                                         O  CH.sub.3                                                                         CH.sub.3                                                                         4-OC.sub.6 H.sub.5 -pyrimidin-2-yl                                                          3.8(s, 3H); 3.75(s, 3H)                        13 H CH.sub.3                                                                         O  CH.sub.3                                                                         CH.sub.3                                                                         4-OCH.sub.2 CF.sub.3,                                                                       3.8(s, 3H); 3.75(s, 3H)                                         6-CH.sub.3 -pyrimidin-2-yl                                   14 H CH.sub.3                                                                         O  CH.sub.3                                                                         CH.sub.3                                                                         6-OCH.sub.2 CF.sub.3 -pyrimidin-4-yl                                                        3.8(s, 3H); 3.75(s, 3H)                        15 H CH.sub.3                                                                         O  CH.sub.3                                                                         CH.sub.3                                                                         4-CH.sub.3 -pyrimidin-2-yl                                                                  123                                            16 H CH.sub.3                                                                         O  CH.sub.3                                                                         CH.sub.3                                                                         4-CH.sub.3, 6-OCH.sub.3 -pyrimidin-2-yl                                                     102                                            17 H CH.sub.3                                                                         O  CH.sub.3                                                                         CH.sub.3                                                                         4-CH.sub.2 CH(CH.sub.3).sub.2 -pyrimidin-2-yl                                               102                                            18 H CH.sub.3                                                                         O  CH.sub.3                                                                         CH.sub.3                                                                         6-OCH.sub.3 -pyrimidin-4-yl                                                                 103                                            19 H CH.sub.3                                                                         O  CH.sub.3                                                                         CH.sub.3                                                                         6-OC.sub.2 H.sub.5 -pyrimidin-4-yl                                                          3.8(s, 3H); 3.75(s, 3H)                        20 H CH.sub.3                                                                         O  CH.sub.3                                                                         CH.sub.3                                                                         4-CH.sub.3, 6-CF.sub.3 -pyrimidin-2-yl                                                      3.8(s, 3H); 3.75(s, 3H)                        21 H CH.sub.3                                                                         O  CH.sub.3                                                                         CH.sub.3                                                                         4-C(CH.sub.3).sub.3 -pyrimidin-2-yl                                                         3.8(s, 3H); 3.75(s, 3H)                        22 H CH.sub.3                                                                         O  CH.sub.3                                                                         CH.sub.3                                                                         4,6-(OCH.sub.3).sub.2 -pyrimidin-2-yl                                                       3.8(s, 3H); 3.75(s, 3H)                        23 H CH.sub.3                                                                         O  CH.sub.3                                                                         CH.sub.3                                                                         5-Cl-pyrimidin-2-yl                                                                         103                                            24 H CH.sub.3                                                                         O  CH.sub.3                                                                         CH.sub.3                                                                         4-OCH.sub.3, 6-CF.sub.3 -pyrimidin-2-yl                                                     90                                             __________________________________________________________________________

Examples of the action against harmful fungi

It was possible to show the fungicidal action of the compounds of theformula I by the following tests:

The active compounds were prepared as a 20% strength emulsion in amixture of 70% by weight of cyclohexanone, 20% by weight of Nekanil® LN(Lutensol® AP6, wetting agent having emulsifier and dispersant actionbased on ethoxylated alkylphenols) and 10% by weight of Emulphor® EL(Emulan® EL, emulsifier based on ethoxylated fatty alcohols) and dilutedwith water according to the concentration desired.

The fungicidal action of the compounds according to the invention wasdetermined in comparison with the known active compound A.18/7 (ExampleNo. 18, Table 7 from WO-A 93/15,046) in the manner described below.

Puccinia recondita (brown rust of wheat)

Leaves of wheat seedlings (Kanzler variety) were dusted with spores ofbrown rust (Puccinia recondita). The plants treated in this way wereincubated for 24 h at 20°-22° C. and a relative atmospheric humidity of90-95% and then treated with the aqueous active compound preparation.After a further 8 days at 20°-22° C. and 65-70% relative atmospherichumidity, the extent of the fungal development was determined.Assessment was carried out visually.

In this test, the plants treated with the compounds 01 and 02 accordingto the invention showed no fungal attack, while the plants treated withthe known active compound A.18/7 were attacked to 25%. The untreatedplants showed an attack of 70%.

In a corresponding test, the plants treated with 250 ppm of thecompounds 04, 06, 07, 08, 09, 10, 11 and 12 according to the inventionshowed a fungal attack of 15% or less while the plants treated with theknown active compound A.18/7 were attacked to 25%. The untreated plantsshowed an attack of 70%.

Pyricularia oryzae (rice blast disease)

Rice seedlings (Tai Nong 67 variety) were sprayed with the activecompound preparation until dripping wet. After 24 hours, the plants weresprayed with an aqueous spore suspension of fungus Pyricularia oryzaeand kept at a relative atmospheric humidity of 95-99% at 22°-24° C. for6 days. Assessment was carried out visually.

In this test, the plants treated with the compounds 01 and 02 accordingto the invention showed no fungal attack, while the plants treated withthe known active compound A.18/7 were attacked to 60%. The untreatedplants likewise showed an attack of 60%.

In a corresponding test, the plants treated with 16 ppm of the compounds06, 07, 09, 10 and 11 according to the invention showed a fungal attackof 25% or less while the plants treated with the known active compoundA.18/7 were attacked to 60%. The untreated plants showed an attack of60%.

Examples of the action against animal pests

It was possible to show the action of the compounds of the generalformula I against animal pests by the following tests:

The active compounds were prepared

a) as a 0.1% strength solution in acetone or

b) as a 10% strength emulsion in a mixture of 70% by weight ofcyclohexanone, 20% by weight of Nekanil® LN (Lutensol® AP6, wettingagent having emulsifier and dispersant action based on ethoxylatedalkylphenols) and 10% by weight of Emulphor® EL (Emulan® EL, emulsifierbased on ethoxylated fatty alcohols)

and diluted with acetone in the case of a) or with water in the case ofb) according to the desired concentration.

After conclusion of the tests, the lowest concentration at which thecompounds still caused an 80-100% inhibition or mortality in comparisonwith untreated control tests was determined in each case (activitythreshold or minimum concentration).

We claim:
 1. An iminooxymethyleneanilide of the formula I ##STR15##where the index and the substituents have the following meanings: n is0, 1, 2, 3 or 4, it being possible for the substituents R to bedifferent if n is greater than 1;R is nitro, cyano, halogen,C₁ -C₁₀-alkyl, C₂ -C₁₀ -alkenyl, C₂ -C₁₀ -alkynyl, C₁ -C₁₀ -alkoxy, C₃ -C₁₀-alkenyloxy and C₃ -C₁₀ -alkynyloxy, it being possible for these groupsto be partially or completely halogenated and/or to carry one to threeof the following radicals:cyano, nitro, hydroxyl, amino, formyl,carboxyl, aminocarbonyl, C₁ -C₆ -alkoxy, C₁ -C₆ -haloalkoxy, C₁ -C₆-alkylthio, C₁ -C₆ -haloalkylthio, C₁ -C₆ -alkylamino, di-C₁ -C₆-alkylamino, C₁ -C₆ -alkylcarbonyl, C₁ -C₆ -alkoxycarbonyl, C₁ -C₆-alkylcarbonyloxy, C₁ -C₆ -alkylaminocarbonyl, di-C₁ -C₆-alkylaminocarbonyl, C₁ -C₆ -alkylcarbonylamino, C₁ -C₆-alkoxycarbonylamino, C₁ -C₆ -alkylcarbonyl-N-C₁ -C₆ -alkylamino, andCR^(iii) =NOR^(iv), R^(iii) being hydrogen, C₁ -C₆ -alkyl, C₂ -C₆-alkenyl, C₂ -C₆ -alkynyl or C₃ -C₁₂ -cycloalkyl and R^(iv) being C₁ -C₆-alkyl, C₃ -C₆ -alkenyl, C₃ -C₆ -alkynyl or aryl-C₁ -C₆ -alkyl, C₃ -C₁₂-cycloalkyl, C₃ -C₁₂ -cycloalkoxy, C₃ -C₁₂ -cycloalkylthio, C₃ -C₁₂-cycloalkylamino, C₃ -C₁₂ -cycloalkyl-N-C₁ -C₆ -alkylamino, each ofwhich is unsubstituted or substituted by customary groups, 3- to12-membered heterocyclyl, heterocyclyloxy, heterocyclylthio,heterocyclylamino or heterocyclyl-N-C₁ -C₆ -alkylamino, each of which isunsubstituted or substituted by customary groups, aryl, aryloxy,arylthio, arylamino, aryl-N-C₁ -C₆ -alkylamino, aryl-C₁ -C₆ -alkoxy,aryl-C₁ -C₆ -alkylthio, aryl-C₁ -C₆ -alkylamino, aryl-C₁ -C₆ -alkyl-N-C₁-C₆ -alkylamino, hetaryl, hetaryloxy, hetarylthio, hetarylamino,hetaryl-N-C₁ -C₆ -alkylamino, hetaryl-C₁ -C₆ -alkoxy, hetaryl-C₁ -C₆-alkylthio, hetaryl-C₁ -C₆ -alkylamino, hetaryl-C₁ -C₆ -alkyl-N-C₁ -C₆-alkylamino, arylcarbonyl, aryloxycarbonyl, arylcarbonyloxy,arylaminocarbonyl, N-aryl-N-C₁ -C₆ -alkylaminocarbonyl,arylcarbonyl-N-C₁ -C₆ -alkylamino, aryloxycarbonylamino,hetarylcarbonyl, hetaryloxycarbonyl, hetarylcarbonyloxy,hetarylaminocarbonyl, N-hetaryl-N-C₁ -C₆ -alkylaminocarbonyl,hetarylcarbonyl-N-C₁ -C₆ -alkylamino and hetaryloxycarbonylamino, eachof which is unsubstituted or substituted by customary groups, in thecase where n is 2, 3 or 4, additionally an unsubstituted or substitutedbridge bonded to two adjacent ring atoms, which contains three or fourmembers from the group consisting of 3 or 4 carbon atoms, and 2 or 3carbon atoms and 1 or 2 nitrogen, oxygen and/or sulfur atoms, it beingpossible for this bridge, together with the ring to which it is bonded,to form a partially unsaturated or aromatic radical; X is a direct bondor CH₂, O or NR^(a) ; R^(a) is hydrogen, C₁ -C₁₀ -alkyl, C₂ -C₁₀-alkenyl, C₂ -C₁₀ -alkynyl, C₃ -C₁₀ -cycloalkyl or C₅ -C₁₀-cycloalkenyl; R¹ is hydrogen,C₁ -C₁₀ -alkyl, C₂ -C₁₀ -alkenyl, C₂ -C₁₀-alkynyl, C₃ -C₁₀ -cycloalkyl, C₅ -C₁₀ -cycloalkenyl, C₁ -C₁₀-alkylcarbonyl or C₁ -C₁₀ -alkoxycarbonyl, it being possible for thesegroups to be partially or completely halogenated and/or to carry one tothree of the following radicals:cyano, nitro, hydroxyl, amino, formyl,carboxyl, aminocarbonyl, C₁ -C₆ -alkoxy, C₁ -C₆ -haloalkoxy, C₁ -C₆-alkylthio, C₁ -C₆ -haloalkylthio, C₁ -C₆ -alkylamino, di-C₁ -C₆-alkylamino, C₁ -C₆ -alkylcarbonyl, C₁ -C₆ -alkoxycarbonyl, C₁ -C₆-alkylcarbonyloxy, C₁ -C₆ -alkylaminocarbonyl, di-C₁ -C₆-alkylaminocarbonyl, C₁ -C₆ -alkylcarbonylamino, C₁ -C₆-alkoxycarbonylamino, C₁ -C₆ -alkylcarbonyl-N-C₁ -C₆ -alkylamino, andCR^(iii) =NOR^(iv), R^(iii) being hydrogen, C₁ -C₆ -alkyl, C₂ -C₆-alkenyl, C₂ -C₆ -alkynyl or C₃ -C₁₂ -cycloalkyl and R^(iv) being C₁ -C₆-alkyl, C₃ -C₆ -alkenyl, C₃ -C₆ -alkynyl or aryl-C₁ -C₆ -alkyl, C₃ -C₁₂-cycloalkyl, C₃ -C₁₂ -cycloalkoxy, C₃ -C₁₂ -cycloalkylthio, C₃ -C₁₂-cycloalkylamino, C₃ -C₁₂ -cycloalkyl-N-C₁ -C₆ -alkylamino, each ofwhich is unsubstituted or substituted by customary groups, 3- to12-membered heterocyclyl, heterocyclyloxy, heterocyclylthio,heterocyclylamino or heterocyclyl-N-C₁ -C₆ -alkylamino, each of which isunsubstituted or substituted by customary groups, aryl, aryloxy,arylthio, arylamino, aryl-N-C₁ -C₆ -alkylamino, aryl-C₁ -C₆ -alkoxy,aryl-C₁ -C₆ -alkylthio, aryl-C₁ -C₆ -alkylamino, aryl-C₁ -C₆ -alkyl-N-C₁-C₆ -alkyl-amino, hetaryl, hetaryloxy, hetarylthio, hetarylamino,hetaryl-N-C₁ -C₆ -alkylamino, hetaryl-C₁ -C₆ -alkoxy, hetaryl-C₁ -C₆-alkylthio, hetaryl-C₁ -C₆ -alkylamino, hetaryl-C₁ -C₆ -alkyl-N-C₁ -C₆-alkylamino, arylcarbonyl, aryloxycarbonyl, arylcarbonyloxy,arylaminocarbonyl, N-aryl-N-C₁ -C₆ -alkylaminocarbonyl,arylcarbonyl-N-C₁ -C₆ -alkylamino, aryloxycarbonylamino,hetarylcarbonyl, hetaryloxycarbonyl, hetarylcarbonyloxy,hetarylaminocarbonyl, N-hetaryl-N-C₁ -C₆ -alkylaminocarbonyl,hetarylcarbonyl-N-C₁ -C₆ -alkylamino and hetaryloxycarbonylamino, eachof which is unsubstituted or substituted by customary groups, R² is C₁-C₁₀ -alkyl, C₂ -C₁₀ -alkenyl, C₂ -C₁₀ -alkynyl, C₃ -C₁₀ -cycloalkyl orC₅ -C₁₀ -cycloalkenyl, or in the case where X is NR^(a), additionallyhydrogen; R³ is hydrogen, cyano, halogen, C₁ -C₁₀ alkyl, C₁ -C₁₀haloalkyl, C₁ -C₁₀ alkoxy, C₁ -C₁₀ haloalkoxy, C₁ -C₁₀ alkylthio, C₁ -C₄-haloalkylthio or C₃ -C₁₀ -cycloalkyl; R⁴ is a 6- to 10-membered mono-or bicyclic, heteroaromatic ring system selected from the groupconsisting of:2-pyridinyl, 3-pyridinyl, 4-pyridinyl, 3-pyridazinyl,4-pyridazinyl, 2-pyrimidinyl, 4-pyrimidinyl, 5-pyrimidinyl, 2-pyrazinyl,1,3,5-triazin-2-yl, 1,2,4-triazin-3-yl, indolyl, quinolinyl,isoquinolinyl and purinyl, which is substituted by customary groups;itbeing possible for the radicals substituted by customary groups to be:partially or completely halogenated,and/or one to four of the followingradicals cyano, nitro, hydroxyl, amino, carboxyl, aminocarbonyl, C₁ -C₆-alkyl, C₁ -C₆ -haloalkyl, C₂ -C₈ -alkenyl, C₂ -C₈ -haloalkenyl, C₂ -C₈-alkenyloxy, C₂ -C₈ -haloalkenyloxy, C₂ -C₈ -alkynyl, C₂ -C₈-haloalkynyl, C₂ -C₈ -alkynyloxy, C₂ -C₈ -haloalkynyloxy, C₁ -C₆-alkoxy, C₁ -C₆ -haloalkoxy, C₁ -C₆ -alkylthio, C₁ -C₆ -haloalkylthio,C₁ -C₆ -alkylamino, di-C₁ -C₆ -alkylamino, C₁ -C₆ -alkylcarbonyl, C₁ -C₆-alkoxycarbonyl, C₁ -C₆ -alkylcarbonyloxy, C₁ -C₆ -alkylaminocarbonyl,di-C₁ -C₆ -alkylaminocarbonyl, C₁ -C₆ -alkylcarbonylamino, C₁ -C₆-alkoxycarbonylamino and C₁ -C₆ -alkylcarbonyl-N-C₁ -C₆-alkylamino,and/or one to three of the following radicals C₃ -C₁₂-cycloalkyl, C₃ -C₁₂ -cycloalkoxy, C₃ -C₁₂ -cycloalkylthio, C₃ -C₁₂-cycloalkylamino, C₃ -C₁₂ -Cycloalkyl-N-C₁ -C₆ -alkylamino, 3- to12-membered heterocyclyl, heterocyclyloxy, heterocyclylthio,heterocyclylamino or heterocyclyl-N-C₁ -C₆ -alkylamino, aryl, aryloxy,arylthio, arylamino, aryl-N-C₁ -C₆ -alkylamino, aryl-C₁ -C₆ -alkoxy,aryl-C₁ -C₆ -alkylthio, aryl-C₁ -C₆ -alkylamino, aryl-C₁ -C₆ -alkyl-N-C₁-C₆ -alkylamino, hetaryl, hetaryloxy, hetarylthio, hetarylamino,hetaryl-N-C₁ -C₆ -alkylamino, hetaryl-C₁ -C₆ -alkoxy, hetaryl-C₁ -C₆-alkylthio, hetaryl-C₁ -C₆ -alkylamino, hetaryl-C₁ -C₆ -alkyl-N-C₁ -C₆-alkylamino, arylcarbonyl, aryloxycarbonyl, arylcarbonyloxy,arylaminocarbonyl, N-aryl-N-C₁ -C₆ -alkylaminocarbonyl,arylcarbonyl-N-C₁ -C₆ -alkylamino, aryloxycarbonylamino,hetarylcarbonyl, hetaryloxycarbonyl, hetarylcarbonyloxy,hetarylaminocarbonyl, N-hetaryl-N-C₁ -C₆ -alkylaminocarbonyl,hetarylcarbonyl-N-C₁ -C₆ -alkylamino and hetaryloxycarbonylamino,and orone or two of the following radicals formyl or CR^(iii) =NOR^(iv),R^(iii) being hydrogen, C₁ -C₆ -alkyl, C₂ -C₆ -alkenyl, C₃ -C₁₀-cycloalkyl or C₂ -C₆ -alkynyl and R^(iv) being C₁ -C₆ -alkyl, C₂ -C₆-alkenyl, C₂ -C₆ -alkynyl and aryl-C₁ -C₆ -alkyl, or a C₃ -C₅ -alkylene,C₃ -C₅ -alkenylene, oxy-C₂ -C₄ -alkylene, oxy-C₁ -C₃ -alkyleneoxy,oxy-C₂ -C₄ -alkenylene, oxy-C₂ -C₄ -alkenyleneoxy or butadienediyl groupbonded to two adjacent C atoms, it being possible for these bridges inturn to be partially or completely halogenated and/or to carry one tothree of the following radicals: C₁ -C₄ -alkyl, C₁ -C₄ -haloalkyl, C₁-C₄ -alkoxy, C₁ -C₄ -haloalkoxy and C₁ -C₄ -alkylthio.
 2. A compound ofthe formula I as claimed in claim 1, where n is 0 or
 1. 3. A compound ofthe formula I as claimed in claim 1, where R is fluorine, chlorine,cyano, methyl and methoxy.
 4. A compound of the formula I as claimed inclaim 1, where X is a direct bond, CH₂, oxygen or NH.
 5. A compound ofthe formula I as claimed in claim 1, where R¹ is hydrogen, C₁ -C₄-alkyl, allyl, propargyl or methoxymethyl.
 6. A compound of the formulaI as claimed in claim 1, where R⁴ is substituted pyridinyl,2-pyrimidinyl, 4-pyrimidinyl, 5-pyrimidinyl, 1,3,5-triazin-2-yl orisoquinolinyl.
 7. A compound of the formula I as claimed in claim 1,where R⁴ is substituted by pyridin-2-yl, cyano, halogen, C₁ -C₆ -alkyl,C₁ -C₆ -alkoxy, C₂ -C₆ -alkenyl, C₂ -C₆ -alkenyloxy, C₂ -C₆ -alkynyl, C₂-C₆ -alkynyloxy, C₁ -C₆ -haloalkyl, C₁ -C₆ -haloalkoxy, C₂ -C₆-haloalkenyl, C₂ -C₆ -haloalkenoxy, C₂ -C₆ -haloalkynyl, C₂ -C₆-haloalkynyloxy, phenyl, phenoxy, hetaryl or hetaryloxy.
 8. A processfor preparing the compounds of the formula I as claimed in claim 1,where R¹ is not hydrogen, which comprises reacting a methyleneanilide ofthe formula II ##STR16## where L¹ is a leaving group, with an oxime ofthe formula III

    HO--N═CR.sup.3 R.sup.4                                 (III)

or its salt.
 9. A process for preparing the compounds of the formula Ias claimed in claim 1, where R¹ is hydrogen, which comprises convertinga nitrobenzene of the formula IV ##STR17## where L² is a leaving group,with an oxime of the formula HO--N═CR³ R⁴ or its salts, into thecorresponding oxime ether of the formula V ##STR18## reducing V in amanner known per se to the hydroxylamine of the formula VI ##STR19## andthen reacting VI a) with an acylating agent of the formula VIIa

    L.sup.3 --COXR.sup.2                                       (VIIa)

where L³ is halogen, phenoxy or the group R² XCO₂, or b) with anisocyanate of the formula VIIb

    O═C═N--R.sup.2                                     (VIIb)

or c) with a cyanate of the formula VIIc

    M.sup.⊕⊖ OCN                                   (VIIc)

where M⁺ is an equivalent of a metal ion, to give a compound accordingto formula I.
 10. A process for preparing the compounds of the formula Ias claimed in claim 1, where R¹ is not hydrogen, which comprisesreacting a compound of the formula I, where R¹ is hydrogen, in a mannerknown per se with a compound of the formula VIII

    R.sup.1 --L.sup.4                                          (VIII)

where L⁴ is a leaving group.
 11. A process for preparing the compoundsof the formula I as claimed in claim 1, which comprises first convertinga methyleneanilide of the formula II ##STR20## with N-hydroxyphthalimide(IX) ##STR21## into the benzyl ether of the formula X ##STR22## thenhydrolyzing X with ammonia, hydrazine or an amine or with acid catalysisto the hydroxylamine ether of the formula XI ##STR23## and then reactingXI with a carbonyl compound of the formula XII

    O═CR.sup.3 R.sup.4                                     (XII)

to give a compound according to formula I.
 12. A process for preparingthe compounds of the formula I as claimed in claim 1, where X is NR^(a),which comprises first converting a methyleneanilide of the formula IIa##STR24## where L¹ is a leaving group, with an oxime of the formulaHO--N═CR³ R⁴ or its salts, into the corresponding oxime ether of theformula XIII ##STR25## and then reacting XIII with an amine of theformula XIV

    H.sub.2 NR.sup.a                                           (XIV)

to give a compound according to formula I.
 13. An intermediate of theformula XV ##STR26## where Q is NO₂, NHOH or N(OR¹)--CO₂ C₆ H₅,n is 0,1, 2, 3 or 4, it being possible for the substituents R to be differentif n is greater than 1; R is nitro, cyano, halogen,C₁ -C₁₀ -alkyl, C₂-C₁₀ -alkenyl, C₂ -C₁₀ -alkynyl, C₁ -C₁₀ -alkoxy, C₃ -C₁₀ -alkenyloxyand C₃ -C₁₀ -alkynyloxy, it being possible for these groups to bepartially or completely halogenated and/or to carry one to three of thefollowing radicals:cyano, nitro, hydroxyl, amino, formyl, carboxyl,aminocarbonyl, C₁ -C₆ -alkoxy, C₁ -C₆ -haloalkoxy, C₁ -C₆ -alkylthio, C₁-C₆ -haloalkylthio, C₁ -C₆ -alkylamino, di-C₁ -C₆ -alkylamino, C₁ -C₆-alkylcarbonyl, C₁ -C₆ -alkoxycarbonyl, C₁ -C₆ -alkylcarbonyloxy, C₁ -C₆-alkylaminocarbonyl, di-C₁ -C₆ -alkylaminocarbonyl, C₁ -C₆-alkvlcarbonylamino, C₁ -C₆ -alkoxycarbonylamino, C₁ -C₆-alkylcarbonyl-N-C₁ -C₆ -alkylamino, and CR^(iii) =NOR^(iv), R^(iii)being hydrogen, C₁ -C₆ -alkyl, C₂ -C₆ -alkenyl, C₂ -C₆ -alkynyl or C₃-C₁₂ -cycloalkyl and R^(iv) being C₁ -C₆ -alkyl, C₃ -C₆ -alkenyl, C₃ -C₆-alkynyl or aryl-C₁ -C₆ -alkyl,C₃ -C₁₂ -cycloalkyl, C₃ -C₁₂-cycloalkoxy, C₃ -C₁₂ -cycloalkylthio, C₃ -C₁₂ -cycloalkylamino, C₃ -C₁₂-cycloalkyl-N-C₁ -C₆ -alkylamino, each of which is unsubstituted orsubstituted by customary groups, 3- to 12-membered heterocyclyl,heterocyclyloxy, heterocyclylthio, heterocyclylamino orheterocyclyl-N-C₁ -C₆ -alkylamino, each of which is unsubstituted orsubstituted by customary groups, aryl, aryloxy, arylthio, arylamino,aryl-N-C₁ -C₆ -alkylamino, aryl-C₁ -C₆ -alkoxy, aryl-C₁ -C₆ -alkylthio,aryl-C₁ -C₆ -alkylamino, aryl-C₁ -C₆ -alkyl-N-C₁ -C₆ -alkylamino,hetaryl, het-aryloxy, hetarylthio, hetarylamino, hetaryl-N-C₁ -C₆-alkylamino, hetaryl-C₁ -C₆ -alkoxy, hetaryl-C₁ -C₆ -alkylthio,het-aryl-C₁ -C₆ -alkylamino, hetaryl-C₁ -C₆ -alkyl-N-C₁ -C₆ -alkylamino,arylcarbonyl, aryloxycarbonyl, arylcarbonyloxy, arylaminocarbonyl,N-aryl-N-C₁ -C₆ -alkylaminocarbonyl, arylcarbonyl-N-C₁ -C₆ -alkylamino,aryloxycarbonylamino, hetarylcarbonyl, hetaryloxycarbonyl,hetarylcarbonyloxy, hetarylaminocarbonyl, N-hetaryl-N-C₁ -C₆-alkylaminocarbonyl, hetarylcarbonyl-N-C₁ -C₆ -alkylamino andhetaryloxycarbonylamino, each of which is unsubstituted or substitutedby customary groups, or in the case where n is 2, 3 or 4 additionally anunsubstituted or substituted bridge bonded to two adjacent ring atoms,which contains three or four members from the group consisting of 3 or 4carbon atoms, and 2 or 3 carbon atoms and 1 or 2 nitrogen, oxygen and/orsulfur atoms, it being possible for this bridge, together with the ringto which it is bonded, to form a partially unsaturated or aromaticradical; X is a direct bond or CH₂, O or NR^(a) ; R^(a) is hydrogen, C₁-C₁₀ -alkyl, C₂ -C₁₀ -alkenyl, C₂ -C₁₀ -alkynyl, C₃ -C₁₀ -cycloalkyl orC₅ -C₁₀ -cycloalkenyl; R¹ is hydrogen,C₁ -C₁₀ -alkyl, C₂ -C₁₀ -alkenyl,C₂ -C₁₀ -alkynyl, C₃ -C₁₀ -cycloalkyl, C₅ -C₁₀ -cycloalkenyl, C₁ -C₁₀-alkylcarbonyl or C₁ -C₁₀ -alkoxycarbonyl, it being possible for thesegroups to be partially or completely halogenated and/or to carry one tothree of the following radicals:cyano, nitro, hydroxyl, amino, formyl,carboxyl, aminocarbonyl, C₁ -C₆ -alkoxy, C₁ -C₆ -haloalkoxy, C₁ -C₆-alkylthio, C₁ -C₆ -haloalkylthio, C₁ -C₆ -alkylamino, di-C₁ -C₆-alkylamino, C₁ -C₆ -alkylcarbonyl, C₁ -C₆ -alkoxycarbonyl, C₁ -C₆-alkylcarbonyloxy, C₁ -C₆ -alkylaminocarbonyl, di-C₁ -C₆-alkylaminocarbonyl, C₁ -C₆ -alkylcarbonylamino, C₁ -C₆-alkoxycarbonylamino, C₁ -C₆ -alkylcarbonyl-N-C₁ -C₆ -alkylamino, andCR^(iii) =NOR^(iv), R^(iii) being hydrogen, C₁ -C₆ -alkyl, C₂ -C₆-alkenyl, C₂ -C₆ -alkynyl or C₃ -C₁₂ -cycloalkyl and R^(iv) being C₁ -C₆-alkyl, C₃ -C₆ -alkenyl, C₃ -C₆ -alkynyl or aryl-C₁ -C₆ -alkyl, C₃ -C₁₂-cycloalkyl, C₃ -C₁₂ -cycloalkoxy, C₃ C₁₂ -cycloalkylthio, C₃ -C₁₂-cycloalkylamino, C₃ -C₁₂ -cycloalkyl-N-C₁ -C₆ -alkylamino, each ofwhich is unsubstituted or substituted by customary groups, 3- to12-membered heterocyclyl, heterocyclyloxy, heterocyclylthio,heterocyclylamino or heterocyclyl-N-C₁ -C₆ -alkylamino, each of which isunsubstituted or substituted by customary groups, aryl, aryloxy,arylthio, arylamino, aryl-N-C₁ -C₆ -alkylamino, aryl-C₁ -C₆ -alkoxy,aryl-C₁ -C₆ -alkylthio, aryl-C₁ -C₆ -alkylamino, aryl-C₁ -C₆ -alkyl-N-C₁-C₆ -alkyl-amino, hetaryl, hetaryloxy, hetarylthio, hetarylamino,hetaryl-N-C₁ -C₆ -alkylamino, hetaryl-C₁ -C₆ -alkoxy, hetaryl-C₁ -C₆-alkylthio, hetaryl-C₁ -C₆ -alkylamino, hetaryl-C₁ -C₆ -alkyl-N-C₁ -C₆-alkylamino, arylcarbonyl, aryloxycarbonyl, arylcarbonyloxy,arylaminocarbonyl, N-aryl-N-C₁ -C₆ -alkylaminocarbonyl,arylcarbonyl-N-C₁ -C₆ -alkylamino, aryloxycarbonylamino,hetarylcarbonyl, hetaryloxycarbonyl, hetarylcarbonyloxy,hetarylaminocarbonyl, N-hetaryl-N-C₁ -C₆ -alkylaminocarbonyl,hetarylcarbonyl-N-C₁ -C₆ -alkylamino and hetaryloxycarbonylamino, eachof which is unsubstituted or substituted by customary groups, R³ ishydrogen, cyano, halogen, C₁ -C₁₀ -alkyl, C₁ -C₁₀ -haloalkyl, C₁ -C₁₀-alkoxy, C₁ -C₁₀ -haloalkoxy, C₁ -C₁₀ -alkylthio, C₁ -C₄ -haloalkylthioor C₃ -C₁₀ -cycloalkyl; R⁴ is a 6- to 10-membered mono- or bicyclic,heteroaromatic ring system selected from the group consistingof:2-pyridinyl, 3-pyridinyl, 4-pyridinyl, 3-pyridazinyl, 4-pyridazinyl,2-pyrimidinyl, 4-pyrimidinyl, 5-pyrimidinyl, 2-pyrazinyl,1,3,5-triazin-2-yl, 1,2,4-triazin-3-yl, indolyl, quinolinyl,isoquinolinyl and purinyl, which is substituted by customary groups;itbeing possible for the radicals substituted by customary groups to be:partially or completely halogenated, and/or one to four of the followingradicals cyano, nitro, hydroxyl, amino, carboxyl, aminocarbonyl, C₁ -C₆-alkyl, C₁ -C₆ -haloalkyl, C₂ -C₈ -alkenyl, C₂ -C₈ -haloalkenyl, C₂ -C₈-alkenyloxy, C₂ -C₈ -haloalkenyloxy, C₂ -C₈ -alkynyl, C₂ -C₈-haloalkynyl, C₂ -C₈ -alkynyloxy, C₂ -C₈ -haloalkynyloxy, C₁ -C₆-alkoxy, C₁ -C₆ -haloalkoxy, C₁ -C₆ -alkylthio, C₁ -C₆ -haloalkylthio,C₁ -C₆ -alkylamino, di-C₁ -C₆ -alkylamino, C₁ -C₆ -alkylcarbonyl, C₁ -C₆-alkoxycarbonyl, C₁ -C₆ -alkylcarbonyloxy, C₁ -C₆ -alkylaminocarbonyl,di-C₁ -C₆ -alkylaminocarbonyl, C₁ -C₆ -alkylcarbonylamino, C₁ -C₆-alkoxycarbonylamino and C₁ -C₆ -alkylcarbonyl-N-C₁ -C₆-alkylamino,and/or one to three of the following radicals C₃ -C₁₂-cycloalkyl, C₃ -C₁₂ -cycloalkoxy, C₃ -C₁₂ -cycloalkylthio, C₃ -C₁₂-cycloalkylamino, C₃ -C₁₂ -cycloalkyl-N-C₁ -C₆ -alkylamino, 3- to12-membered heterocyclyl, heterocyclyloxy, heterocyclylthio,heterocyclylamino or heterocyclyl-N-C₁ -C₆ -alkylamino, aryl, aryloxy,arylthio, arylamino, aryl-N-C₁ -C₆ -alkylamino, aryl-C₁ -C₆ -alkoxy,aryl-C₁ -C₆ -alkylthio, aryl-C₁ -C₆ -alkylamino, aryl-C₁ -C₆ -alkyl-N-C₁-C₆ -alkylamino, hetaryl, hetaryloxy, hetarylthio, hetarylamino,hetaryl-N-C₁ -C₆ -alkylamino, hetaryl-C₁ -C₆ -alkoxy, hetaryl-C₁ -C₆-alkylthio, hetaryl-C₁ -C₆ -alkylamino, hetaryl-C₁ -C₆ -alkyl-N-C₁ -C₆-alkylamino, arylcarbonyl, aryloxycarbonyl, arylcarbonyloxy,arylaminocarbonyl, N-aryl-N-C₁ -C₆ -alkylaminocarbonyl,arylcarbonyl-N-C₁ -C₆ -alkylamino, aryloxycarbonylamino,hetarylcarbonyl, hetaryloxycarbonyl, hetarylcarbonyloxy,hetarylaminocarbonyl, N-hetaryl-N-C₁ -C₆ -alkylaminocarbonyl,hetarylcarbonyl-N-C₁ -C₆ -alkylamino and hetaryloxycarbonylamino,and orone or two of the following radicals formyl or CR^(iii) =NOR^(iv),R^(iii) being hydrogen, C₁ -C₆ -alkyl, C₂ -C₆ -alkenyl, C₃ -C₁₀-cycloalkyl or C₂ -C₆ -alkynyl and R^(iv) being C₁ -C₆ -alkyl, C₂ -C₆-alkenyl, C₂ -C₆ -alkynyl and aryl-C₁ -C₆ -alkyl, or a C₃ -C₅ -alkylene,C₃ -C₅ -alkenylene, oxy-C₂ -C₄ -alkylene, oxy-C₁ -C₃ -alkyleneoxy,oxy-C₂ -C₄ -alkenylene, oxy-C₂ -C₄ -alkenyleneoxy or butadienediyl groupbonded to two adjacent C atoms, it being possible for these bridges inturn to be partially or completely halogenated and/or to carry one tothree of the following radicals: C₁ -C₄ -alkyl, C₁ -C₄ -haloalkyl, C₁-C₄ -alkoxy, C₁ -C₄ -haloalkoxy and C₁ -C₄ -alkylthio.
 14. A compositionsuitable for controlling animal pests or harmful fungi, containing asolid or liquid carrier and a compound of the formula I as claimed inclaim
 1. 15. A method of controlling animal pests or harmful fungi,which comprises treating the fungi or the materials, plants, soil orseed to be protected from fungal attack with an effective amount of acompound of the formula I as claimed in claim 1.